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UniProtKB - Q8N441 (FGRL1_HUMAN)

Entry version 157 (25 May 2022)
Sequence version 1 (01 Oct 2002)
Previous versions | rss
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Protein

Fibroblast growth factor receptor-like 1

Gene

FGFRL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Has a negative effect on cell proliferation.

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q8N441

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-5658623, FGFRL1 modulation of FGFR1 signaling

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q8N441

Protein family/group databases

Transport Classification Database

More...TCDBi		8.A.23.1.6, the basigin (basigin) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Fibroblast growth factor receptor-like 1
Short name:
FGF receptor-like protein 1
Alternative name(s):
FGF homologous factor receptor
FGFR-like protein
Fibroblast growth factor receptor 5
Short name:
FGFR-5
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FGFRL1
Synonyms:FGFR5, FHFR
ORF Names:UNQ480/PRO943
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:3693, FGFRL1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		605830, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8N441

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000127418

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini25 – 378ExtracellularSequence analysisAdd BLAST354
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei379 – 399HelicalSequence analysisAdd BLAST21
Topological domaini400 – 504CytoplasmicSequence analysisAdd BLAST105

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		53834

MalaCards human disease database

More...MalaCardsi		FGFRL1

Open Targets

More...OpenTargetsi		ENSG00000127418

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA28132

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q8N441, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		FGFRL1

Domain mapping of disease mutations (DMDM)

More...DMDMi		68052359

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 241 PublicationAdd BLAST24
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002125025 – 504Fibroblast growth factor receptor-like 1Add BLAST480

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi51 ↔ 99PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi111N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi172 ↔ 221PROSITE-ProRule annotation
Glycosylationi231N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi255N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi268 ↔ 338PROSITE-ProRule annotation
Glycosylationi293N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q8N441

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q8N441

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q8N441

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8N441

PeptideAtlas

More...PeptideAtlasi		Q8N441

PRoteomics IDEntifications database

More...PRIDEi		Q8N441

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		71879

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		1240, 2 N-Linked glycans (1 site)

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q8N441, 4 sites, 2 N-linked glycans (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8N441

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8N441

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed preferentially in cartilaginous tissues and pancreas. Highly expressed in the liver, kidney, heart, brain and skeletal muscle. Weakly expressed in the lung, small intestine and spleen.3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000127418, Expressed in right uterine tube and 154 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q8N441, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8N441, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000127418, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with FGF2 with a low affinity.

By similarity

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		119806, 59 interactors

Protein interaction database and analysis system

More...IntActi		Q8N441, 23 interactors

Molecular INTeraction database

More...MINTi		Q8N441

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000381498

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8N441, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q8N441

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8N441

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini29 – 115Ig-like C2-type 1Add BLAST87
Domaini147 – 237Ig-like C2-type 2Add BLAST91
Domaini246 – 354Ig-like C2-type 3Add BLAST109

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni123 – 155DisorderedSequence analysisAdd BLAST33
Regioni407 – 435DisorderedSequence analysisAdd BLAST29

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi126 – 149Polar residuesSequence analysisAdd BLAST24

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0200, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000156736

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_038830_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8N441

Identification of Orthologs from Complete Genome Data

More...OMAi		WAQPRFT

Database of Orthologous Groups

More...OrthoDBi		612548at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8N441

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.40.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR013098, Ig_I-set
IPR003599, Ig_sub
IPR003598, Ig_sub2

Pfam protein domain database

More...Pfami		View protein in Pfam
PF07679, I-set, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00409, IG, 3 hits
SM00408, IGc2, 3 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48726, SSF48726, 3 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50835, IG_LIKE, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q8N441-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTPSPLLLLL LPPLLLGAFP PAAAARGPPK MADKVVPRQV ARLGRTVRLQ 
        60         70         80         90        100
CPVEGDPPPL TMWTKDGRTI HSGWSRFRVL PQGLKVKQVE REDAGVYVCK 
       110        120        130        140        150
ATNGFGSLSV NYTLVVLDDI SPGKESLGPD SSSGGQEDPA SQQWARPRFT 
       160        170        180        190        200
QPSKMRRRVI ARPVGSSVRL KCVASGHPRP DITWMKDDQA LTRPEAAEPR 
       210        220        230        240        250
KKKWTLSLKN LRPEDSGKYT CRVSNRAGAI NATYKVDVIQ RTRSKPVLTG 
       260        270        280        290        300
THPVNTTVDF GGTTSFQCKV RSDVKPVIQW LKRVEYGAEG RHNSTIDVGG 
       310        320        330        340        350
QKFVVLPTGD VWSRPDGSYL NKLLITRARQ DDAGMYICLG ANTMGYSFRS 
       360        370        380        390        400
AFLTVLPDPK PPGPPVASSS SATSLPWPVV IGIPAGAVFI LGTLLLWLCQ 
       410        420        430        440        450
AQKKPCTPAP APPLPGHRPP GTARDRSGDK DLPSLAALSA GPGVGLCEEH 
       460        470        480        490        500
GSPAAPQHLL GPGPVAGPKL YPKLYTDIHT HTHTHSHTHS HVEGKVHQHI 

HYQC
Length:504
Mass (Da):54,537
Last modified:October 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i56E35E57D5FC141B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RBN8D6RBN8_HUMAN
Fibroblast growth factor receptor-l...
FGFRL1
152Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6REM7D6REM7_HUMAN
Fibroblast growth factor receptor-l...
FGFRL1
80Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti374 – 380Missing in AAK15273 (Ref. 3) Curated7

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_022642362P → Q3 PublicationsCorresponds to variant dbSNP:rs4647930Ensembl.1
Natural variantiVAR_024316464P → L. Corresponds to variant dbSNP:rs4647932Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AJ277437 mRNA Translation: CAC14171.1
AF279689 mRNA Translation: AAK26742.1
AF312678 mRNA Translation: AAK15273.1
AY358303 mRNA Translation: AAQ88670.1
AK314365 mRNA Translation: BAG36996.1
BC036769 mRNA Translation: AAH36769.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS3344.1

NCBI Reference Sequences

More...RefSeqi		NP_001004356.1, NM_001004356.2
NP_001004358.1, NM_001004358.1
NP_068742.2, NM_021923.3
XP_011511788.1, XM_011513486.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000264748.6; ENSP00000264748.6; ENSG00000127418.15
ENST00000398484.6; ENSP00000381498.2; ENSG00000127418.15
ENST00000504138.5; ENSP00000423091.1; ENSG00000127418.15
ENST00000510644.6; ENSP00000425025.1; ENSG00000127418.15

Database of genes from NCBI RefSeq genomes

More...GeneIDi		53834

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:53834

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000510644.6; ENSP00000425025.1; NM_001004356.3; NP_001004356.1

UCSC genome browser

More...UCSCi		uc003gcf.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ277437 mRNA Translation: CAC14171.1
AF279689 mRNA Translation: AAK26742.1
AF312678 mRNA Translation: AAK15273.1
AY358303 mRNA Translation: AAQ88670.1
AK314365 mRNA Translation: BAG36996.1
BC036769 mRNA Translation: AAH36769.1
CCDSiCCDS3344.1
RefSeqiNP_001004356.1, NM_001004356.2
NP_001004358.1, NM_001004358.1
NP_068742.2, NM_021923.3
XP_011511788.1, XM_011513486.1

3D structure databases

AlphaFoldDBiQ8N441
SMRiQ8N441
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi119806, 59 interactors
IntActiQ8N441, 23 interactors
MINTiQ8N441
STRINGi9606.ENSP00000381498

Protein family/group databases

TCDBi8.A.23.1.6, the basigin (basigin) family

PTM databases

GlyConnecti1240, 2 N-Linked glycans (1 site)
GlyGeniQ8N441, 4 sites, 2 N-linked glycans (1 site)
iPTMnetiQ8N441
PhosphoSitePlusiQ8N441

Genetic variation databases

BioMutaiFGFRL1
DMDMi68052359

Proteomic databases

jPOSTiQ8N441
MassIVEiQ8N441
MaxQBiQ8N441
PaxDbiQ8N441
PeptideAtlasiQ8N441
PRIDEiQ8N441
ProteomicsDBi71879

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		22198, 357 antibodies from 31 providers

The DNASU plasmid repository

More...DNASUi		53834

Genome annotation databases

EnsembliENST00000264748.6; ENSP00000264748.6; ENSG00000127418.15
ENST00000398484.6; ENSP00000381498.2; ENSG00000127418.15
ENST00000504138.5; ENSP00000423091.1; ENSG00000127418.15
ENST00000510644.6; ENSP00000425025.1; ENSG00000127418.15
GeneIDi53834
KEGGihsa:53834
MANE-SelectiENST00000510644.6; ENSP00000425025.1; NM_001004356.3; NP_001004356.1
UCSCiuc003gcf.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		53834
DisGeNETi53834

GeneCards: human genes, protein and diseases

More...GeneCardsi		FGFRL1
HGNCiHGNC:3693, FGFRL1
HPAiENSG00000127418, Low tissue specificity
MalaCardsiFGFRL1
MIMi605830, gene
neXtProtiNX_Q8N441
OpenTargetsiENSG00000127418
PharmGKBiPA28132
VEuPathDBiHostDB:ENSG00000127418

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0200, Eukaryota
GeneTreeiENSGT00940000156736
HOGENOMiCLU_038830_1_0_1
InParanoidiQ8N441
OMAiWAQPRFT
OrthoDBi612548at2759
PhylomeDBiQ8N441

Enzyme and pathway databases

PathwayCommonsiQ8N441
ReactomeiR-HSA-5658623, FGFRL1 modulation of FGFR1 signaling
SignaLinkiQ8N441

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		53834, 13 hits in 1079 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		FGFRL1, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		FGFRL1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		53834
PharosiQ8N441, Tbio

Protein Ontology

More...PROi		PR:Q8N441
RNActiQ8N441, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000127418, Expressed in right uterine tube and 154 other tissues
ExpressionAtlasiQ8N441, baseline and differential
GenevisibleiQ8N441, HS

Family and domain databases

Gene3Di2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR013098, Ig_I-set
IPR003599, Ig_sub
IPR003598, Ig_sub2
PfamiView protein in Pfam
PF07679, I-set, 2 hits
SMARTiView protein in SMART
SM00409, IG, 3 hits
SM00408, IGc2, 3 hits
SUPFAMiSSF48726, SSF48726, 3 hits
PROSITEiView protein in PROSITE
PS50835, IG_LIKE, 3 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFGRL1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8N441
Secondary accession number(s): B2RAU9
, Q6PJN1, Q9BXN7, Q9H4D7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: October 1, 2002
Last modified: May 25, 2022
This is version 157 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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