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UniProtKB - Q8N488 (RYBP_HUMAN)

Entry version 167 (29 Sep 2021)
Sequence version 2 (10 May 2005)
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Protein

RING1 and YY1-binding protein

Gene

RYBP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1-like complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:25519132).

Component of a PRC1-like complex that mediates monoubiquitination of histone H2A 'Lys-119' on the X chromosome and is required for normal silencing of one copy of the X chromosome in XX females. May stimulate ubiquitination of histone H2A 'Lys-119' by recruiting the complex to target sites (By similarity).

Inhibits ubiquitination and subsequent degradation of TP53, and thereby plays a role in regulating transcription of TP53 target genes (PubMed:19098711).

May also regulate the ubiquitin-mediated proteasomal degradation of other proteins like FANK1 to regulate apoptosis (PubMed:14765135, PubMed:27060496).

May be implicated in the regulation of the transcription as a repressor of the transcriptional activity of E4TF1 (PubMed:11953439).

May bind to DNA (By similarity).

May play a role in the repression of tumor growth and metastasis in breast cancer by down-regulating SRRM3 (PubMed:27748911).

By similarity5 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri21 – 50RanBP2-typePROSITE-ProRule annotationAdd BLAST30

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Repressor
Biological processApoptosis, Transcription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q8N488

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-8939243, RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
R-HSA-8953750, Transcriptional Regulation by E2F6

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q8N488

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q8N488

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
RING1 and YY1-binding protein
Alternative name(s):
Apoptin-associating protein 1
Short name:
APAP-1
Death effector domain-associated factor
Short name:
DED-associated factor
YY1 and E4TF1-associated factor 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RYBP
Synonyms:DEDAF, YEAF1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:10480, RYBP

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		607535, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8N488

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000163602

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		23429

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA34893

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q8N488, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		RYBP

Domain mapping of disease mutations (DMDM)

More...DMDMi		78102506

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000975501 – 228RING1 and YY1-binding proteinAdd BLAST228

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki77Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei99PhosphoserineCombined sources1
Modified residuei123PhosphoserineCombined sources1
Modified residuei127PhosphoserineCombined sources1
Modified residuei130PhosphoserineCombined sources1
Modified residuei227PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Monoubiquitinated.By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q8N488

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q8N488

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q8N488

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q8N488

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8N488

PeptideAtlas

More...PeptideAtlasi		Q8N488

PRoteomics IDEntifications database

More...PRIDEi		Q8N488

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		71895

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8N488

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8N488

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Down-regulated in breast cancer tissues and in several breast cancer cell lines (at protein level) (PubMed:27748911). Widely expressed with highest levels in lymphoid tissues and placenta.4 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000163602, Expressed in chorionic villus and 252 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8N488, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000163602, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer.

Component of repressive BCOR complex containing Polycomb group subcomplex at least composed of BCOR, PCGF1, RING1 and RNF2/RING2 (PubMed:16943429).

Component of PCR1-like complexes (PubMed:26687479, PubMed:20696397).

Interacts with PCGF1 (PubMed:26687479).

Part of a PCR1-like complex that contains AUTS2, PCGF5, RNF2, CSNK2B AND RYBP (PubMed:25519132).

Interacts with RNF2; the interaction is direct (PubMed:20696397).

Interacts with CBX2, YAF2, RING1 and RNF2 (By similarity).

Interacts with ubiquitin and ubiquitinated proteins (By similarity).

Interacts with ubiquitinated histone H2A (By similarity).

Interacts with apoptin, DEDD, FADD, CASP8, CASP10, YY1 and GABPB1 (PubMed:11395500, PubMed:11953439, PubMed:14765135). Together with GABPB1 and YY1, it forms a ternary complex, probably being the bridge factor between these two transcription factors (PubMed:11953439).

Interacts with MDM2, and thereby inhibits ubiquitination of TP53 (PubMed:19098711).

Identified in a ternary complex containing MDM2, TP53 and RYBP (PubMed:19098711).

Interacts with FANK1; may prevent the ubiquitin-mediated proteasomal degradation of FANK1 (PubMed:27060496).

Interacts with IFT57 (By similarity).

By similarity9 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q8N488
With#Exp.IntAct
ATXN1 [P54253]6EBI-752324,EBI-930964
BANP - isoform 2 [Q8N9N5-2]3EBI-752324,EBI-11524452
BRK1 [Q8WUW1]3EBI-752324,EBI-2837444
COMT - isoform Soluble [P21964-2]3EBI-752324,EBI-10200977
CRYAA2 [A0A140G945]3EBI-752324,EBI-25838900
DCTN1 - isoform 5 [Q14203-5]3EBI-752324,EBI-25840379
DMWD [G5E9A7]3EBI-752324,EBI-10976677
DR1 [Q01658]3EBI-752324,EBI-750300
EAF1 [Q96JC9]3EBI-752324,EBI-769261
ELAVL4 - isoform 2 [P26378-2]3EBI-752324,EBI-21603100
F8 - isoform 2 [P00451-2]3EBI-752324,EBI-25852704
FLNA - isoform 2 [P21333-2]3EBI-752324,EBI-9641086
FUS [P35637]3EBI-752324,EBI-400434
GFAP [P14136]3EBI-752324,EBI-744302
GIPC1 - isoform 2 [O14908-2]3EBI-752324,EBI-25913156
GPC5 [P78333]3EBI-752324,EBI-2558325
GRN [P28799]3EBI-752324,EBI-747754
GTF2B [Q00403]3EBI-752324,EBI-389564
GTF3C3 [Q9Y5Q9]3EBI-752324,EBI-1054873
HTRA2 [O43464]3EBI-752324,EBI-517086
HTT [P42858]9EBI-752324,EBI-466029
KIF1B - isoform 2 [O60333-2]3EBI-752324,EBI-10975473
LMNA [P02545]3EBI-752324,EBI-351935
MAT2A [P31153]3EBI-752324,EBI-1050743
MDM2 [Q00987]11EBI-752324,EBI-389668
NDRG1 [Q92597]3EBI-752324,EBI-716486
NEFL [P07196]3EBI-752324,EBI-475646
NF2 - isoform 4 [P35240-4]3EBI-752324,EBI-1014514
PEX1 [O43933]3EBI-752324,EBI-988601
PKM [P14618]3EBI-752324,EBI-353408
PRKN - isoform 5 [O60260-5]6EBI-752324,EBI-21251460
PSEN1 - isoform 2 [P49768-2]6EBI-752324,EBI-11047108
PSEN2 [P49810]3EBI-752324,EBI-2010251
PSMB1 [P20618]3EBI-752324,EBI-372273
RING1 [Q06587]18EBI-752324,EBI-752313
RING1 - isoform 2 [Q06587-2]3EBI-752324,EBI-7065222
RNF11 [Q9Y3C5]3EBI-752324,EBI-396669
RNF2 [Q99496]18EBI-752324,EBI-722416
SEPTIN5 [Q99719]3EBI-752324,EBI-373345
SNCA [P37840]3EBI-752324,EBI-985879
SNCB [Q16143]3EBI-752324,EBI-727106
SOD1 [P00441]3EBI-752324,EBI-990792
SPRED1 [Q7Z699]3EBI-752324,EBI-5235340
SRP9 [P49458]3EBI-752324,EBI-350743
TARDBP [Q13148]6EBI-752324,EBI-372899
TDP1 [Q9NUW8]3EBI-752324,EBI-2902553
TGM2 - isoform 2 [P21980-2]3EBI-752324,EBI-25842075
TP53 [P04637]3EBI-752324,EBI-366083
UBB [P0CG47]3EBI-752324,EBI-413034
UBC [P0CG48]3EBI-752324,EBI-3390054
XAGE1B [Q9HD64]3EBI-752324,EBI-2340004
Q9P1N43EBI-752324,EBI-25878161
Helicase nsp13 (PRO_0000037319) from Severe acute respiratory syndrome coronavirus.2EBI-752324,EBI-25487926
Trpm7 [Q923J1] from Mus musculus.3EBI-752324,EBI-8010314

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		116997, 89 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q8N488

Database of interacting proteins

More...DIPi		DIP-41435N

Protein interaction database and analysis system

More...IntActi		Q8N488, 99 interactors

Molecular INTeraction database

More...MINTi		Q8N488

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000419494

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8N488, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1228
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8N488

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q8N488

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 21DisorderedSequence analysisAdd BLAST21
Regioni65 – 156DisorderedSequence analysisAdd BLAST92
Regioni143 – 226Interaction with GABPB1 and FANK12 PublicationsAdd BLAST84
Regioni172 – 228DisorderedSequence analysisAdd BLAST57

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 20Basic and acidic residuesSequence analysisAdd BLAST20
Compositional biasi75 – 119Basic and acidic residuesSequence analysisAdd BLAST45
Compositional biasi122 – 141Polar residuesSequence analysisAdd BLAST20

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Intrinsically unstructured in the absence of binding partners. Folds upon binding to DNA or RNF2 (By similarity).By similarity

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri21 – 50RanBP2-typePROSITE-ProRule annotationAdd BLAST30

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4477, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_095374_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8N488

Database of Orthologous Groups

More...OrthoDBi		1634090at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8N488

TreeFam database of animal gene trees

More...TreeFami		TF350501

Family and domain databases

Database of protein disorder

More...DisProti		DP00694

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR039958, RYBP/YAF2
IPR033774, YAF2_RYBP
IPR001876, Znf_RanBP2
IPR036443, Znf_RanBP2_sf

The PANTHER Classification System

More...PANTHERi		PTHR12920, PTHR12920, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF17219, YAF2_RYBP, 1 hit
PF00641, zf-RanBP, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00547, ZnF_RBZ, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF90209, SSF90209, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS01358, ZF_RANBP2_1, 1 hit
PS50199, ZF_RANBP2_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8N488-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTMGDKKSPT RPKRQAKPAA DEGFWDCSVC TFRNSAEAFK CSICDVRKGT 
        60         70         80         90        100
STRKPRINSQ LVAQQVAQQY ATPPPPKKEK KEKVEKQDKE KPEKDKEISP 
       110        120        130        140        150
SVTKKNTNKK TKPKSDILKD PPSEANSIQS ANATTKTSET NHTSRPRLKN 
       160        170        180        190        200
VDRSTAQQLA VTVGNVTVII TDFKEKTRSS STSSSTVTSS AGSEQQNQSS 
       210        220 
SGSESTDKGS SRSSTPKGDM SAVNDESF
Length:228
Mass (Da):24,822
Last modified:May 10, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEB9593460A3F0F4C
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAK63197 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAO73587 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAA89486 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti20A → T in AAH36459 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF179286 mRNA Translation: AAD51858.1
AB029551 mRNA Translation: BAA89486.1 Different initiation.
AY228125 mRNA Translation: AAO73587.1 Different initiation.
AF227959 mRNA Translation: AAK63197.1 Different initiation.
BC014959 mRNA Translation: AAH14959.1
BC036459 mRNA Translation: AAH36459.1

NCBI Reference Sequences

More...RefSeqi		NP_036366.3, NM_012234.6

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000477973; ENSP00000419494; ENSG00000163602

Database of genes from NCBI RefSeq genomes

More...GeneIDi		23429

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:23429

UCSC genome browser

More...UCSCi		uc003dpe.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF179286 mRNA Translation: AAD51858.1
AB029551 mRNA Translation: BAA89486.1 Different initiation.
AY228125 mRNA Translation: AAO73587.1 Different initiation.
AF227959 mRNA Translation: AAK63197.1 Different initiation.
BC014959 mRNA Translation: AAH14959.1
BC036459 mRNA Translation: AAH36459.1
RefSeqiNP_036366.3, NM_012234.6

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3IXSX-ray1.70B/D/F/H/J/L145-179[»]
SMRiQ8N488
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi116997, 89 interactors
CORUMiQ8N488
DIPiDIP-41435N
IntActiQ8N488, 99 interactors
MINTiQ8N488
STRINGi9606.ENSP00000419494

PTM databases

iPTMnetiQ8N488
PhosphoSitePlusiQ8N488

Genetic variation databases

BioMutaiRYBP
DMDMi78102506

Proteomic databases

EPDiQ8N488
jPOSTiQ8N488
MassIVEiQ8N488
MaxQBiQ8N488
PaxDbiQ8N488
PeptideAtlasiQ8N488
PRIDEiQ8N488
ProteomicsDBi71895

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		7772, 465 antibodies

The DNASU plasmid repository

More...DNASUi		23429

Genome annotation databases

EnsembliENST00000477973; ENSP00000419494; ENSG00000163602
GeneIDi23429
KEGGihsa:23429
UCSCiuc003dpe.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		23429
DisGeNETi23429

GeneCards: human genes, protein and diseases

More...GeneCardsi		RYBP
HGNCiHGNC:10480, RYBP
HPAiENSG00000163602, Low tissue specificity
MIMi607535, gene
neXtProtiNX_Q8N488
PharmGKBiPA34893
VEuPathDBiHostDB:ENSG00000163602

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG4477, Eukaryota
HOGENOMiCLU_095374_0_0_1
InParanoidiQ8N488
OrthoDBi1634090at2759
PhylomeDBiQ8N488
TreeFamiTF350501

Enzyme and pathway databases

PathwayCommonsiQ8N488
ReactomeiR-HSA-8939243, RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
R-HSA-8953750, Transcriptional Regulation by E2F6
SignaLinkiQ8N488
SIGNORiQ8N488

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		23429, 7 hits in 158 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		RYBP, human
EvolutionaryTraceiQ8N488

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		RYBP

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		23429
PharosiQ8N488, Tbio

Protein Ontology

More...PROi		PR:Q8N488
RNActiQ8N488, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000163602, Expressed in chorionic villus and 252 other tissues
GenevisibleiQ8N488, HS

Family and domain databases

DisProtiDP00694
InterProiView protein in InterPro
IPR039958, RYBP/YAF2
IPR033774, YAF2_RYBP
IPR001876, Znf_RanBP2
IPR036443, Znf_RanBP2_sf
PANTHERiPTHR12920, PTHR12920, 1 hit
PfamiView protein in Pfam
PF17219, YAF2_RYBP, 1 hit
PF00641, zf-RanBP, 1 hit
SMARTiView protein in SMART
SM00547, ZnF_RBZ, 1 hit
SUPFAMiSSF90209, SSF90209, 1 hit
PROSITEiView protein in PROSITE
PS01358, ZF_RANBP2_1, 1 hit
PS50199, ZF_RANBP2_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRYBP_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8N488
Secondary accession number(s): Q9P2W5, Q9UMW4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: May 10, 2005
Last modified: September 29, 2021
This is version 167 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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