UniProtKB - Q8N3X1 (FNBP4_HUMAN)
Protein
Formin-binding protein 4
Gene
FNBP4
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Recommended name: Formin-binding protein 4Alternative name(s): Formin-binding protein 30 |
Gene namesi | Name:FNBP4 Synonyms:FBP30, KIAA1014 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:19752, FNBP4 |
MIMi | 615265, gene |
neXtProti | NX_Q8N3X1 |
VEuPathDBi | HostDB:ENSG00000109920.12 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 23360 |
OpenTargetsi | ENSG00000109920 |
PharmGKBi | PA134971679 |
Miscellaneous databases
Pharosi | Q8N3X1, Tdark |
Genetic variation databases
BioMutai | FNBP4 |
DMDMi | 313104235 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000289863 | 1 – 1017 | Formin-binding protein 4Add BLAST | 1017 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 18 | PhosphoserineCombined sources | 1 | |
Modified residuei | 116 | PhosphoserineCombined sources | 1 | |
Modified residuei | 124 | PhosphoserineBy similarity | 1 | |
Modified residuei | 172 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 290 | N6-acetyllysineBy similarity | 1 | |
Cross-linki | 301 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)Combined sources | ||
Cross-linki | 335 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 348 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources | ||
Cross-linki | 348 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources | ||
Modified residuei | 427 | PhosphoserineBy similarity | 1 | |
Modified residuei | 432 | PhosphoserineCombined sources | 1 | |
Modified residuei | 435 | PhosphoserineCombined sources | 1 | |
Modified residuei | 438 | PhosphoserineBy similarity | 1 | |
Modified residuei | 442 | PhosphoserineBy similarity | 1 | |
Modified residuei | 464 | PhosphoserineCombined sources | 1 | |
Modified residuei | 479 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 499 | PhosphoserineCombined sources | 1 | |
Modified residuei | 508 | PhosphoserineCombined sources | 1 | |
Modified residuei | 516 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 517 | PhosphothreonineCombined sources | 1 | |
Cross-linki | 519 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources | ||
Cross-linki | 519 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources | ||
Modified residuei | 963 | PhosphoserineCombined sources | 1 | |
Modified residuei | 964 | PhosphoserineCombined sources | 1 | |
Modified residuei | 965 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q8N3X1 |
jPOSTi | Q8N3X1 |
MassIVEi | Q8N3X1 |
MaxQBi | Q8N3X1 |
PaxDbi | Q8N3X1 |
PeptideAtlasi | Q8N3X1 |
PRIDEi | Q8N3X1 |
ProteomicsDBi | 71841 [Q8N3X1-1] 71842 [Q8N3X1-2] |
PTM databases
GlyGeni | Q8N3X1, 3 sites, 1 O-linked glycan (3 sites) |
iPTMneti | Q8N3X1 |
MetOSitei | Q8N3X1 |
PhosphoSitePlusi | Q8N3X1 |
Expressioni
Tissue specificityi
Highly expressed in the eye.1 Publication
Gene expression databases
Bgeei | ENSG00000109920, Expressed in left lobe of thyroid gland and 237 other tissues |
ExpressionAtlasi | Q8N3X1, baseline and differential |
Genevisiblei | Q8N3X1, HS |
Organism-specific databases
HPAi | ENSG00000109920, Low tissue specificity |
Interactioni
Subunit structurei
Binds FMN1.
Interacts with the Arg/Gly-rich-flanked Pro-rich of KHDRBS1/SAM68. Arginine methylation in these regions has no effect on this binding.
1 PublicationBinary interactionsi
Q8N3X1
With | #Exp. | IntAct |
---|---|---|
HTT [P42858] | 6 | EBI-310600,EBI-466029 |
Protein-protein interaction databases
BioGRIDi | 116941, 28 interactors |
DIPi | DIP-31674N |
IntActi | Q8N3X1, 11 interactors |
MINTi | Q8N3X1 |
STRINGi | 9606.ENSP00000263773 |
Miscellaneous databases
RNActi | Q8N3X1, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 214 – 248 | WW 1PROSITE-ProRule annotationAdd BLAST | 35 | |
Domaini | 595 – 629 | WW 2PROSITE-ProRule annotationAdd BLAST | 35 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 630 – 635 | Poly-Glu | 6 | |
Compositional biasi | 701 – 731 | Pro-richAdd BLAST | 31 | |
Compositional biasi | 905 – 925 | Pro-richAdd BLAST | 21 |
Domaini
These WW domains interact with Arg/Gly-rich-flanked Pro-rich domains found in several WW domain-binding proteins (WBPs). The N-terminal WW domain has the greater ligand-binding ability (By similarity).By similarity
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | ENOG502QTDD, Eukaryota |
GeneTreei | ENSGT00390000003450 |
HOGENOMi | CLU_015402_0_0_1 |
InParanoidi | Q8N3X1 |
OMAi | SGCYYYW |
OrthoDBi | 472232at2759 |
PhylomeDBi | Q8N3X1 |
TreeFami | TF331046 |
Family and domain databases
CDDi | cd00201, WW, 2 hits |
InterProi | View protein in InterPro IPR001202, WW_dom IPR036020, WW_dom_sf |
Pfami | View protein in Pfam PF00397, WW, 2 hits |
SMARTi | View protein in SMART SM00456, WW, 2 hits |
SUPFAMi | SSF51045, SSF51045, 2 hits |
PROSITEi | View protein in PROSITE PS01159, WW_DOMAIN_1, 1 hit PS50020, WW_DOMAIN_2, 2 hits |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: Q8N3X1-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MGKKSRAVPG RRPILQLSPP GPRGSTPGRD PEPEPDTEPD STAAVPSQPA
60 70 80 90 100
PSAATTTTTA VTAAAASDDS PSEDEQEAVQ EVPRVVQNPP KPVMTTRPTA
110 120 130 140 150
VKATGGLCLL GAYADSDDDD NDVSEKLAQS KETNGNQSTD IDSTLANFLA
160 170 180 190 200
EIDAITAPQP AAPVGASAPP PTPPRPEPKE AATSTLSSST SNGTDSTQTS
210 220 230 240 250
GWQYDTQCSL AGVGIEMGDW QEVWDENTGC YYYWNTQTNE VTWELPQYLA
260 270 280 290 300
TQVQGLQHYQ PSSVPGAETS FVVNTDIYSK EKTISVSSSK SGPVIAKREV
310 320 330 340 350
KKEVNEGIQA LSNSEEEKKG VAASLLAPLL PEGIKEEEER WRRKVICKEE
360 370 380 390 400
PVSEVKETST TVEEATTIVK PQEIMLDNIE DPSQEDLCSV VQSGESEEEE
410 420 430 440 450
EQDTLELELV LERKKAELRA LEEGDGSVSG SSPRSDISQP ASQDGMRRLM
460 470 480 490 500
SKRGKWKMFV RATSPESTSR SSSKTGRDTP ENGETAIGAE NSEKIDENSD
510 520 530 540 550
KEMEVEESPE KIKVQTTPKV EEEQDLKFQI GELANTLTSK FEFLGINRQS
560 570 580 590 600
ISNFHVLLLQ TETRIADWRE GALNGNYLKR KLQDAAEQLK QYEINATPKG
610 620 630 640 650
WSCHWDRDHR RYFYVNEQSG ESQWEFPDGE EEEEESQAQE NRDETLAKQT
660 670 680 690 700
LKDKTGTDSN STESSETSTG SLCKESFSGQ VSSSSLMPLT PFWTLLQSNV
710 720 730 740 750
PVLQPPLPLE MPPPPPPPPE SPPPPPPPPP PAEDGEIQEV EMEDEGSEEP
760 770 780 790 800
PAPGTEEDTP LKPSAQTTVV TSQSSVDSTI SSSSSTKGIK RKATEISTAV
810 820 830 840 850
VQRSATIGSS PVLYSQSAIA TGHQAAGIGN QATGIGHQTI PVSLPAAGMG
860 870 880 890 900
HQARGMSLQS NYLGLAAAPA IMSYAECSVP IGVTAPSLQP VQARGAVPTA
910 920 930 940 950
TIIEPPPPPP PPPPPPPPAP KMPPPEKTKK GRKDKAKKSK TKMPSLVKKW
960 970 980 990 1000
QSIQRELDEE DNSSSSEEDR ESTAQKRIEE WKQQQLVSGM AERNANFEAL
1010
PEDWRARLKR RKMAPNT
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketF5GXL1 | F5GXL1_HUMAN | Formin-binding protein 4 | FNBP4 | 143 | Annotation score: |
Sequence cautioni
The sequence BAA76858 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 55 – 56 | Missing in BAA76858 (PubMed:10231032).Curated | 2 | |
Sequence conflicti | 55 – 56 | Missing in AAH37404 (PubMed:15489334).Curated | 2 | |
Sequence conflicti | 55 – 56 | Missing in CAB70761 (PubMed:17974005).Curated | 2 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_032623 | 125 | E → G. Corresponds to variant dbSNP:rs34962598EnsemblClinVar. | 1 | |
Natural variantiVAR_075345 | 228 | T → M Rare variant found in a patient with microphthalmia with limb anomalies; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs780064080EnsemblClinVar. | 1 | |
Natural variantiVAR_032624 | 794 | T → A. Corresponds to variant dbSNP:rs35040940EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_040292 | 73 | E → EGK in isoform 2. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB023231 mRNA Translation: BAA76858.2 Different initiation. AC021443 Genomic DNA No translation available. BC037404 mRNA Translation: AAH37404.1 AL137480 mRNA Translation: CAB70761.1 AK022987 mRNA Translation: BAB14348.1 |
CCDSi | CCDS41644.1 [Q8N3X1-1] |
PIRi | T46422 |
RefSeqi | NP_001305268.1, NM_001318339.1 [Q8N3X1-2] NP_056123.2, NM_015308.3 [Q8N3X1-1] |
Genome annotation databases
Ensembli | ENST00000263773; ENSP00000263773; ENSG00000109920 [Q8N3X1-1] ENST00000646180; ENSP00000494562; ENSG00000285182 [Q8N3X1-1] |
GeneIDi | 23360 |
KEGGi | hsa:23360 |
UCSCi | uc009ylv.4, human [Q8N3X1-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB023231 mRNA Translation: BAA76858.2 Different initiation. AC021443 Genomic DNA No translation available. BC037404 mRNA Translation: AAH37404.1 AL137480 mRNA Translation: CAB70761.1 AK022987 mRNA Translation: BAB14348.1 |
CCDSi | CCDS41644.1 [Q8N3X1-1] |
PIRi | T46422 |
RefSeqi | NP_001305268.1, NM_001318339.1 [Q8N3X1-2] NP_056123.2, NM_015308.3 [Q8N3X1-1] |
3D structure databases
SMRi | Q8N3X1 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 116941, 28 interactors |
DIPi | DIP-31674N |
IntActi | Q8N3X1, 11 interactors |
MINTi | Q8N3X1 |
STRINGi | 9606.ENSP00000263773 |
PTM databases
GlyGeni | Q8N3X1, 3 sites, 1 O-linked glycan (3 sites) |
iPTMneti | Q8N3X1 |
MetOSitei | Q8N3X1 |
PhosphoSitePlusi | Q8N3X1 |
Genetic variation databases
BioMutai | FNBP4 |
DMDMi | 313104235 |
Proteomic databases
EPDi | Q8N3X1 |
jPOSTi | Q8N3X1 |
MassIVEi | Q8N3X1 |
MaxQBi | Q8N3X1 |
PaxDbi | Q8N3X1 |
PeptideAtlasi | Q8N3X1 |
PRIDEi | Q8N3X1 |
ProteomicsDBi | 71841 [Q8N3X1-1] 71842 [Q8N3X1-2] |
Protocols and materials databases
Antibodypediai | 26877, 45 antibodies |
DNASUi | 23360 |
Genome annotation databases
Ensembli | ENST00000263773; ENSP00000263773; ENSG00000109920 [Q8N3X1-1] ENST00000646180; ENSP00000494562; ENSG00000285182 [Q8N3X1-1] |
GeneIDi | 23360 |
KEGGi | hsa:23360 |
UCSCi | uc009ylv.4, human [Q8N3X1-1] |
Organism-specific databases
CTDi | 23360 |
DisGeNETi | 23360 |
GeneCardsi | FNBP4 |
HGNCi | HGNC:19752, FNBP4 |
HPAi | ENSG00000109920, Low tissue specificity |
MIMi | 615265, gene |
neXtProti | NX_Q8N3X1 |
OpenTargetsi | ENSG00000109920 |
PharmGKBi | PA134971679 |
VEuPathDBi | HostDB:ENSG00000109920.12 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QTDD, Eukaryota |
GeneTreei | ENSGT00390000003450 |
HOGENOMi | CLU_015402_0_0_1 |
InParanoidi | Q8N3X1 |
OMAi | SGCYYYW |
OrthoDBi | 472232at2759 |
PhylomeDBi | Q8N3X1 |
TreeFami | TF331046 |
Enzyme and pathway databases
PathwayCommonsi | Q8N3X1 |
SignaLinki | Q8N3X1 |
Miscellaneous databases
BioGRID-ORCSi | 23360, 361 hits in 1002 CRISPR screens |
ChiTaRSi | FNBP4, human |
GeneWikii | FNBP4 |
GenomeRNAii | 23360 |
Pharosi | Q8N3X1, Tdark |
PROi | PR:Q8N3X1 |
RNActi | Q8N3X1, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000109920, Expressed in left lobe of thyroid gland and 237 other tissues |
ExpressionAtlasi | Q8N3X1, baseline and differential |
Genevisiblei | Q8N3X1, HS |
Family and domain databases
CDDi | cd00201, WW, 2 hits |
InterProi | View protein in InterPro IPR001202, WW_dom IPR036020, WW_dom_sf |
Pfami | View protein in Pfam PF00397, WW, 2 hits |
SMARTi | View protein in SMART SM00456, WW, 2 hits |
SUPFAMi | SSF51045, SSF51045, 2 hits |
PROSITEi | View protein in PROSITE PS01159, WW_DOMAIN_1, 1 hit PS50020, WW_DOMAIN_2, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | FNBP4_HUMAN | |
Accessioni | Q8N3X1Primary (citable) accession number: Q8N3X1 Secondary accession number(s): Q9H985, Q9NT81, Q9Y2L7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 29, 2007 |
Last sequence update: | November 30, 2010 | |
Last modified: | April 7, 2021 | |
This is version 148 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot