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Protein

Ligand of Numb protein X 2

Gene

LNX2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri50 – 88RING-typePROSITE-ProRule annotationAdd BLAST39

GO - Molecular functioni

Keywordsi

LigandMetal-binding, Zinc

Protein family/group databases

MoonDBiQ8N448 Predicted

Names & Taxonomyi

Protein namesi
Recommended name:
Ligand of Numb protein X 2
Alternative name(s):
Numb-binding protein 2
PDZ domain-containing RING finger protein 1
Gene namesi
Name:LNX2
Synonyms:PDZRN1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

EuPathDBiHostDB:ENSG00000139517.7
HGNCiHGNC:20421 LNX2
MIMi609733 gene
neXtProtiNX_Q8N448

Pathology & Biotechi

Organism-specific databases

DisGeNETi222484
OpenTargetsiENSG00000139517
PharmGKBiPA134899015

Polymorphism and mutation databases

BioMutaiLNX2
DMDMi29840784

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000559151 – 690Ligand of Numb protein X 2Add BLAST690

Proteomic databases

EPDiQ8N448
MaxQBiQ8N448
PaxDbiQ8N448
PeptideAtlasiQ8N448
PRIDEiQ8N448
ProteomicsDBi71884

PTM databases

iPTMnetiQ8N448
PhosphoSitePlusiQ8N448

Expressioni

Gene expression databases

BgeeiENSG00000139517 Expressed in 194 organ(s), highest expression level in jejunal mucosa
CleanExiHS_LNX2
GenevisibleiQ8N448 HS

Organism-specific databases

HPAiHPA040698

Interactioni

Subunit structurei

Interacts with the phosphotyrosine interaction domain of NUMB.By similarity

Binary interactionsi

Protein-protein interaction databases

BioGridi128798, 52 interactors
IntActiQ8N448, 86 interactors
MINTiQ8N448
STRINGi9606.ENSP00000325929

Structurei

Secondary structure

1690
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ8N448
SMRiQ8N448
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8N448

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini233 – 318PDZ 1PROSITE-ProRule annotationAdd BLAST86
Domaini339 – 422PDZ 2PROSITE-ProRule annotationAdd BLAST84
Domaini468 – 554PDZ 3PROSITE-ProRule annotationAdd BLAST87
Domaini600 – 688PDZ 4PROSITE-ProRule annotationAdd BLAST89

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi208 – 211NPXY motif4

Domaini

The NPXY motif is required for the interaction with the PID domain of NUMB. It is however not sufficient.

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri50 – 88RING-typePROSITE-ProRule annotationAdd BLAST39

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG410ITAD Eukaryota
ENOG410Y9FS LUCA
GeneTreeiENSGT00760000119017
HOGENOMiHOG000261605
HOVERGENiHBG039539
InParanoidiQ8N448
KOiK10692
OMAiFNPLCFE
OrthoDBiEOG091G0CBZ
PhylomeDBiQ8N448
TreeFamiTF330709

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR001478 PDZ
IPR036034 PDZ_sf
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS
PfamiView protein in Pfam
PF00595 PDZ, 4 hits
SMARTiView protein in SMART
SM00228 PDZ, 4 hits
SM00184 RING, 1 hit
SUPFAMiSSF50156 SSF50156, 4 hits
PROSITEiView protein in PROSITE
PS50106 PDZ, 4 hits
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8N448-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGTTSDEMVS VEQTSSSSLN PLCFECGQQH WTRENHLYNY QNEVDDDLVC
60 70 80 90 100
HICLQPLLQP LDTPCGHTFC YKCLRNFLQE KDFCPLDRKR LHFKLCKKSS
110 120 130 140 150
ILVHKLLDKL LVLCPFSSVC KDVMQRCDLE AHLKNRCPGA SHRRVALERR
160 170 180 190 200
KTSRTQAEIE NENGPTLLDP AGTLSPEADC LGTGAVPVER HLTSASLSTW
210 220 230 240 250
SEEPGLDNPA FEESAGADTT QQPLSLPEGE ITTIEIHRSN PYIQLGISIV
260 270 280 290 300
GGNETPLINI VIQEVYRDGV IARDGRLLAG DQILQVNNYN ISNVSHNYAR
310 320 330 340 350
AVLSQPCNTL HLTVLRERRF GNRAHNHSDS NSPREEIFQV ALHKRDSGEQ
360 370 380 390 400
LGIKLVRRTD EPGVFILDLL EGGLAAQDGR LSSNDRVLAI NGHDLKYGTP
410 420 430 440 450
ELAAQIIQAS GERVNLTIAR PGKPQPGNTI REAGNHSSSS QHHTPPPYYS
460 470 480 490 500
RPSSHKDLTQ CVTCQEKHIT VKKEPHESLG MTVAGGRGSK SGELPIFVTS
510 520 530 540 550
VPPHGCLARD GRIKRGDVLL NINGIDLTNL SHSEAVAMLK ASAASPAVAL
560 570 580 590 600
KALEVQIVEE ATQNAEEQPS TFSENEYDAS WSPSWVMWLG LPSTLHSCHD
610 620 630 640 650
IVLRRSYLGS WGFSIVGGYE ENHTNQPFFI KTIVLGTPAY YDGRLKCGDM
660 670 680 690
IVAVNGLSTV GMSHSALVPM LKEQRNKVTL TVICWPGSLV
Length:690
Mass (Da):76,004
Last modified:October 1, 2002 - v1
Checksum:iA3F941A477721F1D
GO

Sequence cautioni

The sequence BAD18754 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_024612198S → P. Corresponds to variant dbSNP:rs8002697Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL138699 Genomic DNA No translation available.
BC036755 mRNA Translation: AAH36755.1
AK172771 mRNA Translation: BAD18754.1 Different initiation.
CCDSiCCDS9323.1
RefSeqiNP_699202.1, NM_153371.3
XP_016875923.1, XM_017020434.1
UniGeneiHs.132359

Genome annotation databases

EnsembliENST00000316334; ENSP00000325929; ENSG00000139517
GeneIDi222484
KEGGihsa:222484
UCSCiuc001url.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL138699 Genomic DNA No translation available.
BC036755 mRNA Translation: AAH36755.1
AK172771 mRNA Translation: BAD18754.1 Different initiation.
CCDSiCCDS9323.1
RefSeqiNP_699202.1, NM_153371.3
XP_016875923.1, XM_017020434.1
UniGeneiHs.132359

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2VWRX-ray1.30A336-424[»]
5DINX-ray1.86A/B20-147[»]
5E11X-ray1.80A336-424[»]
5E1YX-ray1.01A336-424[»]
5E21X-ray1.01A336-424[»]
5E22X-ray1.80A/B336-424[»]
ProteinModelPortaliQ8N448
SMRiQ8N448
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128798, 52 interactors
IntActiQ8N448, 86 interactors
MINTiQ8N448
STRINGi9606.ENSP00000325929

Protein family/group databases

MoonDBiQ8N448 Predicted

PTM databases

iPTMnetiQ8N448
PhosphoSitePlusiQ8N448

Polymorphism and mutation databases

BioMutaiLNX2
DMDMi29840784

Proteomic databases

EPDiQ8N448
MaxQBiQ8N448
PaxDbiQ8N448
PeptideAtlasiQ8N448
PRIDEiQ8N448
ProteomicsDBi71884

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000316334; ENSP00000325929; ENSG00000139517
GeneIDi222484
KEGGihsa:222484
UCSCiuc001url.5 human

Organism-specific databases

CTDi222484
DisGeNETi222484
EuPathDBiHostDB:ENSG00000139517.7
GeneCardsiLNX2
HGNCiHGNC:20421 LNX2
HPAiHPA040698
MIMi609733 gene
neXtProtiNX_Q8N448
OpenTargetsiENSG00000139517
PharmGKBiPA134899015
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410ITAD Eukaryota
ENOG410Y9FS LUCA
GeneTreeiENSGT00760000119017
HOGENOMiHOG000261605
HOVERGENiHBG039539
InParanoidiQ8N448
KOiK10692
OMAiFNPLCFE
OrthoDBiEOG091G0CBZ
PhylomeDBiQ8N448
TreeFamiTF330709

Miscellaneous databases

ChiTaRSiLNX2 human
EvolutionaryTraceiQ8N448
GenomeRNAii222484
PROiPR:Q8N448
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000139517 Expressed in 194 organ(s), highest expression level in jejunal mucosa
CleanExiHS_LNX2
GenevisibleiQ8N448 HS

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR001478 PDZ
IPR036034 PDZ_sf
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS
PfamiView protein in Pfam
PF00595 PDZ, 4 hits
SMARTiView protein in SMART
SM00228 PDZ, 4 hits
SM00184 RING, 1 hit
SUPFAMiSSF50156 SSF50156, 4 hits
PROSITEiView protein in PROSITE
PS50106 PDZ, 4 hits
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLNX2_HUMAN
AccessioniPrimary (citable) accession number: Q8N448
Secondary accession number(s): Q5W0P0, Q6ZMH2, Q96SH4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 28, 2003
Last sequence update: October 1, 2002
Last modified: November 7, 2018
This is version 142 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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