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Protein

Mitochondrial import receptor subunit TOM5 homolog

Gene

TOMM5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • protein targeting to mitochondrion Source: UniProtKB

Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-1268020 Mitochondrial protein import
R-HSA-5205685 Pink/Parkin Mediated Mitophagy

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial import receptor subunit TOM5 homolog
Gene namesi
Name:TOMM5
Synonyms:C9orf105, TOM5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000175768.12
HGNCiHGNC:31369 TOMM5
MIMi616169 gene
neXtProtiNX_Q8N4H5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei27 – 45HelicalSequence analysisAdd BLAST19

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000175768
PharmGKBiPA164726670

Polymorphism and mutation databases

BioMutaiTOMM5

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002306711 – 51Mitochondrial import receptor subunit TOM5 homologAdd BLAST51

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Cross-linki10Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Acetylation, Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ8N4H5
MaxQBiQ8N4H5
PeptideAtlasiQ8N4H5
PRIDEiQ8N4H5
ProteomicsDBi71934
TopDownProteomicsiQ8N4H5-1 [Q8N4H5-1]

PTM databases

iPTMnetiQ8N4H5
PhosphoSitePlusiQ8N4H5

Expressioni

Gene expression databases

BgeeiENSG00000175768
CleanExiHS_TOMM5
ExpressionAtlasiQ8N4H5 baseline and differential
GenevisibleiQ8N4H5 HS

Organism-specific databases

HPAiHPA048712

Interactioni

Subunit structurei

Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) which consists of at least 7 different proteins (TOMM5, TOMM6, TOMM7, TOMM20, TOMM22, TOMM40 and TOMM70).1 Publication

Protein-protein interaction databases

BioGridi135117, 5 interactors
CORUMiQ8N4H5
IntActiQ8N4H5, 1 interactor

Structurei

3D structure databases

ProteinModelPortaliQ8N4H5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Tom5 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00390000009431
HOGENOMiHOG000138179
HOVERGENiHBG056232
InParanoidiQ8N4H5
KOiK17773
OMAiTPYVLKK
PhylomeDBiQ8N4H5
TreeFamiTF333449

Family and domain databases

InterProiView protein in InterPro
IPR029179 TOMM5
PANTHERiPTHR28436 PTHR28436, 1 hit
PfamiView protein in Pfam
PF15178 TOM_sub5, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N4H5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFRIEGLAPK LDPEEMKRKM REDVISSIRN FLIYVALLRV TPFILKKLDS

I
Length:51
Mass (Da):6,035
Last modified:October 1, 2002 - v1
Checksum:i5B5204D78754B0FE
GO
Isoform 2 (identifier: Q8N4H5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     41-51: TPFILKKLDSI → SECLPGCDCETSGELTDGHPLTLRGHRGLRTELNGSGEQGGCALKATGICAV

Note: No experimental confirmation available.
Show »
Length:92
Mass (Da):10,033
Checksum:i61F347FC28616523
GO
Isoform 3 (identifier: Q8N4H5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     41-41: T → SECLPGCDCETSGELTDGHPLTLRGHRGLRTELNA

Note: No experimental confirmation available.
Show »
Length:85
Mass (Da):9,655
Checksum:iBD2A49CC8E4B5167
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04698241 – 51TPFILKKLDSI → SECLPGCDCETSGELTDGHP LTLRGHRGLRTELNGSGEQG GCALKATGICAV in isoform 2. CuratedAdd BLAST11
Alternative sequenceiVSP_04698341T → SECLPGCDCETSGELTDGHP LTLRGHRGLRTELNA in isoform 3. Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB435233 mRNA Translation: BAG30953.1
AL513165 Genomic DNA No translation available.
BC034247 mRNA Translation: AAH34247.1
CCDSiCCDS43803.1 [Q8N4H5-1]
CCDS47967.1 [Q8N4H5-3]
CCDS47968.1 [Q8N4H5-2]
RefSeqiNP_001001790.1, NM_001001790.2 [Q8N4H5-1]
NP_001127956.1, NM_001134484.1 [Q8N4H5-2]
NP_001127957.1, NM_001134485.1 [Q8N4H5-3]
UniGeneiHs.130774

Genome annotation databases

EnsembliENST00000321301; ENSP00000313584; ENSG00000175768 [Q8N4H5-1]
ENST00000377773; ENSP00000367004; ENSG00000175768 [Q8N4H5-3]
ENST00000544379; ENSP00000438204; ENSG00000175768 [Q8N4H5-2]
GeneIDi401505
KEGGihsa:401505
UCSCiuc004aaf.4 human [Q8N4H5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiTOM5_HUMAN
AccessioniPrimary (citable) accession number: Q8N4H5
Secondary accession number(s): B2DG07, F6S928, Q5JRT7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: October 1, 2002
Last modified: June 20, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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