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Entry version 141 (07 Apr 2021)
Sequence version 1 (01 Oct 2002)
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Protein

Leucine-rich repeat-containing protein 71

Gene

LRRC71

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q8N4P6

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Leucine-rich repeat-containing protein 71
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LRRC71
Synonyms:C1orf92
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:26556, LRRC71

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8N4P6

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000160838.13

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
149499

Open Targets

More...
OpenTargetsi
ENSG00000160838

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142672476

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8N4P6, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
LRRC71

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74759883

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002845421 – 559Leucine-rich repeat-containing protein 71Add BLAST559

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8N4P6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8N4P6

PeptideAtlas

More...
PeptideAtlasi
Q8N4P6

PRoteomics IDEntifications database

More...
PRIDEi
Q8N4P6

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
71955 [Q8N4P6-1]
71956 [Q8N4P6-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8N4P6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8N4P6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000160838, Expressed in right uterine tube and 129 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8N4P6, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000160838, Tissue enhanced (brain, fallopian tube, testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
127220, 2 interactors

Protein interaction database and analysis system

More...
IntActi
Q8N4P6, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000336661

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8N4P6, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati172 – 193LRR 1Add BLAST22
Repeati196 – 216LRR 2Add BLAST21
Repeati221 – 241LRR 3Add BLAST21
Repeati253 – 266LRR 4Add BLAST14
Repeati281 – 302LRR 5Add BLAST22

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4308, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00440000034367

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_035960_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8N4P6

Identification of Orthologs from Complete Genome Data

More...
OMAi
IDFAELC

Database of Orthologous Groups

More...
OrthoDBi
1139284at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8N4P6

TreeFam database of animal gene trees

More...
TreeFami
TF329605

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.80.10.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001611, Leu-rich_rpt
IPR032675, LRR_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13516, LRR_6, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8N4P6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSSEQSAPGA SPRAPRPGTQ KSSGAVTKKG ERAAKEKPAT VLPPVGEEEP
60 70 80 90 100
KSPEEYQCSG VLETDFAELC TRWGYTDFPK VVNRPRPHPP FVPSASLSEK
110 120 130 140 150
ATLDDPRLSG SCSLNSLESK YVFFRPTIQV ELEQEDSKSV KEIYIRGWKV
160 170 180 190 200
EERILGVFSK CLPPLTQLQA INLWKVGLTD KTLTTFIELL PLCSSTLRKV
210 220 230 240 250
SLEGNPLPEQ SYHKLMALDS TIAHLSLRNN NIDDRGAQLL GQALSTLHSC
260 270 280 290 300
NRTLVSLNLG FNHIGDEGAG YIADGLRLNR SLLWLSLAHN RIQDKGALKL
310 320 330 340 350
AEVLRAFELT HTEVVERRRL LLEKGTQERS RSPSSSRHGD SKTDREKSQM
360 370 380 390 400
VGISNSALVD KTDKTQTMKT PKGLGKKKEK SWELAKKEEK LGSGQSPTQG
410 420 430 440 450
TPKKEDATKA GKGKVTIPEQ KPSRAKGIKI GSREKRSILL ESELVVEATE
460 470 480 490 500
VVNPLLEPVE HRDGKVFMPG NKVLLHLNLI RNRITEVGLE GFLATVQYQM
510 520 530 540 550
QFSKAKSASK GPVGLLWLSL AKNCFAPQCP AYAIIQELML PRDPIKAKLR

EDEAMAFFP
Length:559
Mass (Da):61,825
Last modified:October 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE7FA2674403C21DC
GO
Isoform 2 (identifier: Q8N4P6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-215: Missing.
     443-443: E → EQ
     522-559: KNCFAPQCPA...REDEAMAFFP → VSPFHSLLLK...ASPHNVLRTP

Show »
Length:354
Mass (Da):39,009
Checksum:i0995FA9DBE7E4D6B
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_031773483R → H. Corresponds to variant dbSNP:rs12119908Ensembl.1
Natural variantiVAR_031774503S → A. Corresponds to variant dbSNP:rs822431Ensembl.1
Natural variantiVAR_059593533A → T. Corresponds to variant dbSNP:rs11264585Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0245601 – 215Missing in isoform 2. 1 PublicationAdd BLAST215
Alternative sequenceiVSP_024561443E → EQ in isoform 2. 1 Publication1
Alternative sequenceiVSP_024562522 – 559KNCFA…MAFFP → VSPFHSLLLKQTLPLSAVIL DSCCRQLLSPHFQGRKIASP HNVLRTP in isoform 2. 1 PublicationAdd BLAST38

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK057446 mRNA Translation: BAB71490.1
AL356104 Genomic DNA No translation available.
BC033790 mRNA Translation: AAH33790.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS44249.1 [Q8N4P6-1]

NCBI Reference Sequences

More...
RefSeqi
NP_653303.2, NM_144702.2 [Q8N4P6-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000337428; ENSP00000336661; ENSG00000160838 [Q8N4P6-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
149499

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:149499

UCSC genome browser

More...
UCSCi
uc001fqm.3, human [Q8N4P6-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057446 mRNA Translation: BAB71490.1
AL356104 Genomic DNA No translation available.
BC033790 mRNA Translation: AAH33790.1
CCDSiCCDS44249.1 [Q8N4P6-1]
RefSeqiNP_653303.2, NM_144702.2 [Q8N4P6-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi127220, 2 interactors
IntActiQ8N4P6, 2 interactors
STRINGi9606.ENSP00000336661

PTM databases

iPTMnetiQ8N4P6
PhosphoSitePlusiQ8N4P6

Genetic variation databases

BioMutaiLRRC71
DMDMi74759883

Proteomic databases

MassIVEiQ8N4P6
PaxDbiQ8N4P6
PeptideAtlasiQ8N4P6
PRIDEiQ8N4P6
ProteomicsDBi71955 [Q8N4P6-1]
71956 [Q8N4P6-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
34229, 30 antibodies

The DNASU plasmid repository

More...
DNASUi
149499

Genome annotation databases

EnsembliENST00000337428; ENSP00000336661; ENSG00000160838 [Q8N4P6-1]
GeneIDi149499
KEGGihsa:149499
UCSCiuc001fqm.3, human [Q8N4P6-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
149499
DisGeNETi149499

GeneCards: human genes, protein and diseases

More...
GeneCardsi
LRRC71
HGNCiHGNC:26556, LRRC71
HPAiENSG00000160838, Tissue enhanced (brain, fallopian tube, testis)
neXtProtiNX_Q8N4P6
OpenTargetsiENSG00000160838
PharmGKBiPA142672476
VEuPathDBiHostDB:ENSG00000160838.13

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4308, Eukaryota
GeneTreeiENSGT00440000034367
HOGENOMiCLU_035960_0_0_1
InParanoidiQ8N4P6
OMAiIDFAELC
OrthoDBi1139284at2759
PhylomeDBiQ8N4P6
TreeFamiTF329605

Enzyme and pathway databases

PathwayCommonsiQ8N4P6

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
149499, 11 hits in 984 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
LRRC71, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
149499
PharosiQ8N4P6, Tdark

Protein Ontology

More...
PROi
PR:Q8N4P6
RNActiQ8N4P6, protein

Gene expression databases

BgeeiENSG00000160838, Expressed in right uterine tube and 129 other tissues
GenevisibleiQ8N4P6, HS

Family and domain databases

Gene3Di3.80.10.10, 2 hits
InterProiView protein in InterPro
IPR001611, Leu-rich_rpt
IPR032675, LRR_dom_sf
PfamiView protein in Pfam
PF13516, LRR_6, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLRC71_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8N4P6
Secondary accession number(s): Q96M24
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: October 1, 2002
Last modified: April 7, 2021
This is version 141 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
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