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UniProtKB - Q8N448 (LNX2_HUMAN)
Protein
Ligand of Numb protein X 2
Gene
LNX2
Organism
Homo sapiens (Human)
Status
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 50 – 88 | RING-typePROSITE-ProRule annotationAdd BLAST | 39 |
GO - Molecular functioni
- identical protein binding Source: Ensembl
- metal ion binding Source: UniProtKB-KW
- PDZ domain binding Source: Ensembl
- ubiquitin-protein transferase activity Source: GO_Central
Keywordsi
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q8N448 |
SignaLinki | Q8N448 |
Protein family/group databases
MoonDBi | Q8N448, Predicted |
Names & Taxonomyi
Protein namesi | Recommended name: Ligand of Numb protein X 2Alternative name(s): Numb-binding protein 2 PDZ domain-containing RING finger protein 1 |
Gene namesi | Name:LNX2 Synonyms:PDZRN1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:20421, LNX2 |
MIMi | 609733, gene |
neXtProti | NX_Q8N448 |
VEuPathDBi | HostDB:ENSG00000139517 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 222484 |
OpenTargetsi | ENSG00000139517 |
PharmGKBi | PA134899015 |
Miscellaneous databases
Pharosi | Q8N448, Tbio |
Genetic variation databases
BioMutai | LNX2 |
DMDMi | 29840784 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000055915 | 1 – 690 | Ligand of Numb protein X 2Add BLAST | 690 |
Proteomic databases
EPDi | Q8N448 |
jPOSTi | Q8N448 |
MassIVEi | Q8N448 |
MaxQBi | Q8N448 |
PaxDbi | Q8N448 |
PeptideAtlasi | Q8N448 |
PRIDEi | Q8N448 |
ProteomicsDBi | 71884 |
PTM databases
iPTMneti | Q8N448 |
PhosphoSitePlusi | Q8N448 |
Expressioni
Gene expression databases
Bgeei | ENSG00000139517, Expressed in jejunal mucosa and 211 other tissues |
Genevisiblei | Q8N448, HS |
Organism-specific databases
HPAi | ENSG00000139517, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with the phosphotyrosine interaction domain of NUMB.
By similarityBinary interactionsi
Q8N448
GO - Molecular functioni
- identical protein binding Source: Ensembl
- PDZ domain binding Source: Ensembl
Protein-protein interaction databases
BioGRIDi | 128798, 107 interactors |
IntActi | Q8N448, 110 interactors |
MINTi | Q8N448 |
STRINGi | 9606.ENSP00000325929 |
Miscellaneous databases
RNActi | Q8N448, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q8N448 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q8N448 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 233 – 318 | PDZ 1PROSITE-ProRule annotationAdd BLAST | 86 | |
Domaini | 339 – 422 | PDZ 2PROSITE-ProRule annotationAdd BLAST | 84 | |
Domaini | 468 – 554 | PDZ 3PROSITE-ProRule annotationAdd BLAST | 87 | |
Domaini | 600 – 688 | PDZ 4PROSITE-ProRule annotationAdd BLAST | 89 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 198 – 224 | DisorderedSequence analysisAdd BLAST | 27 | |
Regioni | 418 – 455 | DisorderedSequence analysisAdd BLAST | 38 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 208 – 211 | NPXY motif | 4 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 430 – 455 | Polar residuesSequence analysisAdd BLAST | 26 |
Domaini
The NPXY motif is required for the interaction with the PID domain of NUMB. It is however not sufficient.
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 50 – 88 | RING-typePROSITE-ProRule annotationAdd BLAST | 39 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG3528, Eukaryota |
GeneTreei | ENSGT00940000158381 |
HOGENOMi | CLU_021213_0_0_1 |
InParanoidi | Q8N448 |
OMAi | CSTLQLT |
OrthoDBi | 615205at2759 |
PhylomeDBi | Q8N448 |
TreeFami | TF330709 |
Family and domain databases
Gene3Di | 2.30.42.10, 4 hits 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR001478, PDZ IPR036034, PDZ_sf IPR001841, Znf_RING IPR013083, Znf_RING/FYVE/PHD IPR017907, Znf_RING_CS |
Pfami | View protein in Pfam PF00595, PDZ, 4 hits |
SMARTi | View protein in SMART SM00228, PDZ, 4 hits SM00184, RING, 1 hit |
SUPFAMi | SSF50156, SSF50156, 4 hits |
PROSITEi | View protein in PROSITE PS50106, PDZ, 4 hits PS00518, ZF_RING_1, 1 hit PS50089, ZF_RING_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q8N448-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGTTSDEMVS VEQTSSSSLN PLCFECGQQH WTRENHLYNY QNEVDDDLVC
60 70 80 90 100
HICLQPLLQP LDTPCGHTFC YKCLRNFLQE KDFCPLDRKR LHFKLCKKSS
110 120 130 140 150
ILVHKLLDKL LVLCPFSSVC KDVMQRCDLE AHLKNRCPGA SHRRVALERR
160 170 180 190 200
KTSRTQAEIE NENGPTLLDP AGTLSPEADC LGTGAVPVER HLTSASLSTW
210 220 230 240 250
SEEPGLDNPA FEESAGADTT QQPLSLPEGE ITTIEIHRSN PYIQLGISIV
260 270 280 290 300
GGNETPLINI VIQEVYRDGV IARDGRLLAG DQILQVNNYN ISNVSHNYAR
310 320 330 340 350
AVLSQPCNTL HLTVLRERRF GNRAHNHSDS NSPREEIFQV ALHKRDSGEQ
360 370 380 390 400
LGIKLVRRTD EPGVFILDLL EGGLAAQDGR LSSNDRVLAI NGHDLKYGTP
410 420 430 440 450
ELAAQIIQAS GERVNLTIAR PGKPQPGNTI REAGNHSSSS QHHTPPPYYS
460 470 480 490 500
RPSSHKDLTQ CVTCQEKHIT VKKEPHESLG MTVAGGRGSK SGELPIFVTS
510 520 530 540 550
VPPHGCLARD GRIKRGDVLL NINGIDLTNL SHSEAVAMLK ASAASPAVAL
560 570 580 590 600
KALEVQIVEE ATQNAEEQPS TFSENEYDAS WSPSWVMWLG LPSTLHSCHD
610 620 630 640 650
IVLRRSYLGS WGFSIVGGYE ENHTNQPFFI KTIVLGTPAY YDGRLKCGDM
660 670 680 690
IVAVNGLSTV GMSHSALVPM LKEQRNKVTL TVICWPGSLV
Sequence cautioni
The sequence BAD18754 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_024612 | 198 | S → P. Corresponds to variant dbSNP:rs8002697Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL138699 Genomic DNA No translation available. BC036755 mRNA Translation: AAH36755.1 AK172771 mRNA Translation: BAD18754.1 Different initiation. |
CCDSi | CCDS9323.1 |
RefSeqi | NP_699202.1, NM_153371.3 XP_016875923.1, XM_017020434.1 |
Genome annotation databases
Ensembli | ENST00000316334; ENSP00000325929; ENSG00000139517 ENST00000649248; ENSP00000497224; ENSG00000139517 |
GeneIDi | 222484 |
KEGGi | hsa:222484 |
MANE-Selecti | ENST00000316334.5; ENSP00000325929.3; NM_153371.4; NP_699202.1 |
UCSCi | uc001url.5, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL138699 Genomic DNA No translation available. BC036755 mRNA Translation: AAH36755.1 AK172771 mRNA Translation: BAD18754.1 Different initiation. |
CCDSi | CCDS9323.1 |
RefSeqi | NP_699202.1, NM_153371.3 XP_016875923.1, XM_017020434.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2VWR | X-ray | 1.30 | A | 336-424 | [»] | |
5DIN | X-ray | 1.86 | A/B | 20-147 | [»] | |
5E11 | X-ray | 1.80 | A | 336-424 | [»] | |
5E1Y | X-ray | 1.01 | A | 336-424 | [»] | |
5E21 | X-ray | 1.01 | A | 336-424 | [»] | |
5E22 | X-ray | 1.80 | A/B | 336-424 | [»] | |
SMRi | Q8N448 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 128798, 107 interactors |
IntActi | Q8N448, 110 interactors |
MINTi | Q8N448 |
STRINGi | 9606.ENSP00000325929 |
Protein family/group databases
MoonDBi | Q8N448, Predicted |
PTM databases
iPTMneti | Q8N448 |
PhosphoSitePlusi | Q8N448 |
Genetic variation databases
BioMutai | LNX2 |
DMDMi | 29840784 |
Proteomic databases
EPDi | Q8N448 |
jPOSTi | Q8N448 |
MassIVEi | Q8N448 |
MaxQBi | Q8N448 |
PaxDbi | Q8N448 |
PeptideAtlasi | Q8N448 |
PRIDEi | Q8N448 |
ProteomicsDBi | 71884 |
Protocols and materials databases
Antibodypediai | 22674, 175 antibodies from 22 providers |
DNASUi | 222484 |
Genome annotation databases
Ensembli | ENST00000316334; ENSP00000325929; ENSG00000139517 ENST00000649248; ENSP00000497224; ENSG00000139517 |
GeneIDi | 222484 |
KEGGi | hsa:222484 |
MANE-Selecti | ENST00000316334.5; ENSP00000325929.3; NM_153371.4; NP_699202.1 |
UCSCi | uc001url.5, human |
Organism-specific databases
CTDi | 222484 |
DisGeNETi | 222484 |
GeneCardsi | LNX2 |
HGNCi | HGNC:20421, LNX2 |
HPAi | ENSG00000139517, Low tissue specificity |
MIMi | 609733, gene |
neXtProti | NX_Q8N448 |
OpenTargetsi | ENSG00000139517 |
PharmGKBi | PA134899015 |
VEuPathDBi | HostDB:ENSG00000139517 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3528, Eukaryota |
GeneTreei | ENSGT00940000158381 |
HOGENOMi | CLU_021213_0_0_1 |
InParanoidi | Q8N448 |
OMAi | CSTLQLT |
OrthoDBi | 615205at2759 |
PhylomeDBi | Q8N448 |
TreeFami | TF330709 |
Enzyme and pathway databases
PathwayCommonsi | Q8N448 |
SignaLinki | Q8N448 |
Miscellaneous databases
BioGRID-ORCSi | 222484, 10 hits in 1087 CRISPR screens |
ChiTaRSi | LNX2, human |
EvolutionaryTracei | Q8N448 |
GenomeRNAii | 222484 |
Pharosi | Q8N448, Tbio |
PROi | PR:Q8N448 |
RNActi | Q8N448, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000139517, Expressed in jejunal mucosa and 211 other tissues |
Genevisiblei | Q8N448, HS |
Family and domain databases
Gene3Di | 2.30.42.10, 4 hits 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR001478, PDZ IPR036034, PDZ_sf IPR001841, Znf_RING IPR013083, Znf_RING/FYVE/PHD IPR017907, Znf_RING_CS |
Pfami | View protein in Pfam PF00595, PDZ, 4 hits |
SMARTi | View protein in SMART SM00228, PDZ, 4 hits SM00184, RING, 1 hit |
SUPFAMi | SSF50156, SSF50156, 4 hits |
PROSITEi | View protein in PROSITE PS50106, PDZ, 4 hits PS00518, ZF_RING_1, 1 hit PS50089, ZF_RING_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | LNX2_HUMAN | |
Accessioni | Q8N448Primary (citable) accession number: Q8N448 Secondary accession number(s): Q5W0P0, Q6ZMH2, Q96SH4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 28, 2003 |
Last sequence update: | October 1, 2002 | |
Last modified: | February 23, 2022 | |
This is version 159 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 13
Human chromosome 13: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references