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Entry version 138 (07 Oct 2020)
Sequence version 4 (22 Sep 2009)
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Protein

Choline transporter-like protein 3

Gene

SLC44A3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q8N4M1

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1483191, Synthesis of PC
R-HSA-425366, Transport of bile salts and organic acids, metal ions and amine compounds

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.92.1.3, the choline transporter-like (ctl) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Choline transporter-like protein 3
Alternative name(s):
Solute carrier family 44 member 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLC44A3
Synonyms:CTL3
ORF Names:UNQ558/PRO1115
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000143036.16

Human Gene Nomenclature Database

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HGNCi
HGNC:28689, SLC44A3

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8N4M1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei34 – 54HelicalSequence analysisAdd BLAST21
Transmembranei213 – 233HelicalSequence analysisAdd BLAST21
Transmembranei243 – 263HelicalSequence analysisAdd BLAST21
Transmembranei284 – 304HelicalSequence analysisAdd BLAST21
Transmembranei334 – 354HelicalSequence analysisAdd BLAST21
Transmembranei384 – 404HelicalSequence analysisAdd BLAST21
Transmembranei534 – 554HelicalSequence analysisAdd BLAST21
Transmembranei563 – 583HelicalSequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
126969

Open Targets

More...
OpenTargetsi
ENSG00000143036

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142670900

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8N4M1, Tdark

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB00122, Choline
DB14006, Choline salicylate

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SLC44A3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
259016387

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001917201 – 653Choline transporter-like protein 3Add BLAST653

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi136N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi151N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi412N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi503N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi521N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8N4M1

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8N4M1

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8N4M1

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8N4M1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8N4M1

PeptideAtlas

More...
PeptideAtlasi
Q8N4M1

PRoteomics IDEntifications database

More...
PRIDEi
Q8N4M1

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
21138
21290
71943 [Q8N4M1-1]
71944 [Q8N4M1-2]
71945 [Q8N4M1-3]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q8N4M1, 5 sites

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q8N4M1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8N4M1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000143036, Expressed in muscle tissue and 165 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8N4M1, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8N4M1, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000143036, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
126026, 3 interactors

Protein interaction database and analysis system

More...
IntActi
Q8N4M1, 3 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000271227

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8N4M1, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi477 – 484Cys-rich8

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1362, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160336

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8N4M1

KEGG Orthology (KO)

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KOi
K15282

Identification of Orthologs from Complete Genome Data

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OMAi
KCTDTAW

Database of Orthologous Groups

More...
OrthoDBi
329225at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8N4M1

TreeFam database of animal gene trees

More...
TreeFami
TF313325

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR007603, Choline_transptr-like

The PANTHER Classification System

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PANTHERi
PTHR12385, PTHR12385, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04515, Choline_transpo, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8N4M1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MHCLGAEYLV SAEGAPRQRE WRPQIYRKCT DTAWLFLFFL FWTGLVFIMG
60 70 80 90 100
YSVVAGAAGR LLFGYDSFGN MCGKKNSPVE GAPLSGQDMT LKKHVFFMNS
110 120 130 140 150
CNLEVKGTQL NRMALCVSNC PEEQLDSLEE VQFFANTSGS FLCVYSLNSF
160 170 180 190 200
NYTHSPKADS LCPRLPVPPS KSFPLFNRCV PQTPECYSLF ASVLINDVDT
210 220 230 240 250
LHRILSGIMS GRDTILGLCI LALALSLAMM FTFRFITTLL VHIFISLVIL
260 270 280 290 300
GLLFVCGVLW WLYYDYTNDL SIELDTEREN MKCVLGFAIV STGITAVLLV
310 320 330 340 350
LIFVLRKRIK LTVELFQITN KAISSAPFLL FQPLWTFAIL IFFWVLWVAV
360 370 380 390 400
LLSLGTAGAA QVMEGGQVEY KPLSGIRYMW SYHLIGLIWT SEFILACQQM
410 420 430 440 450
TIAGAVVTCY FNRSKNDPPD HPILSSLSIL FFYHQGTVVK GSFLISVVRI
460 470 480 490 500
PRIIVMYMQN ALKEQQHGAL SRYLFRCCYC CFWCLDKYLL HLNQNAYTTT
510 520 530 540 550
AINGTDFCTS AKDAFKILSK NSSHFTSINC FGDFIIFLGK VLVVCFTVFG
560 570 580 590 600
GLMAFNYNRA FQVWAVPLLL VAFFAYLVAH SFLSVFETVL DALFLCFAVD
610 620 630 640 650
LETNDGSSEK PYFMDQEFLS FVKRSNKLNN ARAQQDKHSL RNEEGTELQA

IVR
Length:653
Mass (Da):73,783
Last modified:September 22, 2009 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i083859F3FC332382
GO
Isoform 2 (identifier: Q8N4M1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-48: Missing.

Show »
Length:605
Mass (Da):68,033
Checksum:i4D3A762E69E3BB24
GO
Isoform 3 (identifier: Q8N4M1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     11-46: Missing.

Show »
Length:617
Mass (Da):69,410
Checksum:i2E5CE3201DEB5EE2
GO
Isoform 4 (identifier: Q8N4M1-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     11-46: Missing.
     107-138: Missing.

Show »
Length:585
Mass (Da):65,853
Checksum:iEB0DF13AC1E723B7
GO
Isoform 5 (identifier: Q8N4M1-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-48: Missing.
     107-138: Missing.
     465-465: Missing.

Show »
Length:572
Mass (Da):64,348
Checksum:i4DDA14D76622D2A2
GO
Isoform 6 (identifier: Q8N4M1-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     107-138: Missing.
     465-465: Missing.

Show »
Length:620
Mass (Da):70,098
Checksum:iD18ABAFA2ECD4B5C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PIC5E9PIC5_HUMAN
Choline transporter-like protein 3
SLC44A3
573Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YD35H0YD35_HUMAN
Choline transporter-like protein 3
SLC44A3
109Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8W7F3F8W7F3_HUMAN
Choline transporter-like protein 3
SLC44A3
163Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YDW5H0YDW5_HUMAN
Choline transporter-like protein 3
SLC44A3
83Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH33858 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAQ89022 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti3C → R in BAG62846 (PubMed:14702039).Curated1
Sequence conflicti316F → L in BAG62846 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_023405438V → I2 PublicationsCorresponds to variant dbSNP:rs859098Ensembl.1
Natural variantiVAR_064752441G → W Found in a renal cell carcinoma sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0361511 – 48Missing in isoform 2 and isoform 5. 2 PublicationsAdd BLAST48
Alternative sequenceiVSP_03615211 – 46Missing in isoform 3 and isoform 4. 1 PublicationAdd BLAST36
Alternative sequenceiVSP_044713107 – 138Missing in isoform 4, isoform 5 and isoform 6. 1 PublicationAdd BLAST32
Alternative sequenceiVSP_045974465Missing in isoform 5 and isoform 6. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK303906 mRNA Translation: BAG64836.1
AK301288 mRNA Translation: BAG62846.1
AK316123 mRNA Translation: BAH14494.1
AC093429 Genomic DNA No translation available.
AL359554 Genomic DNA Translation: CAC36091.1
BC033858 mRNA Translation: AAH33858.2 Different initiation.
BC053877 mRNA Translation: AAH53877.1
AY358659 mRNA Translation: AAQ89022.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS44176.1 [Q8N4M1-1]
CCDS58011.1 [Q8N4M1-6]
CCDS58012.1 [Q8N4M1-4]
CCDS58013.1 [Q8N4M1-3]
CCDS751.1 [Q8N4M1-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001107578.1, NM_001114106.2 [Q8N4M1-1]
NP_001245269.1, NM_001258340.1
NP_001245270.1, NM_001258341.1 [Q8N4M1-6]
NP_001245271.1, NM_001258342.1 [Q8N4M1-3]
NP_001245272.1, NM_001258343.1 [Q8N4M1-4]
NP_001288008.1, NM_001301079.1
NP_689582.2, NM_152369.4 [Q8N4M1-2]
XP_005270498.1, XM_005270441.2 [Q8N4M1-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000271227; ENSP00000271227; ENSG00000143036 [Q8N4M1-1]
ENST00000446120; ENSP00000389143; ENSG00000143036 [Q8N4M1-3]
ENST00000467909; ENSP00000432789; ENSG00000143036 [Q8N4M1-2]
ENST00000527077; ENSP00000433641; ENSG00000143036 [Q8N4M1-4]
ENST00000529450; ENSP00000431836; ENSG00000143036 [Q8N4M1-6]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
126969

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:126969

UCSC genome browser

More...
UCSCi
uc001dqv.6, human [Q8N4M1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK303906 mRNA Translation: BAG64836.1
AK301288 mRNA Translation: BAG62846.1
AK316123 mRNA Translation: BAH14494.1
AC093429 Genomic DNA No translation available.
AL359554 Genomic DNA Translation: CAC36091.1
BC033858 mRNA Translation: AAH33858.2 Different initiation.
BC053877 mRNA Translation: AAH53877.1
AY358659 mRNA Translation: AAQ89022.1 Different initiation.
CCDSiCCDS44176.1 [Q8N4M1-1]
CCDS58011.1 [Q8N4M1-6]
CCDS58012.1 [Q8N4M1-4]
CCDS58013.1 [Q8N4M1-3]
CCDS751.1 [Q8N4M1-2]
RefSeqiNP_001107578.1, NM_001114106.2 [Q8N4M1-1]
NP_001245269.1, NM_001258340.1
NP_001245270.1, NM_001258341.1 [Q8N4M1-6]
NP_001245271.1, NM_001258342.1 [Q8N4M1-3]
NP_001245272.1, NM_001258343.1 [Q8N4M1-4]
NP_001288008.1, NM_001301079.1
NP_689582.2, NM_152369.4 [Q8N4M1-2]
XP_005270498.1, XM_005270441.2 [Q8N4M1-2]

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi126026, 3 interactors
IntActiQ8N4M1, 3 interactors
STRINGi9606.ENSP00000271227

Chemistry databases

DrugBankiDB00122, Choline
DB14006, Choline salicylate

Protein family/group databases

TCDBi2.A.92.1.3, the choline transporter-like (ctl) family

PTM databases

GlyGeniQ8N4M1, 5 sites
iPTMnetiQ8N4M1
PhosphoSitePlusiQ8N4M1

Polymorphism and mutation databases

BioMutaiSLC44A3
DMDMi259016387

Proteomic databases

EPDiQ8N4M1
jPOSTiQ8N4M1
MassIVEiQ8N4M1
MaxQBiQ8N4M1
PaxDbiQ8N4M1
PeptideAtlasiQ8N4M1
PRIDEiQ8N4M1
ProteomicsDBi21138
21290
71943 [Q8N4M1-1]
71944 [Q8N4M1-2]
71945 [Q8N4M1-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
33668, 55 antibodies

The DNASU plasmid repository

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DNASUi
126969

Genome annotation databases

EnsembliENST00000271227; ENSP00000271227; ENSG00000143036 [Q8N4M1-1]
ENST00000446120; ENSP00000389143; ENSG00000143036 [Q8N4M1-3]
ENST00000467909; ENSP00000432789; ENSG00000143036 [Q8N4M1-2]
ENST00000527077; ENSP00000433641; ENSG00000143036 [Q8N4M1-4]
ENST00000529450; ENSP00000431836; ENSG00000143036 [Q8N4M1-6]
GeneIDi126969
KEGGihsa:126969
UCSCiuc001dqv.6, human [Q8N4M1-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
126969
DisGeNETi126969
EuPathDBiHostDB:ENSG00000143036.16

GeneCards: human genes, protein and diseases

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GeneCardsi
SLC44A3
HGNCiHGNC:28689, SLC44A3
HPAiENSG00000143036, Low tissue specificity
neXtProtiNX_Q8N4M1
OpenTargetsiENSG00000143036
PharmGKBiPA142670900

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG1362, Eukaryota
GeneTreeiENSGT00940000160336
InParanoidiQ8N4M1
KOiK15282
OMAiKCTDTAW
OrthoDBi329225at2759
PhylomeDBiQ8N4M1
TreeFamiTF313325

Enzyme and pathway databases

PathwayCommonsiQ8N4M1
ReactomeiR-HSA-1483191, Synthesis of PC
R-HSA-425366, Transport of bile salts and organic acids, metal ions and amine compounds

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
126969, 7 hits in 865 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
SLC44A3, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
126969
PharosiQ8N4M1, Tdark

Protein Ontology

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PROi
PR:Q8N4M1
RNActiQ8N4M1, protein

Gene expression databases

BgeeiENSG00000143036, Expressed in muscle tissue and 165 other tissues
ExpressionAtlasiQ8N4M1, baseline and differential
GenevisibleiQ8N4M1, HS

Family and domain databases

InterProiView protein in InterPro
IPR007603, Choline_transptr-like
PANTHERiPTHR12385, PTHR12385, 1 hit
PfamiView protein in Pfam
PF04515, Choline_transpo, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCTL3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8N4M1
Secondary accession number(s): B4DVY4
, B4E1M4, B7ZA08, E9PJH2, E9PJY8, Q6UWT1, Q7Z6C5, Q9BWY7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: September 22, 2009
Last modified: October 7, 2020
This is version 138 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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