UniProtKB - Q8N4N3 (KLH36_HUMAN)
Protein
Kelch-like protein 36
Gene
KLHL36
Organism
Homo sapiens (Human)
Status
Functioni
Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.1 Publication
: protein ubiquitination Pathwayi
This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.
GO - Molecular functioni
- cullin family protein binding Source: UniProtKB
GO - Biological processi
- protein ubiquitination Source: UniProtKB-UniPathway
Keywordsi
Biological process | Ubl conjugation pathway |
Enzyme and pathway databases
PathwayCommonsi | Q8N4N3 |
UniPathwayi | UPA00143 |
Names & Taxonomyi
Protein namesi | Recommended name: Kelch-like protein 36 |
Gene namesi | Name:KLHL36 Synonyms:C16orf44 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:17844, KLHL36 |
neXtProti | NX_Q8N4N3 |
VEuPathDBi | HostDB:ENSG00000135686.12 |
Pathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000135686 |
PharmGKBi | PA162393612 |
Miscellaneous databases
Pharosi | Q8N4N3, Tdark |
Genetic variation databases
BioMutai | KLHL36 |
DMDMi | 74728879 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000274691 | 1 – 616 | Kelch-like protein 36Add BLAST | 616 |
Proteomic databases
EPDi | Q8N4N3 |
jPOSTi | Q8N4N3 |
MassIVEi | Q8N4N3 |
MaxQBi | Q8N4N3 |
PaxDbi | Q8N4N3 |
PeptideAtlasi | Q8N4N3 |
PRIDEi | Q8N4N3 |
ProteomicsDBi | 71948 [Q8N4N3-1] 71949 [Q8N4N3-2] |
PTM databases
iPTMneti | Q8N4N3 |
PhosphoSitePlusi | Q8N4N3 |
Expressioni
Gene expression databases
Bgeei | ENSG00000135686, Expressed in adipose tissue of abdominal region and 227 other tissues |
ExpressionAtlasi | Q8N4N3, baseline and differential |
Genevisiblei | Q8N4N3, HS |
Organism-specific databases
HPAi | ENSG00000135686, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with CUL3.
1 PublicationBinary interactionsi
Hide detailsQ8N4N3
With | #Exp. | IntAct |
---|---|---|
HEXB [P07686] | 3 | EBI-6426427,EBI-7133736 |
Isoform 2 [Q8N4N3-2]
GO - Molecular functioni
- cullin family protein binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 122886, 27 interactors |
IntActi | Q8N4N3, 32 interactors |
STRINGi | 9606.ENSP00000456743 |
Miscellaneous databases
RNActi | Q8N4N3, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 46 – 113 | BTBPROSITE-ProRule annotationAdd BLAST | 68 | |
Domaini | 148 – 250 | BACKAdd BLAST | 103 | |
Repeati | 296 – 345 | Kelch 1Add BLAST | 50 | |
Repeati | 346 – 397 | Kelch 2Add BLAST | 52 | |
Repeati | 398 – 444 | Kelch 3Add BLAST | 47 | |
Repeati | 446 – 493 | Kelch 4Add BLAST | 48 | |
Repeati | 494 – 546 | Kelch 5Add BLAST | 53 | |
Repeati | 547 – 595 | Kelch 6Add BLAST | 49 |
Keywords - Domaini
Kelch repeat, RepeatPhylogenomic databases
eggNOGi | KOG4441, Eukaryota |
GeneTreei | ENSGT00940000157543 |
HOGENOMi | CLU_004253_14_3_1 |
InParanoidi | Q8N4N3 |
OMAi | VWQGRIY |
OrthoDBi | 250404at2759 |
PhylomeDBi | Q8N4N3 |
TreeFami | TF328485 |
Family and domain databases
Gene3Di | 2.120.10.80, 1 hit |
InterProi | View protein in InterPro IPR011705, BACK IPR017096, BTB-kelch_protein IPR000210, BTB/POZ_dom IPR015915, Kelch-typ_b-propeller IPR006652, Kelch_1 IPR030585, KLHL36 IPR011333, SKP1/BTB/POZ_sf |
PANTHERi | PTHR45632:SF4, PTHR45632:SF4, 1 hit |
Pfami | View protein in Pfam PF07707, BACK, 1 hit PF00651, BTB, 1 hit PF01344, Kelch_1, 4 hits |
PIRSFi | PIRSF037037, Kelch-like_protein_gigaxonin, 1 hit |
SMARTi | View protein in SMART SM00875, BACK, 1 hit SM00225, BTB, 1 hit SM00612, Kelch, 6 hits |
SUPFAMi | SSF117281, SSF117281, 1 hit SSF54695, SSF54695, 1 hit |
PROSITEi | View protein in PROSITE PS50097, BTB, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q8N4N3-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MMEGSRQTRV SRPYKISESS KVYRWADHSS TVLQRLNEQR LRGLFCDVVL
60 70 80 90 100
VADEQRVPAH RNLLAVCSDY FNSMFTIGMR EAFQKEVELI GASYIGLKAV
110 120 130 140 150
VDFLYGGELV LDGGNIDYVL ETAHLLQIWT VVDFCCEYLE QEVSEDNYLY
160 170 180 190 200
LQELASIYSL KRLDAFIDGF ILNHFGTLSF TPDFLQNVSM QKLCVYLSSS
210 220 230 240 250
EVQRECEHDL LQAALQWLTQ QPEREAHARQ VLENIHFPLI PKNDLLHRVK
260 270 280 290 300
PAVCSLLPKE ANCEGFIEEA VRYHNNLAAQ PVMQTKRTAL RTNQERLLFV
310 320 330 340 350
GGEVSERCLE LSDDTCYLDA KSEQWVKETP LPARRSHHCV AVLGGFIFIA
360 370 380 390 400
GGSFSRDNGG DAASNLLYRY DPRCKQWIKV ASMNQRRVDF YLASIEDMLV
410 420 430 440 450
AIGGRNENGA LSSVETYSPK TDSWSYVAGL PRFTYGHAGT IYKDFVYISG
460 470 480 490 500
GHDYQIGPYR KNLLCYDHRT DVWEERRPMT TARGWHSMCS LGDSIYSIGG
510 520 530 540 550
SDDNIESMER FDVLGVEAYS PQCNQWTRVA PLLHANSESG VAVWEGRIYI
560 570 580 590 600
LGGYSWENTA FSKTVQVYDR EADKWSRGVD LPKAIAGGSA CVCALEPRPE
610
DKKKKGKGKR HQDRGQ
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH3BQE9 | H3BQE9_HUMAN | Kelch-like protein 36 | KLHL36 | 115 | Annotation score: | ||
H3BQW5 | H3BQW5_HUMAN | Kelch-like protein 36 | KLHL36 | 62 | Annotation score: | ||
H3BPB9 | H3BPB9_HUMAN | Kelch-like protein 36 | KLHL36 | 97 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 494 | S → G in BAB14124 (PubMed:14702039).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_022867 | 369 – 431 | Missing in isoform 2. 1 PublicationAdd BLAST | 63 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK022605 mRNA Translation: BAB14124.1 BC032400 mRNA Translation: AAH32400.1 BC033821 mRNA Translation: AAH33821.1 |
CCDSi | CCDS10948.1 [Q8N4N3-1] CCDS76909.1 [Q8N4N3-2] |
RefSeqi | NP_001290380.1, NM_001303451.1 [Q8N4N3-2] NP_079007.2, NM_024731.3 [Q8N4N3-1] XP_005256206.1, XM_005256149.2 [Q8N4N3-1] XP_016879163.1, XM_017023674.1 XP_016879164.1, XM_017023675.1 |
Genome annotation databases
Ensembli | ENST00000258157; ENSP00000258157; ENSG00000135686 [Q8N4N3-2] ENST00000564996; ENSP00000456743; ENSG00000135686 [Q8N4N3-1] |
GeneIDi | 79786 |
KEGGi | hsa:79786 |
UCSCi | uc002fig.4, human [Q8N4N3-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK022605 mRNA Translation: BAB14124.1 BC032400 mRNA Translation: AAH32400.1 BC033821 mRNA Translation: AAH33821.1 |
CCDSi | CCDS10948.1 [Q8N4N3-1] CCDS76909.1 [Q8N4N3-2] |
RefSeqi | NP_001290380.1, NM_001303451.1 [Q8N4N3-2] NP_079007.2, NM_024731.3 [Q8N4N3-1] XP_005256206.1, XM_005256149.2 [Q8N4N3-1] XP_016879163.1, XM_017023674.1 XP_016879164.1, XM_017023675.1 |
3D structure databases
SMRi | Q8N4N3 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 122886, 27 interactors |
IntActi | Q8N4N3, 32 interactors |
STRINGi | 9606.ENSP00000456743 |
PTM databases
iPTMneti | Q8N4N3 |
PhosphoSitePlusi | Q8N4N3 |
Genetic variation databases
BioMutai | KLHL36 |
DMDMi | 74728879 |
Proteomic databases
EPDi | Q8N4N3 |
jPOSTi | Q8N4N3 |
MassIVEi | Q8N4N3 |
MaxQBi | Q8N4N3 |
PaxDbi | Q8N4N3 |
PeptideAtlasi | Q8N4N3 |
PRIDEi | Q8N4N3 |
ProteomicsDBi | 71948 [Q8N4N3-1] 71949 [Q8N4N3-2] |
Protocols and materials databases
Antibodypediai | 17099, 85 antibodies |
DNASUi | 79786 |
Genome annotation databases
Ensembli | ENST00000258157; ENSP00000258157; ENSG00000135686 [Q8N4N3-2] ENST00000564996; ENSP00000456743; ENSG00000135686 [Q8N4N3-1] |
GeneIDi | 79786 |
KEGGi | hsa:79786 |
UCSCi | uc002fig.4, human [Q8N4N3-1] |
Organism-specific databases
CTDi | 79786 |
GeneCardsi | KLHL36 |
HGNCi | HGNC:17844, KLHL36 |
HPAi | ENSG00000135686, Low tissue specificity |
neXtProti | NX_Q8N4N3 |
OpenTargetsi | ENSG00000135686 |
PharmGKBi | PA162393612 |
VEuPathDBi | HostDB:ENSG00000135686.12 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4441, Eukaryota |
GeneTreei | ENSGT00940000157543 |
HOGENOMi | CLU_004253_14_3_1 |
InParanoidi | Q8N4N3 |
OMAi | VWQGRIY |
OrthoDBi | 250404at2759 |
PhylomeDBi | Q8N4N3 |
TreeFami | TF328485 |
Enzyme and pathway databases
UniPathwayi | UPA00143 |
PathwayCommonsi | Q8N4N3 |
Miscellaneous databases
BioGRID-ORCSi | 79786, 7 hits in 872 CRISPR screens |
ChiTaRSi | KLHL36, human |
GenomeRNAii | 79786 |
Pharosi | Q8N4N3, Tdark |
PROi | PR:Q8N4N3 |
RNActi | Q8N4N3, protein |
Gene expression databases
Bgeei | ENSG00000135686, Expressed in adipose tissue of abdominal region and 227 other tissues |
ExpressionAtlasi | Q8N4N3, baseline and differential |
Genevisiblei | Q8N4N3, HS |
Family and domain databases
Gene3Di | 2.120.10.80, 1 hit |
InterProi | View protein in InterPro IPR011705, BACK IPR017096, BTB-kelch_protein IPR000210, BTB/POZ_dom IPR015915, Kelch-typ_b-propeller IPR006652, Kelch_1 IPR030585, KLHL36 IPR011333, SKP1/BTB/POZ_sf |
PANTHERi | PTHR45632:SF4, PTHR45632:SF4, 1 hit |
Pfami | View protein in Pfam PF07707, BACK, 1 hit PF00651, BTB, 1 hit PF01344, Kelch_1, 4 hits |
PIRSFi | PIRSF037037, Kelch-like_protein_gigaxonin, 1 hit |
SMARTi | View protein in SMART SM00875, BACK, 1 hit SM00225, BTB, 1 hit SM00612, Kelch, 6 hits |
SUPFAMi | SSF117281, SSF117281, 1 hit SSF54695, SSF54695, 1 hit |
PROSITEi | View protein in PROSITE PS50097, BTB, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | KLH36_HUMAN | |
Accessioni | Q8N4N3Primary (citable) accession number: Q8N4N3 Secondary accession number(s): Q8N5G6, Q9H9U6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 6, 2007 |
Last sequence update: | October 1, 2002 | |
Last modified: | February 10, 2021 | |
This is version 144 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM