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Protein

GTP-binding protein 8

Gene

GTPBP8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi124MagnesiumBy similarity1
Metal bindingi148MagnesiumBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi117 – 124GTPBy similarity8
Nucleotide bindingi146 – 150GTPBy similarity5
Nucleotide bindingi164 – 167GTPBy similarity4
Nucleotide bindingi226 – 229GTPBy similarity4
Nucleotide bindingi261 – 263GTPBy similarity3

GO - Molecular functioni

Keywordsi

LigandGTP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
GTP-binding protein 8
Gene namesi
Name:GTPBP8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000163607.14
HGNCiHGNC:25007 GTPBP8
neXtProtiNX_Q8N3Z3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi29083
OpenTargetsiENSG00000163607
PharmGKBiPA142671705

Polymorphism and mutation databases

BioMutaiGTPBP8
DMDMi74728797

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003386121 – 284GTP-binding protein 8Add BLAST284

Proteomic databases

EPDiQ8N3Z3
MaxQBiQ8N3Z3
PaxDbiQ8N3Z3
PeptideAtlasiQ8N3Z3
PRIDEiQ8N3Z3
ProteomicsDBi71853
71854 [Q8N3Z3-2]
71855 [Q8N3Z3-3]

PTM databases

iPTMnetiQ8N3Z3
PhosphoSitePlusiQ8N3Z3

Expressioni

Gene expression databases

BgeeiENSG00000163607
CleanExiHS_GTPBP8
ExpressionAtlasiQ8N3Z3 baseline and differential
GenevisibleiQ8N3Z3 HS

Organism-specific databases

HPAiHPA034831
HPA058631

Interactioni

Protein-protein interaction databases

BioGridi118853, 13 interactors
IntActiQ8N3Z3, 2 interactors
STRINGi9606.ENSP00000373176

Structurei

3D structure databases

ProteinModelPortaliQ8N3Z3
SMRiQ8N3Z3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini109 – 282EngB-type GAdd BLAST174

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2486 Eukaryota
COG0218 LUCA
GeneTreeiENSGT00390000001083
HOGENOMiHOG000009834
HOVERGENiHBG055007
InParanoidiQ8N3Z3
PhylomeDBiQ8N3Z3
TreeFamiTF331089

Family and domain databases

HAMAPiMF_00321 GTPase_EngB, 1 hit
InterProiView protein in InterPro
IPR030393 G_ENGB_dom
IPR019987 GTP-bd_ribosome_bio_YsxC
IPR006073 GTP_binding_domain
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF01926 MMR_HSR1, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR03598 GTPase_YsxC, 1 hit
PROSITEiView protein in PROSITE
PS51706 G_ENGB, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N3Z3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAPGLRLGA GRLFEMPAVL ERLSRYNSTS QAFAEVLRLP KQQLRKLLYP
60 70 80 90 100
LQEVERFLAP YGRQDLHLRI FDPSPEDIAR ADNIFTATER NRIDYVSSAV
110 120 130 140 150
RIDHAPDLPR PEVCFIGRSN VGKSSLIKAL FSLAPEVEVR VSKKPGHTKK
160 170 180 190 200
MNFFKVGKHF TVVDMPGYGF RAPEDFVDMV ETYLKERRNL KRTFLLVDSV
210 220 230 240 250
VGIQKTDNIA IEMCEEFALP YVIVLTKIDK SSKGHLLKQV LQIQKFVNMK
260 270 280
TQGCFPQLFP VSAVTFSGIH LLRCFIASVT GSLD
Length:284
Mass (Da):32,147
Last modified:October 1, 2002 - v1
Checksum:i446AF4FFBC1E6E65
GO
Isoform 2 (identifier: Q8N3Z3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     113-145: Missing.

Note: No experimental confirmation available.
Show »
Length:251
Mass (Da):28,604
Checksum:iD1031C4F4EF93895
GO
Isoform 3 (identifier: Q8N3Z3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     113-121: VCFIGRSNV → LEENIFISG
     122-284: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. No experimental confirmation available.
Show »
Length:121
Mass (Da):13,848
Checksum:i6705362389ED1379
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti101R → C in BAF82300 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_048934242Q → H. Corresponds to variant dbSNP:rs1054263Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_034055113 – 145Missing in isoform 2. 1 PublicationAdd BLAST33
Alternative sequenceiVSP_034056113 – 121VCFIGRSNV → LEENIFISG in isoform 3. 1 Publication9
Alternative sequenceiVSP_034057122 – 284Missing in isoform 3. 1 PublicationAdd BLAST163

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK289611 mRNA Translation: BAF82300.1
AK292651 mRNA Translation: BAF85340.1
AC074044 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW79655.1
BC010137 mRNA No translation available.
BC037163 mRNA Translation: AAH37163.1
CCDSiCCDS33820.1 [Q8N3Z3-1]
CCDS33821.1 [Q8N3Z3-2]
RefSeqiNP_054889.2, NM_014170.2 [Q8N3Z3-1]
NP_612494.1, NM_138485.1 [Q8N3Z3-2]
UniGeneiHs.127496

Genome annotation databases

EnsembliENST00000295864; ENSP00000295864; ENSG00000163607 [Q8N3Z3-3]
ENST00000383677; ENSP00000373175; ENSG00000163607 [Q8N3Z3-2]
ENST00000383678; ENSP00000373176; ENSG00000163607 [Q8N3Z3-1]
ENST00000485330; ENSP00000418877; ENSG00000163607 [Q8N3Z3-2]
GeneIDi29083
KEGGihsa:29083
UCSCiuc003dzn.4 human [Q8N3Z3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiGTPB8_HUMAN
AccessioniPrimary (citable) accession number: Q8N3Z3
Secondary accession number(s): A6NE99
, A6NN11, A8K0P6, Q5I0Y4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: October 1, 2002
Last modified: June 20, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

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