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Entry version 104 (16 Oct 2019)
Sequence version 4 (25 Oct 2017)
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Protein

PiggyBac transposable element-derived protein 5

Gene

PGBD5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transposase that mediates sequence-specific genomic rearrangements (PubMed:26406119, PubMed:28504702). Can induce genomic rearrangements that inactivate the HPRT1 gene (PubMed:27491780).3 Publications

Miscellaneous

Has been domesticated very early in vertebrate evolution, approximately 500 million years ago, in the common ancestor of cephalochordates and vertebrates.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionEndonuclease, Hydrolase, Nuclease
Biological processTransposition

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
PiggyBac transposable element-derived protein 5 (EC:3.1.-.-)
Alternative name(s):
PiggyBac domain-related protein 51 Publication
PiggyBac transposase 51 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PGBD5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:19405 PGBD5

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
616791 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8N414

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Induces site-specific DNA rearrangements, including intrachromosomal deletions, as well as inversions, duplications and translocations, in rhabdoid tumors that share developmental origin with cells that normally express PGBD5, even though these tumors may not exhibit apparent widespread genomic instability. This activity recurrently targets regulatory elements and tumor suppressor genes and promotes cell transformation.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi237D → A: Loss of DNA transposase activity and of cell transforming activity. 2 Publications1
Mutagenesisi244D → A: No effect on DNA transposase activity. 1 Publication1
Mutagenesisi257E → A: Decreased DNA transposase activity. 1 Publication1
Mutagenesisi261D → A: Decreased DNA transposase activity. 1 Publication1
Mutagenesisi263D → A: Loss of DNA transposase activity and of cell transforming activity. 2 Publications1
Mutagenesisi272E → A: No effect on DNA transposase activity. 1 Publication1
Mutagenesisi274E → A: No effect on DNA transposase activity. 1 Publication1
Mutagenesisi305E → A: Decreased DNA transposase activity. 1 Publication1
Mutagenesisi310D → A: No effect on DNA transposase activity. 1 Publication1
Mutagenesisi313D → A: No effect on DNA transposase activity. 1 Publication1
Mutagenesisi353E → A: Decreased DNA transposase activity. 1 Publication1
Mutagenesisi354E → A: No effect on DNA transposase activity. 1 Publication1
Mutagenesisi356E → A: No effect on DNA transposase activity. 1 Publication1
Mutagenesisi372D → A: No effect on DNA transposase activity. 1 Publication1
Mutagenesisi434E → A: No effect on DNA transposase activity, nor on cell transforming activity. 2 Publications1
Mutagenesisi442E → A: No effect on DNA transposase activity, nor on cell transforming activity. 2 Publications1
Mutagenesisi455D → A: Loss of DNA transposase activity. No effect on cell transforming activity. 2 Publications1
Mutagenesisi456D → A: No effect on DNA transposase activity. 1 Publication1
Mutagenesisi494D → A: No effect on DNA transposase activity. 1 Publication1
Mutagenesisi508E → A: No effect on DNA transposase activity. 1 Publication1
Mutagenesisi513E → A: No effect on DNA transposase activity. 1 Publication1
Mutagenesisi518E → A: No effect on DNA transposase activity. 1 Publication1
Mutagenesisi519D → A: No effect on DNA transposase activity. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
79605

Open Targets

More...
OpenTargetsi
ENSG00000177614

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134905621

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8N414

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PGBD5

Domain mapping of disease mutations (DMDM)

More...
DMDMi
300669682

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002880561 – 524PiggyBac transposable element-derived protein 5Add BLAST524

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei521PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8N414

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8N414

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8N414

PeptideAtlas

More...
PeptideAtlasi
Q8N414

PRoteomics IDEntifications database

More...
PRIDEi
Q8N414

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
71865

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8N414

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8N414

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000177614 Expressed in 168 organ(s), highest expression level in entorhinal cortex

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA065010

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
122741, 2 interactors

Protein interaction database and analysis system

More...
IntActi
Q8N414, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000431404

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IJ9Y Eukaryota
ENOG410XP35 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00510000047893

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000115519

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8N414

Identification of Orthologs from Complete Genome Data

More...
OMAi
HIVAFRS

Database of Orthologous Groups

More...
OrthoDBi
1139412at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8N414

TreeFam database of animal gene trees

More...
TreeFami
TF332005

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029526 PGBD
IPR042423 PGBD5

The PANTHER Classification System

More...
PANTHERi
PTHR28576 PTHR28576, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13843 DDE_Tnp_1_7, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8N414-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAEGGGGARR RAPALLEAAR ARYESLHISD DVFGESGPDS GGNPFYSTSA
60 70 80 90 100
ASRSSSAASS DDEREPPGPP GAAPPPPRAP DAQEPEEDEA GAGWSAALRD
110 120 130 140 150
RPPPRFEDTG GPTRKMPPSA SAVDFFQLFV PDNVLKNMVV QTNMYAKKFQ
160 170 180 190 200
ERFGSDGAWV EVTLTEMKAF LGYMISTSIS HCESVLSIWS GGFYSNRSLA
210 220 230 240 250
LVMSQARFEK ILKYFHVVAF RSSQTTHGLY KVQPFLDSLQ NSFDSAFRPS
260 270 280 290 300
QTQVLHEPLI DEDPVFIATC TERELRKRKK RKFSLWVRQC SSTGFIIQIY
310 320 330 340 350
VHLKEGGGPD GLDALKNKPQ LHSMVARSLC RNAAGKNYII FTGPSITSLT
360 370 380 390 400
LFEEFEKQGI YCCGLLRARK SDCTGLPLSM LTNPATPPAR GQYQIKMKGN
410 420 430 440 450
MSLICWYNKG HFRFLTNAYS PVQQGVIIKR KSGEIPCPLA VEAFAAHLSY
460 470 480 490 500
ICRYDDKYSK YFISHKPNKT WQQVFWFAIS IAINNAYILY KMSDAYHVKR
510 520
YSRAQFGERL VRELLGLEDA SPTH
Length:524
Mass (Da):58,464
Last modified:October 25, 2017 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i049D3B3D983B295B
GO
Isoform 2 (identifier: Q8N414-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-110: MAEGGGGARR...RPPPRFEDTG → MPDYRTRALF...RDLQPSDSFT

Note: No experimental confirmation available.1 Publication
Show »
Length:455
Mass (Da):51,642
Checksum:iDF3393BFADC6F5F0
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAG59784 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAH14339 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti314A → V in AAI50639 (PubMed:15489334).Curated1
Sequence conflicti411H → Y in BAG59784 (PubMed:14702039).Curated1
Sequence conflicti469K → Q in BAH14339 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0591311 – 110MAEGG…FEDTG → MPDYRTRALFVQSTLGDSAG PELQLLSIVPGRDLQPSDSF T in isoform 2. 1 PublicationAdd BLAST110

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL691479 Genomic DNA No translation available.
AL133516 Genomic DNA No translation available.
BC013901 mRNA Translation: AAH13901.1
BC027466 mRNA Translation: AAH27466.1
BC036865 mRNA Translation: AAH36865.1
BC150638 mRNA Translation: AAI50639.1
KF670820 mRNA Translation: AGX00581.1
AK297321 mRNA Translation: BAG59784.1 Different initiation.
AK315968 mRNA Translation: BAH14339.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS81430.1 [Q8N414-1]

NCBI Reference Sequences

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RefSeqi
NP_001245240.1, NM_001258311.1 [Q8N414-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000391860; ENSP00000375733; ENSG00000177614 [Q8N414-1]
ENST00000525115; ENSP00000431404; ENSG00000177614 [Q8N414-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
79605

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:79605

UCSC genome browser

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UCSCi
uc057qgx.1 human [Q8N414-1]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL691479 Genomic DNA No translation available.
AL133516 Genomic DNA No translation available.
BC013901 mRNA Translation: AAH13901.1
BC027466 mRNA Translation: AAH27466.1
BC036865 mRNA Translation: AAH36865.1
BC150638 mRNA Translation: AAI50639.1
KF670820 mRNA Translation: AGX00581.1
AK297321 mRNA Translation: BAG59784.1 Different initiation.
AK315968 mRNA Translation: BAH14339.1 Different initiation.
CCDSiCCDS81430.1 [Q8N414-1]
RefSeqiNP_001245240.1, NM_001258311.1 [Q8N414-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi122741, 2 interactors
IntActiQ8N414, 1 interactor
STRINGi9606.ENSP00000431404

PTM databases

iPTMnetiQ8N414
PhosphoSitePlusiQ8N414

Polymorphism and mutation databases

BioMutaiPGBD5
DMDMi300669682

Proteomic databases

EPDiQ8N414
MassIVEiQ8N414
PaxDbiQ8N414
PeptideAtlasiQ8N414
PRIDEiQ8N414
ProteomicsDBi71865

Genome annotation databases

EnsembliENST00000391860; ENSP00000375733; ENSG00000177614 [Q8N414-1]
ENST00000525115; ENSP00000431404; ENSG00000177614 [Q8N414-2]
GeneIDi79605
KEGGihsa:79605
UCSCiuc057qgx.1 human [Q8N414-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
79605
DisGeNETi79605

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PGBD5
HGNCiHGNC:19405 PGBD5
HPAiHPA065010
MIMi616791 gene
neXtProtiNX_Q8N414
OpenTargetsiENSG00000177614
PharmGKBiPA134905621

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IJ9Y Eukaryota
ENOG410XP35 LUCA
GeneTreeiENSGT00510000047893
HOGENOMiHOG000115519
InParanoidiQ8N414
OMAiHIVAFRS
OrthoDBi1139412at2759
PhylomeDBiQ8N414
TreeFamiTF332005

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
PGBD5 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
79605
PharosiQ8N414

Protein Ontology

More...
PROi
PR:Q8N414

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000177614 Expressed in 168 organ(s), highest expression level in entorhinal cortex

Family and domain databases

InterProiView protein in InterPro
IPR029526 PGBD
IPR042423 PGBD5
PANTHERiPTHR28576 PTHR28576, 1 hit
PfamiView protein in Pfam
PF13843 DDE_Tnp_1_7, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPGBD5_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8N414
Secondary accession number(s): A0A0A0MS21
, A0PJF3, B4DM72, B7Z9K3, B9EK58, Q5SR37, Q6PJN2, U3REJ1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: October 25, 2017
Last modified: October 16, 2019
This is version 104 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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