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Protein

Ligand of Numb protein X 2

Gene

LNX2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri50 – 88RING-typePROSITE-ProRule annotationAdd BLAST39

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

Protein family/group databases

MoonDB Database of extreme multifunctional and moonlighting proteins

More...
MoonDBi
Q8N448 Predicted

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ligand of Numb protein X 2
Alternative name(s):
Numb-binding protein 2
PDZ domain-containing RING finger protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LNX2
Synonyms:PDZRN1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000139517.7

Human Gene Nomenclature Database

More...
HGNCi
HGNC:20421 LNX2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
609733 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8N448

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
222484

Open Targets

More...
OpenTargetsi
ENSG00000139517

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134899015

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
LNX2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
29840784

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000559151 – 690Ligand of Numb protein X 2Add BLAST690

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8N448

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8N448

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8N448

PeptideAtlas

More...
PeptideAtlasi
Q8N448

PRoteomics IDEntifications database

More...
PRIDEi
Q8N448

ProteomicsDB human proteome resource

More...
ProteomicsDBi
71884

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8N448

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8N448

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000139517 Expressed in 194 organ(s), highest expression level in jejunal mucosa

CleanEx database of gene expression profiles

More...
CleanExi
HS_LNX2

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8N448 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA040698

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with the phosphotyrosine interaction domain of NUMB.By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
128798, 52 interactors

Protein interaction database and analysis system

More...
IntActi
Q8N448, 87 interactors

Molecular INTeraction database

More...
MINTi
Q8N448

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000325929

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1690
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q8N448

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8N448

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q8N448

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini233 – 318PDZ 1PROSITE-ProRule annotationAdd BLAST86
Domaini339 – 422PDZ 2PROSITE-ProRule annotationAdd BLAST84
Domaini468 – 554PDZ 3PROSITE-ProRule annotationAdd BLAST87
Domaini600 – 688PDZ 4PROSITE-ProRule annotationAdd BLAST89

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi208 – 211NPXY motif4

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The NPXY motif is required for the interaction with the PID domain of NUMB. It is however not sufficient.

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri50 – 88RING-typePROSITE-ProRule annotationAdd BLAST39

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410ITAD Eukaryota
ENOG410Y9FS LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158381

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000261605

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG039539

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8N448

KEGG Orthology (KO)

More...
KOi
K10692

Identification of Orthologs from Complete Genome Data

More...
OMAi
FNPLCFE

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0CBZ

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8N448

TreeFam database of animal gene trees

More...
TreeFami
TF330709

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001478 PDZ
IPR036034 PDZ_sf
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00595 PDZ, 4 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00228 PDZ, 4 hits
SM00184 RING, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50156 SSF50156, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50106 PDZ, 4 hits
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8N448-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGTTSDEMVS VEQTSSSSLN PLCFECGQQH WTRENHLYNY QNEVDDDLVC
60 70 80 90 100
HICLQPLLQP LDTPCGHTFC YKCLRNFLQE KDFCPLDRKR LHFKLCKKSS
110 120 130 140 150
ILVHKLLDKL LVLCPFSSVC KDVMQRCDLE AHLKNRCPGA SHRRVALERR
160 170 180 190 200
KTSRTQAEIE NENGPTLLDP AGTLSPEADC LGTGAVPVER HLTSASLSTW
210 220 230 240 250
SEEPGLDNPA FEESAGADTT QQPLSLPEGE ITTIEIHRSN PYIQLGISIV
260 270 280 290 300
GGNETPLINI VIQEVYRDGV IARDGRLLAG DQILQVNNYN ISNVSHNYAR
310 320 330 340 350
AVLSQPCNTL HLTVLRERRF GNRAHNHSDS NSPREEIFQV ALHKRDSGEQ
360 370 380 390 400
LGIKLVRRTD EPGVFILDLL EGGLAAQDGR LSSNDRVLAI NGHDLKYGTP
410 420 430 440 450
ELAAQIIQAS GERVNLTIAR PGKPQPGNTI REAGNHSSSS QHHTPPPYYS
460 470 480 490 500
RPSSHKDLTQ CVTCQEKHIT VKKEPHESLG MTVAGGRGSK SGELPIFVTS
510 520 530 540 550
VPPHGCLARD GRIKRGDVLL NINGIDLTNL SHSEAVAMLK ASAASPAVAL
560 570 580 590 600
KALEVQIVEE ATQNAEEQPS TFSENEYDAS WSPSWVMWLG LPSTLHSCHD
610 620 630 640 650
IVLRRSYLGS WGFSIVGGYE ENHTNQPFFI KTIVLGTPAY YDGRLKCGDM
660 670 680 690
IVAVNGLSTV GMSHSALVPM LKEQRNKVTL TVICWPGSLV
Length:690
Mass (Da):76,004
Last modified:October 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA3F941A477721F1D
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAD18754 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_024612198S → P. Corresponds to variant dbSNP:rs8002697Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL138699 Genomic DNA No translation available.
BC036755 mRNA Translation: AAH36755.1
AK172771 mRNA Translation: BAD18754.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS9323.1

NCBI Reference Sequences

More...
RefSeqi
NP_699202.1, NM_153371.3
XP_016875923.1, XM_017020434.1

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.132359

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000316334; ENSP00000325929; ENSG00000139517
ENST00000649248; ENSP00000497224; ENSG00000139517

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
222484

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:222484

UCSC genome browser

More...
UCSCi
uc001url.5 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL138699 Genomic DNA No translation available.
BC036755 mRNA Translation: AAH36755.1
AK172771 mRNA Translation: BAD18754.1 Different initiation.
CCDSiCCDS9323.1
RefSeqiNP_699202.1, NM_153371.3
XP_016875923.1, XM_017020434.1
UniGeneiHs.132359

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2VWRX-ray1.30A336-424[»]
5DINX-ray1.86A/B20-147[»]
5E11X-ray1.80A336-424[»]
5E1YX-ray1.01A336-424[»]
5E21X-ray1.01A336-424[»]
5E22X-ray1.80A/B336-424[»]
ProteinModelPortaliQ8N448
SMRiQ8N448
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128798, 52 interactors
IntActiQ8N448, 87 interactors
MINTiQ8N448
STRINGi9606.ENSP00000325929

Protein family/group databases

MoonDBiQ8N448 Predicted

PTM databases

iPTMnetiQ8N448
PhosphoSitePlusiQ8N448

Polymorphism and mutation databases

BioMutaiLNX2
DMDMi29840784

Proteomic databases

EPDiQ8N448
MaxQBiQ8N448
PaxDbiQ8N448
PeptideAtlasiQ8N448
PRIDEiQ8N448
ProteomicsDBi71884

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000316334; ENSP00000325929; ENSG00000139517
ENST00000649248; ENSP00000497224; ENSG00000139517
GeneIDi222484
KEGGihsa:222484
UCSCiuc001url.5 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
222484
DisGeNETi222484
EuPathDBiHostDB:ENSG00000139517.7

GeneCards: human genes, protein and diseases

More...
GeneCardsi
LNX2
HGNCiHGNC:20421 LNX2
HPAiHPA040698
MIMi609733 gene
neXtProtiNX_Q8N448
OpenTargetsiENSG00000139517
PharmGKBiPA134899015

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410ITAD Eukaryota
ENOG410Y9FS LUCA
GeneTreeiENSGT00940000158381
HOGENOMiHOG000261605
HOVERGENiHBG039539
InParanoidiQ8N448
KOiK10692
OMAiFNPLCFE
OrthoDBiEOG091G0CBZ
PhylomeDBiQ8N448
TreeFamiTF330709

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
LNX2 human
EvolutionaryTraceiQ8N448

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
222484

Protein Ontology

More...
PROi
PR:Q8N448

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000139517 Expressed in 194 organ(s), highest expression level in jejunal mucosa
CleanExiHS_LNX2
GenevisibleiQ8N448 HS

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR001478 PDZ
IPR036034 PDZ_sf
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS
PfamiView protein in Pfam
PF00595 PDZ, 4 hits
SMARTiView protein in SMART
SM00228 PDZ, 4 hits
SM00184 RING, 1 hit
SUPFAMiSSF50156 SSF50156, 4 hits
PROSITEiView protein in PROSITE
PS50106 PDZ, 4 hits
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLNX2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8N448
Secondary accession number(s): Q5W0P0, Q6ZMH2, Q96SH4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 28, 2003
Last sequence update: October 1, 2002
Last modified: December 5, 2018
This is version 143 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
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