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UniProtKB - Q8N3Z0 (PRS35_HUMAN)
Protein
Inactive serine protease 35
Gene
PRSS35
Organism
Homo sapiens (Human)
Status
Functioni
Caution
Although related to peptidase S1 family, lacks the conserved active Ser residue in position 346 which is replaced by a Thr, suggesting that it has no protease activity.Curated
Keywordsi
Molecular function | Serine protease homolog |
Enzyme and pathway databases
PathwayCommonsi | Q8N3Z0 |
SignaLinki | Q8N3Z0 |
Protein family/group databases
MEROPSi | S01.994 |
Names & Taxonomyi
Protein namesi | Recommended name: Inactive serine protease 35 |
Gene namesi | Name:PRSS35 Synonyms:C6orf158 ORF Names:UNQ522/PRO1057 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:21387, PRSS35 |
neXtProti | NX_Q8N3Z0 |
VEuPathDBi | HostDB:ENSG00000146250 |
Subcellular locationi
Extracellular region or secreted
- Secreted Curated
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 167681 |
OpenTargetsi | ENSG00000146250 |
PharmGKBi | PA134974089 |
Miscellaneous databases
Pharosi | Q8N3Z0, Tbio |
Genetic variation databases
BioMutai | PRSS35 |
DMDMi | 158563845 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 16 | Sequence analysisAdd BLAST | 16 | |
ChainiPRO_0000299358 | 17 – 413 | Inactive serine protease 35Add BLAST | 397 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 90 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 154 ↔ 170 | By similarity |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
MassIVEi | Q8N3Z0 |
PaxDbi | Q8N3Z0 |
PeptideAtlasi | Q8N3Z0 |
PRIDEi | Q8N3Z0 |
ProteomicsDBi | 71852 |
TopDownProteomicsi | Q8N3Z0 |
PTM databases
GlyGeni | Q8N3Z0, 1 site |
iPTMneti | Q8N3Z0 |
PhosphoSitePlusi | Q8N3Z0 |
Expressioni
Gene expression databases
Bgeei | ENSG00000146250, Expressed in tibia and 148 other tissues |
Genevisiblei | Q8N3Z0, HS |
Organism-specific databases
HPAi | ENSG00000146250, Tissue enriched (retina) |
Interactioni
Binary interactionsi
Q8N3Z0
With | #Exp. | IntAct |
---|---|---|
C1QBP [Q07021] | 4 | EBI-20628340,EBI-347528 |
Protein-protein interaction databases
BioGRIDi | 127949, 6 interactors |
IntActi | Q8N3Z0, 32 interactors |
STRINGi | 9606.ENSP00000358714 |
Miscellaneous databases
RNActi | Q8N3Z0, protein |
Structurei
3D structure databases
AlphaFoldDBi | Q8N3Z0 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 124 – 408 | Peptidase S1Add BLAST | 285 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 191 – 250 | DisorderedSequence analysisAdd BLAST | 60 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 191 – 206 | Basic residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 207 – 225 | Basic and acidic residuesSequence analysisAdd BLAST | 19 |
Sequence similaritiesi
Belongs to the peptidase S1 family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502QV0K, Eukaryota |
GeneTreei | ENSGT00390000000155 |
HOGENOMi | CLU_055829_0_0_1 |
InParanoidi | Q8N3Z0 |
OMAi | MEQDFMW |
OrthoDBi | 1245017at2759 |
PhylomeDBi | Q8N3Z0 |
TreeFami | TF329011 |
Family and domain databases
Gene3Di | 2.40.10.10, 1 hit |
InterProi | View protein in InterPro IPR009003, Peptidase_S1_PA IPR043504, Peptidase_S1_PA_chymotrypsin IPR001254, Trypsin_dom IPR018114, TRYPSIN_HIS |
Pfami | View protein in Pfam PF00089, Trypsin, 1 hit |
SUPFAMi | SSF50494, SSF50494, 1 hit |
PROSITEi | View protein in PROSITE PS00134, TRYPSIN_HIS, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q8N3Z0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MENMLLWLIF FTPGWTLIDG SEMEWDFMWH LRKVPRIVSE RTFHLTSPAF
60 70 80 90 100
EADAKMMVNT VCGIECQKEL PTPSLSELED YLSYETVFEN GTRTLTRVKV
110 120 130 140 150
QDLVLEPTQN ITTKGVSVRR KRQVYGTDSR FSILDKRFLT NFPFSTAVKL
160 170 180 190 200
STGCSGILIS PQHVLTAAHC VHDGKDYVKG SKKLRVGLLK MRNKSGGKKR
210 220 230 240 250
RGSKRSRREA SGGDQREGTR EHLRERAKGG RRRKKSGRGQ RIAEGRPSFQ
260 270 280 290 300
WTRVKNTHIP KGWARGGMGD ATLDYDYALL ELKRAHKKKY MELGISPTIK
310 320 330 340 350
KMPGGMIHFS GFDNDRADQL VYRFCSVSDE SNDLLYQYCD AESGSTGSGV
360 370 380 390 400
YLRLKDPDKK NWKRKIIAVY SGHQWVDVHG VQKDYNVAVR ITPLKYAQIC
410
LWIHGNDANC AYG
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_034810 | 224 | R → Q3 PublicationsCorresponds to variant dbSNP:rs504593Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY358661 mRNA Translation: AAQ89024.1 AK291928 mRNA Translation: BAF84617.1 AL121939 Genomic DNA No translation available. CH471051 Genomic DNA Translation: EAW48663.1 BC037170 mRNA Translation: AAH37170.1 |
CCDSi | CCDS4999.1 |
RefSeqi | NP_001163894.1, NM_001170423.1 NP_699193.2, NM_153362.2 |
Genome annotation databases
Ensembli | ENST00000369700.4; ENSP00000358714.3; ENSG00000146250.7 |
GeneIDi | 167681 |
KEGGi | hsa:167681 |
MANE-Selecti | ENST00000369700.4; ENSP00000358714.3; NM_153362.3; NP_699193.2 |
UCSCi | uc003pjz.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY358661 mRNA Translation: AAQ89024.1 AK291928 mRNA Translation: BAF84617.1 AL121939 Genomic DNA No translation available. CH471051 Genomic DNA Translation: EAW48663.1 BC037170 mRNA Translation: AAH37170.1 |
CCDSi | CCDS4999.1 |
RefSeqi | NP_001163894.1, NM_001170423.1 NP_699193.2, NM_153362.2 |
3D structure databases
AlphaFoldDBi | Q8N3Z0 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 127949, 6 interactors |
IntActi | Q8N3Z0, 32 interactors |
STRINGi | 9606.ENSP00000358714 |
Protein family/group databases
MEROPSi | S01.994 |
PTM databases
GlyGeni | Q8N3Z0, 1 site |
iPTMneti | Q8N3Z0 |
PhosphoSitePlusi | Q8N3Z0 |
Genetic variation databases
BioMutai | PRSS35 |
DMDMi | 158563845 |
Proteomic databases
MassIVEi | Q8N3Z0 |
PaxDbi | Q8N3Z0 |
PeptideAtlasi | Q8N3Z0 |
PRIDEi | Q8N3Z0 |
ProteomicsDBi | 71852 |
TopDownProteomicsi | Q8N3Z0 |
Protocols and materials databases
Antibodypediai | 31685, 81 antibodies from 18 providers |
DNASUi | 167681 |
Genome annotation databases
Ensembli | ENST00000369700.4; ENSP00000358714.3; ENSG00000146250.7 |
GeneIDi | 167681 |
KEGGi | hsa:167681 |
MANE-Selecti | ENST00000369700.4; ENSP00000358714.3; NM_153362.3; NP_699193.2 |
UCSCi | uc003pjz.4, human |
Organism-specific databases
CTDi | 167681 |
DisGeNETi | 167681 |
GeneCardsi | PRSS35 |
HGNCi | HGNC:21387, PRSS35 |
HPAi | ENSG00000146250, Tissue enriched (retina) |
neXtProti | NX_Q8N3Z0 |
OpenTargetsi | ENSG00000146250 |
PharmGKBi | PA134974089 |
VEuPathDBi | HostDB:ENSG00000146250 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QV0K, Eukaryota |
GeneTreei | ENSGT00390000000155 |
HOGENOMi | CLU_055829_0_0_1 |
InParanoidi | Q8N3Z0 |
OMAi | MEQDFMW |
OrthoDBi | 1245017at2759 |
PhylomeDBi | Q8N3Z0 |
TreeFami | TF329011 |
Enzyme and pathway databases
PathwayCommonsi | Q8N3Z0 |
SignaLinki | Q8N3Z0 |
Miscellaneous databases
BioGRID-ORCSi | 167681, 15 hits in 1069 CRISPR screens |
GenomeRNAii | 167681 |
Pharosi | Q8N3Z0, Tbio |
PROi | PR:Q8N3Z0 |
RNActi | Q8N3Z0, protein |
Gene expression databases
Bgeei | ENSG00000146250, Expressed in tibia and 148 other tissues |
Genevisiblei | Q8N3Z0, HS |
Family and domain databases
Gene3Di | 2.40.10.10, 1 hit |
InterProi | View protein in InterPro IPR009003, Peptidase_S1_PA IPR043504, Peptidase_S1_PA_chymotrypsin IPR001254, Trypsin_dom IPR018114, TRYPSIN_HIS |
Pfami | View protein in Pfam PF00089, Trypsin, 1 hit |
SUPFAMi | SSF50494, SSF50494, 1 hit |
PROSITEi | View protein in PROSITE PS00134, TRYPSIN_HIS, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PRS35_HUMAN | |
Accessioni | Q8N3Z0Primary (citable) accession number: Q8N3Z0 Secondary accession number(s): A8K7B3, Q9BQP6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 11, 2007 |
Last sequence update: | September 11, 2007 | |
Last modified: | May 25, 2022 | |
This is version 146 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Peptidase families
Classification of peptidase families and list of entries - Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - SIMILARITY comments
Index of protein domains and families