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UniProtKB - Q8N412 (STPG2_HUMAN)

Entry version 119 (25 May 2022)
Sequence version 1 (01 Oct 2002)
Previous versions | rss
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Protein

Sperm-tail PG-rich repeat-containing protein 2

Gene

STPG2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q8N412

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q8N412

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sperm-tail PG-rich repeat-containing protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:STPG2
Synonyms:C4orf37
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:28712, STPG2

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8N412

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000163116

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		285555

Open Targets

More...OpenTargetsi		ENSG00000163116

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA162379799

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q8N412, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		STPG2

Domain mapping of disease mutations (DMDM)

More...DMDMi		74728806

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003119601 – 459Sperm-tail PG-rich repeat-containing protein 2Add BLAST459

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8N412

PeptideAtlas

More...PeptideAtlasi		Q8N412

PRoteomics IDEntifications database

More...PRIDEi		Q8N412

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		1767, 1 N-Linked glycan (1 site)

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q8N412, 1 site, 1 N-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8N412

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8N412

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000163116, Expressed in corpus callosum and 89 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q8N412, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8N412, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000163116, Tissue enhanced (brain, testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		130143, 7 interactors

Protein interaction database and analysis system

More...IntActi		Q8N412, 3 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000295268

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8N412, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q8N412

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati21 – 30STPGR 110
Repeati63 – 73STPGR 2Add BLAST11
Repeati119 – 148STPGR 3Add BLAST30
Repeati157 – 203STPGR 4Add BLAST47
Repeati213 – 243STPGR 5Add BLAST31
Repeati257 – 268STPGR 6Add BLAST12
Repeati351 – 377STPGR 7Add BLAST27
Repeati400 – 410STPGR 8Add BLAST11
Repeati433 – 443STPGR 9Add BLAST11

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1198, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000001063

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_040300_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8N412

Identification of Orthologs from Complete Genome Data

More...OMAi		KTSYYEN

Database of Orthologous Groups

More...OrthoDBi		710636at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8N412

TreeFam database of animal gene trees

More...TreeFami		TF328881

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR010736, SHIPPO-rpt

Pfam protein domain database

More...Pfami		View protein in Pfam
PF07004, SHIPPO-rpt, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8N412-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MYDRAPRLLK LAEGGSTEAH VGPGSYQVPF LKQQATGSNA PFLSLTARES 
        60         70         80         90        100
TFTIASSIEK AVPGPGHYNV SEAQKISRSP TLTRSVDVPS IPSCGKSYGY 
       110        120        130        140        150
HINDDGSIIK CFPPACDSTL GPAYYKPQFD VSNATLKYKG IHFGNSSGRQ 
       160        170        180        190        200
ELPKKSGPGP GQYDIVQKKT SYYENVNIKR DQQQNYCSFI PRLYEIIVLQ 
       210        220        230        240        250
EKKKRFLPMK SITPAPGTYN EPRTALKSLK KTSGLKNIPF GQSAVRFTQD 
       260        270        280        290        300
IRTEEMPGPG FYNVLNNTII ASVRNICSKK QKKSAFGSSV PRTFFSVQKE 
       310        320        330        340        350
ACATPGPADY QEFWHSQGVG ISDELPNLTN KYAAFLSRAK RTMKVPDMVI 
       360        370        380        390        400
PAPGSYDVHK SYEMSQVKHK YMPPRSLVAK RKHASFLSAT PRCLEKVTDG 
       410        420        430        440        450
PGPAAYNPVL RKSCPIPLFV KASKRFEESK EITPGPATYE ISQEKKKGNL 

IGEMAADIM
Length:459
Mass (Da):50,660
Last modified:October 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i17CA66DA1237B534
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YAZ7H0YAZ7_HUMAN
Sperm-tail PG-rich repeat-containin...
STPG2
186Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_037359111C → W. Corresponds to variant dbSNP:rs13131259Ensembl.1
Natural variantiVAR_037360112F → V. Corresponds to variant dbSNP:rs13131258Ensembl.1
Natural variantiVAR_037361125Y → H. Corresponds to variant dbSNP:rs17558193Ensembl.1
Natural variantiVAR_037362178I → V. Corresponds to variant dbSNP:rs2903150Ensembl.1
Natural variantiVAR_037363279K → R. Corresponds to variant dbSNP:rs7654193Ensembl.1
Natural variantiVAR_037364420V → A. Corresponds to variant dbSNP:rs17026871Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
CH471057 Genomic DNA Translation: EAX06067.1
BC036870 mRNA Translation: AAH36870.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS3645.1

NCBI Reference Sequences

More...RefSeqi		NP_777612.1, NM_174952.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000295268.4; ENSP00000295268.3; ENSG00000163116.10

Database of genes from NCBI RefSeq genomes

More...GeneIDi		285555

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:285555

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000295268.4; ENSP00000295268.3; NM_174952.3; NP_777612.1

UCSC genome browser

More...UCSCi		uc003htt.3, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471057 Genomic DNA Translation: EAX06067.1
BC036870 mRNA Translation: AAH36870.1
CCDSiCCDS3645.1
RefSeqiNP_777612.1, NM_174952.2

3D structure databases

AlphaFoldDBiQ8N412
ModBaseiSearch...
SWISS-MODEL-WorkspaceiSubmit a new modelling project...

Protein-protein interaction databases

BioGRIDi130143, 7 interactors
IntActiQ8N412, 3 interactors
STRINGi9606.ENSP00000295268

PTM databases

GlyConnecti1767, 1 N-Linked glycan (1 site)
GlyGeniQ8N412, 1 site, 1 N-linked glycan (1 site)
iPTMnetiQ8N412
PhosphoSitePlusiQ8N412

Genetic variation databases

BioMutaiSTPG2
DMDMi74728806

Proteomic databases

PaxDbiQ8N412
PeptideAtlasiQ8N412
PRIDEiQ8N412

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		67933, 26 antibodies from 7 providers

The DNASU plasmid repository

More...DNASUi		285555

Genome annotation databases

EnsembliENST00000295268.4; ENSP00000295268.3; ENSG00000163116.10
GeneIDi285555
KEGGihsa:285555
MANE-SelectiENST00000295268.4; ENSP00000295268.3; NM_174952.3; NP_777612.1
UCSCiuc003htt.3, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		285555
DisGeNETi285555

GeneCards: human genes, protein and diseases

More...GeneCardsi		STPG2
HGNCiHGNC:28712, STPG2
HPAiENSG00000163116, Tissue enhanced (brain, testis)
neXtProtiNX_Q8N412
OpenTargetsiENSG00000163116
PharmGKBiPA162379799
VEuPathDBiHostDB:ENSG00000163116

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1198, Eukaryota
GeneTreeiENSGT00390000001063
HOGENOMiCLU_040300_1_0_1
InParanoidiQ8N412
OMAiKTSYYEN
OrthoDBi710636at2759
PhylomeDBiQ8N412
TreeFamiTF328881

Enzyme and pathway databases

PathwayCommonsiQ8N412
SignaLinkiQ8N412

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		285555, 7 hits in 1066 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		STPG2, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		285555
PharosiQ8N412, Tdark

Protein Ontology

More...PROi		PR:Q8N412
RNActiQ8N412, protein

Gene expression databases

BgeeiENSG00000163116, Expressed in corpus callosum and 89 other tissues
ExpressionAtlasiQ8N412, baseline and differential
GenevisibleiQ8N412, HS

Family and domain databases

InterProiView protein in InterPro
IPR010736, SHIPPO-rpt
PfamiView protein in Pfam
PF07004, SHIPPO-rpt, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSTPG2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8N412
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: October 1, 2002
Last modified: May 25, 2022
This is version 119 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
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