Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Prostaglandin reductase 3

Gene

ZADH2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto-PGE2-alpha with highest efficienty towards 15-keto-PGE2-alpha. Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei185NADP; via amide nitrogen1 Publication1
Binding sitei205NADP1 Publication1
Binding sitei209NADP1 Publication1
Binding sitei224NADP1 Publication1
Binding sitei247NADP1 Publication1
Binding sitei269NADP; via carbonyl oxygen1 Publication1
Binding sitei275NADP1 Publication1
Binding sitei361NADP1 Publication1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi303 – 305NADP1 Publication3

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase
LigandNADP

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Prostaglandin reductase 3 (EC:1.3.1.48By similarity)
Short name:
PRG-3
Alternative name(s):
Zinc-binding alcohol dehydrogenase domain-containing protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZADH2Imported
Synonyms:PTGR3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 18

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000180011.6

Human Gene Nomenclature Database

More...
HGNCi
HGNC:28697 ZADH2

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8N4Q0

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Peroxisome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
284273

Open Targets

More...
OpenTargetsi
ENSG00000180011

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134951623

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZADH2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74728888

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002234671 – 377Prostaglandin reductase 3Add BLAST377

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei35N6-acetyllysineBy similarity1
Modified residuei299PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8N4Q0

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8N4Q0

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8N4Q0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8N4Q0

PeptideAtlas

More...
PeptideAtlasi
Q8N4Q0

PRoteomics IDEntifications database

More...
PRIDEi
Q8N4Q0

ProteomicsDB human proteome resource

More...
ProteomicsDBi
71957

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8N4Q0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8N4Q0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000180011 Expressed in 193 organ(s), highest expression level in quadriceps femoris

CleanEx database of gene expression profiles

More...
CleanExi
HS_ZADH2

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8N4Q0 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8N4Q0 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA021468
HPA053646

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
129813, 16 interactors

Protein interaction database and analysis system

More...
IntActi
Q8N4Q0, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000323678

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1377
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2C0CX-ray1.45A/B33-371[»]
2WEKX-ray1.90A/B33-371[»]
2X1HX-ray1.75A/B33-371[»]
2X7HX-ray1.60A/B25-371[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q8N4Q0

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8N4Q0

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q8N4Q0

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IQ9R Eukaryota
COG2130 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00920000149172

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000294682

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG056525

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8N4Q0

KEGG Orthology (KO)

More...
KOi
K07119

Identification of Orthologs from Complete Genome Data

More...
OMAi
YMAPGSF

Database of Orthologous Groups

More...
OrthoDBi
929126at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8N4Q0

TreeFam database of animal gene trees

More...
TreeFami
TF328691

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013149 ADH_C
IPR013154 ADH_N
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
IPR020843 PKS_ER
IPR002364 Quin_OxRdtase/zeta-crystal_CS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08240 ADH_N, 1 hit
PF00107 ADH_zinc_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00829 PKS_ER, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50129 SSF50129, 1 hit
SSF51735 SSF51735, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01162 QOR_ZETA_CRYSTAL, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8N4Q0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLRLVPTGAR AIVDMSYARH FLDFQGSAIP QAMQKLVVTR LSPNFREAVT
60 70 80 90 100
LSRDCPVPLP GDGDLLVRNR FVGVNASDIN YSAGRYDPSV KPPFDIGFEG
110 120 130 140 150
IGEVVALGLS ASARYTVGQA VAYMAPGSFA EYTVVPASIA TPVPSVKPEY
160 170 180 190 200
LTLLVSGTTA YISLKELGGL SEGKKVLVTA AAGGTGQFAM QLSKKAKCHV
210 220 230 240 250
IGTCSSDEKS AFLKSLGCDR PINYKTEPVG TVLKQEYPEG VDVVYESVGG
260 270 280 290 300
AMFDLAVDAL ATKGRLIVIG FISGYQTPTG LSPVKAGTLP AKLLKKSASV
310 320 330 340 350
QGFFLNHYLS KYQAAMSHLL EMCVSGDLVC EVDLGDLSPE GRFTGLESIF
360 370
RAVNYMYMGK NTGKIVVELP HSVNSKL
Length:377
Mass (Da):40,140
Last modified:October 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9CDC927D815314D1
GO
Isoform 2 (identifier: Q8N4Q0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-123: Missing.

Note: No experimental confirmation available.
Show »
Length:254
Mass (Da):26,900
Checksum:i1335CE641CBEE387
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3QQQ7J3QQQ7_HUMAN
Prostaglandin reductase 3
ZADH2
101Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KTQ8J3KTQ8_HUMAN
Prostaglandin reductase 3
ZADH2
154Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_048202323C → F. Corresponds to variant dbSNP:rs17056661Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0557961 – 123Missing in isoform 2. 1 PublicationAdd BLAST123

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK292880 mRNA Translation: BAF85569.1
AK302801 mRNA Translation: BAG64003.1
AC025105 Genomic DNA No translation available.
CH471117 Genomic DNA Translation: EAW66569.1
BC033780 mRNA Translation: AAH33780.1
BC078661 mRNA Translation: AAH78661.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS12008.1 [Q8N4Q0-1]
CCDS77198.1 [Q8N4Q0-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001293022.1, NM_001306093.1 [Q8N4Q0-2]
NP_787103.1, NM_175907.5 [Q8N4Q0-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.465433
Hs.719383

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000322342; ENSP00000323678; ENSG00000180011 [Q8N4Q0-1]
ENST00000537114; ENSP00000440111; ENSG00000180011 [Q8N4Q0-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
284273

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:284273

UCSC genome browser

More...
UCSCi
uc002llx.4 human [Q8N4Q0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK292880 mRNA Translation: BAF85569.1
AK302801 mRNA Translation: BAG64003.1
AC025105 Genomic DNA No translation available.
CH471117 Genomic DNA Translation: EAW66569.1
BC033780 mRNA Translation: AAH33780.1
BC078661 mRNA Translation: AAH78661.1
CCDSiCCDS12008.1 [Q8N4Q0-1]
CCDS77198.1 [Q8N4Q0-2]
RefSeqiNP_001293022.1, NM_001306093.1 [Q8N4Q0-2]
NP_787103.1, NM_175907.5 [Q8N4Q0-1]
UniGeneiHs.465433
Hs.719383

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2C0CX-ray1.45A/B33-371[»]
2WEKX-ray1.90A/B33-371[»]
2X1HX-ray1.75A/B33-371[»]
2X7HX-ray1.60A/B25-371[»]
ProteinModelPortaliQ8N4Q0
SMRiQ8N4Q0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129813, 16 interactors
IntActiQ8N4Q0, 2 interactors
STRINGi9606.ENSP00000323678

PTM databases

iPTMnetiQ8N4Q0
PhosphoSitePlusiQ8N4Q0

Polymorphism and mutation databases

BioMutaiZADH2
DMDMi74728888

Proteomic databases

EPDiQ8N4Q0
jPOSTiQ8N4Q0
MaxQBiQ8N4Q0
PaxDbiQ8N4Q0
PeptideAtlasiQ8N4Q0
PRIDEiQ8N4Q0
ProteomicsDBi71957

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
284273
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000322342; ENSP00000323678; ENSG00000180011 [Q8N4Q0-1]
ENST00000537114; ENSP00000440111; ENSG00000180011 [Q8N4Q0-2]
GeneIDi284273
KEGGihsa:284273
UCSCiuc002llx.4 human [Q8N4Q0-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
284273
DisGeNETi284273
EuPathDBiHostDB:ENSG00000180011.6

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ZADH2
HGNCiHGNC:28697 ZADH2
HPAiHPA021468
HPA053646
neXtProtiNX_Q8N4Q0
OpenTargetsiENSG00000180011
PharmGKBiPA134951623

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IQ9R Eukaryota
COG2130 LUCA
GeneTreeiENSGT00920000149172
HOGENOMiHOG000294682
HOVERGENiHBG056525
InParanoidiQ8N4Q0
KOiK07119
OMAiYMAPGSF
OrthoDBi929126at2759
PhylomeDBiQ8N4Q0
TreeFamiTF328691

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ZADH2 human
EvolutionaryTraceiQ8N4Q0

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
284273

Protein Ontology

More...
PROi
PR:Q8N4Q0

Gene expression databases

BgeeiENSG00000180011 Expressed in 193 organ(s), highest expression level in quadriceps femoris
CleanExiHS_ZADH2
ExpressionAtlasiQ8N4Q0 baseline and differential
GenevisibleiQ8N4Q0 HS

Family and domain databases

InterProiView protein in InterPro
IPR013149 ADH_C
IPR013154 ADH_N
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
IPR020843 PKS_ER
IPR002364 Quin_OxRdtase/zeta-crystal_CS
PfamiView protein in Pfam
PF08240 ADH_N, 1 hit
PF00107 ADH_zinc_N, 1 hit
SMARTiView protein in SMART
SM00829 PKS_ER, 1 hit
SUPFAMiSSF50129 SSF50129, 1 hit
SSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS01162 QOR_ZETA_CRYSTAL, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPTGR3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8N4Q0
Secondary accession number(s): A8KA15, B4DZ91
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: October 1, 2002
Last modified: January 16, 2019
This is version 143 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again