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Protein
Submitted name:

CA6 protein

Gene

CA6

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei85Proton acceptorPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
CA6 proteinImported
Submitted name:
Carbonic anhydrase 6Imported
Gene namesi
Name:CA6Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000131686.14
HGNCiHGNC:1380 CA6

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000131686
PharmGKBiPA25995

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_501458904318 – 179Sequence analysisAdd BLAST162

Expressioni

Gene expression databases

BgeeiENSG00000131686 Expressed in 70 organ(s), highest expression level in parotid gland

Interactioni

Binary interactionsi

Protein-protein interaction databases

IntActiQ8N4G4, 3 interactors

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini21 – 179Alpha-carbonic anhydraseInterPro annotationAdd BLAST159

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

GeneTreeiENSGT00760000118915
HOGENOMiHOG000148738

Family and domain databases

Gene3Di3.10.200.10, 1 hit
InterProiView protein in InterPro
IPR001148 CA_dom
IPR036398 CA_dom_sf
IPR023561 Carbonic_anhydrase_a-class
IPR018428 Carbonic_anhydrase_CA6
PANTHERiPTHR18952 PTHR18952, 1 hit
PTHR18952:SF110 PTHR18952:SF110, 1 hit
PfamiView protein in Pfam
PF00194 Carb_anhydrase, 1 hit
SMARTiView protein in SMART
SM01057 Carb_anhydrase, 1 hit
SUPFAMiSSF51069 SSF51069, 1 hit
PROSITEiView protein in PROSITE
PS51144 ALPHA_CA_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q8N4G4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRALVLLLSL FLLGGQAQHV SDWTYSEGAL DEAHWPQHYP ACGGQRQSPI
60 70 80 90 100
NLQRTKVRYN PSLKGLNMTG YETQAGEFPM VNNGHTDWQA ELFLPSLSSP
110 120 130 140 150
CGEGAKHKGQ RQWLCSPSLD SWWEAIIDGG SLWATLAECG LRAEGPEEGR
160 170
HMEEKSPASQ GACSGSRLPI SRGPCTFFL
Length:179
Mass (Da):19,672
Last modified:October 1, 2002 - v1
Checksum:i8CED532904798A48
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P23280CAH6_HUMAN
Carbonic anhydrase 6
CA6
308Annotation score:
F8W148F8W148_HUMAN
Carbonic anhydrase 6
CA6
187Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL139415 Genomic DNA No translation available.
BC034350 mRNA Translation: AAH34350.1
UniGeneiHs.100322

Genome annotation databases

EnsembliENST00000480186; ENSP00000435280; ENSG00000131686
UCSCiuc057caa.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL139415 Genomic DNA No translation available.
BC034350 mRNA Translation: AAH34350.1
UniGeneiHs.100322

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8N4G4, 3 interactors

Protocols and materials databases

DNASUi765
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000480186; ENSP00000435280; ENSG00000131686
UCSCiuc057caa.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000131686.14
HGNCiHGNC:1380 CA6
OpenTargetsiENSG00000131686
PharmGKBiPA25995
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00760000118915
HOGENOMiHOG000148738

Gene expression databases

BgeeiENSG00000131686 Expressed in 70 organ(s), highest expression level in parotid gland

Family and domain databases

Gene3Di3.10.200.10, 1 hit
InterProiView protein in InterPro
IPR001148 CA_dom
IPR036398 CA_dom_sf
IPR023561 Carbonic_anhydrase_a-class
IPR018428 Carbonic_anhydrase_CA6
PANTHERiPTHR18952 PTHR18952, 1 hit
PTHR18952:SF110 PTHR18952:SF110, 1 hit
PfamiView protein in Pfam
PF00194 Carb_anhydrase, 1 hit
SMARTiView protein in SMART
SM01057 Carb_anhydrase, 1 hit
SUPFAMiSSF51069 SSF51069, 1 hit
PROSITEiView protein in PROSITE
PS51144 ALPHA_CA_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ8N4G4_HUMAN
AccessioniPrimary (citable) accession number: Q8N4G4
Entry historyiIntegrated into UniProtKB/TrEMBL: October 1, 2002
Last sequence update: October 1, 2002
Last modified: October 10, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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