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Protein

Leukocyte immunoglobulin-like receptor subfamily B member 2

Gene

LILRB2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C, HLA-G and HLA-F alleles (PubMed:11169396, PubMed:12853576, PubMed:16455647, PubMed:20448110, PubMed:27859042). Involved in the down-regulation of the immune response and the development of tolerance. Recognizes HLA-G in complex with B2M/beta-2 microglobulin and a nonamer self-peptide (peptide-bound HLA-G-B2M) triggering differentiation of type 1 regulatory T cells and myeloid-derived suppressor cells, both of which actively maintain maternal-fetal tolerance (PubMed:20448110, PubMed:27859042, PubMed:16455647). Competes with CD8A for binding to class I MHC antigens. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions (PubMed:11875462, PubMed:12853576, PubMed:9548455, PubMed:9842885).8 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • amyloid-beta binding Source: ARUK-UCL
  • cell adhesion molecule binding Source: BHF-UCL
  • inhibitory MHC class I receptor activity Source: BHF-UCL
  • MHC class Ib protein binding Source: BHF-UCL
  • MHC class I protein binding Source: UniProtKB
  • protein-containing complex binding Source: ARUK-UCL
  • protein homodimerization activity Source: ARUK-UCL
  • protein phosphatase 1 binding Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor
Biological processAdaptive immunity, Immunity

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-6798695 Neutrophil degranulation

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q8N423

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Leukocyte immunoglobulin-like receptor subfamily B member 2
Short name:
LIR-2
Short name:
Leukocyte immunoglobulin-like receptor 2
Alternative name(s):
CD85 antigen-like family member D
Immunoglobulin-like transcript 4
Short name:
ILT-4
Monocyte/macrophage immunoglobulin-like receptor 10
Short name:
MIR-10
CD_antigen: CD85d
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LILRB2Imported
Synonyms:ILT42 Publications, LIR2, MIR10
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000131042.13

Human Gene Nomenclature Database

More...
HGNCi
HGNC:6606 LILRB2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
604815 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8N423

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini22 – 461ExtracellularSequence analysisAdd BLAST440
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei462 – 482HelicalSequence analysisAdd BLAST21
Topological domaini483 – 598CytoplasmicSequence analysisAdd BLAST116

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
10288

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA30380

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
LILRB2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
311033485

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 21Sequence analysisAdd BLAST21
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001482122 – 598Leukocyte immunoglobulin-like receptor subfamily B member 2Add BLAST577

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi49 ↔ 98PROSITE-ProRule annotationCombined sources1 Publication
Disulfide bondi144 ↔ 196PROSITE-ProRule annotationCombined sources1 Publication
Disulfide bondi156 ↔ 166PROSITE-ProRule annotationCombined sources1 Publication
Disulfide bondi245 ↔ 296PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi280N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi301N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi340N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi345 ↔ 396PROSITE-ProRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated on tyrosine residues. Dephosphorylated by PTPN6.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8N423

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q8N423

PeptideAtlas

More...
PeptideAtlasi
Q8N423

PRoteomics IDEntifications database

More...
PRIDEi
Q8N423

ProteomicsDB human proteome resource

More...
ProteomicsDBi
71866
71867 [Q8N423-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8N423

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8N423

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in monocytes and at lower levels in myeloid and plasmacytoid dendritic cells. Expressed in tolerogenic IL10-producing dendritic cells (PubMed:20448110). Expressed in myeloid-derived suppressor cells during pregnancy (PubMed:27859042). Detected at low levels in natural killer (NK) cells. Expressed in B cells.4 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000131042 Expressed in 139 organ(s), highest expression level in blood

CleanEx database of gene expression profiles

More...
CleanExi
HS_LILRB2

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8N423 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8N423 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds PTPN6 when phosphorylated. Binds FCGR1A. Interacts with peptide-bound HLA-G-B2M; this interaction is direct (PubMed:16455647). Interacts with peptide-bound HLA-F-B2M; this interaction is direct (PubMed:11169396).2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

Database of interacting proteins

More...
DIPi
DIP-59888N

Protein interaction database and analysis system

More...
IntActi
Q8N423, 23 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000375629

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1598
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DYPX-ray2.50D24-219[»]
2GW5X-ray1.80A24-219[»]
4LLAX-ray2.50A/B/C222-419[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q8N423

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8N423

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q8N423

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini27 – 110Ig-like C2-type 1Add BLAST84
Domaini111 – 229Ig-like C2-type 2Add BLAST119
Domaini230 – 318Ig-like C2-type 3Add BLAST89
Domaini330 – 419Ig-like C2-type 4Add BLAST90

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi531 – 536ITIM motif 16
Motifi560 – 565ITIM motif 26
Motifi590 – 595ITIM motif 36

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IKJD Eukaryota
ENOG41116BR LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000234395

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG074353

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8N423

Database of Orthologous Groups

More...
OrthoDBi
1000446at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8N423

TreeFam database of animal gene trees

More...
TreeFami
TF336644

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13895 Ig_2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00409 IG, 3 hits
SM00408 IGc2, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726 SSF48726, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50835 IG_LIKE, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 11 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8N423-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTPIVTVLIC LGLSLGPRTH VQTGTIPKPT LWAEPDSVIT QGSPVTLSCQ
60 70 80 90 100
GSLEAQEYRL YREKKSASWI TRIRPELVKN GQFHIPSITW EHTGRYGCQY
110 120 130 140 150
YSRARWSELS DPLVLVMTGA YPKPTLSAQP SPVVTSGGRV TLQCESQVAF
160 170 180 190 200
GGFILCKEGE EEHPQCLNSQ PHARGSSRAI FSVGPVSPNR RWSHRCYGYD
210 220 230 240 250
LNSPYVWSSP SDLLELLVPG VSKKPSLSVQ PGPVVAPGES LTLQCVSDVG
260 270 280 290 300
YDRFVLYKEG ERDLRQLPGR QPQAGLSQAN FTLGPVSRSY GGQYRCYGAH
310 320 330 340 350
NLSSECSAPS DPLDILITGQ IRGTPFISVQ PGPTVASGEN VTLLCQSWRQ
360 370 380 390 400
FHTFLLTKAG AADAPLRLRS IHEYPKYQAE FPMSPVTSAH AGTYRCYGSL
410 420 430 440 450
NSDPYLLSHP SEPLELVVSG PSMGSSPPPT GPISTPAGPE DQPLTPTGSD
460 470 480 490 500
PQSGLGRHLG VVIGILVAVV LLLLLLLLLF LILRHRRQGK HWTSTQRKAD
510 520 530 540 550
FQHPAGAVGP EPTDRGLQWR SSPAADAQEE NLYAAVKDTQ PEDGVEMDTR
560 570 580 590
AAASEAPQDV TYAQLHSLTL RRKATEPPPS QEREPPAEPS IYATLAIH
Length:598
Mass (Da):65,039
Last modified:November 2, 2010 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i33E9737AFCAFCE2D
GO
Isoform 2 (identifier: Q8N423-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     437-437: Missing.

Note: Alternative use of an acceptor site. No experimental confirmation available.
Show »
Length:597
Mass (Da):64,968
Checksum:iE6C0FDA134C5F3C3
GO
Isoform 3 (identifier: Q8N423-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     495-510: TQRKADFQHPAGAVGP → SPAQLPTPRKKTSMLP
     511-598: Missing.

Show »
Length:510
Mass (Da):55,458
Checksum:iCFD221E533DBC3F7
GO
Isoform 4 (identifier: Q8N423-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-116: Missing.

Note: Gene prediction based on cDNA data.
Show »
Length:482
Mass (Da):51,959
Checksum:iD8A3DCC118CB7A06
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2JNH0A0A0G2JNH0_HUMAN
Leukocyte immunoglobulin-like recep...
LILRB2
510Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JNE7A0A0G2JNE7_HUMAN
Leukocyte immunoglobulin-like recep...
LILRB2
498Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JNT8A0A0G2JNT8_HUMAN
Leukocyte immunoglobulin-like recep...
LILRB2
585Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JNQ7A0A0G2JNQ7_HUMAN
Leukocyte immunoglobulin-like recep...
LILRB2
597Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C0C3H7C0C3_HUMAN
Leukocyte immunoglobulin-like recep...
LILRB2
210Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JN35A0A0G2JN35_HUMAN
Leukocyte immunoglobulin-like recep...
LILRB2
602Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JPH5A0A0G2JPH5_HUMAN
Leukocyte immunoglobulin-like recep...
LILRB2
603Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JLS7A0A0G2JLS7_HUMAN
Leukocyte immunoglobulin-like recep...
LILRB2
219Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JM05A0A0G2JM05_HUMAN
Leukocyte immunoglobulin-like recep...
LILRB2
218Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JMW1A0A0G2JMW1_HUMAN
Leukocyte immunoglobulin-like recep...
LILRB2
37Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There is more potential isoformShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti583R → G in AAH36827 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01699720H → R. Corresponds to variant dbSNP:rs383369Ensembl.1
Natural variantiVAR_016998161E → D4 PublicationsCorresponds to variant dbSNP:rs373032Ensembl.1
Natural variantiVAR_047432235V → M. Corresponds to variant dbSNP:rs386056Ensembl.1
Natural variantiVAR_016999300H → Y4 PublicationsCorresponds to variant dbSNP:rs7247538Ensembl.1
Natural variantiVAR_017000306C → W4 PublicationsCorresponds to variant dbSNP:rs7247451Ensembl.1
Natural variantiVAR_061314322R → H4 PublicationsCorresponds to variant dbSNP:rs1128646Ensembl.1
Natural variantiVAR_047433324T → R. Corresponds to variant dbSNP:rs7247055Ensembl.1
Natural variantiVAR_047434326F → S. Corresponds to variant dbSNP:rs7246737Ensembl.1
Natural variantiVAR_047435349R → G. Corresponds to variant dbSNP:rs7247025Ensembl.1
Natural variantiVAR_061315403D → N. Corresponds to variant dbSNP:rs4993133Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0557181 – 116Missing in isoform 4. CuratedAdd BLAST116
Alternative sequenceiVSP_008458437Missing in isoform 2. 1 Publication1
Alternative sequenceiVSP_055719495 – 510TQRKA…GAVGP → SPAQLPTPRKKTSMLP in isoform 3. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_055720511 – 598Missing in isoform 3. 1 PublicationAdd BLAST88

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF025528 mRNA Translation: AAB87662.1
AF283986 mRNA Translation: AAL36990.1
AF283987 mRNA Translation: AAL36991.1
AC010518 Genomic DNA No translation available.
BC036827 mRNA Translation: AAH36827.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS12886.1 [Q8N423-1]
CCDS42612.1 [Q8N423-2]
CCDS62791.1 [Q8N423-4]
CCDS62792.1 [Q8N423-3]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.655652

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000314446; ENSP00000319960; ENSG00000131042
ENST00000391746; ENSP00000375626; ENSG00000131042
ENST00000391748; ENSP00000375628; ENSG00000131042
ENST00000391749; ENSP00000375629; ENSG00000131042
ENST00000434421; ENSP00000410117; ENSG00000131042
ENST00000610886; ENSP00000482933; ENSG00000276146
ENST00000614225; ENSP00000480841; ENSG00000275463 [Q8N423-4]
ENST00000617341; ENSP00000484373; ENSG00000276146
ENST00000617886; ENSP00000483553; ENSG00000276146
ENST00000618392; ENSP00000480302; ENSG00000274513
ENST00000618705; ENSP00000481208; ENSG00000275463 [Q8N423-1]
ENST00000619122; ENSP00000483478; ENSG00000275463 [Q8N423-3]
ENST00000621020; ENSP00000483014; ENSG00000275463 [Q8N423-2]

UCSC genome browser

More...
UCSCi
uc010eri.4 human [Q8N423-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF025528 mRNA Translation: AAB87662.1
AF283986 mRNA Translation: AAL36990.1
AF283987 mRNA Translation: AAL36991.1
AC010518 Genomic DNA No translation available.
BC036827 mRNA Translation: AAH36827.1
CCDSiCCDS12886.1 [Q8N423-1]
CCDS42612.1 [Q8N423-2]
CCDS62791.1 [Q8N423-4]
CCDS62792.1 [Q8N423-3]
UniGeneiHs.655652

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DYPX-ray2.50D24-219[»]
2GW5X-ray1.80A24-219[»]
4LLAX-ray2.50A/B/C222-419[»]
ProteinModelPortaliQ8N423
SMRiQ8N423
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-59888N
IntActiQ8N423, 23 interactors
STRINGi9606.ENSP00000375629

PTM databases

iPTMnetiQ8N423
PhosphoSitePlusiQ8N423

Polymorphism and mutation databases

BioMutaiLILRB2
DMDMi311033485

Proteomic databases

jPOSTiQ8N423
PaxDbiQ8N423
PeptideAtlasiQ8N423
PRIDEiQ8N423
ProteomicsDBi71866
71867 [Q8N423-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
10288
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000314446; ENSP00000319960; ENSG00000131042
ENST00000391746; ENSP00000375626; ENSG00000131042
ENST00000391748; ENSP00000375628; ENSG00000131042
ENST00000391749; ENSP00000375629; ENSG00000131042
ENST00000434421; ENSP00000410117; ENSG00000131042
ENST00000610886; ENSP00000482933; ENSG00000276146
ENST00000614225; ENSP00000480841; ENSG00000275463 [Q8N423-4]
ENST00000617341; ENSP00000484373; ENSG00000276146
ENST00000617886; ENSP00000483553; ENSG00000276146
ENST00000618392; ENSP00000480302; ENSG00000274513
ENST00000618705; ENSP00000481208; ENSG00000275463 [Q8N423-1]
ENST00000619122; ENSP00000483478; ENSG00000275463 [Q8N423-3]
ENST00000621020; ENSP00000483014; ENSG00000275463 [Q8N423-2]
UCSCiuc010eri.4 human [Q8N423-1]

Organism-specific databases

DisGeNETi10288
EuPathDBiHostDB:ENSG00000131042.13

GeneCards: human genes, protein and diseases

More...
GeneCardsi
LILRB2
HGNCiHGNC:6606 LILRB2
MIMi604815 gene
neXtProtiNX_Q8N423
PharmGKBiPA30380

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IKJD Eukaryota
ENOG41116BR LUCA
HOGENOMiHOG000234395
HOVERGENiHBG074353
InParanoidiQ8N423
OrthoDBi1000446at2759
PhylomeDBiQ8N423
TreeFamiTF336644

Enzyme and pathway databases

ReactomeiR-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-6798695 Neutrophil degranulation
SIGNORiQ8N423

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
LILRB2 human
EvolutionaryTraceiQ8N423

Protein Ontology

More...
PROi
PR:Q8N423

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000131042 Expressed in 139 organ(s), highest expression level in blood
CleanExiHS_LILRB2
ExpressionAtlasiQ8N423 baseline and differential
GenevisibleiQ8N423 HS

Family and domain databases

Gene3Di2.60.40.10, 4 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
PfamiView protein in Pfam
PF13895 Ig_2, 1 hit
SMARTiView protein in SMART
SM00409 IG, 3 hits
SM00408 IGc2, 3 hits
SUPFAMiSSF48726 SSF48726, 4 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLIRB2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8N423
Secondary accession number(s): A8MU67
, C9JF29, O75017, Q8NHJ7, Q8NHJ8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: November 2, 2010
Last modified: January 16, 2019
This is version 160 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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