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Protein

Leukocyte immunoglobulin-like receptor subfamily B member 2

Gene

LILRB2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Involved in the down-regulation of the immune response and the development of tolerance. Competes with CD8A for binding to class I MHC antigens. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.4 Publications

GO - Molecular functioni

  • amyloid-beta binding Source: ARUK-UCL
  • cell adhesion molecule binding Source: BHF-UCL
  • inhibitory MHC class I receptor activity Source: BHF-UCL
  • MHC class Ib protein binding Source: BHF-UCL
  • MHC class I protein binding Source: UniProtKB
  • protein-containing complex binding Source: ARUK-UCL
  • protein homodimerization activity Source: ARUK-UCL
  • protein phosphatase 1 binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionReceptor
Biological processAdaptive immunity, Immunity

Enzyme and pathway databases

ReactomeiR-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-6798695 Neutrophil degranulation
SIGNORiQ8N423

Names & Taxonomyi

Protein namesi
Recommended name:
Leukocyte immunoglobulin-like receptor subfamily B member 2
Short name:
LIR-2
Short name:
Leukocyte immunoglobulin-like receptor 2
Alternative name(s):
CD85 antigen-like family member D
Immunoglobulin-like transcript 4
Short name:
ILT-4
Monocyte/macrophage immunoglobulin-like receptor 10
Short name:
MIR-10
CD_antigen: CD85d
Gene namesi
Name:LILRB2
Synonyms:ILT4, LIR2, MIR10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000131042.13
HGNCiHGNC:6606 LILRB2
MIMi604815 gene
neXtProtiNX_Q8N423

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 461ExtracellularSequence analysisAdd BLAST440
Transmembranei462 – 482HelicalSequence analysisAdd BLAST21
Topological domaini483 – 598CytoplasmicSequence analysisAdd BLAST116

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi10288
PharmGKBiPA30380

Polymorphism and mutation databases

BioMutaiLILRB2
DMDMi311033485

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000001482122 – 598Leukocyte immunoglobulin-like receptor subfamily B member 2Add BLAST577

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi49 ↔ 98PROSITE-ProRule annotationCombined sources1 Publication
Disulfide bondi144 ↔ 196PROSITE-ProRule annotationCombined sources1 Publication
Disulfide bondi156 ↔ 166PROSITE-ProRule annotationCombined sources1 Publication
Disulfide bondi245 ↔ 296PROSITE-ProRule annotation
Glycosylationi280N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi301N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi340N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi345 ↔ 396PROSITE-ProRule annotation

Post-translational modificationi

Phosphorylated on tyrosine residues. Dephosphorylated by PTPN6.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ8N423
PeptideAtlasiQ8N423
PRIDEiQ8N423
ProteomicsDBi71866
71867 [Q8N423-2]

PTM databases

iPTMnetiQ8N423
PhosphoSitePlusiQ8N423

Expressioni

Tissue specificityi

Expressed on monocytes and B-cells, and at lower levels on dendritic cells. Detected at low levels in natural killer (NK) cells.2 Publications

Gene expression databases

BgeeiENSG00000131042 Expressed in 139 organ(s), highest expression level in blood
CleanExiHS_LILRB2
ExpressionAtlasiQ8N423 baseline and differential
GenevisibleiQ8N423 HS

Interactioni

Subunit structurei

Binds PTPN6 when phosphorylated. Binds FCGR1A.

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

DIPiDIP-59888N
IntActiQ8N423, 23 interactors
STRINGi9606.ENSP00000375629

Structurei

Secondary structure

1598
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ8N423
SMRiQ8N423
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8N423

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 110Ig-like C2-type 1Add BLAST84
Domaini111 – 229Ig-like C2-type 2Add BLAST119
Domaini230 – 318Ig-like C2-type 3Add BLAST89
Domaini330 – 419Ig-like C2-type 4Add BLAST90

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi531 – 536ITIM motif 16
Motifi560 – 565ITIM motif 26
Motifi590 – 595ITIM motif 36

Domaini

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKJD Eukaryota
ENOG41116BR LUCA
HOGENOMiHOG000234395
HOVERGENiHBG074353
InParanoidiQ8N423
OrthoDBiEOG091G0D6W
PhylomeDBiQ8N423
TreeFamiTF336644

Family and domain databases

Gene3Di2.60.40.10, 4 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
PfamiView protein in Pfam
PF13895 Ig_2, 1 hit
SMARTiView protein in SMART
SM00409 IG, 3 hits
SM00408 IGc2, 3 hits
SUPFAMiSSF48726 SSF48726, 4 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 2 hits

Sequences (4+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 11 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8N423-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTPIVTVLIC LGLSLGPRTH VQTGTIPKPT LWAEPDSVIT QGSPVTLSCQ
60 70 80 90 100
GSLEAQEYRL YREKKSASWI TRIRPELVKN GQFHIPSITW EHTGRYGCQY
110 120 130 140 150
YSRARWSELS DPLVLVMTGA YPKPTLSAQP SPVVTSGGRV TLQCESQVAF
160 170 180 190 200
GGFILCKEGE EEHPQCLNSQ PHARGSSRAI FSVGPVSPNR RWSHRCYGYD
210 220 230 240 250
LNSPYVWSSP SDLLELLVPG VSKKPSLSVQ PGPVVAPGES LTLQCVSDVG
260 270 280 290 300
YDRFVLYKEG ERDLRQLPGR QPQAGLSQAN FTLGPVSRSY GGQYRCYGAH
310 320 330 340 350
NLSSECSAPS DPLDILITGQ IRGTPFISVQ PGPTVASGEN VTLLCQSWRQ
360 370 380 390 400
FHTFLLTKAG AADAPLRLRS IHEYPKYQAE FPMSPVTSAH AGTYRCYGSL
410 420 430 440 450
NSDPYLLSHP SEPLELVVSG PSMGSSPPPT GPISTPAGPE DQPLTPTGSD
460 470 480 490 500
PQSGLGRHLG VVIGILVAVV LLLLLLLLLF LILRHRRQGK HWTSTQRKAD
510 520 530 540 550
FQHPAGAVGP EPTDRGLQWR SSPAADAQEE NLYAAVKDTQ PEDGVEMDTR
560 570 580 590
AAASEAPQDV TYAQLHSLTL RRKATEPPPS QEREPPAEPS IYATLAIH
Length:598
Mass (Da):65,039
Last modified:November 2, 2010 - v4
Checksum:i33E9737AFCAFCE2D
GO
Isoform 2 (identifier: Q8N423-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     437-437: Missing.

Note: Alternative use of an acceptor site. No experimental confirmation available.
Show »
Length:597
Mass (Da):64,968
Checksum:iE6C0FDA134C5F3C3
GO
Isoform 3 (identifier: Q8N423-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     495-510: TQRKADFQHPAGAVGP → SPAQLPTPRKKTSMLP
     511-598: Missing.

Show »
Length:510
Mass (Da):55,458
Checksum:iCFD221E533DBC3F7
GO
Isoform 4 (identifier: Q8N423-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-116: Missing.

Note: Gene prediction based on cDNA data.
Show »
Length:482
Mass (Da):51,959
Checksum:iD8A3DCC118CB7A06
GO

Computationally mapped potential isoform sequencesi

There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2JNQ7A0A0G2JNQ7_HUMAN
Leukocyte immunoglobulin-like recep...
LILRB2
597Annotation score:
A0A0G2JNE7A0A0G2JNE7_HUMAN
Leukocyte immunoglobulin-like recep...
LILRB2
498Annotation score:
A0A0G2JNH0A0A0G2JNH0_HUMAN
Leukocyte immunoglobulin-like recep...
LILRB2
510Annotation score:
A0A0G2JNT8A0A0G2JNT8_HUMAN
Leukocyte immunoglobulin-like recep...
LILRB2
585Annotation score:
H7C0C3H7C0C3_HUMAN
Leukocyte immunoglobulin-like recep...
LILRB2
210Annotation score:
A0A0G2JPH5A0A0G2JPH5_HUMAN
Leukocyte immunoglobulin-like recep...
LILRB2
603Annotation score:
A0A0G2JN35A0A0G2JN35_HUMAN
Leukocyte immunoglobulin-like recep...
LILRB2
602Annotation score:
A0A0G2JLS7A0A0G2JLS7_HUMAN
Leukocyte immunoglobulin-like recep...
LILRB2
219Annotation score:
A0A0G2JM05A0A0G2JM05_HUMAN
Leukocyte immunoglobulin-like recep...
LILRB2
218Annotation score:
A0A0G2JMW1A0A0G2JMW1_HUMAN
Leukocyte immunoglobulin-like recep...
LILRB2
37Annotation score:
There is more potential isoformShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti583R → G in AAH36827 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01699720H → R. Corresponds to variant dbSNP:rs383369Ensembl.1
Natural variantiVAR_016998161E → D4 PublicationsCorresponds to variant dbSNP:rs373032Ensembl.1
Natural variantiVAR_047432235V → M. Corresponds to variant dbSNP:rs386056Ensembl.1
Natural variantiVAR_016999300H → Y4 PublicationsCorresponds to variant dbSNP:rs7247538Ensembl.1
Natural variantiVAR_017000306C → W4 PublicationsCorresponds to variant dbSNP:rs7247451Ensembl.1
Natural variantiVAR_061314322R → H4 PublicationsCorresponds to variant dbSNP:rs1128646Ensembl.1
Natural variantiVAR_047433324T → R. Corresponds to variant dbSNP:rs7247055Ensembl.1
Natural variantiVAR_047434326F → S. Corresponds to variant dbSNP:rs7246737Ensembl.1
Natural variantiVAR_047435349R → G. Corresponds to variant dbSNP:rs7247025Ensembl.1
Natural variantiVAR_061315403D → N. Corresponds to variant dbSNP:rs4993133Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0557181 – 116Missing in isoform 4. CuratedAdd BLAST116
Alternative sequenceiVSP_008458437Missing in isoform 2. 1 Publication1
Alternative sequenceiVSP_055719495 – 510TQRKA…GAVGP → SPAQLPTPRKKTSMLP in isoform 3. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_055720511 – 598Missing in isoform 3. 1 PublicationAdd BLAST88

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF025528 mRNA Translation: AAB87662.1
AF283986 mRNA Translation: AAL36990.1
AF283987 mRNA Translation: AAL36991.1
AC010518 Genomic DNA No translation available.
BC036827 mRNA Translation: AAH36827.1
CCDSiCCDS12886.1 [Q8N423-1]
CCDS42612.1 [Q8N423-2]
CCDS62791.1 [Q8N423-4]
CCDS62792.1 [Q8N423-3]
UniGeneiHs.655652

Genome annotation databases

EnsembliENST00000314446; ENSP00000319960; ENSG00000131042
ENST00000391746; ENSP00000375626; ENSG00000131042
ENST00000391748; ENSP00000375628; ENSG00000131042
ENST00000391749; ENSP00000375629; ENSG00000131042
ENST00000434421; ENSP00000410117; ENSG00000131042
ENST00000610886; ENSP00000482933; ENSG00000276146
ENST00000614225; ENSP00000480841; ENSG00000275463 [Q8N423-4]
ENST00000617341; ENSP00000484373; ENSG00000276146
ENST00000617886; ENSP00000483553; ENSG00000276146
ENST00000618392; ENSP00000480302; ENSG00000274513
ENST00000618705; ENSP00000481208; ENSG00000275463 [Q8N423-1]
ENST00000619122; ENSP00000483478; ENSG00000275463 [Q8N423-3]
ENST00000621020; ENSP00000483014; ENSG00000275463 [Q8N423-2]
UCSCiuc010eri.4 human [Q8N423-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF025528 mRNA Translation: AAB87662.1
AF283986 mRNA Translation: AAL36990.1
AF283987 mRNA Translation: AAL36991.1
AC010518 Genomic DNA No translation available.
BC036827 mRNA Translation: AAH36827.1
CCDSiCCDS12886.1 [Q8N423-1]
CCDS42612.1 [Q8N423-2]
CCDS62791.1 [Q8N423-4]
CCDS62792.1 [Q8N423-3]
UniGeneiHs.655652

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DYPX-ray2.50D24-219[»]
2GW5X-ray1.80A24-219[»]
4LLAX-ray2.50A/B/C222-419[»]
ProteinModelPortaliQ8N423
SMRiQ8N423
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-59888N
IntActiQ8N423, 23 interactors
STRINGi9606.ENSP00000375629

PTM databases

iPTMnetiQ8N423
PhosphoSitePlusiQ8N423

Polymorphism and mutation databases

BioMutaiLILRB2
DMDMi311033485

Proteomic databases

PaxDbiQ8N423
PeptideAtlasiQ8N423
PRIDEiQ8N423
ProteomicsDBi71866
71867 [Q8N423-2]

Protocols and materials databases

DNASUi10288
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000314446; ENSP00000319960; ENSG00000131042
ENST00000391746; ENSP00000375626; ENSG00000131042
ENST00000391748; ENSP00000375628; ENSG00000131042
ENST00000391749; ENSP00000375629; ENSG00000131042
ENST00000434421; ENSP00000410117; ENSG00000131042
ENST00000610886; ENSP00000482933; ENSG00000276146
ENST00000614225; ENSP00000480841; ENSG00000275463 [Q8N423-4]
ENST00000617341; ENSP00000484373; ENSG00000276146
ENST00000617886; ENSP00000483553; ENSG00000276146
ENST00000618392; ENSP00000480302; ENSG00000274513
ENST00000618705; ENSP00000481208; ENSG00000275463 [Q8N423-1]
ENST00000619122; ENSP00000483478; ENSG00000275463 [Q8N423-3]
ENST00000621020; ENSP00000483014; ENSG00000275463 [Q8N423-2]
UCSCiuc010eri.4 human [Q8N423-1]

Organism-specific databases

DisGeNETi10288
EuPathDBiHostDB:ENSG00000131042.13
GeneCardsiLILRB2
HGNCiHGNC:6606 LILRB2
MIMi604815 gene
neXtProtiNX_Q8N423
PharmGKBiPA30380
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKJD Eukaryota
ENOG41116BR LUCA
HOGENOMiHOG000234395
HOVERGENiHBG074353
InParanoidiQ8N423
OrthoDBiEOG091G0D6W
PhylomeDBiQ8N423
TreeFamiTF336644

Enzyme and pathway databases

ReactomeiR-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-6798695 Neutrophil degranulation
SIGNORiQ8N423

Miscellaneous databases

ChiTaRSiLILRB2 human
EvolutionaryTraceiQ8N423
PROiPR:Q8N423
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000131042 Expressed in 139 organ(s), highest expression level in blood
CleanExiHS_LILRB2
ExpressionAtlasiQ8N423 baseline and differential
GenevisibleiQ8N423 HS

Family and domain databases

Gene3Di2.60.40.10, 4 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
PfamiView protein in Pfam
PF13895 Ig_2, 1 hit
SMARTiView protein in SMART
SM00409 IG, 3 hits
SM00408 IGc2, 3 hits
SUPFAMiSSF48726 SSF48726, 4 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiLIRB2_HUMAN
AccessioniPrimary (citable) accession number: Q8N423
Secondary accession number(s): A8MU67
, C9JF29, O75017, Q8NHJ7, Q8NHJ8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: November 2, 2010
Last modified: November 7, 2018
This is version 158 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
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