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Entry version 136 (22 Apr 2020)
Sequence version 4 (13 Nov 2007)
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Protein

Ligand-dependent nuclear receptor corepressor-like protein

Gene

LCORL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May act as transcription activator that binds DNA elements with the sequence 5'-CCCTATCGATCGATCTCTACCT-3'. May play a role in spermatogenesis (By similarity).By similarity

Caution

A report observed N-glycosylation at Asn-493 (PubMed:19139490). However, as the protein is predicted to act as a DNA-binding transcription activator, additional evidence is required to confirm this result.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi544 – 564H-T-H motifPROSITE-ProRule annotationAdd BLAST21

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ligand-dependent nuclear receptor corepressor-like protein
Short name:
LCoR-like protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LCORL
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:30776 LCORL

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
611799 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8N3X6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
254251

Open Targets

More...
OpenTargetsi
ENSG00000178177

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA145148507

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8N3X6 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
LCORL

Domain mapping of disease mutations (DMDM)

More...
DMDMi
160395582

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003104631 – 602Ligand-dependent nuclear receptor corepressor-like proteinAdd BLAST602

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki242Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki319Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki340Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki397Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8N3X6

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8N3X6

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8N3X6

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8N3X6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8N3X6

PeptideAtlas

More...
PeptideAtlasi
Q8N3X6

PRoteomics IDEntifications database

More...
PRIDEi
Q8N3X6

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
71844 [Q8N3X6-1]
71845 [Q8N3X6-2]
71846 [Q8N3X6-3]

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
2054

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8N3X6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8N3X6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000178177 Expressed in buccal mucosa cell and 198 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8N3X6 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8N3X6 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000178177 Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Show more details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
129025, 6 interactors

Protein interaction database and analysis system

More...
IntActi
Q8N3X6, 3 interactors

Molecular INTeraction database

More...
MINTi
Q8N3X6

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000371661

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8N3X6 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8N3X6

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini516 – 568HTH psq-typePROSITE-ProRule annotationAdd BLAST53

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi9 – 31Ala-richAdd BLAST23

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4565 Eukaryota
ENOG4111GCI LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162414

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_076618_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8N3X6

Identification of Orthologs from Complete Genome Data

More...
OMAi
FNMTDSG

Database of Orthologous Groups

More...
OrthoDBi
47456at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8N3X6

TreeFam database of animal gene trees

More...
TreeFami
TF319589

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR009057 Homeobox-like_sf
IPR007889 HTH_Psq

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05225 HTH_psq, 2 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF46689 SSF46689, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50960 HTH_PSQ, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8N3X6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDKGRERMAA AAAAAAAAAA AAQCRSPRCA AERRGFRREL DSWRHRLMHC
60 70 80 90 100
VGFESILEGL YGPRLRRDLS LFEDCEPEEL TDWSMDEKCS FCNLQREAVS
110 120 130 140 150
DCIPSLDSSQ STPTEELSSQ GQSNTDKIEC QAENYLNALF RKKDLPQNCD
160 170 180 190 200
PNIPLVAQEL MKKMIRQFAI EYISKSGKTQ ENRNGSIGPS IVCKSIQMNQ
210 220 230 240 250
AENSLQEEQE GPLDLTVNRM QEQNTQQGDG VLDLSTKKTS IKSEESSICD
260 270 280 290 300
PSSENSVAGR LHRNREDYVE RSAEFADGLL SKALKDIQSG ALDINKAGIL
310 320 330 340 350
YGIPQKTLLL HLEALPAGKP ASFKNKTRDF HDSYSYKDSK ETCAVLQKVA
360 370 380 390 400
LWARAQAERT EKSKLNLLET SEIKFPTAST YLHQLTLQKM VTQFKEKNES
410 420 430 440 450
LQYETSNPTV QLKIPQLRVS SVSKSQPDGS GLLDVMYQVS KTSSVLEGSA
460 470 480 490 500
LQKLKNILPK QNKIECSGPV THSSVDSYFL HGDLSPLCLN SKNGTVDGTS
510 520 530 540 550
ENTEDGLDRK DSKQPRKKRG RYRQYDHEIM EEAIAMVMSG KMSVSKAQGI
560 570 580 590 600
YGVPHSTLEY KVKERSGTLK TPPKKKLRLP DTGLYNMTDS GTGSCKNSSK

PV
Length:602
Mass (Da):66,964
Last modified:November 13, 2007 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i05245F999E5A61D7
GO
Isoform 2 (identifier: Q8N3X6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-389: Missing.

Show »
Length:213
Mass (Da):23,504
Checksum:iF466768931A99290
GO
Isoform 3 (identifier: Q8N3X6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     260-318: RLHRNREDYV...LLHLEALPAG → MLQVKTDEKL...HNQNLKSEEK
     319-602: Missing.

Show »
Length:318
Mass (Da):35,408
Checksum:iA793EDAC37D7BEA7
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JI46C9JI46_HUMAN
Ligand-dependent nuclear receptor c...
LCORL MLR1, hCG_1660774
518Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1B0GVP4A0A1B0GVP4_HUMAN
Ligand-dependent nuclear receptor c...
LCORL
1,871Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RA10D6RA10_HUMAN
Ligand-dependent nuclear receptor c...
LCORL
79Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1B0GWC6A0A1B0GWC6_HUMAN
Ligand-dependent nuclear receptor c...
LCORL
77Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti407N → S in BAB70892 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0292871 – 389Missing in isoform 2. 1 PublicationAdd BLAST389
Alternative sequenceiVSP_029288260 – 318RLHRN…ALPAG → MLQVKTDEKLNVSDENTASC PLSPIKMCLNRPIEWNLNLT TASLTSCTVHNQNLKSEEK in isoform 3. 1 PublicationAdd BLAST59
Alternative sequenceiVSP_029289319 – 602Missing in isoform 3. 1 PublicationAdd BLAST284

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK055258 mRNA Translation: BAB70892.1
AC005768 Genomic DNA No translation available.
AC079399 Genomic DNA No translation available.
CH471069 Genomic DNA Translation: EAW92786.1
BC037322 mRNA Translation: AAH37322.3

The Consensus CDS (CCDS) project

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CCDSi
CCDS3425.1 [Q8N3X6-3]
CCDS54749.1 [Q8N3X6-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001159611.1, NM_001166139.2 [Q8N3X6-1]
NP_710153.2, NM_153686.8 [Q8N3X6-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000326877; ENSP00000317566; ENSG00000178177 [Q8N3X6-3]
ENST00000382226; ENSP00000371661; ENSG00000178177 [Q8N3X6-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
254251

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:254251

UCSC genome browser

More...
UCSCi
uc003gpq.4 human [Q8N3X6-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055258 mRNA Translation: BAB70892.1
AC005768 Genomic DNA No translation available.
AC079399 Genomic DNA No translation available.
CH471069 Genomic DNA Translation: EAW92786.1
BC037322 mRNA Translation: AAH37322.3
CCDSiCCDS3425.1 [Q8N3X6-3]
CCDS54749.1 [Q8N3X6-1]
RefSeqiNP_001159611.1, NM_001166139.2 [Q8N3X6-1]
NP_710153.2, NM_153686.8 [Q8N3X6-3]

3D structure databases

SMRiQ8N3X6
ModBaseiSearch...

Protein-protein interaction databases

BioGridi129025, 6 interactors
IntActiQ8N3X6, 3 interactors
MINTiQ8N3X6
STRINGi9606.ENSP00000371661

PTM databases

GlyConnecti2054
iPTMnetiQ8N3X6
PhosphoSitePlusiQ8N3X6

Polymorphism and mutation databases

BioMutaiLCORL
DMDMi160395582

Proteomic databases

EPDiQ8N3X6
jPOSTiQ8N3X6
MassIVEiQ8N3X6
MaxQBiQ8N3X6
PaxDbiQ8N3X6
PeptideAtlasiQ8N3X6
PRIDEiQ8N3X6
ProteomicsDBi71844 [Q8N3X6-1]
71845 [Q8N3X6-2]
71846 [Q8N3X6-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
23115 131 antibodies

The DNASU plasmid repository

More...
DNASUi
254251

Genome annotation databases

EnsembliENST00000326877; ENSP00000317566; ENSG00000178177 [Q8N3X6-3]
ENST00000382226; ENSP00000371661; ENSG00000178177 [Q8N3X6-1]
GeneIDi254251
KEGGihsa:254251
UCSCiuc003gpq.4 human [Q8N3X6-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
254251
DisGeNETi254251

GeneCards: human genes, protein and diseases

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GeneCardsi
LCORL
HGNCiHGNC:30776 LCORL
HPAiENSG00000178177 Low tissue specificity
MIMi611799 gene
neXtProtiNX_Q8N3X6
OpenTargetsiENSG00000178177
PharmGKBiPA145148507

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG4565 Eukaryota
ENOG4111GCI LUCA
GeneTreeiENSGT00940000162414
HOGENOMiCLU_076618_1_0_1
InParanoidiQ8N3X6
OMAiFNMTDSG
OrthoDBi47456at2759
PhylomeDBiQ8N3X6
TreeFamiTF319589

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
LCORL human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
254251
PharosiQ8N3X6 Tbio

Protein Ontology

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PROi
PR:Q8N3X6
RNActiQ8N3X6 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000178177 Expressed in buccal mucosa cell and 198 other tissues
ExpressionAtlasiQ8N3X6 baseline and differential
GenevisibleiQ8N3X6 HS

Family and domain databases

InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR007889 HTH_Psq
PfamiView protein in Pfam
PF05225 HTH_psq, 2 hits
SUPFAMiSSF46689 SSF46689, 2 hits
PROSITEiView protein in PROSITE
PS50960 HTH_PSQ, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLCORL_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8N3X6
Secondary accession number(s): Q96NK1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: November 13, 2007
Last modified: April 22, 2020
This is version 136 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
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