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Entry version 154 (02 Dec 2020)
Sequence version 2 (12 Apr 2005)
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Protein

Follistatin-related protein 5

Gene

FSTL5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) of the calcium-binding region(s) within the protein. One common calcium-binding motif is the EF-hand, but other calcium-binding motifs also exist.<p><a href='/help/ca_bind' target='_top'>More...</a></p>Calcium bindingi188 – 2001PROSITE-ProRule annotationAdd BLAST13
Calcium bindingi226 – 2382PROSITE-ProRule annotationAdd BLAST13

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandCalcium, Metal-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

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PathwayCommonsi
Q8N475

Protein family/group databases

MEROPS protease database

More...
MEROPSi
I01.977

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Follistatin-related protein 5
Alternative name(s):
Follistatin-like protein 5
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FSTL5
Synonyms:KIAA1263
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

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EuPathDBi
HostDB:ENSG00000168843.13

Human Gene Nomenclature Database

More...
HGNCi
HGNC:21386, FSTL5

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8N475

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
56884

Open Targets

More...
OpenTargetsi
ENSG00000168843

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134978045

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8N475, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
FSTL5

Domain mapping of disease mutations (DMDM)

More...
DMDMi
62510692

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 20Sequence analysisAdd BLAST20
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001011821 – 847Follistatin-related protein 5Add BLAST827

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi89 ↔ 119PROSITE-ProRule annotation
Disulfide bondi93 ↔ 112PROSITE-ProRule annotation
Disulfide bondi101 ↔ 133PROSITE-ProRule annotation
Disulfide bondi270 ↔ 321By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi318N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi362 ↔ 413By similarity
Glycosylationi394N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q8N475

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q8N475

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8N475

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8N475

PeptideAtlas

More...
PeptideAtlasi
Q8N475

PRoteomics IDEntifications database

More...
PRIDEi
Q8N475

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
19487
71893 [Q8N475-1]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q8N475, 2 sites

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8N475

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8N475

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000168843, Expressed in cerebellar vermis and 111 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q8N475, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000168843, Tissue enriched (brain)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
121216, 2 interactors

Protein interaction database and analysis system

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IntActi
Q8N475, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000305334

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8N475, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q8N475

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini83 – 135Kazal-likePROSITE-ProRule annotationAdd BLAST53
Domaini175 – 210EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini211 – 246EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini250 – 337Ig-like 1Add BLAST88
Domaini341 – 426Ig-like 2Add BLAST86

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QPNV, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156495

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_007849_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8N475

Identification of Orthologs from Complete Genome Data

More...
OMAi
KYGYVTH

Database of Orthologous Groups

More...
OrthoDBi
1065760at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q8N475

TreeFam database of animal gene trees

More...
TreeFami
TF350473

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.10, 1 hit
2.60.40.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011992, EF-hand-dom_pair
IPR018247, EF_Hand_1_Ca_BS
IPR002048, EF_hand_dom
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR003599, Ig_sub
IPR003598, Ig_sub2
IPR002350, Kazal_dom
IPR036058, Kazal_dom_sf
IPR015943, WD40/YVTN_repeat-like_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07648, Kazal_2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00409, IG, 2 hits
SM00408, IGc2, 2 hits
SM00280, KAZAL, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF100895, SSF100895, 1 hit
SSF47473, SSF47473, 1 hit
SSF48726, SSF48726, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00018, EF_HAND_1, 2 hits
PS50222, EF_HAND_2, 1 hit
PS50835, IG_LIKE, 2 hits
PS51465, KAZAL_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8N475-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MFKCWSVVLV LGFIFLESEG RPTKEGGYGL KSYQPLMRLR HKQEKNQESS
60 70 80 90 100
RVKGFMIQDG PFGSCENKYC GLGRHCVTSR ETGQAECACM DLCKRHYKPV
110 120 130 140 150
CGSDGEFYEN HCEVHRAACL KKQKITIVHN EDCFFKGDKC KTTEYSKMKN
160 170 180 190 200
MLLDLQNQKY IMQENENPNG DDISRKKLLV DQMFKYFDAD SNGLVDINEL
210 220 230 240 250
TQVIKQEELG KDLFDCTLYV LLKYDDFNAD KHLALEEFYR AFQVIQLSLP
260 270 280 290 300
EDQKLSITAA TVGQSAVLSC AIQGTLRPPI IWKRNNIILN NLDLEDINDF
310 320 330 340 350
GDDGSLYITK VTTTHVGNYT CYADGYEQVY QTHIFQVNVP PVIRVYPESQ
360 370 380 390 400
AREPGVTASL RCHAEGIPKP QLGWLKNGID ITPKLSKQLT LQANGSEVHI
410 420 430 440 450
SNVRYEDTGA YTCIAKNEAG VDEDISSLFV EDSARKTLAN ILWREEGLGI
460 470 480 490 500
GNMFYVFYED GIKVIQPIEC EFQRHIKPSE KLLGFQDEVC PKAEGDEVQR
510 520 530 540 550
CVWASAVNVK DKFIYVAQPT LDRVLIVDVQ SQKVVQAVST DPVPVKLHYD
560 570 580 590 600
KSHDQVWVLS WGTLEKTSPT LQVITLASGN VPHHTIHTQP VGKQFDRVDD
610 620 630 640 650
FFIPTTTLII THMRFGFILH KDEAALQKID LETMSYIKTI NLKDYKCVPQ
660 670 680 690 700
SLAYTHLGGY YFIGCKPDST GAVSPQVMVD GVTDSVIGFN SDVTGTPYVS
710 720 730 740 750
PDGHYLVSIN DVKGLVRVQY ITIRGEIQEA FDIYTNLHIS DLAFQPSFTE
760 770 780 790 800
AHQYNIYGSS STQTDVLFVE LSSGKVKMIK SLKEPLKAEE WPWNRKNRQI
810 820 830 840
QDSGLFGQYL MTPSKDSLFI LDGRLNKLNC EITEVEKGNT VIWVGDA
Length:847
Mass (Da):95,751
Last modified:April 12, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAA8ECA182FF6CDB6
GO
Isoform 2 (identifier: Q8N475-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     43-43: Missing.

Show »
Length:846
Mass (Da):95,623
Checksum:i254D3EBC85178C61
GO
Isoform 3 (identifier: Q8N475-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     43-43: Missing.
     438-447: LANILWREEG → R

Show »
Length:837
Mass (Da):94,597
Checksum:iEF11265F82EB6139
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA86577 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti145Y → C in CAB70877 (PubMed:17974005).Curated1
Sequence conflicti159K → R in CAB70877 (PubMed:17974005).Curated1
Sequence conflicti193G → D in CAB70877 (PubMed:17974005).Curated1
Sequence conflicti293D → G in CAB70877 (PubMed:17974005).Curated1
Sequence conflicti492K → I in CAB70877 (PubMed:17974005).Curated1
Sequence conflicti560S → G in AK315152 (PubMed:14702039).Curated1
Sequence conflicti567T → S in AAH36502 (PubMed:15489334).Curated1
Sequence conflicti631L → I in AAH36502 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03613592L → I in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs747628234Ensembl.1
Natural variantiVAR_049092711D → Y. Corresponds to variant dbSNP:rs3749598Ensembl.1
Natural variantiVAR_049093815K → E. Corresponds to variant dbSNP:rs17040982Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_04621543Missing in isoform 2 and isoform 3. 2 Publications1
Alternative sequenceiVSP_046216438 – 447LANILWREEG → R in isoform 3. 1 Publication10

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB033089 mRNA Translation: BAA86577.1 Different initiation.
AK315152 mRNA No translation available.
AC023136 Genomic DNA No translation available.
AC079227 Genomic DNA No translation available.
AC084281 Genomic DNA No translation available.
AC096717 Genomic DNA No translation available.
AC104793 Genomic DNA No translation available.
AC105251 Genomic DNA No translation available.
AC108163 Genomic DNA No translation available.
BC036502 mRNA Translation: AAH36502.1
AL137695 mRNA Translation: CAB70877.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS3802.1 [Q8N475-1]
CCDS47157.1 [Q8N475-3]
CCDS47158.1 [Q8N475-2]

Protein sequence database of the Protein Information Resource

More...
PIRi
T46283

NCBI Reference Sequences

More...
RefSeqi
NP_001121899.1, NM_001128427.2 [Q8N475-2]
NP_001121900.1, NM_001128428.2 [Q8N475-3]
NP_064501.2, NM_020116.4 [Q8N475-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000306100; ENSP00000305334; ENSG00000168843 [Q8N475-1]
ENST00000379164; ENSP00000368462; ENSG00000168843 [Q8N475-2]
ENST00000427802; ENSP00000389270; ENSG00000168843 [Q8N475-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
56884

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:56884

UCSC genome browser

More...
UCSCi
uc003iqh.5, human [Q8N475-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB033089 mRNA Translation: BAA86577.1 Different initiation.
AK315152 mRNA No translation available.
AC023136 Genomic DNA No translation available.
AC079227 Genomic DNA No translation available.
AC084281 Genomic DNA No translation available.
AC096717 Genomic DNA No translation available.
AC104793 Genomic DNA No translation available.
AC105251 Genomic DNA No translation available.
AC108163 Genomic DNA No translation available.
BC036502 mRNA Translation: AAH36502.1
AL137695 mRNA Translation: CAB70877.1
CCDSiCCDS3802.1 [Q8N475-1]
CCDS47157.1 [Q8N475-3]
CCDS47158.1 [Q8N475-2]
PIRiT46283
RefSeqiNP_001121899.1, NM_001128427.2 [Q8N475-2]
NP_001121900.1, NM_001128428.2 [Q8N475-3]
NP_064501.2, NM_020116.4 [Q8N475-1]

3D structure databases

SMRiQ8N475
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi121216, 2 interactors
IntActiQ8N475, 2 interactors
STRINGi9606.ENSP00000305334

Protein family/group databases

MEROPSiI01.977

PTM databases

GlyGeniQ8N475, 2 sites
iPTMnetiQ8N475
PhosphoSitePlusiQ8N475

Polymorphism and mutation databases

BioMutaiFSTL5
DMDMi62510692

Proteomic databases

EPDiQ8N475
MassIVEiQ8N475
MaxQBiQ8N475
PaxDbiQ8N475
PeptideAtlasiQ8N475
PRIDEiQ8N475
ProteomicsDBi19487
71893 [Q8N475-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
28231, 94 antibodies

Genome annotation databases

EnsembliENST00000306100; ENSP00000305334; ENSG00000168843 [Q8N475-1]
ENST00000379164; ENSP00000368462; ENSG00000168843 [Q8N475-2]
ENST00000427802; ENSP00000389270; ENSG00000168843 [Q8N475-3]
GeneIDi56884
KEGGihsa:56884
UCSCiuc003iqh.5, human [Q8N475-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
56884
DisGeNETi56884
EuPathDBiHostDB:ENSG00000168843.13

GeneCards: human genes, protein and diseases

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GeneCardsi
FSTL5
HGNCiHGNC:21386, FSTL5
HPAiENSG00000168843, Tissue enriched (brain)
neXtProtiNX_Q8N475
OpenTargetsiENSG00000168843
PharmGKBiPA134978045

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502QPNV, Eukaryota
GeneTreeiENSGT00940000156495
HOGENOMiCLU_007849_1_0_1
InParanoidiQ8N475
OMAiKYGYVTH
OrthoDBi1065760at2759
PhylomeDBiQ8N475
TreeFamiTF350473

Enzyme and pathway databases

PathwayCommonsiQ8N475

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
56884, 6 hits in 843 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
FSTL5, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
56884
PharosiQ8N475, Tbio

Protein Ontology

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PROi
PR:Q8N475
RNActiQ8N475, protein

Gene expression databases

BgeeiENSG00000168843, Expressed in cerebellar vermis and 111 other tissues
GenevisibleiQ8N475, HS

Family and domain databases

Gene3Di2.130.10.10, 1 hit
2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR011992, EF-hand-dom_pair
IPR018247, EF_Hand_1_Ca_BS
IPR002048, EF_hand_dom
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR003599, Ig_sub
IPR003598, Ig_sub2
IPR002350, Kazal_dom
IPR036058, Kazal_dom_sf
IPR015943, WD40/YVTN_repeat-like_dom_sf
PfamiView protein in Pfam
PF07648, Kazal_2, 1 hit
SMARTiView protein in SMART
SM00409, IG, 2 hits
SM00408, IGc2, 2 hits
SM00280, KAZAL, 1 hit
SUPFAMiSSF100895, SSF100895, 1 hit
SSF47473, SSF47473, 1 hit
SSF48726, SSF48726, 2 hits
PROSITEiView protein in PROSITE
PS00018, EF_HAND_1, 2 hits
PS50222, EF_HAND_2, 1 hit
PS50835, IG_LIKE, 2 hits
PS51465, KAZAL_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFSTL5_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8N475
Secondary accession number(s): E9PCP6, Q9NSW7, Q9ULF7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: April 12, 2005
Last modified: December 2, 2020
This is version 154 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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