UniProtKB - Q8N448 (LNX2_HUMAN)

BLAST

>sp|Q8N448|LNX2_HUMAN Ligand of Numb protein X 2 OS=Homo sapiens OX=9606 GN=LNX2 PE=1 SV=1
MGTTSDEMVSVEQTSSSSLNPLCFECGQQHWTRENHLYNYQNEVDDDLVCHICLQPLLQP
LDTPCGHTFCYKCLRNFLQEKDFCPLDRKRLHFKLCKKSSILVHKLLDKLLVLCPFSSVC
KDVMQRCDLEAHLKNRCPGASHRRVALERRKTSRTQAEIENENGPTLLDPAGTLSPEADC
LGTGAVPVERHLTSASLSTWSEEPGLDNPAFEESAGADTTQQPLSLPEGEITTIEIHRSN
PYIQLGISIVGGNETPLINIVIQEVYRDGVIARDGRLLAGDQILQVNNYNISNVSHNYAR
AVLSQPCNTLHLTVLRERRFGNRAHNHSDSNSPREEIFQVALHKRDSGEQLGIKLVRRTD
EPGVFILDLLEGGLAAQDGRLSSNDRVLAINGHDLKYGTPELAAQIIQASGERVNLTIAR
PGKPQPGNTIREAGNHSSSSQHHTPPPYYSRPSSHKDLTQCVTCQEKHITVKKEPHESLG
MTVAGGRGSKSGELPIFVTSVPPHGCLARDGRIKRGDVLLNINGIDLTNLSHSEAVAMLK
ASAASPAVALKALEVQIVEEATQNAEEQPSTFSENEYDASWSPSWVMWLGLPSTLHSCHD
IVLRRSYLGSWGFSIVGGYEENHTNQPFFIKTIVLGTPAYYDGRLKCGDMIVAVNGLSTV
GMSHSALVPMLKEQRNKVTLTVICWPGSLV

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History
Entry version 142 (07 Nov 2018)
Sequence version 1 (01 Oct 2002)
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Protein

Ligand of Numb protein X 2

Gene

LNX2

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	50 – 88	RING-typePROSITE-ProRule annotationAdd BLAST		39

GO - Molecular functionⁱ

metal ion binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Ligand	Metal-binding, Zinc

Ligand

Metal-binding, Zinc

Protein family/group databases

MoonDBⁱ	Q8N448 Predicted

MoonDBⁱ

Q8N448 Predicted

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Ligand of Numb protein X 2 Alternative name(s): Numb-binding protein 2 PDZ domain-containing RING finger protein 1
Gene namesⁱ	Name:LNX2 Synonyms:PDZRN1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 13

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000139517.7
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:20421 LNX2
MIMⁱ	609733 gene
neXtProtⁱ	NX_Q8N448

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	222484
Open Targets More...OpenTargetsⁱ	ENSG00000139517
PharmGKBⁱ	PA134899015

Polymorphism and mutation databases

BioMutaⁱ	LNX2
DMDMⁱ	29840784

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000055915	1 – 690	Ligand of Numb protein X 2Add BLAST		690

Proteomic databases

EPDⁱ	Q8N448
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q8N448
PaxDbⁱ	Q8N448
PeptideAtlas More...PeptideAtlasⁱ	Q8N448
PRIDEⁱ	Q8N448
ProteomicsDBⁱ	71884

PTM databases

iPTMnetⁱ	Q8N448
PhosphoSitePlusⁱ	Q8N448

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000139517 Expressed in 194 organ(s), highest expression level in jejunal mucosa
CleanExⁱ	HS_LNX2
Genevisibleⁱ	Q8N448 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA040698

HPAⁱ

HPA040698

Interactionⁱ

Subunit structureⁱ

Interacts with the phosphotyrosine interaction domain of NUMB.By similarity

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
	P0C206	4	EBI-2340947,EBI-9675596	From Human T-cell leukemia virus 1 (isolate Caribbea HS-35 subtype A).
	Q85601	4	EBI-2340947,EBI-9676175	From Human T-cell leukemia virus 2.
FHL3	Q13643	4	EBI-2340947,EBI-741101
Hoxa1	P09022	3	EBI-2340947,EBI-3957603	From Mus musculus.
MRFAP1L1	Q96HT8	4	EBI-2340947,EBI-748896
tax	P03410	4	EBI-2340947,EBI-9676218	From Human T-cell leukemia virus 2.
tax	P14079	4	EBI-2340947,EBI-9675698	From Human T-cell leukemia virus 1 (isolate Caribbea HS-35 subtype A).

Protein-protein interaction databases

BioGridⁱ	128798, 52 interactors
IntActⁱ	Q8N448, 86 interactors
Molecular INTeraction database More...MINTⁱ	Q8N448
STRINGⁱ	9606.ENSP00000325929

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Turnⁱ	24 – 26	Combined sources	3
Beta strandⁱ	39 – 42	Combined sources	4
Helixⁱ	46 – 48	Combined sources	3
Turnⁱ	51 – 53	Combined sources	3
Beta strandⁱ	58 – 62	Combined sources	5
Beta strandⁱ	68 – 70	Combined sources	3
Helixⁱ	71 – 77	Combined sources	7
Turnⁱ	78 – 80	Combined sources	3
Turnⁱ	85 – 87	Combined sources	3
Helixⁱ	93 – 95	Combined sources	3
Helixⁱ	101 – 108	Combined sources	8
Beta strandⁱ	111 – 113	Combined sources	3
Turnⁱ	117 – 119	Combined sources	3
Beta strandⁱ	123 – 125	Combined sources	3
Helixⁱ	126 – 128	Combined sources	3
Helixⁱ	129 – 135	Combined sources	7
Beta strandⁱ	336 – 343	Combined sources	8
Beta strandⁱ	353 – 356	Combined sources	4
Beta strandⁱ	359 – 361	Combined sources	3
Beta strandⁱ	363 – 369	Combined sources	7
Helixⁱ	374 – 378	Combined sources	5
Beta strandⁱ	386 – 390	Combined sources	5
Helixⁱ	400 – 408	Combined sources	9
Beta strandⁱ	412 – 422	Combined sources	11

Show more details

3D structure databases

ProteinModelPortalⁱ	Q8N448
SMRⁱ	Q8N448
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q8N448

EvolutionaryTraceⁱ

Q8N448

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	233 – 318	PDZ 1PROSITE-ProRule annotationAdd BLAST	86
Domainⁱ	339 – 422	PDZ 2PROSITE-ProRule annotationAdd BLAST	84
Domainⁱ	468 – 554	PDZ 3PROSITE-ProRule annotationAdd BLAST	87
Domainⁱ	600 – 688	PDZ 4PROSITE-ProRule annotationAdd BLAST	89

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	208 – 211	NPXY motif		4

Domainⁱ

The NPXY motif is required for the interaction with the PID domain of NUMB. It is however not sufficient.

Zinc finger

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	50 – 88	RING-typePROSITE-ProRule annotationAdd BLAST		39

Keywords - Domainⁱ

Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	ENOG410ITAD Eukaryota ENOG410Y9FS LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119017
HOGENOMⁱ	HOG000261605
HOVERGENⁱ	HBG039539
InParanoidⁱ	Q8N448
KEGG Orthology (KO) More...KOⁱ	K10692
OMAⁱ	FNPLCFE
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0CBZ
PhylomeDBⁱ	Q8N448
TreeFamⁱ	TF330709

Family and domain databases

Gene3Dⁱ	3.30.40.10, 1 hit
InterProⁱ	View protein in InterPro IPR001478 PDZ IPR036034 PDZ_sf IPR001841 Znf_RING IPR013083 Znf_RING/FYVE/PHD IPR017907 Znf_RING_CS
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00595 PDZ, 4 hits
SMARTⁱ	View protein in SMART SM00228 PDZ, 4 hits SM00184 RING, 1 hit
SUPFAMⁱ	SSF50156 SSF50156, 4 hits
PROSITEⁱ	View protein in PROSITE PS50106 PDZ, 4 hits PS00518 ZF_RING_1, 1 hit PS50089 ZF_RING_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q8N448-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MGTTSDEMVS VEQTSSSSLN PLCFECGQQH WTRENHLYNY QNEVDDDLVC 
        60         70         80         90        100
HICLQPLLQP LDTPCGHTFC YKCLRNFLQE KDFCPLDRKR LHFKLCKKSS 
       110        120        130        140        150
ILVHKLLDKL LVLCPFSSVC KDVMQRCDLE AHLKNRCPGA SHRRVALERR 
       160        170        180        190        200
KTSRTQAEIE NENGPTLLDP AGTLSPEADC LGTGAVPVER HLTSASLSTW 
       210        220        230        240        250
SEEPGLDNPA FEESAGADTT QQPLSLPEGE ITTIEIHRSN PYIQLGISIV 
       260        270        280        290        300
GGNETPLINI VIQEVYRDGV IARDGRLLAG DQILQVNNYN ISNVSHNYAR 
       310        320        330        340        350
AVLSQPCNTL HLTVLRERRF GNRAHNHSDS NSPREEIFQV ALHKRDSGEQ 
       360        370        380        390        400
LGIKLVRRTD EPGVFILDLL EGGLAAQDGR LSSNDRVLAI NGHDLKYGTP 
       410        420        430        440        450
ELAAQIIQAS GERVNLTIAR PGKPQPGNTI REAGNHSSSS QHHTPPPYYS 
       460        470        480        490        500
RPSSHKDLTQ CVTCQEKHIT VKKEPHESLG MTVAGGRGSK SGELPIFVTS 
       510        520        530        540        550
VPPHGCLARD GRIKRGDVLL NINGIDLTNL SHSEAVAMLK ASAASPAVAL 
       560        570        580        590        600
KALEVQIVEE ATQNAEEQPS TFSENEYDAS WSPSWVMWLG LPSTLHSCHD 
       610        620        630        640        650
IVLRRSYLGS WGFSIVGGYE ENHTNQPFFI KTIVLGTPAY YDGRLKCGDM 
       660        670        680        690
IVAVNGLSTV GMSHSALVPM LKEQRNKVTL TVICWPGSLV

Length:690

Mass (Da):76,004

Last modified:October 1, 2002 - v1

Checksum:ⁱA3F941A477721F1D

Sequence cautionⁱ

The sequence BAD18754 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_024612	198	S → P. Corresponds to variant dbSNP:rs8002697Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL138699 Genomic DNA No translation available. BC036755 mRNA Translation: AAH36755.1 AK172771 mRNA Translation: BAD18754.1 Different initiation.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS9323.1
NCBI Reference Sequences More...RefSeqⁱ	NP_699202.1, NM_153371.3 XP_016875923.1, XM_017020434.1
UniGeneⁱ	Hs.132359

Genome annotation databases

Ensemblⁱ	ENST00000316334; ENSP00000325929; ENSG00000139517
GeneIDⁱ	222484
KEGGⁱ	hsa:222484
UCSC genome browser More...UCSCⁱ	uc001url.5 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Protein	Similar proteins		Species	Score	Length	Source
Q8N448	Ligand of Numb protein X 2		MOUSE		687	UniRef90_Q8N448
ligand of Numb protein X 2		DIPOR		693
Uncharacterized protein		RHIRO		692
Ligand of Numb protein X 2 (Fragment)		MACMU		150
ligand of Numb protein X 2 isoform X1		URSMA		692
+78

Protein	Similar proteins		Species	Score	Length	Source
Q8N448	Ligand of Numb protein X 2		MOUSE		687	UniRef50_Q8N448
ligand of Numb protein X 2		DIPOR		693
Uncharacterized protein		RHIRO		692
Ligand of Numb protein X 2 (Fragment)		MACMU		150
Uncharacterized protein		RHIBE		692
+426

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL138699 Genomic DNA No translation available. BC036755 mRNA Translation: AAH36755.1 AK172771 mRNA Translation: BAD18754.1 Different initiation.
CCDSⁱ	CCDS9323.1
RefSeqⁱ	NP_699202.1, NM_153371.3 XP_016875923.1, XM_017020434.1
UniGeneⁱ	Hs.132359

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2VWR	X-ray	1.30	A	336-424	[»]
	5DIN	X-ray	1.86	A/B	20-147	[»]
	5E11	X-ray	1.80	A	336-424	[»]
	5E1Y	X-ray	1.01	A	336-424	[»]
	5E21	X-ray	1.01	A	336-424	[»]
	5E22	X-ray	1.80	A/B	336-424	[»]
ProteinModelPortalⁱ	Q8N448
SMRⁱ	Q8N448
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	128798, 52 interactors
IntActⁱ	Q8N448, 86 interactors
MINTⁱ	Q8N448
STRINGⁱ	9606.ENSP00000325929

Protein family/group databases

MoonDBⁱ	Q8N448 Predicted

MoonDBⁱ

Q8N448 Predicted

PTM databases

iPTMnetⁱ	Q8N448
PhosphoSitePlusⁱ	Q8N448

Polymorphism and mutation databases

BioMutaⁱ	LNX2
DMDMⁱ	29840784

Proteomic databases

EPDⁱ	Q8N448
MaxQBⁱ	Q8N448
PaxDbⁱ	Q8N448
PeptideAtlasⁱ	Q8N448
PRIDEⁱ	Q8N448
ProteomicsDBⁱ	71884

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000316334; ENSP00000325929; ENSG00000139517
GeneIDⁱ	222484
KEGGⁱ	hsa:222484
UCSCⁱ	uc001url.5 human

Organism-specific databases

CTDⁱ	222484
DisGeNETⁱ	222484
EuPathDBⁱ	HostDB:ENSG00000139517.7
GeneCardsⁱ	LNX2
HGNCⁱ	HGNC:20421 LNX2
HPAⁱ	HPA040698
MIMⁱ	609733 gene
neXtProtⁱ	NX_Q8N448
OpenTargetsⁱ	ENSG00000139517
PharmGKBⁱ	PA134899015
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410ITAD Eukaryota ENOG410Y9FS LUCA
GeneTreeⁱ	ENSGT00760000119017
HOGENOMⁱ	HOG000261605
HOVERGENⁱ	HBG039539
InParanoidⁱ	Q8N448
KOⁱ	K10692
OMAⁱ	FNPLCFE
OrthoDBⁱ	EOG091G0CBZ
PhylomeDBⁱ	Q8N448
TreeFamⁱ	TF330709

Miscellaneous databases

ChiTaRSⁱ	LNX2 human
EvolutionaryTraceⁱ	Q8N448
GenomeRNAiⁱ	222484
Protein Ontology More...PROⁱ	PR:Q8N448
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000139517 Expressed in 194 organ(s), highest expression level in jejunal mucosa
CleanExⁱ	HS_LNX2
Genevisibleⁱ	Q8N448 HS

Family and domain databases

Gene3Dⁱ	3.30.40.10, 1 hit
InterProⁱ	View protein in InterPro IPR001478 PDZ IPR036034 PDZ_sf IPR001841 Znf_RING IPR013083 Znf_RING/FYVE/PHD IPR017907 Znf_RING_CS
Pfamⁱ	View protein in Pfam PF00595 PDZ, 4 hits
SMARTⁱ	View protein in SMART SM00228 PDZ, 4 hits SM00184 RING, 1 hit
SUPFAMⁱ	SSF50156 SSF50156, 4 hits
PROSITEⁱ	View protein in PROSITE PS50106 PDZ, 4 hits PS00518 ZF_RING_1, 1 hit PS50089 ZF_RING_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	LNX2_HUMAN
Accessionⁱ	Q8N448Primary (citable) accession number: Q8N448 Secondary accession number(s): Q5W0P0, Q6ZMH2, Q96SH4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 28, 2003
	Last sequence update:	October 1, 2002
	Last modified:	November 7, 2018
	This is version 142 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 13
Human chromosome 13: entries, gene names and cross-references to MIM

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UniProtKB - Q8N448 (LNX2_HUMAN)

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Ligand of Numb protein X 2

LNX2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Motif

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ