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Entry version 126 (10 Apr 2019)
Sequence version 1 (01 Oct 2002)
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Protein

Syntaxin-19

Gene

STX19

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role in endosomal trafficking of the epidermal growth factor receptor (EGFR).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • SNAP receptor activity Source: GO_Central
  • SNARE binding Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Syntaxin-19
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:STX19
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000178750.2

Human Gene Nomenclature Database

More...
HGNCi
HGNC:19300 STX19

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8N4C7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000178750

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142670857

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
STX19

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74728839

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002637091 – 294Syntaxin-19Add BLAST294

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8N4C7

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q8N4C7

PeptideAtlas

More...
PeptideAtlasi
Q8N4C7

PRoteomics IDEntifications database

More...
PRIDEi
Q8N4C7

ProteomicsDB human proteome resource

More...
ProteomicsDBi
71916

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8N4C7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8N4C7

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q8N4C7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000178750 Expressed in 99 organ(s), highest expression level in colonic mucosa

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8N4C7 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA030604

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with EGFR.1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
136105, 21 interactors

Protein interaction database and analysis system

More...
IntActi
Q8N4C7, 10 interactors

Molecular INTeraction database

More...
MINTi
Q8N4C7

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000320679

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q8N4C7

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8N4C7

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini209 – 271t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd BLAST63

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi280 – 291Cys-richAdd BLAST12

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the syntaxin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0810 Eukaryota
COG5074 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182652

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000286023

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG099780

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8N4C7

KEGG Orthology (KO)

More...
KOi
K08487

Identification of Orthologs from Complete Genome Data

More...
OMAi
IQAEHIN

Database of Orthologous Groups

More...
OrthoDBi
1033833at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8N4C7

TreeFam database of animal gene trees

More...
TreeFami
TF313763

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00179 SynN, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR010989 SNARE
IPR015708 STX19
IPR006012 Syntaxin/epimorphin_CS
IPR006011 Syntaxin_N
IPR000727 T_SNARE_dom

The PANTHER Classification System

More...
PANTHERi
PTHR19957:SF29 PTHR19957:SF29, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00804 Syntaxin, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00397 t_SNARE, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47661 SSF47661, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00914 SYNTAXIN, 1 hit
PS50192 T_SNARE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8N4C7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKDRLQELKQ RTKEIELSRD SHVSTTETEE QGVFLQQAVI YEREPVAERH
60 70 80 90 100
LHEIQKLQES INNLADNVQK FGQQQKSLVA SMRRFSLLKR ESTITKEIKI
110 120 130 140 150
QAEYINRSLN DLVKEVKKSE VENGPSSVVT RILKSQHAAM FRHFQQIMFI
160 170 180 190 200
YNDTIAAKQE KCKTFILRQL EVAGKEMSEE DVNDMLHQGK WEVFNESLLT
210 220 230 240 250
EINITKAQLS EIEQRHKELV NLENQIKDLR DLFIQISLLV EEQGESINNI
260 270 280 290
EMTVNSTKEY VNNTKEKFGL AVKYKKRNPC RVLCCWCCPC CSSK
Length:294
Mass (Da):34,324
Last modified:October 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1A7FE896916DCE57
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF461456 mRNA Translation: AAQ04780.1
BC034696 mRNA Translation: AAH34696.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS33793.1

NCBI Reference Sequences

More...
RefSeqi
NP_001001850.1, NM_001001850.2
XP_011511144.1, XM_011512842.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.679768

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000315099; ENSP00000320679; ENSG00000178750

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
415117

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:415117

UCSC genome browser

More...
UCSCi
uc003drh.2 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF461456 mRNA Translation: AAQ04780.1
BC034696 mRNA Translation: AAH34696.1
CCDSiCCDS33793.1
RefSeqiNP_001001850.1, NM_001001850.2
XP_011511144.1, XM_011512842.2
UniGeneiHs.679768

3D structure databases

ProteinModelPortaliQ8N4C7
SMRiQ8N4C7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi136105, 21 interactors
IntActiQ8N4C7, 10 interactors
MINTiQ8N4C7
STRINGi9606.ENSP00000320679

PTM databases

iPTMnetiQ8N4C7
PhosphoSitePlusiQ8N4C7
SwissPalmiQ8N4C7

Polymorphism and mutation databases

BioMutaiSTX19
DMDMi74728839

Proteomic databases

jPOSTiQ8N4C7
PaxDbiQ8N4C7
PeptideAtlasiQ8N4C7
PRIDEiQ8N4C7
ProteomicsDBi71916

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000315099; ENSP00000320679; ENSG00000178750
GeneIDi415117
KEGGihsa:415117
UCSCiuc003drh.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
415117
EuPathDBiHostDB:ENSG00000178750.2

GeneCards: human genes, protein and diseases

More...
GeneCardsi
STX19
HGNCiHGNC:19300 STX19
HPAiHPA030604
neXtProtiNX_Q8N4C7
OpenTargetsiENSG00000178750
PharmGKBiPA142670857

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0810 Eukaryota
COG5074 LUCA
GeneTreeiENSGT00950000182652
HOGENOMiHOG000286023
HOVERGENiHBG099780
InParanoidiQ8N4C7
KOiK08487
OMAiIQAEHIN
OrthoDBi1033833at2759
PhylomeDBiQ8N4C7
TreeFamiTF313763

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
415117

Protein Ontology

More...
PROi
PR:Q8N4C7

Gene expression databases

BgeeiENSG00000178750 Expressed in 99 organ(s), highest expression level in colonic mucosa
GenevisibleiQ8N4C7 HS

Family and domain databases

CDDicd00179 SynN, 1 hit
InterProiView protein in InterPro
IPR010989 SNARE
IPR015708 STX19
IPR006012 Syntaxin/epimorphin_CS
IPR006011 Syntaxin_N
IPR000727 T_SNARE_dom
PANTHERiPTHR19957:SF29 PTHR19957:SF29, 1 hit
PfamiView protein in Pfam
PF00804 Syntaxin, 1 hit
SMARTiView protein in SMART
SM00397 t_SNARE, 1 hit
SUPFAMiSSF47661 SSF47661, 1 hit
PROSITEiView protein in PROSITE
PS00914 SYNTAXIN, 1 hit
PS50192 T_SNARE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSTX19_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8N4C7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: October 1, 2002
Last modified: April 10, 2019
This is version 126 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
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