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Protein

Mitochondrial intermembrane space import and assembly protein 40

Gene

CHCHD4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Functions as chaperone and catalyzes the formation of disulfide bonds in substrate proteins, such as COX17, COX19 and MICU1 (PubMed:16185709, PubMed:26387864, PubMed:19182799, PubMed:21059946, PubMed:23186364, PubMed:23676665). Required for the import and folding of small cysteine-containing proteins (small Tim) in the mitochondrial intermembrane space (IMS). Precursor proteins to be imported into the IMS are translocated in their reduced form into the mitochondria. The oxidized form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with the reduced precursor protein, resulting in oxidation of the precursor protein that now contains an intramolecular disulfide bond and is able to undergo folding in the IMS (PubMed:16185709, PubMed:19182799, PubMed:21059946, PubMed:23676665). Reduced CHCHD4/MIA40 is then reoxidized by GFER/ERV1 via a disulfide relay system (PubMed:23186364). Mediates formation of disulfide bond in MICU1 in the IMS, promoting formation of the MICU1-MICU2 heterodimer that regulates mitochondrial calcium uptake (PubMed:26387864).6 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • protein disulfide oxidoreductase activity Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase
Biological processProtein transport, Translocation, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1268020 Mitochondrial protein import

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Mitochondrial intermembrane space import and assembly protein 40
Alternative name(s):
Coiled-coil-helix-coiled-coil-helix domain-containing protein 4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CHCHD4
Synonyms:MIA40
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000163528.12

Human Gene Nomenclature Database

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HGNCi
HGNC:26467 CHCHD4

Online Mendelian Inheritance in Man (OMIM)

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MIMi
611077 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8N4Q1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi53C → S: Does not strongly affect import and stability of CHCHD4 in mitochondria; when associated with S-55. No effect on disulfide exchange with substrate proteins. 3 Publications1
Mutagenesisi55C → S: Does not strongly affect import and stability of CHCHD4 in mitochondria; when associated with S-53. Nearly abolishes disulfide exchange with substrate proteins. 2 Publications1
Mutagenesisi64C → S: Affects import and stability of CHCHD4 in mitochondria; when associated with S-74. 1 Publication1
Mutagenesisi74C → S: Affects import and stability of CHCHD4 in mitochondria; when associated with S-64. 1 Publication1
Mutagenesisi87C → S: Strongly affects import and stability of CHCHD4 in mitochondria; when associated with S-97. 1 Publication1
Mutagenesisi97C → S: Strongly affects import and stability of CHCHD4 in mitochondria; when associated with S-87. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
131474

Open Targets

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OpenTargetsi
ENSG00000163528

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134990707

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CHCHD4

Domain mapping of disease mutations (DMDM)

More...
DMDMi
62510498

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001291651 – 142Mitochondrial intermembrane space import and assembly protein 40Add BLAST142

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi53 ↔ 55Redox-active1 Publication1 Publication
Disulfide bondi64 ↔ 97PROSITE-ProRule annotationCombined sources2 Publications
Disulfide bondi74 ↔ 87PROSITE-ProRule annotationCombined sources2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Forms intrachain disulfide bridges, but exists in different redox states.

Keywords - PTMi

Disulfide bond

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8N4Q1

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8N4Q1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8N4Q1

PeptideAtlas

More...
PeptideAtlasi
Q8N4Q1

PRoteomics IDEntifications database

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PRIDEi
Q8N4Q1

ProteomicsDB human proteome resource

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ProteomicsDBi
71958
71959 [Q8N4Q1-2]

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
Q8N4Q1-1 [Q8N4Q1-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8N4Q1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8N4Q1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in all tissues tested, suggesting an ubiquitous expression.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000163528 Expressed in 197 organ(s), highest expression level in deltoid

CleanEx database of gene expression profiles

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CleanExi
HS_CHCHD4

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q8N4Q1 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q8N4Q1 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA034688
HPA063727

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer (PubMed:19182799). Can form homooligomers (PubMed:16185709). Interacts with GFER and forms transient disulfide bonds with GFER (PubMed:23186364, PubMed:23676665). Interacts with MICU1 (PubMed:26387864). Interacts with COX19 forming transient intermolecular disulfide bridges (PubMed:23676665).4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
COX17Q140612EBI-15755238,EBI-711311

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
126282, 74 interactors

Database of interacting proteins

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DIPi
DIP-48483N

Protein interaction database and analysis system

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IntActi
Q8N4Q1, 17 interactors

Molecular INTeraction database

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MINTi
Q8N4Q1

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000295767

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1142
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Database of protein disorder

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DisProti
DP00912

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q8N4Q1

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8N4Q1

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q8N4Q1

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini61 – 105CHCHPROSITE-ProRule annotationAdd BLAST45

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi64 – 74Cx9C motif 1PROSITE-ProRule annotationAdd BLAST11
Motifi87 – 97Cx9C motif 2PROSITE-ProRule annotationAdd BLAST11

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi108 – 117Asp/Glu-rich (acidic)Curated10

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The CHCH domain contains a conserved twin Cys-X9-Cys motif which is required for import and stability of MIA40 in mitochondria.Curated

Keywords - Domaini

Redox-active center

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4149 Eukaryota
ENOG4111V0I LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000013132

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000013070

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG050937

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q8N4Q1

KEGG Orthology (KO)

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KOi
K17782

Identification of Orthologs from Complete Genome Data

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OMAi
CVIRTGC

Database for complete collections of gene phylogenies

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PhylomeDBi
Q8N4Q1

TreeFam database of animal gene trees

More...
TreeFami
TF314054

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR010625 CHCH
IPR039289 CHCHD4

The PANTHER Classification System

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PANTHERi
PTHR21622 PTHR21622, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF06747 CHCH, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51808 CHCH, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8N4Q1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSYCRQEGKD RIIFVTKEDH ETPSSAELVA DDPNDPYEEH GLILPNGNIN
60 70 80 90 100
WNCPCLGGMA SGPCGEQFKS AFSCFHYSTE EIKGSDCVDQ FRAMQECMQK
110 120 130 140
YPDLYPQEDE DEEEEREKKP AEQAEETAPI EATATKEEEG SS
Length:142
Mass (Da):15,996
Last modified:October 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i87563CADF249800C
GO
Isoform 2 (identifier: Q8N4Q1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-6: MSYCRQ → MPVSYSSVTTRYYHRAGAE

Note: No experimental confirmation available.
Show »
Length:155
Mass (Da):17,385
Checksum:iC0477CE14E8775FD
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0184331 – 6MSYCRQ → MPVSYSSVTTRYYHRAGAE in isoform 2. 1 Publication6

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK056271 mRNA Translation: BAB71132.1
AK290764 mRNA Translation: BAF83453.1
CH471055 Genomic DNA Translation: EAW64180.1
BC017082 mRNA Translation: AAH17082.2
BC033775 mRNA Translation: AAH33775.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS2617.1 [Q8N4Q1-2]
CCDS43054.1 [Q8N4Q1-1]

NCBI Reference Sequences

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RefSeqi
NP_001091972.1, NM_001098502.1 [Q8N4Q1-1]
NP_653237.1, NM_144636.2 [Q8N4Q1-2]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.517815

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000295767; ENSP00000295767; ENSG00000163528 [Q8N4Q1-2]
ENST00000396914; ENSP00000380122; ENSG00000163528 [Q8N4Q1-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
131474

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:131474

UCSC genome browser

More...
UCSCi
uc003byi.5 human [Q8N4Q1-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056271 mRNA Translation: BAB71132.1
AK290764 mRNA Translation: BAF83453.1
CH471055 Genomic DNA Translation: EAW64180.1
BC017082 mRNA Translation: AAH17082.2
BC033775 mRNA Translation: AAH33775.1
CCDSiCCDS2617.1 [Q8N4Q1-2]
CCDS43054.1 [Q8N4Q1-1]
RefSeqiNP_001091972.1, NM_001098502.1 [Q8N4Q1-1]
NP_653237.1, NM_144636.2 [Q8N4Q1-2]
UniGeneiHs.517815

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2K3JNMR-A1-142[»]
2L0YNMR-A1-142[»]
DisProtiDP00912
ProteinModelPortaliQ8N4Q1
SMRiQ8N4Q1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126282, 74 interactors
DIPiDIP-48483N
IntActiQ8N4Q1, 17 interactors
MINTiQ8N4Q1
STRINGi9606.ENSP00000295767

PTM databases

iPTMnetiQ8N4Q1
PhosphoSitePlusiQ8N4Q1

Polymorphism and mutation databases

BioMutaiCHCHD4
DMDMi62510498

Proteomic databases

EPDiQ8N4Q1
MaxQBiQ8N4Q1
PaxDbiQ8N4Q1
PeptideAtlasiQ8N4Q1
PRIDEiQ8N4Q1
ProteomicsDBi71958
71959 [Q8N4Q1-2]
TopDownProteomicsiQ8N4Q1-1 [Q8N4Q1-1]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000295767; ENSP00000295767; ENSG00000163528 [Q8N4Q1-2]
ENST00000396914; ENSP00000380122; ENSG00000163528 [Q8N4Q1-1]
GeneIDi131474
KEGGihsa:131474
UCSCiuc003byi.5 human [Q8N4Q1-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
131474
DisGeNETi131474
EuPathDBiHostDB:ENSG00000163528.12

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CHCHD4
HGNCiHGNC:26467 CHCHD4
HPAiHPA034688
HPA063727
MIMi611077 gene
neXtProtiNX_Q8N4Q1
OpenTargetsiENSG00000163528
PharmGKBiPA134990707

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG4149 Eukaryota
ENOG4111V0I LUCA
GeneTreeiENSGT00390000013132
HOGENOMiHOG000013070
HOVERGENiHBG050937
InParanoidiQ8N4Q1
KOiK17782
OMAiCVIRTGC
PhylomeDBiQ8N4Q1
TreeFamiTF314054

Enzyme and pathway databases

ReactomeiR-HSA-1268020 Mitochondrial protein import

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
CHCHD4 human
EvolutionaryTraceiQ8N4Q1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
131474

Protein Ontology

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PROi
PR:Q8N4Q1

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000163528 Expressed in 197 organ(s), highest expression level in deltoid
CleanExiHS_CHCHD4
ExpressionAtlasiQ8N4Q1 baseline and differential
GenevisibleiQ8N4Q1 HS

Family and domain databases

InterProiView protein in InterPro
IPR010625 CHCH
IPR039289 CHCHD4
PANTHERiPTHR21622 PTHR21622, 1 hit
PfamiView protein in Pfam
PF06747 CHCH, 1 hit
PROSITEiView protein in PROSITE
PS51808 CHCH, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMIA40_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8N4Q1
Secondary accession number(s): A8K3Z9, Q96AI2, Q96MY6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: October 1, 2002
Last modified: November 7, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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