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Protein

Solute carrier family 22 member 24

Gene

SLC22A24

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processIon transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 22 member 24
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000197658.9
HGNCiHGNC:28542 SLC22A24
MIMi611698 gene
neXtProtiNX_Q8N4F4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei16 – 36HelicalSequence analysisAdd BLAST21
Transmembranei146 – 166HelicalSequence analysisAdd BLAST21
Transmembranei178 – 200HelicalSequence analysisAdd BLAST23
Transmembranei204 – 226HelicalSequence analysisAdd BLAST23
Transmembranei233 – 253HelicalSequence analysisAdd BLAST21
Transmembranei260 – 280HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi283238

Polymorphism and mutation databases

DMDMi74728846

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003175261 – 322Solute carrier family 22 member 24Add BLAST322

Proteomic databases

PaxDbiQ8N4F4
PeptideAtlasiQ8N4F4
PRIDEiQ8N4F4
ProteomicsDBi71927

PTM databases

PhosphoSitePlusiQ8N4F4

Expressioni

Gene expression databases

BgeeiENSG00000197658 Expressed in 4 organ(s), highest expression level in buccal mucosa cell
CleanExiHS_SLC22A24
ExpressionAtlasiQ8N4F4 baseline and differential
GenevisibleiQ8N4F4 HS

Organism-specific databases

HPAiHPA045015

Interactioni

Protein-protein interaction databases

BioGridi129508, 1 interactor
IntActiQ8N4F4, 1 interactor
STRINGi9606.ENSP00000396586

Structurei

3D structure databases

ProteinModelPortaliQ8N4F4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0255 Eukaryota
COG0477 LUCA
HOGENOMiHOG000234569
HOVERGENiHBG108433
InParanoidiQ8N4F4
KOiK08206
PhylomeDBiQ8N4F4

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR011701 MFS
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
PfamiView protein in Pfam
PF07690 MFS_1, 1 hit
SUPFAMiSSF103473 SSF103473, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q8N4F4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGFDVLLDQV GGMGRFQICL IAFFCITNIL LFPNIVLENF TAFTPSHRCW
60 70 80 90 100
VPLLDNDSVS DNDTGTLSKD DLLRISIPLD SNLRPQKCQR FIHPQWQLLH
110 120 130 140 150
LNGTFPNTNE PDTEPCVDGW VYDRSSFLST IVTEWDLVCE SQSLKSMVQS
160 170 180 190 200
LFMAGSLLGG LIYGHLSDRV GRKIICKLCF LQLAISNTCA AFAPTFLVYC
210 220 230 240 250
ILRFLAGFST MTILGNTFIL SLEWTLPRSR SMTIMVLLCS YSVGQMLLGG
260 270 280 290 300
LAFAIQDWHI LQLTVSTPII VLFLSSWYEQ SPHSLPVSEA MVDIERKIVT
310 320
PGICSVSGLV LSHDVHSTYC VT
Length:322
Mass (Da):35,933
Last modified:October 1, 2002 - v1
Checksum:i6A4A7C1E2616747D
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JC66C9JC66_HUMAN
Solute carrier family 22 member 24
SLC22A24
551Annotation score:
A0A087WWM3A0A087WWM3_HUMAN
Solute carrier family 22 member 24
SLC22A24
552Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC034394 mRNA Translation: AAH34394.1
CCDSiCCDS76422.1
RefSeqiNP_775857.2, NM_173586.2
UniGeneiHs.375139

Genome annotation databases

EnsembliENST00000326192; ENSP00000321549; ENSG00000197658
GeneIDi283238
KEGGihsa:283238
UCSCiuc010rmn.3 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC034394 mRNA Translation: AAH34394.1
CCDSiCCDS76422.1
RefSeqiNP_775857.2, NM_173586.2
UniGeneiHs.375139

3D structure databases

ProteinModelPortaliQ8N4F4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129508, 1 interactor
IntActiQ8N4F4, 1 interactor
STRINGi9606.ENSP00000396586

PTM databases

PhosphoSitePlusiQ8N4F4

Polymorphism and mutation databases

DMDMi74728846

Proteomic databases

PaxDbiQ8N4F4
PeptideAtlasiQ8N4F4
PRIDEiQ8N4F4
ProteomicsDBi71927

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000326192; ENSP00000321549; ENSG00000197658
GeneIDi283238
KEGGihsa:283238
UCSCiuc010rmn.3 human

Organism-specific databases

CTDi283238
DisGeNETi283238
EuPathDBiHostDB:ENSG00000197658.9
GeneCardsiSLC22A24
H-InvDBiHIX0009734
HGNCiHGNC:28542 SLC22A24
HPAiHPA045015
MIMi611698 gene
neXtProtiNX_Q8N4F4
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0255 Eukaryota
COG0477 LUCA
HOGENOMiHOG000234569
HOVERGENiHBG108433
InParanoidiQ8N4F4
KOiK08206
PhylomeDBiQ8N4F4

Miscellaneous databases

ChiTaRSiSLC22A24 human
GenomeRNAii283238
PROiPR:Q8N4F4
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000197658 Expressed in 4 organ(s), highest expression level in buccal mucosa cell
CleanExiHS_SLC22A24
ExpressionAtlasiQ8N4F4 baseline and differential
GenevisibleiQ8N4F4 HS

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR011701 MFS
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
PfamiView protein in Pfam
PF07690 MFS_1, 1 hit
SUPFAMiSSF103473 SSF103473, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiS22AO_HUMAN
AccessioniPrimary (citable) accession number: Q8N4F4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: October 1, 2002
Last modified: September 12, 2018
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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