UniProtKB - Q8N434 (SVOPL_HUMAN)
Protein
Putative transporter SVOPL
Gene
SVOPL
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- transmembrane transporter activity Source: InterPro
Keywordsi
Biological process | Transport |
Enzyme and pathway databases
PathwayCommonsi | Q8N434 |
Protein family/group databases
TCDBi | 2.A.1.82.6, the major facilitator superfamily (mfs) |
Names & Taxonomyi
Protein namesi | Recommended name: Putative transporter SVOPLAlternative name(s): SV2-related protein-like SVOP-like protein |
Gene namesi | Name:SVOPL |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:27034, SVOPL |
MIMi | 611700, gene |
neXtProti | NX_Q8N434 |
VEuPathDBi | HostDB:ENSG00000157703.15 |
Subcellular locationi
Other locations
- Membrane Curated; Multi-pass membrane protein Curated
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 48 – 68 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 86 – 106 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 121 – 141 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 179 – 199 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 203 – 223 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 281 – 301 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 348 – 368 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 383 – 403 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 429 – 449 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 458 – 478 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000157703 |
PharmGKBi | PA162405089 |
Miscellaneous databases
Pharosi | Q8N434, Tdark |
Genetic variation databases
BioMutai | SVOPL |
DMDMi | 152112307 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000294461 | 1 – 492 | Putative transporter SVOPLAdd BLAST | 492 |
Proteomic databases
PaxDbi | Q8N434 |
PeptideAtlasi | Q8N434 |
PRIDEi | Q8N434 |
ProteomicsDBi | 71874 [Q8N434-1] 71875 [Q8N434-2] |
PTM databases
iPTMneti | Q8N434 |
PhosphoSitePlusi | Q8N434 |
Expressioni
Gene expression databases
Bgeei | ENSG00000157703, Expressed in secondary oocyte and 109 other tissues |
ExpressionAtlasi | Q8N434, baseline and differential |
Genevisiblei | Q8N434, HS |
Organism-specific databases
HPAi | ENSG00000157703, Tissue enhanced (parathyroid gland, salivary gland) |
Interactioni
Binary interactionsi
Isoform 2 [Q8N434-2]
With | #Exp. | IntAct |
---|---|---|
TMEM42 [Q69YG0] | 3 | EBI-23750686,EBI-12038591 |
Protein-protein interaction databases
BioGRIDi | 126453, 11 interactors |
IntActi | Q8N434, 2 interactors |
STRINGi | 9606.ENSP00000405482 |
Miscellaneous databases
RNActi | Q8N434, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the major facilitator superfamily.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0253, Eukaryota |
GeneTreei | ENSGT00940000158632 |
HOGENOMi | CLU_001265_46_0_1 |
InParanoidi | Q8N434 |
OMAi | QIWIIWL |
OrthoDBi | 1430447at2759 |
PhylomeDBi | Q8N434 |
TreeFami | TF313465 |
Family and domain databases
InterProi | View protein in InterPro IPR011701, MFS IPR020846, MFS_dom IPR005828, MFS_sugar_transport-like IPR036259, MFS_trans_sf |
Pfami | View protein in Pfam PF07690, MFS_1, 1 hit PF00083, Sugar_tr, 1 hit |
SUPFAMi | SSF103473, SSF103473, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q8N434-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MATKPTEPVT ILSLRKLSLG TAEPQVKEPK TFTVEDAVET IGFGRFHIAL
60 70 80 90 100
FLIMGSTGVV EAMEIMLIAV VSPVIRCEWQ LENWQVALVT TMVFFGYMVF
110 120 130 140 150
SILFGLLADR YGRWKILLIS FLWGAYFSLL TSFAPSYIWF VFLRTMVGCG
160 170 180 190 200
VSGHSQGLII KTEFLPTKYR GYMLPLSQVF WLAGSLLIIG LASVIIPTIG
210 220 230 240 250
WRWLIRVASI PGIILIVAFK FIPESARFNV STGNTRAALA TLERVAKMNR
260 270 280 290 300
SVMPEGKLVE PVLEKRGRFA DLLDAKYLRT TLQIWVIWLG ISFAYYGVIL
310 320 330 340 350
ASAELLERDL VCGSKSDSAV VVTGGDSGES QSPCYCHMFA PSDYRTMIIS
360 370 380 390 400
TIGEIALNPL NILGINFLGR RLSLSITMGC TALFFLLLNI CTSSAGLIGF
410 420 430 440 450
LFMLRALVAA NFNTVYIYTA EVYPTTMRAL GMGTSGSLCR IGAMVAPFIS
460 470 480 490
QVLMSASILG ALCLFSSVCV VCAISAFTLP IETKGRALQQ IK
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketC9JVJ9 | C9JVJ9_HUMAN | Putative transporter SVOPL | SVOPL | 372 | Annotation score: | ||
F8WES3 | F8WES3_HUMAN | Putative transporter SVOPL | SVOPL | 233 | Annotation score: | ||
A0A6I8PL26 | A0A6I8PL26_HUMAN | Putative transporter SVOPL | SVOPL | 100 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_033188 | 385 | F → C. Corresponds to variant dbSNP:rs2305816Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_026651 | 1 – 152 | Missing in isoform 2. 1 PublicationAdd BLAST | 152 | |
Alternative sequenceiVSP_026652 | 153 – 157 | GHSQG → MAAGR in isoform 2. 1 Publication | 5 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC013429 Genomic DNA No translation available. AC020983 Genomic DNA No translation available. BC036796 mRNA Translation: AAH36796.1 |
CCDSi | CCDS47721.1 [Q8N434-1] CCDS5848.1 [Q8N434-2] |
RefSeqi | NP_001132928.1, NM_001139456.1 [Q8N434-1] NP_777619.1, NM_174959.3 [Q8N434-2] XP_005250200.1, XM_005250143.3 XP_011514099.1, XM_011515797.2 [Q8N434-2] XP_016867236.1, XM_017011747.1 [Q8N434-2] XP_016867237.1, XM_017011748.1 [Q8N434-2] |
Genome annotation databases
Ensembli | ENST00000288513; ENSP00000288513; ENSG00000157703 [Q8N434-2] ENST00000419765; ENSP00000405482; ENSG00000157703 [Q8N434-1] ENST00000436657; ENSP00000417018; ENSG00000157703 [Q8N434-2] ENST00000674285; ENSP00000501457; ENSG00000157703 [Q8N434-1] |
GeneIDi | 136306 |
KEGGi | hsa:136306 |
UCSCi | uc003vue.4, human [Q8N434-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC013429 Genomic DNA No translation available. AC020983 Genomic DNA No translation available. BC036796 mRNA Translation: AAH36796.1 |
CCDSi | CCDS47721.1 [Q8N434-1] CCDS5848.1 [Q8N434-2] |
RefSeqi | NP_001132928.1, NM_001139456.1 [Q8N434-1] NP_777619.1, NM_174959.3 [Q8N434-2] XP_005250200.1, XM_005250143.3 XP_011514099.1, XM_011515797.2 [Q8N434-2] XP_016867236.1, XM_017011747.1 [Q8N434-2] XP_016867237.1, XM_017011748.1 [Q8N434-2] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 126453, 11 interactors |
IntActi | Q8N434, 2 interactors |
STRINGi | 9606.ENSP00000405482 |
Protein family/group databases
TCDBi | 2.A.1.82.6, the major facilitator superfamily (mfs) |
PTM databases
iPTMneti | Q8N434 |
PhosphoSitePlusi | Q8N434 |
Genetic variation databases
BioMutai | SVOPL |
DMDMi | 152112307 |
Proteomic databases
PaxDbi | Q8N434 |
PeptideAtlasi | Q8N434 |
PRIDEi | Q8N434 |
ProteomicsDBi | 71874 [Q8N434-1] 71875 [Q8N434-2] |
Protocols and materials databases
Antibodypediai | 18208, 91 antibodies |
Genome annotation databases
Ensembli | ENST00000288513; ENSP00000288513; ENSG00000157703 [Q8N434-2] ENST00000419765; ENSP00000405482; ENSG00000157703 [Q8N434-1] ENST00000436657; ENSP00000417018; ENSG00000157703 [Q8N434-2] ENST00000674285; ENSP00000501457; ENSG00000157703 [Q8N434-1] |
GeneIDi | 136306 |
KEGGi | hsa:136306 |
UCSCi | uc003vue.4, human [Q8N434-1] |
Organism-specific databases
CTDi | 136306 |
GeneCardsi | SVOPL |
HGNCi | HGNC:27034, SVOPL |
HPAi | ENSG00000157703, Tissue enhanced (parathyroid gland, salivary gland) |
MIMi | 611700, gene |
neXtProti | NX_Q8N434 |
OpenTargetsi | ENSG00000157703 |
PharmGKBi | PA162405089 |
VEuPathDBi | HostDB:ENSG00000157703.15 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0253, Eukaryota |
GeneTreei | ENSGT00940000158632 |
HOGENOMi | CLU_001265_46_0_1 |
InParanoidi | Q8N434 |
OMAi | QIWIIWL |
OrthoDBi | 1430447at2759 |
PhylomeDBi | Q8N434 |
TreeFami | TF313465 |
Enzyme and pathway databases
PathwayCommonsi | Q8N434 |
Miscellaneous databases
BioGRID-ORCSi | 136306, 1 hit in 986 CRISPR screens |
ChiTaRSi | SVOPL, human |
GenomeRNAii | 136306 |
Pharosi | Q8N434, Tdark |
PROi | PR:Q8N434 |
RNActi | Q8N434, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000157703, Expressed in secondary oocyte and 109 other tissues |
ExpressionAtlasi | Q8N434, baseline and differential |
Genevisiblei | Q8N434, HS |
Family and domain databases
InterProi | View protein in InterPro IPR011701, MFS IPR020846, MFS_dom IPR005828, MFS_sugar_transport-like IPR036259, MFS_trans_sf |
Pfami | View protein in Pfam PF07690, MFS_1, 1 hit PF00083, Sugar_tr, 1 hit |
SUPFAMi | SSF103473, SSF103473, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SVOPL_HUMAN | |
Accessioni | Q8N434Primary (citable) accession number: Q8N434 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 10, 2007 |
Last sequence update: | July 10, 2007 | |
Last modified: | April 7, 2021 | |
This is version 144 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families