UniProtKB - Q8N461 (FXL16_HUMAN)
Protein
F-box/LRR-repeat protein 16
Gene
FBXL16
Organism
Homo sapiens (Human)
Status
Functioni
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.By similarity
GO - Biological processi
- post-translational protein modification Source: Reactome
- protein polyubiquitination Source: Reactome
- SCF-dependent proteasomal ubiquitin-dependent protein catabolic process Source: GO_Central
- ubiquitin-dependent protein catabolic process Source: GO_Central
Keywordsi
Biological process | Ubl conjugation pathway |
Enzyme and pathway databases
PathwayCommonsi | Q8N461 |
Reactomei | R-HSA-8951664, Neddylation R-HSA-983168, Antigen processing: Ubiquitination & Proteasome degradation |
Names & Taxonomyi
Protein namesi | Recommended name: F-box/LRR-repeat protein 16Alternative name(s): F-box and leucine-rich repeat protein 16 |
Gene namesi | Name:FBXL16 Synonyms:C16orf22, FBL16 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000127585.11 |
HGNCi | HGNC:14150, FBXL16 |
MIMi | 609082, gene |
neXtProti | NX_Q8N461 |
Subcellular locationi
Cytosol
- cytosol Source: Reactome
Other locations
- SCF ubiquitin ligase complex Source: GO_Central
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 146330 |
OpenTargetsi | ENSG00000127585 |
PharmGKBi | PA25536 |
Miscellaneous databases
Pharosi | Q8N461, Tdark |
Polymorphism and mutation databases
BioMutai | FBXL16 |
DMDMi | 116242480 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000119863 | 1 – 479 | F-box/LRR-repeat protein 16Add BLAST | 479 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 92 | Omega-N-methylarginineBy similarity | 1 |
Keywords - PTMi
MethylationProteomic databases
EPDi | Q8N461 |
jPOSTi | Q8N461 |
MassIVEi | Q8N461 |
MaxQBi | Q8N461 |
PaxDbi | Q8N461 |
PeptideAtlasi | Q8N461 |
PRIDEi | Q8N461 |
ProteomicsDBi | 3581 71888 [Q8N461-1] |
PTM databases
iPTMneti | Q8N461 |
PhosphoSitePlusi | Q8N461 |
Expressioni
Gene expression databases
Bgeei | ENSG00000127585, Expressed in caudate nucleus and 192 other tissues |
Genevisiblei | Q8N461, HS |
Organism-specific databases
HPAi | ENSG00000127585, Tissue enriched (brain) |
Interactioni
Subunit structurei
Interacts with SKP1 and CUL1.
By similarityProtein-protein interaction databases
BioGRIDi | 126979, 16 interactors |
IntActi | Q8N461, 11 interactors |
MINTi | Q8N461 |
STRINGi | 9606.ENSP00000380746 |
Miscellaneous databases
RNActi | Q8N461, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 94 – 139 | F-boxAdd BLAST | 46 | |
Repeati | 244 – 266 | LRR 1Add BLAST | 23 | |
Repeati | 267 – 290 | LRR 2Add BLAST | 24 | |
Repeati | 319 – 343 | LRR 3Add BLAST | 25 | |
Repeati | 345 – 369 | LRR 4Add BLAST | 25 | |
Repeati | 371 – 395 | LRR 5Add BLAST | 25 | |
Repeati | 396 – 420 | LRR 6Add BLAST | 25 | |
Repeati | 446 – 470 | LRR 7Add BLAST | 25 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 10 – 94 | Pro-richAdd BLAST | 85 |
Keywords - Domaini
Leucine-rich repeat, RepeatPhylogenomic databases
eggNOGi | KOG1947, Eukaryota |
GeneTreei | ENSGT00940000159138 |
HOGENOMi | CLU_027026_1_0_1 |
InParanoidi | Q8N461 |
OMAi | KSPCVTR |
OrthoDBi | 1282076at2759 |
PhylomeDBi | Q8N461 |
TreeFami | TF324260 |
Family and domain databases
Gene3Di | 3.80.10.10, 2 hits |
InterProi | View protein in InterPro IPR036047, F-box-like_dom_sf IPR001611, Leu-rich_rpt IPR006553, Leu-rich_rpt_Cys-con_subtyp IPR032675, LRR_dom_sf |
Pfami | View protein in Pfam PF13516, LRR_6, 3 hits |
SMARTi | View protein in SMART SM00367, LRR_CC, 8 hits |
SUPFAMi | SSF81383, SSF81383, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q8N461-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSSPGIDGDP KPPCLPRNGL VKLPGQPNGL GAASITKGTP ATKNRPCQPP
60 70 80 90 100
PPPTLPPPSL AAPLSRAALA GGPCTPAGGP ASALAPGHPA ERPPLATDEK
110 120 130 140 150
ILNGLFWYFS ACEKCVLAQV CKAWRRVLYQ PKFWAGLTPV LHAKELYNVL
160 170 180 190 200
PGGEKEFVNL QGFAARGFEG FCLVGVSDLD ICEFIDNYAL SKKGVKAMSL
210 220 230 240 250
KRSTITDAGL EVMLEQMQGV VRLELSGCND FTEAGLWSSL SARITSLSVS
260 270 280 290 300
DCINVADDAI AAISQLLPNL AELSLQAYHV TDTALAYFTA RQGHSTHTLR
310 320 330 340 350
LLSCWEITNH GVVNVVHSLP NLTALSLSGC SKVTDDGVEL VAENLRKLRS
360 370 380 390 400
LDLSWCPRIT DMALEYVACD LHRLEELVLD RCVRITDTGL SYLSTMSSLR
410 420 430 440 450
SLYLRWCCQV QDFGLKHLLA LGSLRLLSLA GCPLLTTTGL SGLVQLQELE
460 470
ELELTNCPGA TPELFKYFSQ HLPRCLVIE
Sequence cautioni
The sequence AAK61245 differs from that shown. Reason: Erroneous gene model prediction.Curated
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_028163 | 429 | L → P2 PublicationsCorresponds to variant dbSNP:rs17855603Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_056996 | 1 – 212 | Missing in isoform 2. 1 PublicationAdd BLAST | 212 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK091054 mRNA Translation: BAG52271.1 AE006464 Genomic DNA Translation: AAK61245.1 Sequence problems. Z92544 Genomic DNA No translation available. Z97653 Genomic DNA No translation available. CH471112 Genomic DNA Translation: EAW85749.1 CH471112 Genomic DNA Translation: EAW85750.1 BC036680 mRNA Translation: AAH36680.1 |
CCDSi | CCDS10421.1 [Q8N461-1] |
RefSeqi | NP_699181.2, NM_153350.3 [Q8N461-1] |
Genome annotation databases
Ensembli | ENST00000324361; ENSP00000318674; ENSG00000127585 [Q8N461-1] ENST00000397621; ENSP00000380746; ENSG00000127585 [Q8N461-1] ENST00000562563; ENSP00000455217; ENSG00000127585 [Q8N461-2] |
GeneIDi | 146330 |
KEGGi | hsa:146330 |
UCSCi | uc002cjb.4, human [Q8N461-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK091054 mRNA Translation: BAG52271.1 AE006464 Genomic DNA Translation: AAK61245.1 Sequence problems. Z92544 Genomic DNA No translation available. Z97653 Genomic DNA No translation available. CH471112 Genomic DNA Translation: EAW85749.1 CH471112 Genomic DNA Translation: EAW85750.1 BC036680 mRNA Translation: AAH36680.1 |
CCDSi | CCDS10421.1 [Q8N461-1] |
RefSeqi | NP_699181.2, NM_153350.3 [Q8N461-1] |
3D structure databases
SMRi | Q8N461 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 126979, 16 interactors |
IntActi | Q8N461, 11 interactors |
MINTi | Q8N461 |
STRINGi | 9606.ENSP00000380746 |
PTM databases
iPTMneti | Q8N461 |
PhosphoSitePlusi | Q8N461 |
Polymorphism and mutation databases
BioMutai | FBXL16 |
DMDMi | 116242480 |
Proteomic databases
EPDi | Q8N461 |
jPOSTi | Q8N461 |
MassIVEi | Q8N461 |
MaxQBi | Q8N461 |
PaxDbi | Q8N461 |
PeptideAtlasi | Q8N461 |
PRIDEi | Q8N461 |
ProteomicsDBi | 3581 71888 [Q8N461-1] |
Protocols and materials databases
Antibodypediai | 22839, 125 antibodies |
DNASUi | 146330 |
Genome annotation databases
Ensembli | ENST00000324361; ENSP00000318674; ENSG00000127585 [Q8N461-1] ENST00000397621; ENSP00000380746; ENSG00000127585 [Q8N461-1] ENST00000562563; ENSP00000455217; ENSG00000127585 [Q8N461-2] |
GeneIDi | 146330 |
KEGGi | hsa:146330 |
UCSCi | uc002cjb.4, human [Q8N461-1] |
Organism-specific databases
CTDi | 146330 |
DisGeNETi | 146330 |
EuPathDBi | HostDB:ENSG00000127585.11 |
GeneCardsi | FBXL16 |
HGNCi | HGNC:14150, FBXL16 |
HPAi | ENSG00000127585, Tissue enriched (brain) |
MIMi | 609082, gene |
neXtProti | NX_Q8N461 |
OpenTargetsi | ENSG00000127585 |
PharmGKBi | PA25536 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1947, Eukaryota |
GeneTreei | ENSGT00940000159138 |
HOGENOMi | CLU_027026_1_0_1 |
InParanoidi | Q8N461 |
OMAi | KSPCVTR |
OrthoDBi | 1282076at2759 |
PhylomeDBi | Q8N461 |
TreeFami | TF324260 |
Enzyme and pathway databases
PathwayCommonsi | Q8N461 |
Reactomei | R-HSA-8951664, Neddylation R-HSA-983168, Antigen processing: Ubiquitination & Proteasome degradation |
Miscellaneous databases
BioGRID-ORCSi | 146330, 2 hits in 842 CRISPR screens |
ChiTaRSi | FBXL16, human |
GenomeRNAii | 146330 |
Pharosi | Q8N461, Tdark |
PROi | PR:Q8N461 |
RNActi | Q8N461, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000127585, Expressed in caudate nucleus and 192 other tissues |
Genevisiblei | Q8N461, HS |
Family and domain databases
Gene3Di | 3.80.10.10, 2 hits |
InterProi | View protein in InterPro IPR036047, F-box-like_dom_sf IPR001611, Leu-rich_rpt IPR006553, Leu-rich_rpt_Cys-con_subtyp IPR032675, LRR_dom_sf |
Pfami | View protein in Pfam PF13516, LRR_6, 3 hits |
SMARTi | View protein in SMART SM00367, LRR_CC, 8 hits |
SUPFAMi | SSF81383, SSF81383, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | FXL16_HUMAN | |
Accessioni | Q8N461Primary (citable) accession number: Q8N461 Secondary accession number(s): B3KR59 Q9UJI0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 19, 2004 |
Last sequence update: | October 17, 2006 | |
Last modified: | December 2, 2020 | |
This is version 156 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations