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Entry version 137 (10 Apr 2019)
Sequence version 2 (14 Apr 2009)
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Protein

Zinc finger CCHC domain-containing protein 7

Gene

ZCCHC7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

It is uncertain whether Met-1 or Met-2 is the initiator.Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri241 – 258CCHC-type 1PROSITE-ProRule annotationAdd BLAST18
Zinc fingeri263 – 280CCHC-type 2PROSITE-ProRule annotationAdd BLAST18
Zinc fingeri304 – 321CCHC-type 3PROSITE-ProRule annotationAdd BLAST18
Zinc fingeri348 – 365CCHC-type 4PROSITE-ProRule annotationAdd BLAST18

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger CCHC domain-containing protein 7
Alternative name(s):
TRAMP-like complex RNA-binding factor ZCCHC7
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZCCHC7
ORF Names:HSPC086
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000147905.17

Human Gene Nomenclature Database

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HGNCi
HGNC:26209 ZCCHC7

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8N3Z6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

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OpenTargetsi
ENSG00000147905

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA128394734

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZCCHC7

Domain mapping of disease mutations (DMDM)

More...
DMDMi
226693603

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001509591 – 543Zinc finger CCHC domain-containing protein 7Add BLAST543

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki131Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki139Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki141Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki239Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki254Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki339Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki412Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki417Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki435Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki478Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei482PhosphoserineCombined sources1
Modified residuei485PhosphoserineCombined sources1
Cross-linki487Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki490Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki493Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki537Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q8N3Z6

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q8N3Z6

MaxQB - The MaxQuant DataBase

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MaxQBi
Q8N3Z6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8N3Z6

PeptideAtlas

More...
PeptideAtlasi
Q8N3Z6

PRoteomics IDEntifications database

More...
PRIDEi
Q8N3Z6

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8N3Z6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8N3Z6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000147905 Expressed in 197 organ(s), highest expression level in female gonad

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q8N3Z6 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8N3Z6 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA020600
HPA021088
HPA029522

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of a nucleolar TRAMP-like complex, an ATP-dependent exosome regulatory complex consisting of a helicase (MTREX), an oligadenylate polymerase (TENT4B or TENT4A), and a substrate specific RNA-binding factor (ZCCHC7 or ZCCHC8). Several TRAMP-like complexes exist with specific compositions and are associated with nuclear, or nucleolar RNA exosomes.1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
123934, 29 interactors

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...
ELMi
Q8N3Z6

Protein interaction database and analysis system

More...
IntActi
Q8N3Z6, 17 interactors

Molecular INTeraction database

More...
MINTi
Q8N3Z6

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000443113

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q8N3Z6

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri241 – 258CCHC-type 1PROSITE-ProRule annotationAdd BLAST18
Zinc fingeri263 – 280CCHC-type 2PROSITE-ProRule annotationAdd BLAST18
Zinc fingeri304 – 321CCHC-type 3PROSITE-ProRule annotationAdd BLAST18
Zinc fingeri348 – 365CCHC-type 4PROSITE-ProRule annotationAdd BLAST18

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IUGX Eukaryota
ENOG41123PW LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000183041

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG094757

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8N3Z6

KEGG Orthology (KO)

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KOi
K12597

Identification of Orthologs from Complete Genome Data

More...
OMAi
CLERSSW

Database of Orthologous Groups

More...
OrthoDBi
1535084at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8N3Z6

TreeFam database of animal gene trees

More...
TreeFami
TF329448

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR001878 Znf_CCHC
IPR036875 Znf_CCHC_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00098 zf-CCHC, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00343 ZnF_C2HC, 4 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57756 SSF57756, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50158 ZF_CCHC, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8N3Z6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMFGGYETIE AYEDDLYRDE SSSELSVDSE VEFQLYSQIH YAQDLDDVIR
60 70 80 90 100
EEEHEEKNSG NSESSSSKPN QKKLIVLSDS EVIQLSDGSE VITLSDEDSI
110 120 130 140 150
YRCKGKNVRV QAQENAHGLS SSLQSNELVD KKCKSDIEKP KSEERSGVIR
160 170 180 190 200
EVMIIEVSSS EEEESTISEG DNVESWMLLG CEVDDKDDDI LLNLVGCENS
210 220 230 240 250
VTEGEDGINW SISDKDIEAQ IANNRTPGRW TQRYYSANKN IICRNCDKRG
260 270 280 290 300
HLSKNCPLPR KVRRCFLCSR RGHLLYSCPA PLCEYCPVPK MLDHSCLFRH
310 320 330 340 350
SWDKQCDRCH MLGHYTDACT EIWRQYHLTT KPGPPKKPKT PSRPSALAYC
360 370 380 390 400
YHCAQKGHYG HECPEREVYD PSPVSPFICY YDDKYEIQER EKRLKQKIKV
410 420 430 440 450
LKKNGVIPEP SKLPYIKAAN ENPHHDIRKG RASWKSNRWP QENKETQKEM
460 470 480 490 500
KNKNRNWEKH RKADRHREVD EDFPRGPKTY SSPGSFKTQK PSKPFHRSSH
510 520 530 540
YHTSREDKSP KEGKRGKQKK KERCWEDDDN DNLFLIKQRK KKS
Length:543
Mass (Da):63,052
Last modified:April 14, 2009 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1EDB6DD168C28EE6
GO
Isoform 2 (identifier: Q8N3Z6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     205-206: ED → QE
     207-543: Missing.

Show »
Length:206
Mass (Da):23,094
Checksum:i8066E398C03F4A26
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
X6R4A7X6R4A7_HUMAN
Zinc finger CCHC domain-containing ...
ZCCHC7
205Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH36940 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB15418 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence BAC11087 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAG37581 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti3F → L in BAB15418 (PubMed:14702039).Curated1
Sequence conflicti65S → P in AAH22434 (PubMed:15489334).Curated1
Sequence conflicti214D → G in BAC11087 (PubMed:14702039).Curated1
Sequence conflicti233R → W in BAC11087 (PubMed:14702039).Curated1
Sequence conflicti443N → D in BAC11087 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_054958118G → D. Corresponds to variant dbSNP:rs35119826Ensembl.1
Natural variantiVAR_054959539R → K. Corresponds to variant dbSNP:rs1051465Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_013841205 – 206ED → QE in isoform 2. 1 Publication2
Alternative sequenceiVSP_013842207 – 543Missing in isoform 2. 1 PublicationAdd BLAST337

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK026264 mRNA Translation: BAB15418.1 Sequence problems.
AK074608 mRNA Translation: BAC11087.1 Different initiation.
AK315128 mRNA Translation: BAG37581.1 Different initiation.
AL512604 Genomic DNA No translation available.
AL158155 Genomic DNA No translation available.
CH471071 Genomic DNA Translation: EAW58288.1
CH471071 Genomic DNA Translation: EAW58289.1
BC022434 mRNA Translation: AAH22434.1
BC036940 mRNA Translation: AAH36940.1 Different initiation.
AF161349 mRNA Translation: AAF28909.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS6608.2 [Q8N3Z6-1]

NCBI Reference Sequences

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RefSeqi
NP_001276048.1, NM_001289119.1 [Q8N3Z6-1]
NP_001276049.1, NM_001289120.1 [Q8N3Z6-1]
NP_001276050.1, NM_001289121.1 [Q8N3Z6-1]
NP_115602.2, NM_032226.2 [Q8N3Z6-1]
XP_005251665.1, XM_005251608.4 [Q8N3Z6-1]
XP_005251669.1, XM_005251612.2 [Q8N3Z6-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.654700

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000336755; ENSP00000337839; ENSG00000147905 [Q8N3Z6-1]
ENST00000534928; ENSP00000443113; ENSG00000147905 [Q8N3Z6-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
84186

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:84186

UCSC genome browser

More...
UCSCi
uc003zzq.4 human [Q8N3Z6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK026264 mRNA Translation: BAB15418.1 Sequence problems.
AK074608 mRNA Translation: BAC11087.1 Different initiation.
AK315128 mRNA Translation: BAG37581.1 Different initiation.
AL512604 Genomic DNA No translation available.
AL158155 Genomic DNA No translation available.
CH471071 Genomic DNA Translation: EAW58288.1
CH471071 Genomic DNA Translation: EAW58289.1
BC022434 mRNA Translation: AAH22434.1
BC036940 mRNA Translation: AAH36940.1 Different initiation.
AF161349 mRNA Translation: AAF28909.1
CCDSiCCDS6608.2 [Q8N3Z6-1]
RefSeqiNP_001276048.1, NM_001289119.1 [Q8N3Z6-1]
NP_001276049.1, NM_001289120.1 [Q8N3Z6-1]
NP_001276050.1, NM_001289121.1 [Q8N3Z6-1]
NP_115602.2, NM_032226.2 [Q8N3Z6-1]
XP_005251665.1, XM_005251608.4 [Q8N3Z6-1]
XP_005251669.1, XM_005251612.2 [Q8N3Z6-1]
UniGeneiHs.654700

3D structure databases

ProteinModelPortaliQ8N3Z6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123934, 29 interactors
ELMiQ8N3Z6
IntActiQ8N3Z6, 17 interactors
MINTiQ8N3Z6
STRINGi9606.ENSP00000443113

PTM databases

iPTMnetiQ8N3Z6
PhosphoSitePlusiQ8N3Z6

Polymorphism and mutation databases

BioMutaiZCCHC7
DMDMi226693603

Proteomic databases

EPDiQ8N3Z6
jPOSTiQ8N3Z6
MaxQBiQ8N3Z6
PaxDbiQ8N3Z6
PeptideAtlasiQ8N3Z6
PRIDEiQ8N3Z6

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
84186
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000336755; ENSP00000337839; ENSG00000147905 [Q8N3Z6-1]
ENST00000534928; ENSP00000443113; ENSG00000147905 [Q8N3Z6-1]
GeneIDi84186
KEGGihsa:84186
UCSCiuc003zzq.4 human [Q8N3Z6-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
84186
EuPathDBiHostDB:ENSG00000147905.17

GeneCards: human genes, protein and diseases

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GeneCardsi
ZCCHC7
HGNCiHGNC:26209 ZCCHC7
HPAiHPA020600
HPA021088
HPA029522
neXtProtiNX_Q8N3Z6
OpenTargetsiENSG00000147905
PharmGKBiPA128394734

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IUGX Eukaryota
ENOG41123PW LUCA
GeneTreeiENSGT00950000183041
HOVERGENiHBG094757
InParanoidiQ8N3Z6
KOiK12597
OMAiCLERSSW
OrthoDBi1535084at2759
PhylomeDBiQ8N3Z6
TreeFamiTF329448

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ZCCHC7 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
84186

Protein Ontology

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PROi
PR:Q8N3Z6

Gene expression databases

BgeeiENSG00000147905 Expressed in 197 organ(s), highest expression level in female gonad
ExpressionAtlasiQ8N3Z6 baseline and differential
GenevisibleiQ8N3Z6 HS

Family and domain databases

InterProiView protein in InterPro
IPR001878 Znf_CCHC
IPR036875 Znf_CCHC_sf
PfamiView protein in Pfam
PF00098 zf-CCHC, 1 hit
SMARTiView protein in SMART
SM00343 ZnF_C2HC, 4 hits
SUPFAMiSSF57756 SSF57756, 1 hit
PROSITEiView protein in PROSITE
PS50158 ZF_CCHC, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZCHC7_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8N3Z6
Secondary accession number(s): B2RCI4
, D3DRQ0, Q5T0Q8, Q5T0Q9, Q5T0R0, Q8N2M1, Q8N4J2, Q8TBK8, Q9H648, Q9P0F0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: April 14, 2009
Last modified: April 10, 2019
This is version 137 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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