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UniProtKB - Q8N441 (FGRL1_HUMAN)
Protein
Fibroblast growth factor receptor-like 1
Gene
FGFRL1
Organism
Homo sapiens (Human)
Status
Functioni
Has a negative effect on cell proliferation.
By similarityGO - Molecular functioni
- fibroblast growth factor-activated receptor activity Source: UniProtKB
- fibroblast growth factor binding Source: GO_Central
- heparin binding Source: UniProtKB
- identical protein binding Source: UniProtKB
GO - Biological processi
- cell-cell adhesion via plasma-membrane adhesion molecules Source: UniProtKB
- diaphragm development Source: Ensembl
- heart valve morphogenesis Source: Ensembl
- negative regulation of cell population proliferation Source: Ensembl
- skeletal system development Source: Ensembl
- ventricular septum morphogenesis Source: Ensembl
Keywordsi
Molecular function | Receptor |
Enzyme and pathway databases
PathwayCommonsi | Q8N441 |
Reactomei | R-HSA-5658623, FGFRL1 modulation of FGFR1 signaling |
SignaLinki | Q8N441 |
Protein family/group databases
TCDBi | 8.A.23.1.6, the basigin (basigin) family |
Names & Taxonomyi
Protein namesi | Recommended name: Fibroblast growth factor receptor-like 1Short name: FGF receptor-like protein 1 Alternative name(s): FGF homologous factor receptor FGFR-like protein Fibroblast growth factor receptor 5 Short name: FGFR-5 |
Gene namesi | Name:FGFRL1 Synonyms:FGFR5, FHFR ORF Names:UNQ480/PRO943 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:3693, FGFRL1 |
MIMi | 605830, gene |
neXtProti | NX_Q8N441 |
VEuPathDBi | HostDB:ENSG00000127418 |
Subcellular locationi
Other locations
- Membrane 1 Publication; Single-pass type I membrane protein 1 Publication
Note: Predominantly localized in the plasma membrane but also detected in the Golgi and in secretory vesicles.
Golgi apparatus
- Golgi apparatus Source: UniProtKB
Plasma Membrane
- plasma membrane Source: UniProtKB
Other locations
- cell-cell contact zone Source: UniProtKB
- integral component of membrane Source: UniProtKB-KW
- transport vesicle Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 25 – 378 | ExtracellularSequence analysisAdd BLAST | 354 | |
Transmembranei | 379 – 399 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 400 – 504 | CytoplasmicSequence analysisAdd BLAST | 105 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 53834 |
MalaCardsi | FGFRL1 |
OpenTargetsi | ENSG00000127418 |
PharmGKBi | PA28132 |
Miscellaneous databases
Pharosi | Q8N441, Tbio |
Genetic variation databases
BioMutai | FGFRL1 |
DMDMi | 68052359 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 24 | 1 PublicationAdd BLAST | 24 | |
ChainiPRO_0000021250 | 25 – 504 | Fibroblast growth factor receptor-like 1Add BLAST | 480 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 51 ↔ 99 | PROSITE-ProRule annotation | ||
Glycosylationi | 111 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 172 ↔ 221 | PROSITE-ProRule annotation | ||
Glycosylationi | 231 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 255 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 268 ↔ 338 | PROSITE-ProRule annotation | ||
Glycosylationi | 293 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
jPOSTi | Q8N441 |
MassIVEi | Q8N441 |
MaxQBi | Q8N441 |
PaxDbi | Q8N441 |
PeptideAtlasi | Q8N441 |
PRIDEi | Q8N441 |
ProteomicsDBi | 71879 |
PTM databases
GlyConnecti | 1240, 2 N-Linked glycans (1 site) |
GlyGeni | Q8N441, 4 sites, 2 N-linked glycans (1 site) |
iPTMneti | Q8N441 |
PhosphoSitePlusi | Q8N441 |
Expressioni
Tissue specificityi
Expressed preferentially in cartilaginous tissues and pancreas. Highly expressed in the liver, kidney, heart, brain and skeletal muscle. Weakly expressed in the lung, small intestine and spleen.3 Publications
Gene expression databases
Bgeei | ENSG00000127418, Expressed in right uterine tube and 154 other tissues |
ExpressionAtlasi | Q8N441, baseline and differential |
Genevisiblei | Q8N441, HS |
Organism-specific databases
HPAi | ENSG00000127418, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with FGF2 with a low affinity.
By similarityGO - Molecular functioni
- fibroblast growth factor binding Source: GO_Central
- identical protein binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 119806, 59 interactors |
IntActi | Q8N441, 23 interactors |
MINTi | Q8N441 |
STRINGi | 9606.ENSP00000381498 |
Miscellaneous databases
RNActi | Q8N441, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 29 – 115 | Ig-like C2-type 1Add BLAST | 87 | |
Domaini | 147 – 237 | Ig-like C2-type 2Add BLAST | 91 | |
Domaini | 246 – 354 | Ig-like C2-type 3Add BLAST | 109 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 123 – 155 | DisorderedSequence analysisAdd BLAST | 33 | |
Regioni | 407 – 435 | DisorderedSequence analysisAdd BLAST | 29 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 126 – 149 | Polar residuesSequence analysisAdd BLAST | 24 |
Keywords - Domaini
Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0200, Eukaryota |
GeneTreei | ENSGT00940000156736 |
HOGENOMi | CLU_038830_1_0_1 |
InParanoidi | Q8N441 |
OMAi | WAQPRFT |
OrthoDBi | 612548at2759 |
PhylomeDBi | Q8N441 |
Family and domain databases
Gene3Di | 2.60.40.10, 3 hits |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR013098, Ig_I-set IPR003599, Ig_sub IPR003598, Ig_sub2 |
Pfami | View protein in Pfam PF07679, I-set, 2 hits |
SMARTi | View protein in SMART SM00409, IG, 3 hits SM00408, IGc2, 3 hits |
SUPFAMi | SSF48726, SSF48726, 3 hits |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 3 hits |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q8N441-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTPSPLLLLL LPPLLLGAFP PAAAARGPPK MADKVVPRQV ARLGRTVRLQ
60 70 80 90 100
CPVEGDPPPL TMWTKDGRTI HSGWSRFRVL PQGLKVKQVE REDAGVYVCK
110 120 130 140 150
ATNGFGSLSV NYTLVVLDDI SPGKESLGPD SSSGGQEDPA SQQWARPRFT
160 170 180 190 200
QPSKMRRRVI ARPVGSSVRL KCVASGHPRP DITWMKDDQA LTRPEAAEPR
210 220 230 240 250
KKKWTLSLKN LRPEDSGKYT CRVSNRAGAI NATYKVDVIQ RTRSKPVLTG
260 270 280 290 300
THPVNTTVDF GGTTSFQCKV RSDVKPVIQW LKRVEYGAEG RHNSTIDVGG
310 320 330 340 350
QKFVVLPTGD VWSRPDGSYL NKLLITRARQ DDAGMYICLG ANTMGYSFRS
360 370 380 390 400
AFLTVLPDPK PPGPPVASSS SATSLPWPVV IGIPAGAVFI LGTLLLWLCQ
410 420 430 440 450
AQKKPCTPAP APPLPGHRPP GTARDRSGDK DLPSLAALSA GPGVGLCEEH
460 470 480 490 500
GSPAAPQHLL GPGPVAGPKL YPKLYTDIHT HTHTHSHTHS HVEGKVHQHI
HYQC
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketD6RBN8 | D6RBN8_HUMAN | Fibroblast growth factor receptor-l... | FGFRL1 | 152 | Annotation score: | ||
D6REM7 | D6REM7_HUMAN | Fibroblast growth factor receptor-l... | FGFRL1 | 80 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 374 – 380 | Missing in AAK15273 (Ref. 3) Curated | 7 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_022642 | 362 | P → Q3 PublicationsCorresponds to variant dbSNP:rs4647930Ensembl. | 1 | |
Natural variantiVAR_024316 | 464 | P → L. Corresponds to variant dbSNP:rs4647932Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ277437 mRNA Translation: CAC14171.1 AF279689 mRNA Translation: AAK26742.1 AF312678 mRNA Translation: AAK15273.1 AY358303 mRNA Translation: AAQ88670.1 AK314365 mRNA Translation: BAG36996.1 BC036769 mRNA Translation: AAH36769.1 |
CCDSi | CCDS3344.1 |
RefSeqi | NP_001004356.1, NM_001004356.2 NP_001004358.1, NM_001004358.1 NP_068742.2, NM_021923.3 XP_011511788.1, XM_011513486.1 |
Genome annotation databases
Ensembli | ENST00000264748.6; ENSP00000264748.6; ENSG00000127418.15 ENST00000398484.6; ENSP00000381498.2; ENSG00000127418.15 ENST00000504138.5; ENSP00000423091.1; ENSG00000127418.15 ENST00000510644.6; ENSP00000425025.1; ENSG00000127418.15 |
GeneIDi | 53834 |
KEGGi | hsa:53834 |
MANE-Selecti | ENST00000510644.6; ENSP00000425025.1; NM_001004356.3; NP_001004356.1 |
UCSCi | uc003gcf.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ277437 mRNA Translation: CAC14171.1 AF279689 mRNA Translation: AAK26742.1 AF312678 mRNA Translation: AAK15273.1 AY358303 mRNA Translation: AAQ88670.1 AK314365 mRNA Translation: BAG36996.1 BC036769 mRNA Translation: AAH36769.1 |
CCDSi | CCDS3344.1 |
RefSeqi | NP_001004356.1, NM_001004356.2 NP_001004358.1, NM_001004358.1 NP_068742.2, NM_021923.3 XP_011511788.1, XM_011513486.1 |
3D structure databases
AlphaFoldDBi | Q8N441 |
SMRi | Q8N441 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 119806, 59 interactors |
IntActi | Q8N441, 23 interactors |
MINTi | Q8N441 |
STRINGi | 9606.ENSP00000381498 |
Protein family/group databases
TCDBi | 8.A.23.1.6, the basigin (basigin) family |
PTM databases
GlyConnecti | 1240, 2 N-Linked glycans (1 site) |
GlyGeni | Q8N441, 4 sites, 2 N-linked glycans (1 site) |
iPTMneti | Q8N441 |
PhosphoSitePlusi | Q8N441 |
Genetic variation databases
BioMutai | FGFRL1 |
DMDMi | 68052359 |
Proteomic databases
jPOSTi | Q8N441 |
MassIVEi | Q8N441 |
MaxQBi | Q8N441 |
PaxDbi | Q8N441 |
PeptideAtlasi | Q8N441 |
PRIDEi | Q8N441 |
ProteomicsDBi | 71879 |
Protocols and materials databases
Antibodypediai | 22198, 357 antibodies from 31 providers |
DNASUi | 53834 |
Genome annotation databases
Ensembli | ENST00000264748.6; ENSP00000264748.6; ENSG00000127418.15 ENST00000398484.6; ENSP00000381498.2; ENSG00000127418.15 ENST00000504138.5; ENSP00000423091.1; ENSG00000127418.15 ENST00000510644.6; ENSP00000425025.1; ENSG00000127418.15 |
GeneIDi | 53834 |
KEGGi | hsa:53834 |
MANE-Selecti | ENST00000510644.6; ENSP00000425025.1; NM_001004356.3; NP_001004356.1 |
UCSCi | uc003gcf.4, human |
Organism-specific databases
CTDi | 53834 |
DisGeNETi | 53834 |
GeneCardsi | FGFRL1 |
HGNCi | HGNC:3693, FGFRL1 |
HPAi | ENSG00000127418, Low tissue specificity |
MalaCardsi | FGFRL1 |
MIMi | 605830, gene |
neXtProti | NX_Q8N441 |
OpenTargetsi | ENSG00000127418 |
PharmGKBi | PA28132 |
VEuPathDBi | HostDB:ENSG00000127418 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0200, Eukaryota |
GeneTreei | ENSGT00940000156736 |
HOGENOMi | CLU_038830_1_0_1 |
InParanoidi | Q8N441 |
OMAi | WAQPRFT |
OrthoDBi | 612548at2759 |
PhylomeDBi | Q8N441 |
Enzyme and pathway databases
PathwayCommonsi | Q8N441 |
Reactomei | R-HSA-5658623, FGFRL1 modulation of FGFR1 signaling |
SignaLinki | Q8N441 |
Miscellaneous databases
BioGRID-ORCSi | 53834, 13 hits in 1079 CRISPR screens |
ChiTaRSi | FGFRL1, human |
GeneWikii | FGFRL1 |
GenomeRNAii | 53834 |
Pharosi | Q8N441, Tbio |
PROi | PR:Q8N441 |
RNActi | Q8N441, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000127418, Expressed in right uterine tube and 154 other tissues |
ExpressionAtlasi | Q8N441, baseline and differential |
Genevisiblei | Q8N441, HS |
Family and domain databases
Gene3Di | 2.60.40.10, 3 hits |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR013098, Ig_I-set IPR003599, Ig_sub IPR003598, Ig_sub2 |
Pfami | View protein in Pfam PF07679, I-set, 2 hits |
SMARTi | View protein in SMART SM00409, IG, 3 hits SM00408, IGc2, 3 hits |
SUPFAMi | SSF48726, SSF48726, 3 hits |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 3 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | FGRL1_HUMAN | |
Accessioni | Q8N441Primary (citable) accession number: Q8N441 Secondary accession number(s): B2RAU9 Q9H4D7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 21, 2005 |
Last sequence update: | October 1, 2002 | |
Last modified: | May 25, 2022 | |
This is version 157 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot