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UniProtKB - Q8N413 (S2545_HUMAN)
Protein
Solute carrier family 25 member 45
Gene
SLC25A45
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- acyl carnitine transmembrane transporter activity Source: GO_Central
GO - Biological processi
- acyl carnitine transport Source: GO_Central
- amino acid transport Source: GO_Central
Keywordsi
Biological process | Transport |
Enzyme and pathway databases
PathwayCommonsi | Q8N413 |
Protein family/group databases
TCDBi | 2.A.29.8.7, the mitochondrial carrier (mc) family |
Names & Taxonomyi
Protein namesi | Recommended name: Solute carrier family 25 member 45 |
Gene namesi | Name:SLC25A45 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:27442, SLC25A45 |
MIMi | 610825, gene |
neXtProti | NX_Q8N413 |
VEuPathDBi | HostDB:ENSG00000162241 |
Subcellular locationi
Mitochondrion
- Mitochondrion inner membrane By similarity; Multi-pass membrane protein By similarity
Mitochondrion
- mitochondrial inner membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 6 – 26 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Transmembranei | 63 – 83 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Transmembranei | 100 – 120 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Transmembranei | 166 – 186 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Transmembranei | 202 – 222 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Transmembranei | 266 – 286 | Helical; Name=6Sequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Membrane, Mitochondrion, Mitochondrion inner membranePathology & Biotechi
Organism-specific databases
DisGeNETi | 283130 |
OpenTargetsi | ENSG00000162241 |
PharmGKBi | PA162403718 |
Miscellaneous databases
Pharosi | Q8N413, Tdark |
Genetic variation databases
BioMutai | SLC25A45 |
DMDMi | 150416125 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000291826 | 1 – 288 | Solute carrier family 25 member 45Add BLAST | 288 |
Proteomic databases
MassIVEi | Q8N413 |
PaxDbi | Q8N413 |
PeptideAtlasi | Q8N413 |
PRIDEi | Q8N413 |
ProteomicsDBi | 71861 [Q8N413-1] 71862 [Q8N413-2] |
Expressioni
Gene expression databases
Bgeei | ENSG00000162241, Expressed in pancreas and 176 other tissues |
ExpressionAtlasi | Q8N413, baseline and differential |
Genevisiblei | Q8N413, HS |
Organism-specific databases
HPAi | ENSG00000162241, Tissue enhanced (pancreas) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 129470, 1 interactor |
STRINGi | 9606.ENSP00000381782 |
Miscellaneous databases
RNActi | Q8N413, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 1 – 83 | Solcar 1Add BLAST | 83 | |
Repeati | 97 – 191 | Solcar 2Add BLAST | 95 | |
Repeati | 199 – 286 | Solcar 3Add BLAST | 88 |
Sequence similaritiesi
Keywords - Domaini
Repeat, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0758, Eukaryota |
GeneTreei | ENSGT00940000161002 |
InParanoidi | Q8N413 |
OMAi | MQTAPKG |
OrthoDBi | 1072378at2759 |
PhylomeDBi | Q8N413 |
TreeFami | TF351739 |
Family and domain databases
Gene3Di | 1.50.40.10, 1 hit |
InterProi | View protein in InterPro IPR002067, Mit_carrier IPR018108, Mitochondrial_sb/sol_carrier IPR023395, Mt_carrier_dom_sf |
Pfami | View protein in Pfam PF00153, Mito_carr, 3 hits |
PRINTSi | PR00926, MITOCARRIER |
SUPFAMi | SSF103506, SSF103506, 1 hit |
PROSITEi | View protein in PROSITE PS50920, SOLCAR, 3 hits |
s (4+)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q8N413-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MPVEEFVAGW ISGALGLVLG HPFDTVKVRL QTQTTYRGIV DCMVKIYRHE
60 70 80 90 100
SLLGFFKGMS FPIASIAVVN SVLFGVYSNT LLVLTATSHQ ERRAQPPSYM
110 120 130 140 150
HIFLAGCTGG FLQAYCLAPF DLIKVRLQNQ TEPRAQPGSP PPRYQGPVHC
160 170 180 190 200
AASIFREEGP RGLFRGAWAL TLRDTPTVGI YFITYEGLCR QYTPEGQNPS
210 220 230 240 250
SATVLVAGGF AGIASWVAAT PLDMIKSRMQ MDGLRRRVYQ GMLDCMVSSI
260 270 280
RQEGLGVFFR GVTINSARAF PVNAVTFLSY EYLLRWWG
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE9PK53 | E9PK53_HUMAN | Solute carrier family 25 member 45 | SLC25A45 | 118 | Annotation score: | ||
E9PJQ3 | E9PJQ3_HUMAN | Solute carrier family 25 member 45 | SLC25A45 | 226 | Annotation score: | ||
E9PMF0 | E9PMF0_HUMAN | Solute carrier family 25 member 45 | SLC25A45 | 50 | Annotation score: | ||
E9PJ15 | E9PJ15_HUMAN | Solute carrier family 25 member 45 | SLC25A45 | 36 | Annotation score: | ||
E9PJW2 | E9PJW2_HUMAN | Solute carrier family 25 member 45 | SLC25A45 | 47 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 153 | S → P in AAT09000 (Ref. 1) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_032866 | 224 | M → V2 PublicationsCorresponds to variant dbSNP:rs624307Ensembl. | 1 | |
Natural variantiVAR_050135 | 251 | R → Q. Corresponds to variant dbSNP:rs7108281Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_026246 | 1 – 42 | Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST | 42 | |
Alternative sequenceiVSP_026247 | 28 – 51 | Missing in isoform 4. 1 PublicationAdd BLAST | 24 | |
Alternative sequenceiVSP_026248 | 52 – 113 | Missing in isoform 3. 1 PublicationAdd BLAST | 62 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY597807 mRNA Translation: AAT09000.1 AP000944 Genomic DNA No translation available. BC036869 mRNA Translation: AAH36869.1 BC041100 mRNA No translation available. |
CCDSi | CCDS41670.1 [Q8N413-1] CCDS41671.1 [Q8N413-2] CCDS60850.1 [Q8N413-4] |
RefSeqi | NP_001070709.2, NM_001077241.2 [Q8N413-2] NP_001265179.2, NM_001278250.2 [Q8N413-4] NP_001265180.2, NM_001278251.2 [Q8N413-2] NP_001287749.1, NM_001300820.1 NP_872362.3, NM_182556.3 [Q8N413-1] XP_006718572.1, XM_006718509.3 XP_006718573.1, XM_006718510.3 XP_011543245.1, XM_011544943.2 XP_011543246.1, XM_011544944.2 XP_011543251.1, XM_011544949.2 XP_016873052.1, XM_017017563.1 XP_016873053.1, XM_017017564.1 XP_016873054.1, XM_017017565.1 XP_016873055.1, XM_017017566.1 XP_016873056.1, XM_017017567.1 XP_016873057.1, XM_017017568.1 XP_016873058.1, XM_017017569.1 XP_016873059.1, XM_017017570.1 XP_016873060.1, XM_017017571.1 |
Genome annotation databases
Ensembli | ENST00000294187.10; ENSP00000294187.6; ENSG00000162241.13 [Q8N413-2] ENST00000398802.6; ENSP00000381782.1; ENSG00000162241.13 ENST00000527174.5; ENSP00000435489.1; ENSG00000162241.13 ENST00000534028.5; ENSP00000431769.1; ENSG00000162241.13 [Q8N413-4] |
GeneIDi | 283130 |
KEGGi | hsa:283130 |
MANE-Selecti | ENST00000398802.6; ENSP00000381782.1; NM_182556.4; NP_872362.4 |
UCSCi | uc001odq.3, human [Q8N413-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY597807 mRNA Translation: AAT09000.1 AP000944 Genomic DNA No translation available. BC036869 mRNA Translation: AAH36869.1 BC041100 mRNA No translation available. |
CCDSi | CCDS41670.1 [Q8N413-1] CCDS41671.1 [Q8N413-2] CCDS60850.1 [Q8N413-4] |
RefSeqi | NP_001070709.2, NM_001077241.2 [Q8N413-2] NP_001265179.2, NM_001278250.2 [Q8N413-4] NP_001265180.2, NM_001278251.2 [Q8N413-2] NP_001287749.1, NM_001300820.1 NP_872362.3, NM_182556.3 [Q8N413-1] XP_006718572.1, XM_006718509.3 XP_006718573.1, XM_006718510.3 XP_011543245.1, XM_011544943.2 XP_011543246.1, XM_011544944.2 XP_011543251.1, XM_011544949.2 XP_016873052.1, XM_017017563.1 XP_016873053.1, XM_017017564.1 XP_016873054.1, XM_017017565.1 XP_016873055.1, XM_017017566.1 XP_016873056.1, XM_017017567.1 XP_016873057.1, XM_017017568.1 XP_016873058.1, XM_017017569.1 XP_016873059.1, XM_017017570.1 XP_016873060.1, XM_017017571.1 |
3D structure databases
AlphaFoldDBi | Q8N413 |
SMRi | Q8N413 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 129470, 1 interactor |
STRINGi | 9606.ENSP00000381782 |
Protein family/group databases
TCDBi | 2.A.29.8.7, the mitochondrial carrier (mc) family |
Genetic variation databases
BioMutai | SLC25A45 |
DMDMi | 150416125 |
Proteomic databases
MassIVEi | Q8N413 |
PaxDbi | Q8N413 |
PeptideAtlasi | Q8N413 |
PRIDEi | Q8N413 |
ProteomicsDBi | 71861 [Q8N413-1] 71862 [Q8N413-2] |
Protocols and materials databases
Antibodypediai | 7360, 38 antibodies from 19 providers |
DNASUi | 283130 |
Genome annotation databases
Ensembli | ENST00000294187.10; ENSP00000294187.6; ENSG00000162241.13 [Q8N413-2] ENST00000398802.6; ENSP00000381782.1; ENSG00000162241.13 ENST00000527174.5; ENSP00000435489.1; ENSG00000162241.13 ENST00000534028.5; ENSP00000431769.1; ENSG00000162241.13 [Q8N413-4] |
GeneIDi | 283130 |
KEGGi | hsa:283130 |
MANE-Selecti | ENST00000398802.6; ENSP00000381782.1; NM_182556.4; NP_872362.4 |
UCSCi | uc001odq.3, human [Q8N413-1] |
Organism-specific databases
CTDi | 283130 |
DisGeNETi | 283130 |
GeneCardsi | SLC25A45 |
HGNCi | HGNC:27442, SLC25A45 |
HPAi | ENSG00000162241, Tissue enhanced (pancreas) |
MIMi | 610825, gene |
neXtProti | NX_Q8N413 |
OpenTargetsi | ENSG00000162241 |
PharmGKBi | PA162403718 |
VEuPathDBi | HostDB:ENSG00000162241 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0758, Eukaryota |
GeneTreei | ENSGT00940000161002 |
InParanoidi | Q8N413 |
OMAi | MQTAPKG |
OrthoDBi | 1072378at2759 |
PhylomeDBi | Q8N413 |
TreeFami | TF351739 |
Enzyme and pathway databases
PathwayCommonsi | Q8N413 |
Miscellaneous databases
BioGRID-ORCSi | 283130, 17 hits in 1070 CRISPR screens |
ChiTaRSi | SLC25A45, human |
GenomeRNAii | 283130 |
Pharosi | Q8N413, Tdark |
PROi | PR:Q8N413 |
RNActi | Q8N413, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000162241, Expressed in pancreas and 176 other tissues |
ExpressionAtlasi | Q8N413, baseline and differential |
Genevisiblei | Q8N413, HS |
Family and domain databases
Gene3Di | 1.50.40.10, 1 hit |
InterProi | View protein in InterPro IPR002067, Mit_carrier IPR018108, Mitochondrial_sb/sol_carrier IPR023395, Mt_carrier_dom_sf |
Pfami | View protein in Pfam PF00153, Mito_carr, 3 hits |
PRINTSi | PR00926, MITOCARRIER |
SUPFAMi | SSF103506, SSF103506, 1 hit |
PROSITEi | View protein in PROSITE PS50920, SOLCAR, 3 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | S2545_HUMAN | |
Accessioni | Q8N413Primary (citable) accession number: Q8N413 Secondary accession number(s): Q6PL49, Q8IW29 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 26, 2007 |
Last sequence update: | June 26, 2007 | |
Last modified: | May 25, 2022 | |
This is version 140 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families