Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Solute carrier family 25 member 45

Gene

SLC25A45

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport

Protein family/group databases

TCDBi2.A.29.8.7 the mitochondrial carrier (mc) family

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 25 member 45
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000162241.12
HGNCiHGNC:27442 SLC25A45
MIMi610825 gene
neXtProtiNX_Q8N413

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei6 – 26Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei63 – 83Helical; Name=2Sequence analysisAdd BLAST21
Transmembranei100 – 120Helical; Name=3Sequence analysisAdd BLAST21
Transmembranei166 – 186Helical; Name=4Sequence analysisAdd BLAST21
Transmembranei202 – 222Helical; Name=5Sequence analysisAdd BLAST21
Transmembranei266 – 286Helical; Name=6Sequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi283130
OpenTargetsiENSG00000162241
PharmGKBiPA162403718

Polymorphism and mutation databases

BioMutaiSLC25A45
DMDMi150416125

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002918261 – 288Solute carrier family 25 member 45Add BLAST288

Proteomic databases

PaxDbiQ8N413
PeptideAtlasiQ8N413
PRIDEiQ8N413
ProteomicsDBi71861
71862 [Q8N413-2]
71863 [Q8N413-3]
71864 [Q8N413-4]

Expressioni

Gene expression databases

BgeeiENSG00000162241
CleanExiHS_SLC25A45
ExpressionAtlasiQ8N413 baseline and differential
GenevisibleiQ8N413 HS

Organism-specific databases

HPAiHPA050821

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000381782

Structurei

3D structure databases

ProteinModelPortaliQ8N413
SMRiQ8N413
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati1 – 83Solcar 1Add BLAST83
Repeati97 – 191Solcar 2Add BLAST95
Repeati199 – 286Solcar 3Add BLAST88

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0758 Eukaryota
ENOG410XS86 LUCA
GeneTreeiENSGT00700000104295
HOGENOMiHOG000168307
HOVERGENiHBG003500
InParanoidiQ8N413
KOiK15123
OMAiDENHKFR
OrthoDBiEOG091G0HVE
PhylomeDBiQ8N413
TreeFamiTF351739

Family and domain databases

Gene3Di1.50.40.10, 1 hit
InterProiView protein in InterPro
IPR002067 Mit_carrier
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
PRINTSiPR00926 MITOCARRIER
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N413-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPVEEFVAGW ISGALGLVLG HPFDTVKVRL QTQTTYRGIV DCMVKIYRHE
60 70 80 90 100
SLLGFFKGMS FPIASIAVVN SVLFGVYSNT LLVLTATSHQ ERRAQPPSYM
110 120 130 140 150
HIFLAGCTGG FLQAYCLAPF DLIKVRLQNQ TEPRAQPGSP PPRYQGPVHC
160 170 180 190 200
AASIFREEGP RGLFRGAWAL TLRDTPTVGI YFITYEGLCR QYTPEGQNPS
210 220 230 240 250
SATVLVAGGF AGIASWVAAT PLDMIKSRMQ MDGLRRRVYQ GMLDCMVSSI
260 270 280
RQEGLGVFFR GVTINSARAF PVNAVTFLSY EYLLRWWG
Length:288
Mass (Da):31,906
Last modified:June 26, 2007 - v2
Checksum:iBD8EF1D8A2BFB296
GO
Isoform 2 (identifier: Q8N413-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-42: Missing.

Note: No experimental confirmation available.
Show »
Length:246
Mass (Da):27,319
Checksum:i3DD46F818E36CA50
GO
Isoform 3 (identifier: Q8N413-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-42: Missing.
     52-113: Missing.

Note: No experimental confirmation available.
Show »
Length:184
Mass (Da):20,631
Checksum:i603EA67772E2A639
GO
Isoform 4 (identifier: Q8N413-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     28-51: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:264
Mass (Da):29,027
Checksum:i05876BDB4AA7A1C7
GO

Sequence cautioni

Isoform 4 : The sequence BC041100 differs from that shown. Reason: Frameshift at position 208.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti153S → P in AAT09000 (Ref. 1) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_032866224M → V2 PublicationsCorresponds to variant dbSNP:rs624307Ensembl.1
Natural variantiVAR_050135251R → Q. Corresponds to variant dbSNP:rs7108281Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0262461 – 42Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST42
Alternative sequenceiVSP_02624728 – 51Missing in isoform 4. 1 PublicationAdd BLAST24
Alternative sequenceiVSP_02624852 – 113Missing in isoform 3. 1 PublicationAdd BLAST62

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY597807 mRNA Translation: AAT09000.1
AP000944 Genomic DNA No translation available.
BC036869 mRNA Translation: AAH36869.1
BC041100 mRNA No translation available.
CCDSiCCDS41670.1 [Q8N413-1]
CCDS41671.1 [Q8N413-2]
CCDS60850.1 [Q8N413-4]
RefSeqiNP_001070709.2, NM_001077241.2
NP_001265179.2, NM_001278250.2
NP_001265180.2, NM_001278251.2
NP_001287749.1, NM_001300820.1
NP_872362.3, NM_182556.3
XP_006718572.1, XM_006718509.3 [Q8N413-2]
XP_006718573.1, XM_006718510.3 [Q8N413-2]
XP_011543245.1, XM_011544943.2 [Q8N413-2]
XP_011543246.1, XM_011544944.2 [Q8N413-2]
XP_011543251.1, XM_011544949.2 [Q8N413-2]
XP_016873052.1, XM_017017563.1 [Q8N413-2]
XP_016873053.1, XM_017017564.1 [Q8N413-2]
XP_016873054.1, XM_017017565.1 [Q8N413-2]
XP_016873055.1, XM_017017566.1
XP_016873056.1, XM_017017567.1 [Q8N413-2]
XP_016873057.1, XM_017017568.1 [Q8N413-2]
XP_016873058.1, XM_017017569.1 [Q8N413-2]
XP_016873059.1, XM_017017570.1
XP_016873060.1, XM_017017571.1
UniGeneiHs.661604

Genome annotation databases

EnsembliENST00000294187; ENSP00000294187; ENSG00000162241 [Q8N413-2]
ENST00000398802; ENSP00000381782; ENSG00000162241 [Q8N413-1]
ENST00000527174; ENSP00000435489; ENSG00000162241 [Q8N413-1]
ENST00000534028; ENSP00000431769; ENSG00000162241 [Q8N413-4]
GeneIDi283130
KEGGihsa:283130
UCSCiuc001odq.3 human [Q8N413-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiS2545_HUMAN
AccessioniPrimary (citable) accession number: Q8N413
Secondary accession number(s): Q6PL49, Q8IW29
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: June 26, 2007
Last modified: June 20, 2018
This is version 118 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health