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UniProtKB - Q8N413 (S2545_HUMAN)

Entry version 140 (25 May 2022)
Sequence version 2 (26 Jun 2007)
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Protein

Solute carrier family 25 member 45

Gene

SLC25A45

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransport

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q8N413

Protein family/group databases

Transport Classification Database

More...TCDBi		2.A.29.8.7, the mitochondrial carrier (mc) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Solute carrier family 25 member 45
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLC25A45
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:27442, SLC25A45

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		610825, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8N413

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000162241

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei6 – 26Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei63 – 83Helical; Name=2Sequence analysisAdd BLAST21
Transmembranei100 – 120Helical; Name=3Sequence analysisAdd BLAST21
Transmembranei166 – 186Helical; Name=4Sequence analysisAdd BLAST21
Transmembranei202 – 222Helical; Name=5Sequence analysisAdd BLAST21
Transmembranei266 – 286Helical; Name=6Sequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		283130

Open Targets

More...OpenTargetsi		ENSG00000162241

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA162403718

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q8N413, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SLC25A45

Domain mapping of disease mutations (DMDM)

More...DMDMi		150416125

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002918261 – 288Solute carrier family 25 member 45Add BLAST288

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q8N413

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8N413

PeptideAtlas

More...PeptideAtlasi		Q8N413

PRoteomics IDEntifications database

More...PRIDEi		Q8N413

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		71861 [Q8N413-1]
71862 [Q8N413-2]

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000162241, Expressed in pancreas and 176 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q8N413, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8N413, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000162241, Tissue enhanced (pancreas)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		129470, 1 interactor

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000381782

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8N413, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q8N413

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8N413

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati1 – 83Solcar 1Add BLAST83
Repeati97 – 191Solcar 2Add BLAST95
Repeati199 – 286Solcar 3Add BLAST88

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the mitochondrial carrier (TC 2.A.29) family. [View classification]Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0758, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000161002

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8N413

Identification of Orthologs from Complete Genome Data

More...OMAi		MQTAPKG

Database of Orthologous Groups

More...OrthoDBi		1072378at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8N413

TreeFam database of animal gene trees

More...TreeFami		TF351739

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.50.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR002067, Mit_carrier
IPR018108, Mitochondrial_sb/sol_carrier
IPR023395, Mt_carrier_dom_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00153, Mito_carr, 3 hits

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00926, MITOCARRIER

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF103506, SSF103506, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50920, SOLCAR, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8N413-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPVEEFVAGW ISGALGLVLG HPFDTVKVRL QTQTTYRGIV DCMVKIYRHE 
        60         70         80         90        100
SLLGFFKGMS FPIASIAVVN SVLFGVYSNT LLVLTATSHQ ERRAQPPSYM 
       110        120        130        140        150
HIFLAGCTGG FLQAYCLAPF DLIKVRLQNQ TEPRAQPGSP PPRYQGPVHC 
       160        170        180        190        200
AASIFREEGP RGLFRGAWAL TLRDTPTVGI YFITYEGLCR QYTPEGQNPS 
       210        220        230        240        250
SATVLVAGGF AGIASWVAAT PLDMIKSRMQ MDGLRRRVYQ GMLDCMVSSI 
       260        270        280 
RQEGLGVFFR GVTINSARAF PVNAVTFLSY EYLLRWWG
Length:288
Mass (Da):31,906
Last modified:June 26, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBD8EF1D8A2BFB296
GO
Isoform 2 (identifier: Q8N413-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-42: Missing.

Show »
Length:246
Mass (Da):27,319
Checksum:i3DD46F818E36CA50
GO
Isoform 3 (identifier: Q8N413-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-42: Missing.
     52-113: Missing.

Show »
Length:184
Mass (Da):20,631
Checksum:i603EA67772E2A639
GO
Isoform 4 (identifier: Q8N413-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     28-51: Missing.

Show »
Length:264
Mass (Da):29,027
Checksum:i05876BDB4AA7A1C7
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PK53E9PK53_HUMAN
Solute carrier family 25 member 45
SLC25A45
118Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PJQ3E9PJQ3_HUMAN
Solute carrier family 25 member 45
SLC25A45
226Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PMF0E9PMF0_HUMAN
Solute carrier family 25 member 45
SLC25A45
50Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PJ15E9PJ15_HUMAN
Solute carrier family 25 member 45
SLC25A45
36Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PJW2E9PJW2_HUMAN
Solute carrier family 25 member 45
SLC25A45
47Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BC041100 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti153S → P in AAT09000 (Ref. 1) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_032866224M → V2 PublicationsCorresponds to variant dbSNP:rs624307Ensembl.1
Natural variantiVAR_050135251R → Q. Corresponds to variant dbSNP:rs7108281Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0262461 – 42Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST42
Alternative sequenceiVSP_02624728 – 51Missing in isoform 4. 1 PublicationAdd BLAST24
Alternative sequenceiVSP_02624852 – 113Missing in isoform 3. 1 PublicationAdd BLAST62

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AY597807 mRNA Translation: AAT09000.1
AP000944 Genomic DNA No translation available.
BC036869 mRNA Translation: AAH36869.1
BC041100 mRNA No translation available.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS41670.1 [Q8N413-1]
CCDS41671.1 [Q8N413-2]
CCDS60850.1 [Q8N413-4]

NCBI Reference Sequences

More...RefSeqi		NP_001070709.2, NM_001077241.2 [Q8N413-2]
NP_001265179.2, NM_001278250.2 [Q8N413-4]
NP_001265180.2, NM_001278251.2 [Q8N413-2]
NP_001287749.1, NM_001300820.1
NP_872362.3, NM_182556.3 [Q8N413-1]
XP_006718572.1, XM_006718509.3
XP_006718573.1, XM_006718510.3
XP_011543245.1, XM_011544943.2
XP_011543246.1, XM_011544944.2
XP_011543251.1, XM_011544949.2
XP_016873052.1, XM_017017563.1
XP_016873053.1, XM_017017564.1
XP_016873054.1, XM_017017565.1
XP_016873055.1, XM_017017566.1
XP_016873056.1, XM_017017567.1
XP_016873057.1, XM_017017568.1
XP_016873058.1, XM_017017569.1
XP_016873059.1, XM_017017570.1
XP_016873060.1, XM_017017571.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000294187.10; ENSP00000294187.6; ENSG00000162241.13 [Q8N413-2]
ENST00000398802.6; ENSP00000381782.1; ENSG00000162241.13
ENST00000527174.5; ENSP00000435489.1; ENSG00000162241.13
ENST00000534028.5; ENSP00000431769.1; ENSG00000162241.13 [Q8N413-4]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		283130

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:283130

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000398802.6; ENSP00000381782.1; NM_182556.4; NP_872362.4

UCSC genome browser

More...UCSCi		uc001odq.3, human [Q8N413-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY597807 mRNA Translation: AAT09000.1
AP000944 Genomic DNA No translation available.
BC036869 mRNA Translation: AAH36869.1
BC041100 mRNA No translation available.
CCDSiCCDS41670.1 [Q8N413-1]
CCDS41671.1 [Q8N413-2]
CCDS60850.1 [Q8N413-4]
RefSeqiNP_001070709.2, NM_001077241.2 [Q8N413-2]
NP_001265179.2, NM_001278250.2 [Q8N413-4]
NP_001265180.2, NM_001278251.2 [Q8N413-2]
NP_001287749.1, NM_001300820.1
NP_872362.3, NM_182556.3 [Q8N413-1]
XP_006718572.1, XM_006718509.3
XP_006718573.1, XM_006718510.3
XP_011543245.1, XM_011544943.2
XP_011543246.1, XM_011544944.2
XP_011543251.1, XM_011544949.2
XP_016873052.1, XM_017017563.1
XP_016873053.1, XM_017017564.1
XP_016873054.1, XM_017017565.1
XP_016873055.1, XM_017017566.1
XP_016873056.1, XM_017017567.1
XP_016873057.1, XM_017017568.1
XP_016873058.1, XM_017017569.1
XP_016873059.1, XM_017017570.1
XP_016873060.1, XM_017017571.1

3D structure databases

AlphaFoldDBiQ8N413
SMRiQ8N413
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi129470, 1 interactor
STRINGi9606.ENSP00000381782

Protein family/group databases

TCDBi2.A.29.8.7, the mitochondrial carrier (mc) family

Genetic variation databases

BioMutaiSLC25A45
DMDMi150416125

Proteomic databases

MassIVEiQ8N413
PaxDbiQ8N413
PeptideAtlasiQ8N413
PRIDEiQ8N413
ProteomicsDBi71861 [Q8N413-1]
71862 [Q8N413-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		7360, 38 antibodies from 19 providers

The DNASU plasmid repository

More...DNASUi		283130

Genome annotation databases

EnsembliENST00000294187.10; ENSP00000294187.6; ENSG00000162241.13 [Q8N413-2]
ENST00000398802.6; ENSP00000381782.1; ENSG00000162241.13
ENST00000527174.5; ENSP00000435489.1; ENSG00000162241.13
ENST00000534028.5; ENSP00000431769.1; ENSG00000162241.13 [Q8N413-4]
GeneIDi283130
KEGGihsa:283130
MANE-SelectiENST00000398802.6; ENSP00000381782.1; NM_182556.4; NP_872362.4
UCSCiuc001odq.3, human [Q8N413-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		283130
DisGeNETi283130

GeneCards: human genes, protein and diseases

More...GeneCardsi		SLC25A45
HGNCiHGNC:27442, SLC25A45
HPAiENSG00000162241, Tissue enhanced (pancreas)
MIMi610825, gene
neXtProtiNX_Q8N413
OpenTargetsiENSG00000162241
PharmGKBiPA162403718
VEuPathDBiHostDB:ENSG00000162241

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0758, Eukaryota
GeneTreeiENSGT00940000161002
InParanoidiQ8N413
OMAiMQTAPKG
OrthoDBi1072378at2759
PhylomeDBiQ8N413
TreeFamiTF351739

Enzyme and pathway databases

PathwayCommonsiQ8N413

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		283130, 17 hits in 1070 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		SLC25A45, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		283130
PharosiQ8N413, Tdark

Protein Ontology

More...PROi		PR:Q8N413
RNActiQ8N413, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000162241, Expressed in pancreas and 176 other tissues
ExpressionAtlasiQ8N413, baseline and differential
GenevisibleiQ8N413, HS

Family and domain databases

Gene3Di1.50.40.10, 1 hit
InterProiView protein in InterPro
IPR002067, Mit_carrier
IPR018108, Mitochondrial_sb/sol_carrier
IPR023395, Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153, Mito_carr, 3 hits
PRINTSiPR00926, MITOCARRIER
SUPFAMiSSF103506, SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920, SOLCAR, 3 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiS2545_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8N413
Secondary accession number(s): Q6PL49, Q8IW29
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: June 26, 2007
Last modified: May 25, 2022
This is version 140 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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