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UniProtKB - Q8N461 (FXL16_HUMAN)

Entry version 159 (02 Jun 2021)
Sequence version 2 (17 Oct 2006)
Previous versions | rss
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Protein

F-box/LRR-repeat protein 16

Gene

FBXL16

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q8N461

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-8951664, Neddylation
R-HSA-983168, Antigen processing: Ubiquitination & Proteasome degradation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
F-box/LRR-repeat protein 16
Alternative name(s):
F-box and leucine-rich repeat protein 16
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FBXL16
Synonyms:C16orf22, FBL16
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:14150, FBXL16

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		609082, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8N461

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000127585.11

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		146330

Open Targets

More...OpenTargetsi		ENSG00000127585

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA25536

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q8N461, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		FBXL16

Domain mapping of disease mutations (DMDM)

More...DMDMi		116242480

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001198631 – 479F-box/LRR-repeat protein 16Add BLAST479

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei92Omega-N-methylarginineBy similarity1

Keywords - PTMi

Methylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q8N461

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q8N461

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q8N461

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q8N461

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8N461

PeptideAtlas

More...PeptideAtlasi		Q8N461

PRoteomics IDEntifications database

More...PRIDEi		Q8N461

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		3581
71888 [Q8N461-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8N461

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8N461

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000127585, Expressed in caudate nucleus and 192 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8N461, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000127585, Tissue enriched (brain)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with SKP1 and CUL1.

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		126979, 16 interactors

Protein interaction database and analysis system

More...IntActi		Q8N461, 11 interactors

Molecular INTeraction database

More...MINTi		Q8N461

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000380746

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8N461, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8N461

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini94 – 139F-boxAdd BLAST46
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati244 – 266LRR 1Add BLAST23
Repeati267 – 290LRR 2Add BLAST24
Repeati319 – 343LRR 3Add BLAST25
Repeati345 – 369LRR 4Add BLAST25
Repeati371 – 395LRR 5Add BLAST25
Repeati396 – 420LRR 6Add BLAST25
Repeati446 – 470LRR 7Add BLAST25

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 62DisorderedSequence analysisAdd BLAST62

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi44 – 60Pro residuesSequence analysisAdd BLAST17

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1947, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000159138

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_027026_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8N461

Identification of Orthologs from Complete Genome Data

More...OMAi		KSPCVTR

Database of Orthologous Groups

More...OrthoDBi		1282076at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8N461

TreeFam database of animal gene trees

More...TreeFami		TF324260

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.80.10.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR036047, F-box-like_dom_sf
IPR001611, Leu-rich_rpt
IPR006553, Leu-rich_rpt_Cys-con_subtyp
IPR032675, LRR_dom_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF13516, LRR_6, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00367, LRR_CC, 8 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF81383, SSF81383, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8N461-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSSPGIDGDP KPPCLPRNGL VKLPGQPNGL GAASITKGTP ATKNRPCQPP 
        60         70         80         90        100
PPPTLPPPSL AAPLSRAALA GGPCTPAGGP ASALAPGHPA ERPPLATDEK 
       110        120        130        140        150
ILNGLFWYFS ACEKCVLAQV CKAWRRVLYQ PKFWAGLTPV LHAKELYNVL 
       160        170        180        190        200
PGGEKEFVNL QGFAARGFEG FCLVGVSDLD ICEFIDNYAL SKKGVKAMSL 
       210        220        230        240        250
KRSTITDAGL EVMLEQMQGV VRLELSGCND FTEAGLWSSL SARITSLSVS 
       260        270        280        290        300
DCINVADDAI AAISQLLPNL AELSLQAYHV TDTALAYFTA RQGHSTHTLR 
       310        320        330        340        350
LLSCWEITNH GVVNVVHSLP NLTALSLSGC SKVTDDGVEL VAENLRKLRS 
       360        370        380        390        400
LDLSWCPRIT DMALEYVACD LHRLEELVLD RCVRITDTGL SYLSTMSSLR 
       410        420        430        440        450
SLYLRWCCQV QDFGLKHLLA LGSLRLLSLA GCPLLTTTGL SGLVQLQELE 
       460        470 
ELELTNCPGA TPELFKYFSQ HLPRCLVIE
Length:479
Mass (Da):51,658
Last modified:October 17, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBC5E2EF407142A5A
GO
Isoform 2 (identifier: Q8N461-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-212: Missing.

Show »
Length:267
Mass (Da):29,423
Checksum:i657FB1C6B0077BEB
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAK61245 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_028163429L → P2 PublicationsCorresponds to variant dbSNP:rs17855603Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0569961 – 212Missing in isoform 2. 1 PublicationAdd BLAST212

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK091054 mRNA Translation: BAG52271.1
AE006464 Genomic DNA Translation: AAK61245.1 Sequence problems.
Z92544 Genomic DNA No translation available.
Z97653 Genomic DNA No translation available.
CH471112 Genomic DNA Translation: EAW85749.1
CH471112 Genomic DNA Translation: EAW85750.1
BC036680 mRNA Translation: AAH36680.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS10421.1 [Q8N461-1]

NCBI Reference Sequences

More...RefSeqi		NP_699181.2, NM_153350.3 [Q8N461-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000324361; ENSP00000318674; ENSG00000127585 [Q8N461-1]
ENST00000397621; ENSP00000380746; ENSG00000127585 [Q8N461-1]
ENST00000562563; ENSP00000455217; ENSG00000127585 [Q8N461-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		146330

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:146330

UCSC genome browser

More...UCSCi		uc002cjb.4, human [Q8N461-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK091054 mRNA Translation: BAG52271.1
AE006464 Genomic DNA Translation: AAK61245.1 Sequence problems.
Z92544 Genomic DNA No translation available.
Z97653 Genomic DNA No translation available.
CH471112 Genomic DNA Translation: EAW85749.1
CH471112 Genomic DNA Translation: EAW85750.1
BC036680 mRNA Translation: AAH36680.1
CCDSiCCDS10421.1 [Q8N461-1]
RefSeqiNP_699181.2, NM_153350.3 [Q8N461-1]

3D structure databases

SMRiQ8N461
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi126979, 16 interactors
IntActiQ8N461, 11 interactors
MINTiQ8N461
STRINGi9606.ENSP00000380746

PTM databases

iPTMnetiQ8N461
PhosphoSitePlusiQ8N461

Genetic variation databases

BioMutaiFBXL16
DMDMi116242480

Proteomic databases

EPDiQ8N461
jPOSTiQ8N461
MassIVEiQ8N461
MaxQBiQ8N461
PaxDbiQ8N461
PeptideAtlasiQ8N461
PRIDEiQ8N461
ProteomicsDBi3581
71888 [Q8N461-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		22839, 125 antibodies

The DNASU plasmid repository

More...DNASUi		146330

Genome annotation databases

EnsembliENST00000324361; ENSP00000318674; ENSG00000127585 [Q8N461-1]
ENST00000397621; ENSP00000380746; ENSG00000127585 [Q8N461-1]
ENST00000562563; ENSP00000455217; ENSG00000127585 [Q8N461-2]
GeneIDi146330
KEGGihsa:146330
UCSCiuc002cjb.4, human [Q8N461-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		146330
DisGeNETi146330

GeneCards: human genes, protein and diseases

More...GeneCardsi		FBXL16
HGNCiHGNC:14150, FBXL16
HPAiENSG00000127585, Tissue enriched (brain)
MIMi609082, gene
neXtProtiNX_Q8N461
OpenTargetsiENSG00000127585
PharmGKBiPA25536
VEuPathDBiHostDB:ENSG00000127585.11

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1947, Eukaryota
GeneTreeiENSGT00940000159138
HOGENOMiCLU_027026_1_0_1
InParanoidiQ8N461
OMAiKSPCVTR
OrthoDBi1282076at2759
PhylomeDBiQ8N461
TreeFamiTF324260

Enzyme and pathway databases

PathwayCommonsiQ8N461
ReactomeiR-HSA-8951664, Neddylation
R-HSA-983168, Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		146330, 2 hits in 991 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		FBXL16, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		146330
PharosiQ8N461, Tdark

Protein Ontology

More...PROi		PR:Q8N461
RNActiQ8N461, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000127585, Expressed in caudate nucleus and 192 other tissues
GenevisibleiQ8N461, HS

Family and domain databases

Gene3Di3.80.10.10, 2 hits
InterProiView protein in InterPro
IPR036047, F-box-like_dom_sf
IPR001611, Leu-rich_rpt
IPR006553, Leu-rich_rpt_Cys-con_subtyp
IPR032675, LRR_dom_sf
PfamiView protein in Pfam
PF13516, LRR_6, 3 hits
SMARTiView protein in SMART
SM00367, LRR_CC, 8 hits
SUPFAMiSSF81383, SSF81383, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFXL16_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8N461
Secondary accession number(s): B3KR59
, D3DU60, Q2MHR2, Q96S14, Q9UJI0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: October 17, 2006
Last modified: June 2, 2021
This is version 159 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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