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Protein

Spermatid maturation protein 1

Gene

SPEM1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Required for proper cytoplasm removal during spermatogenesis.By similarity

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, Spermatogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Spermatid maturation protein 1
Gene namesi
Name:SPEM1
Synonyms:C17orf83
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000181323.7
HGNCiHGNC:32429 SPEM1
MIMi615116 gene
neXtProtiNX_Q8N4L4

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei29 – 49HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000181323
PharmGKBiPA162404476

Polymorphism and mutation databases

BioMutaiSPEM1
DMDMi74728870

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003078061 – 309Spermatid maturation protein 1Add BLAST309

Proteomic databases

PaxDbiQ8N4L4
PeptideAtlasiQ8N4L4
PRIDEiQ8N4L4
ProteomicsDBi71940

PTM databases

iPTMnetiQ8N4L4
PhosphoSitePlusiQ8N4L4

Expressioni

Gene expression databases

BgeeiENSG00000181323 Expressed in 17 organ(s), highest expression level in right testis
CleanExiHS_SPEM1
GenevisibleiQ8N4L4 HS

Interactioni

Protein-protein interaction databases

BioGridi131920, 2 interactors
IntActiQ8N4L4, 1 interactor
STRINGi9606.ENSP00000315554

Structurei

3D structure databases

ProteinModelPortaliQ8N4L4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili259 – 285Sequence analysisAdd BLAST27

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi209 – 214Poly-Pro6

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J2CE Eukaryota
ENOG41118KW LUCA
GeneTreeiENSGT00510000049389
HOGENOMiHOG000154380
HOVERGENiHBG108506
InParanoidiQ8N4L4
OMAiAWAPDTD
OrthoDBiEOG091G0L7A
PhylomeDBiQ8N4L4
TreeFamiTF338031

Family and domain databases

InterProiView protein in InterPro
IPR031368 SPEM1_N
PfamiView protein in Pfam
PF15670 Spem1, 1 hit

Sequencei

Sequence statusi: Complete.

Q8N4L4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAMVERPRPE WASYHNCNSN SCQDLGNSVL LLLGLIICIN ISINIVTLLW
60 70 80 90 100
SRFRGVLYQV FHDTICEKEA PKSSLLRKQT QPPKKQSSPA VHLRCTMDPV
110 120 130 140 150
MMTVSPPPAH RHRRRGSPTR CAHCPVAWAP DTDDEKPHQY PAICSYHWDV
160 170 180 190 200
PEDWEGFQHT QGTWVPWSQD APESPPQTIR FQPTVEERPL KTGIWSELGL
210 220 230 240 250
RAYVYPVNPP PPSPEAPSHK NGGEGAVPEA EAAQYQPVPA PTLGPAVIPE
260 270 280 290 300
FSRHRSSGRI VYDARDMRRR LRELTREVEA LSGCYPLASG SSTAEETSKN

WVYRSLTGR
Length:309
Mass (Da):34,773
Last modified:October 1, 2002 - v1
Checksum:i55C2CAD33C8670E0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC033882 mRNA Translation: AAH33882.1
CCDSiCCDS42254.1
RefSeqiNP_955371.2, NM_199339.2
UniGeneiHs.710599

Genome annotation databases

EnsembliENST00000323675; ENSP00000315554; ENSG00000181323
ENST00000640564; ENSP00000492561; ENSG00000284598
GeneIDi374768
KEGGihsa:374768
UCSCiuc002ggv.3 human

Similar proteinsi

Entry informationi

Entry nameiSPEM1_HUMAN
AccessioniPrimary (citable) accession number: Q8N4L4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: October 1, 2002
Last modified: September 12, 2018
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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