UniProtKB - Q8N4C6 (NIN_HUMAN)
Ninein
NIN
Functioni
Miscellaneous
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 245 – 252 | GTPSequence analysis | 8 | |
Nucleotide bindingi | 300 – 304 | GTPSequence analysis | 5 | |
Nucleotide bindingi | 420 – 423 | GTPSequence analysis | 4 |
GO - Molecular functioni
- calcium ion binding Source: InterPro
- GTP binding Source: UniProtKB-KW
- kinase binding Source: Ensembl
- microtubule minus-end binding Source: Ensembl
GO - Biological processi
- centriole-centriole cohesion Source: GO_Central
- centrosome localization Source: GO_Central
- centrosome-templated microtubule nucleation Source: GO_Central
- collateral sprouting Source: Ensembl
- corpus callosum morphogenesis Source: Ensembl
- corticospinal tract morphogenesis Source: Ensembl
- microtubule anchoring at centrosome Source: UniProtKB
- positive regulation of axonogenesis Source: Ensembl
- positive regulation of microtubule polymerization Source: Ensembl
- protein localization Source: GO_Central
Keywordsi
Ligand | GTP-binding, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | Q8N4C6 |
SIGNORi | Q8N4C6 |
Names & Taxonomyi
Protein namesi | Recommended name: NineinShort name: hNinein Alternative name(s): Glycogen synthase kinase 3 beta-interacting protein Short name: GSK3B-interacting protein |
Gene namesi | Name:NIN Synonyms:KIAA1565 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:14906, NIN |
MIMi | 608684, gene |
neXtProti | NX_Q8N4C6 |
VEuPathDBi | HostDB:ENSG00000100503.23 |
Subcellular locationi
Cytoskeleton
- centrosome 6 Publications
- centriole 1 Publication
Note: Component of the core centrosome. Arranged in a tubular conformation with an open and a closed end within the centrosome. In the mother centrosome, it localizes at both ends of the centrosome tube, including the site of centrosome duplication, while in the daughter centrosome it is present only at the closed end. Requires PCM1 for centrosome localization. Localizes to the subdistal appendage region of the centriole in a DCTN1-dependent manner.3 Publications
Other locations
- Cytoplasm By similarity
Note: Seems to have a dominant-negative effect on localization of other isoforms, promoting their dissociation from the centrosome.By similarity
Cytoskeleton
- centriole Source: UniProtKB
- centrosome Source: UniProtKB
- cytoplasmic microtubule Source: Ensembl
- mitotic spindle Source: UniProtKB
- mitotic spindle pole Source: GO_Central
- pericentriolar material Source: MGI
- spindle pole Source: MGI
Nucleus
- nucleolus Source: HPA
- nucleoplasm Source: HPA
Plasma Membrane
- plasma membrane Source: Ensembl
Other locations
- apical part of cell Source: Ensembl
- axonal growth cone Source: Ensembl
- centriolar subdistal appendage Source: GO_Central
- ciliary transition fiber Source: GO_Central
- dendrite Source: Ensembl
Keywords - Cellular componenti
Cytoplasm, Cytoskeleton, MicrotubulePathology & Biotechi
Involvement in diseasei
Seckel syndrome 7 (SCKL7)1 Publication
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_069083 | 1222 | Q → R in SCKL7; does not disrupt protein expression or localization or affect mitotic functions in an obvious way. 1 PublicationCorresponds to variant dbSNP:rs187464517EnsemblClinVar. | 1 | |
Natural variantiVAR_069084 | 1709 | N → S in SCKL7; does not disrupt protein expression or localization or affect mitotic functions in an obvious way. 1 PublicationCorresponds to variant dbSNP:rs387907308Ensembl. | 1 |
Keywords - Diseasei
Disease variant, Dwarfism, Mental retardationOrganism-specific databases
DisGeNETi | 51199 |
MalaCardsi | NIN |
MIMi | 614851, phenotype |
OpenTargetsi | ENSG00000100503 |
Orphaneti | 319675, Microcephalic primordial dwarfism, Dauber type |
PharmGKBi | PA31630 |
Miscellaneous databases
Pharosi | Q8N4C6, Tbio |
Genetic variation databases
BioMutai | NIN |
DMDMi | 311033487 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000096844 | 1 – 2090 | NineinAdd BLAST | 2090 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 152 | PhosphoserineCombined sources | 1 | |
Modified residuei | 269 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1550 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1837 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q8N4C6 |
jPOSTi | Q8N4C6 |
MassIVEi | Q8N4C6 |
MaxQBi | Q8N4C6 |
PaxDbi | Q8N4C6 |
PeptideAtlasi | Q8N4C6 |
PRIDEi | Q8N4C6 |
ProteomicsDBi | 71907 [Q8N4C6-1] 71908 [Q8N4C6-10] 71909 [Q8N4C6-11] 71910 [Q8N4C6-2] 71911 [Q8N4C6-4] 71912 [Q8N4C6-5] 71913 [Q8N4C6-6] 71914 [Q8N4C6-7] 71915 [Q8N4C6-9] |
PTM databases
iPTMneti | Q8N4C6 |
PhosphoSitePlusi | Q8N4C6 |
Expressioni
Tissue specificityi
Developmental stagei
Gene expression databases
Bgeei | ENSG00000100503, Expressed in amniotic fluid and 213 other tissues |
ExpressionAtlasi | Q8N4C6, baseline and differential |
Genevisiblei | Q8N4C6, HS |
Organism-specific databases
HPAi | ENSG00000100503, Low tissue specificity |
Interactioni
Subunit structurei
Homooligomer.
Interacts with GSK3B/GSK3-beta via its C-terminal domain (PubMed:11004522).
Interacts with C14ORF166, such interaction may prevent its phosphorylation by GSK3B (PubMed:15147888).
Interacts with AUNIP (via N-terminus) (PubMed:20596670).
Identified in a complex with AUNIP and AURKA (PubMed:20596670).
Interacts with CCDC120 (PubMed:28422092).
Interacts (via C-terminus) with CEP250 (By similarity).
Interacts with CEP170 (By similarity).
Interacts with the gamma-tubulin ring complex component TUBGCP3 (By similarity).
Interacts with gamma-tubulin (By similarity). Isoform 6 does not interact with CEP170 or CEP250 (By similarity).
By similarity4 PublicationsBinary interactionsi
Hide detailsQ8N4C6
With | #Exp. | IntAct |
---|---|---|
CCDC120 [Q96HB5] | 11 | EBI-1164022,EBI-744556 |
GSK3B [P49841] | 3 | EBI-1164022,EBI-373586 |
RTRAF [Q9Y224] | 4 | EBI-1164022,EBI-1104547 |
GO - Molecular functioni
- kinase binding Source: Ensembl
- microtubule minus-end binding Source: Ensembl
Protein-protein interaction databases
BioGRIDi | 119372, 317 interactors |
IntActi | Q8N4C6, 121 interactors |
MINTi | Q8N4C6 |
STRINGi | 9606.ENSP00000371472 |
Chemistry databases
BindingDBi | Q8N4C6 |
Miscellaneous databases
RNActi | Q8N4C6, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 8 – 43 | EF-hand 1PROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 42 – 77 | EF-hand 2PROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 182 – 217 | EF-hand 3PROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 219 – 252 | EF-hand 4PROSITE-ProRule annotationAdd BLAST | 34 | |
Domaini | 317 – 352 | EF-hand 5PROSITE-ProRule annotationAdd BLAST | 36 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 802 – 1505 | Important for interaction with CEP170By similarityAdd BLAST | 704 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 357 – 570 | Sequence analysisAdd BLAST | 214 | |
Coiled coili | 625 – 1027 | Sequence analysisAdd BLAST | 403 | |
Coiled coili | 1068 – 1099 | Sequence analysisAdd BLAST | 32 | |
Coiled coili | 1181 – 1341 | Sequence analysisAdd BLAST | 161 | |
Coiled coili | 1441 – 1816 | Sequence analysisAdd BLAST | 376 | |
Coiled coili | 1854 – 1885 | Sequence analysisAdd BLAST | 32 | |
Coiled coili | 1922 – 2067 | Sequence analysisAdd BLAST | 146 |
Domaini
Keywords - Domaini
Coiled coil, RepeatPhylogenomic databases
eggNOGi | ENOG502QZCC, Eukaryota |
GeneTreei | ENSGT00660000095541 |
HOGENOMi | CLU_001462_1_1_1 |
InParanoidi | Q8N4C6 |
OMAi | RMKQVEG |
OrthoDBi | 95801at2759 |
PhylomeDBi | Q8N4C6 |
TreeFami | TF325139 |
Family and domain databases
InterProi | View protein in InterPro IPR011992, EF-hand-dom_pair IPR002048, EF_hand_dom IPR029664, NIN |
PANTHERi | PTHR18905:SF11, PTHR18905:SF11, 1 hit |
SUPFAMi | SSF47473, SSF47473, 1 hit |
PROSITEi | View protein in PROSITE PS50222, EF_HAND_2, 5 hits |
s (9+)i Sequence
Sequence statusi: Complete.
This entry describes 9 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 9 described isoforms and 12 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MDEVEQDQHE ARLKELFDSF DTTGTGSLGQ EELTDLCHML SLEEVAPVLQ
60 70 80 90 100
QTLLQDNLLG RVHFDQFKEA LILILSRTLS NEEHFQEPDC SLEAQPKYVR
110 120 130 140 150
GGKRYGRRSL PEFQESVEEF PEVTVIEPLD EEARPSHIPA GDCSEHWKTQ
160 170 180 190 200
RSEEYEAEGQ LRFWNPDDLN ASQSGSSPPQ DWIEEKLQEV CEDLGITRDG
210 220 230 240 250
HLNRKKLVSI CEQYGLQNVD GEMLEEVFHN LDPDGTMSVE DFFYGLFKNG
260 270 280 290 300
KSLTPSASTP YRQLKRHLSM QSFDESGRRT TTSSAMTSTI GFRVFSCLDD
310 320 330 340 350
GMGHASVERI LDTWQEEGIE NSQEILKALD FSLDGNINLT ELTLALENEL
360 370 380 390 400
LVTKNSIHQA ALASFKAEIR HLLERVDQVV REKEKLRSDL DKAEKLKSLM
410 420 430 440 450
ASEVDDHHAA IERRNEYNLR KLDEEYKERI AALKNELRKE REQILQQAGK
460 470 480 490 500
QRLELEQEIE KAKTEENYIR DRLALSLKEN SRLENELLEN AEKLAEYENL
510 520 530 540 550
TNKLQRNLEN VLAEKFGDLD PSSAEFFLQE ERLTQMRNEY ERQCRVLQDQ
560 570 580 590 600
VDELQSELEE YRAQGRVLRL PLKNSPSEEV EANSGGIEPE HGLGSEECNP
610 620 630 640 650
LNMSIEAELV IEQMKEQHHR DICCLRLELE DKVRHYEKQL DETVVSCKKA
660 670 680 690 700
QENMKQRHEN ETHTLEKQIS DLKNEIAELQ GQAAVLKEAH HEATCRHEEE
710 720 730 740 750
KKQLQVKLEE EKTHLQEKLR LQHEMELKAR LTQAQASFER EREGLQSSAW
760 770 780 790 800
TEEKVRGLTQ ELEQFHQEQL TSLVEKHTLE KEELRKELLE KHQRELQEGR
810 820 830 840 850
EKMETECNRR TSQIEAQFQS DCQKVTERCE SALQSLEGRY RQELKDLQEQ
860 870 880 890 900
QREEKSQWEF EKDELTQECA EAQELLKETL KREKTTSLVL TQEREMLEKT
910 920 930 940 950
YKEHLNSMVV ERQQLLQDLE DLRNVSETQQ SLLSDQILEL KSSHKRELRE
960 970 980 990 1000
REEVLCQAGA SEQLASQRLE RLEMEHDQER QEMMSKLLAM ENIHKATCET
1010 1020 1030 1040 1050
ADRERAEMST EISRLQSKIK EMQQATSPLS MLQSGCQVIG EEEVEGDGAL
1060 1070 1080 1090 1100
SLLQQGEQLL EENGDVLLSL QRAHEQAVKE NVKMATEISR LQQRLQKLEP
1110 1120 1130 1140 1150
GLVMSSCLDE PATEFFGNTA EQTEQFLQQN RTKQVEGVTR RHVLSDLEDD
1160 1170 1180 1190 1200
EVRDLGSTGT SSVQRQEVKI EESEASVEGF SELENSEETR TESWELKNQI
1210 1220 1230 1240 1250
SQLQEQLMML CADCDRASEK KQDLLFDVSV LKKKLKMLER IPEASPKYKL
1260 1270 1280 1290 1300
LYEDVSREND CLQEELRMME TRYDEALENN KELTAEVFRL QDELKKMEEV
1310 1320 1330 1340 1350
TETFLSLEKS YDEVKIENEG LNVLVLRLQG KIEKLQESVV QRCDCCLWEA
1360 1370 1380 1390 1400
SLENLEIEPD GNILQLNQTL EECVPRVRSV HHVIEECKQE NQYLEGNTQL
1410 1420 1430 1440 1450
LEKVKAHEIA WLHGTIQTHQ ERPRVQNQVI LEENTTLLGF QDKHFQHQAT
1460 1470 1480 1490 1500
IAELELEKTK LQELTRKLKE RVTILVKQKD VLSHGEKEEE LKAMMHDLQI
1510 1520 1530 1540 1550
TCSEMQQKVE LLRYESEKLQ QENSILRNEI TTLNEEDSIS NLKLGTLNGS
1560 1570 1580 1590 1600
QEEMWQKTET VKQENAAVQK MVENLKKQIS ELKIKNQQLD LENTELSQKN
1610 1620 1630 1640 1650
SQNQEKLQEL NQRLTEMLCQ KEKEPGNSAL EEREQEKFNL KEELERCKVQ
1660 1670 1680 1690 1700
SSTLVSSLEA ELSEVKIQTH IVQQENHLLK DELEKMKQLH RCPDLSDFQQ
1710 1720 1730 1740 1750
KISSVLSYNE KLLKEKEALS EELNSCVDKL AKSSLLEHRI ATMKQEQKSW
1760 1770 1780 1790 1800
EHQSASLKSQ LVASQEKVQN LEDTVQNVNL QMSRMKSDLR VTQQEKEALK
1810 1820 1830 1840 1850
QEVMSLHKQL QNAGGKSWAP EIATHPSGLH NQQKRLSWDK LDHLMNEEQQ
1860 1870 1880 1890 1900
LLWQENERLQ TMVQNTKAEL THSREKVRQL ESNLLPKHQK HLNPSGTMNP
1910 1920 1930 1940 1950
TEQEKLSLKR ECDQFQKEQS PANRKVSQMN SLEQELETIH LENEGLKKKQ
1960 1970 1980 1990 2000
VKLDEQLMEM QHLRSTATPS PSPHAWDLQL LQQQACPMVP REQFLQLQRQ
2010 2020 2030 2040 2050
LLQAERINQH LQEELENRTS ETNTPQGNQE QLVTVMEERM IEVEQKLKLV
2060 2070 2080 2090
KRLLQEKVNQ LKEQVSLPGH LCSPTSHSSF NSSFTSLYCH
The sequence of this isoform differs from the canonical sequence as follows:
492-508: Missing.
2065-2090: VSLPGHLCSPTSHSSFNSSFTSLYCH → LCKNTKADAM...PLTSTPPLRS
The sequence of this isoform differs from the canonical sequence as follows:
492-508: Missing.
2027-2046: GNQEQLVTVMEERMIEVEQK → ALLPEQRAVHADSYRRIGHL
2047-2090: Missing.
Computationally mapped potential isoform sequencesi
There are 12 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketC9J066 | C9J066_HUMAN | Ninein | NIN | 2,046 | Annotation score: | ||
H0YDJ4 | H0YDJ4_HUMAN | Ninein | NIN | 1,537 | Annotation score: | ||
H9KV85 | H9KV85_HUMAN | Ninein | NIN | 1,581 | Annotation score: | ||
E9PN67 | E9PN67_HUMAN | Ninein | NIN | 1,989 | Annotation score: | ||
A0A669KBI5 | A0A669KBI5_HUMAN | Ninein | NIN | 597 | Annotation score: | ||
A0A0B4J215 | A0A0B4J215_HUMAN | Ninein | NIN | 140 | Annotation score: | ||
E9PJH9 | E9PJH9_HUMAN | Ninein | NIN | 101 | Annotation score: | ||
A0A669KBE5 | A0A669KBE5_HUMAN | Ninein | NIN | 373 | Annotation score: | ||
H7C162 | H7C162_HUMAN | Ninein | NIN | 396 | Annotation score: | ||
R4GN85 | R4GN85_HUMAN | Ninein | NIN | 116 | Annotation score: | ||
There are more potential isoformsShow all |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 137 | H → Y in AAF23015 (PubMed:11004522).Curated | 1 | |
Sequence conflicti | 137 | H → Y in AAG33512 (PubMed:11162463).Curated | 1 | |
Sequence conflicti | 177 | S → F in AAF23015 (PubMed:11004522).Curated | 1 | |
Sequence conflicti | 203 | N → D in AAG33512 (PubMed:11162463).Curated | 1 | |
Sequence conflicti | 223 | M → I in AAG33512 (PubMed:11162463).Curated | 1 | |
Sequence conflicti | 295 | F → I in AAG33512 (PubMed:11162463).Curated | 1 | |
Sequence conflicti | 369 | I → V in AAG33512 (PubMed:11162463).Curated | 1 | |
Sequence conflicti | 399 | L → S in AAG33512 (PubMed:11162463).Curated | 1 | |
Sequence conflicti | 568 | L → F in AAG33512 (PubMed:11162463).Curated | 1 | |
Sequence conflicti | 809 | R → I in AAF23015 (PubMed:11004522).Curated | 1 | |
Sequence conflicti | 812 | S → T in AAG33512 (PubMed:11162463).Curated | 1 | |
Sequence conflicti | 945 | K → I in AAG33512 (PubMed:11162463).Curated | 1 | |
Sequence conflicti | 977 | D → A in AAG33512 (PubMed:11162463).Curated | 1 | |
Sequence conflicti | 980 | R → G in AAF23015 (PubMed:11004522).Curated | 1 | |
Sequence conflicti | 1054 | Q → H in AAG33512 (PubMed:11162463).Curated | 1 | |
Sequence conflicti | 1067 | L → F in AAG33512 (PubMed:11162463).Curated | 1 | |
Sequence conflicti | 1070 | L → Q in AAF23015 (PubMed:11004522).Curated | 1 | |
Sequence conflicti | 1150 | D → G in AAF23015 (PubMed:11004522).Curated | 1 | |
Sequence conflicti | 1237 | M → I in AAF23015 (PubMed:11004522).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_019453 | 1111 | P → A. Corresponds to variant dbSNP:rs2236316Ensembl. | 1 | |
Natural variantiVAR_051235 | 1125 | Q → P3 PublicationsCorresponds to variant dbSNP:rs12882191Ensembl. | 1 | |
Natural variantiVAR_069083 | 1222 | Q → R in SCKL7; does not disrupt protein expression or localization or affect mitotic functions in an obvious way. 1 PublicationCorresponds to variant dbSNP:rs187464517EnsemblClinVar. | 1 | |
Natural variantiVAR_019454 | 1320 | G → E4 PublicationsCorresponds to variant dbSNP:rs2073347Ensembl. | 1 | |
Natural variantiVAR_069084 | 1709 | N → S in SCKL7; does not disrupt protein expression or localization or affect mitotic functions in an obvious way. 1 PublicationCorresponds to variant dbSNP:rs387907308Ensembl. | 1 | |
Natural variantiVAR_019455 | 1837 | S → T. Corresponds to variant dbSNP:rs12717411Ensembl. | 1 | |
Natural variantiVAR_051236 | 1934 | Q → E. Corresponds to variant dbSNP:rs2295847Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_040039 | 1 – 38 | Missing in isoform 8. 1 PublicationAdd BLAST | 38 | |
Alternative sequenceiVSP_010950 | 1 – 35 | MDEVE…EELTD → MAEVTVPRVYVVFGIHCIMA KASSDVQVSGFHRKIQHVKN E in isoform 5. 1 PublicationAdd BLAST | 35 | |
Alternative sequenceiVSP_010952 | 492 – 508 | Missing in isoform 2, isoform 3 and isoform 4. 2 PublicationsAdd BLAST | 17 | |
Alternative sequenceiVSP_010953 | 800 – 1512 | Missing in isoform 6 and isoform 9. 2 PublicationsAdd BLAST | 713 | |
Alternative sequenceiVSP_010954 | 1555 | Missing in isoform 6. 1 Publication | 1 | |
Alternative sequenceiVSP_010955 | 1960 – 1988 | MQHLR…QACPM → NSVVGSSREGCSSLPEIVCE DAAPEVHCDA in isoform 6. 1 PublicationAdd BLAST | 29 | |
Alternative sequenceiVSP_010956 | 1989 – 2090 | Missing in isoform 6. 1 PublicationAdd BLAST | 102 | |
Alternative sequenceiVSP_010957 | 2027 – 2046 | GNQEQ…EVEQK → ALLPEQRAVHADSYRRIGHL in isoform 4. 2 PublicationsAdd BLAST | 20 | |
Alternative sequenceiVSP_010958 | 2047 – 2090 | Missing in isoform 4. 2 PublicationsAdd BLAST | 44 | |
Alternative sequenceiVSP_010960 | 2065 – 2090 | VSLPG…SLYCH → LCKNTKADAMVKDLYVENAQ LLKALEVTEQRQKTAEKKNY LLEEKIASLSNIVRNLTPAP LTSTPPLRS in isoform 3 and isoform 7. 2 PublicationsAdd BLAST | 26 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF212162 mRNA Translation: AAF23015.2 AF302773 mRNA Translation: AAG33512.2 AF223937 mRNA Translation: AAK00628.1 Sequence problems. AF223938 mRNA Translation: AAK00629.1 Sequence problems. AF223939 mRNA Translation: AAK00630.1 Sequence problems. AB046785 mRNA Translation: BAB13391.2 Different initiation. AL133485 Genomic DNA No translation available. AL606834 Genomic DNA No translation available. BC034708 mRNA Translation: AAH34708.2 BC065521 mRNA Translation: AAH65521.1 Sequence problems. BC090932 mRNA Translation: AAH90932.1 AY027794 mRNA Translation: AAK27375.1 AY027795 mRNA Translation: AAK27376.1 AY027796 mRNA Translation: AAK27377.1 AF186776 mRNA Translation: AAG17027.1 AK027054 mRNA Translation: BAB15640.1 Different initiation. |
CCDSi | CCDS32078.2 [Q8N4C6-11] CCDS32079.1 [Q8N4C6-1] |
RefSeqi | NP_057434.4, NM_016350.4 [Q8N4C6-11] NP_065972.3, NM_020921.3 [Q8N4C6-7] NP_891989.2, NM_182944.2 NP_891991.1, NM_182946.1 [Q8N4C6-1] XP_011535125.1, XM_011536823.2 [Q8N4C6-5] |
Genome annotation databases
Ensembli | ENST00000245441; ENSP00000245441; ENSG00000100503 [Q8N4C6-7] ENST00000324330; ENSP00000324210; ENSG00000100503 [Q8N4C6-11] ENST00000382041; ENSP00000371472; ENSG00000100503 [Q8N4C6-1] ENST00000382043; ENSP00000371474; ENSG00000100503 [Q8N4C6-11] ENST00000530997; ENSP00000436092; ENSG00000100503 [Q8N4C6-7] |
GeneIDi | 51199 |
KEGGi | hsa:51199 |
UCSCi | uc001wyi.3, human [Q8N4C6-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF212162 mRNA Translation: AAF23015.2 AF302773 mRNA Translation: AAG33512.2 AF223937 mRNA Translation: AAK00628.1 Sequence problems. AF223938 mRNA Translation: AAK00629.1 Sequence problems. AF223939 mRNA Translation: AAK00630.1 Sequence problems. AB046785 mRNA Translation: BAB13391.2 Different initiation. AL133485 Genomic DNA No translation available. AL606834 Genomic DNA No translation available. BC034708 mRNA Translation: AAH34708.2 BC065521 mRNA Translation: AAH65521.1 Sequence problems. BC090932 mRNA Translation: AAH90932.1 AY027794 mRNA Translation: AAK27375.1 AY027795 mRNA Translation: AAK27376.1 AY027796 mRNA Translation: AAK27377.1 AF186776 mRNA Translation: AAG17027.1 AK027054 mRNA Translation: BAB15640.1 Different initiation. |
CCDSi | CCDS32078.2 [Q8N4C6-11] CCDS32079.1 [Q8N4C6-1] |
RefSeqi | NP_057434.4, NM_016350.4 [Q8N4C6-11] NP_065972.3, NM_020921.3 [Q8N4C6-7] NP_891989.2, NM_182944.2 NP_891991.1, NM_182946.1 [Q8N4C6-1] XP_011535125.1, XM_011536823.2 [Q8N4C6-5] |
3D structure databases
SMRi | Q8N4C6 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 119372, 317 interactors |
IntActi | Q8N4C6, 121 interactors |
MINTi | Q8N4C6 |
STRINGi | 9606.ENSP00000371472 |
Chemistry databases
BindingDBi | Q8N4C6 |
PTM databases
iPTMneti | Q8N4C6 |
PhosphoSitePlusi | Q8N4C6 |
Genetic variation databases
BioMutai | NIN |
DMDMi | 311033487 |
Proteomic databases
EPDi | Q8N4C6 |
jPOSTi | Q8N4C6 |
MassIVEi | Q8N4C6 |
MaxQBi | Q8N4C6 |
PaxDbi | Q8N4C6 |
PeptideAtlasi | Q8N4C6 |
PRIDEi | Q8N4C6 |
ProteomicsDBi | 71907 [Q8N4C6-1] 71908 [Q8N4C6-10] 71909 [Q8N4C6-11] 71910 [Q8N4C6-2] 71911 [Q8N4C6-4] 71912 [Q8N4C6-5] 71913 [Q8N4C6-6] 71914 [Q8N4C6-7] 71915 [Q8N4C6-9] |
Protocols and materials databases
Antibodypediai | 23688, 137 antibodies |
Genome annotation databases
Ensembli | ENST00000245441; ENSP00000245441; ENSG00000100503 [Q8N4C6-7] ENST00000324330; ENSP00000324210; ENSG00000100503 [Q8N4C6-11] ENST00000382041; ENSP00000371472; ENSG00000100503 [Q8N4C6-1] ENST00000382043; ENSP00000371474; ENSG00000100503 [Q8N4C6-11] ENST00000530997; ENSP00000436092; ENSG00000100503 [Q8N4C6-7] |
GeneIDi | 51199 |
KEGGi | hsa:51199 |
UCSCi | uc001wyi.3, human [Q8N4C6-1] |
Organism-specific databases
CTDi | 51199 |
DisGeNETi | 51199 |
GeneCardsi | NIN |
HGNCi | HGNC:14906, NIN |
HPAi | ENSG00000100503, Low tissue specificity |
MalaCardsi | NIN |
MIMi | 608684, gene 614851, phenotype |
neXtProti | NX_Q8N4C6 |
OpenTargetsi | ENSG00000100503 |
Orphaneti | 319675, Microcephalic primordial dwarfism, Dauber type |
PharmGKBi | PA31630 |
VEuPathDBi | HostDB:ENSG00000100503.23 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QZCC, Eukaryota |
GeneTreei | ENSGT00660000095541 |
HOGENOMi | CLU_001462_1_1_1 |
InParanoidi | Q8N4C6 |
OMAi | RMKQVEG |
OrthoDBi | 95801at2759 |
PhylomeDBi | Q8N4C6 |
TreeFami | TF325139 |
Enzyme and pathway databases
PathwayCommonsi | Q8N4C6 |
SIGNORi | Q8N4C6 |
Miscellaneous databases
BioGRID-ORCSi | 51199, 6 hits in 874 CRISPR screens |
ChiTaRSi | NIN, human |
GeneWikii | NIN_(gene) |
GenomeRNAii | 51199 |
Pharosi | Q8N4C6, Tbio |
PROi | PR:Q8N4C6 |
RNActi | Q8N4C6, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000100503, Expressed in amniotic fluid and 213 other tissues |
ExpressionAtlasi | Q8N4C6, baseline and differential |
Genevisiblei | Q8N4C6, HS |
Family and domain databases
InterProi | View protein in InterPro IPR011992, EF-hand-dom_pair IPR002048, EF_hand_dom IPR029664, NIN |
PANTHERi | PTHR18905:SF11, PTHR18905:SF11, 1 hit |
SUPFAMi | SSF47473, SSF47473, 1 hit |
PROSITEi | View protein in PROSITE PS50222, EF_HAND_2, 5 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | NIN_HUMAN | |
Accessioni | Q8N4C6Primary (citable) accession number: Q8N4C6 Secondary accession number(s): A6NDB8 Q9UH61 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 19, 2004 |
Last sequence update: | November 2, 2010 | |
Last modified: | February 10, 2021 | |
This is version 170 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 14
Human chromosome 14: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot