UniProtKB - Q8N3X1 (FNBP4_HUMAN)

BLAST

>sp|Q8N3X1|FNBP4_HUMAN Formin-binding protein 4 OS=Homo sapiens OX=9606 GN=FNBP4 PE=1 SV=3
MGKKSRAVPGRRPILQLSPPGPRGSTPGRDPEPEPDTEPDSTAAVPSQPAPSAATTTTTA
VTAAAASDDSPSEDEQEAVQEVPRVVQNPPKPVMTTRPTAVKATGGLCLLGAYADSDDDD
NDVSEKLAQSKETNGNQSTDIDSTLANFLAEIDAITAPQPAAPVGASAPPPTPPRPEPKE
AATSTLSSSTSNGTDSTQTSGWQYDTQCSLAGVGIEMGDWQEVWDENTGCYYYWNTQTNE
VTWELPQYLATQVQGLQHYQPSSVPGAETSFVVNTDIYSKEKTISVSSSKSGPVIAKREV
KKEVNEGIQALSNSEEEKKGVAASLLAPLLPEGIKEEEERWRRKVICKEEPVSEVKETST
TVEEATTIVKPQEIMLDNIEDPSQEDLCSVVQSGESEEEEEQDTLELELVLERKKAELRA
LEEGDGSVSGSSPRSDISQPASQDGMRRLMSKRGKWKMFVRATSPESTSRSSSKTGRDTP
ENGETAIGAENSEKIDENSDKEMEVEESPEKIKVQTTPKVEEEQDLKFQIGELANTLTSK
FEFLGINRQSISNFHVLLLQTETRIADWREGALNGNYLKRKLQDAAEQLKQYEINATPKG
WSCHWDRDHRRYFYVNEQSGESQWEFPDGEEEEEESQAQENRDETLAKQTLKDKTGTDSN
STESSETSTGSLCKESFSGQVSSSSLMPLTPFWTLLQSNVPVLQPPLPLEMPPPPPPPPE
SPPPPPPPPPPAEDGEIQEVEMEDEGSEEPPAPGTEEDTPLKPSAQTTVVTSQSSVDSTI
SSSSSTKGIKRKATEISTAVVQRSATIGSSPVLYSQSAIATGHQAAGIGNQATGIGHQTI
PVSLPAAGMGHQARGMSLQSNYLGLAAAPAIMSYAECSVPIGVTAPSLQPVQARGAVPTA
TIIEPPPPPPPPPPPPPPAPKMPPPEKTKKGRKDKAKKSKTKMPSLVKKWQSIQRELDEE
DNSSSSEEDRESTAQKRIEEWKQQQLVSGMAERNANFEALPEDWRARLKRRKMAPNT

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History
Entry version 134 (07 Nov 2018)
Sequence version 3 (30 Nov 2010)
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Protein

Formin-binding protein 4

Gene

FNBP4

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Enzyme and pathway databases

SignaLinkⁱ	Q8N3X1

SignaLinkⁱ

Q8N3X1

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Formin-binding protein 4 Alternative name(s): Formin-binding protein 30
Gene namesⁱ	Name:FNBP4 Synonyms:FBP30, KIAA1014
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 11

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000109920.12
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:19752 FNBP4
MIMⁱ	615265 gene
neXtProtⁱ	NX_Q8N3X1

Subcellular locationⁱ

GO - Cellular component

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000109920
PharmGKBⁱ	PA134971679

Polymorphism and mutation databases

BioMutaⁱ	FNBP4
DMDMⁱ	313104235

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000289863	1 – 1017	Formin-binding protein 4Add BLAST		1017

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	18	PhosphoserineCombined sources	1
Modified residueⁱ	116	PhosphoserineCombined sources	1
Modified residueⁱ	124	PhosphoserineBy similarity	1
Modified residueⁱ	172	PhosphothreonineCombined sources	1
Modified residueⁱ	290	N6-acetyllysineBy similarity	1
Cross-linkⁱ	301	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)Combined sources
Cross-linkⁱ	335	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	348	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Cross-linkⁱ	348	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residueⁱ	427	PhosphoserineBy similarity	1
Modified residueⁱ	432	PhosphoserineCombined sources	1
Modified residueⁱ	435	PhosphoserineCombined sources	1
Modified residueⁱ	438	PhosphoserineBy similarity	1
Modified residueⁱ	442	PhosphoserineBy similarity	1
Modified residueⁱ	464	PhosphoserineCombined sources	1
Modified residueⁱ	479	PhosphothreonineCombined sources	1
Modified residueⁱ	499	PhosphoserineCombined sources	1
Modified residueⁱ	508	PhosphoserineCombined sources	1
Modified residueⁱ	516	PhosphothreonineCombined sources	1
Modified residueⁱ	517	PhosphothreonineCombined sources	1
Cross-linkⁱ	519	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Cross-linkⁱ	519	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residueⁱ	963	PhosphoserineCombined sources	1
Modified residueⁱ	964	PhosphoserineCombined sources	1
Modified residueⁱ	965	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	Q8N3X1
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q8N3X1
PaxDbⁱ	Q8N3X1
PeptideAtlas More...PeptideAtlasⁱ	Q8N3X1
PRIDEⁱ	Q8N3X1
ProteomicsDBⁱ	71841 71842 [Q8N3X1-2]

PTM databases

iPTMnetⁱ	Q8N3X1
PhosphoSitePlusⁱ	Q8N3X1

Miscellaneous databases

PMAP-CutDBⁱ	Q8N3X1

PMAP-CutDBⁱ

Q8N3X1

Expressionⁱ

Tissue specificityⁱ

Highly expressed in the eye.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000109920 Expressed in 226 organ(s), highest expression level in left lobe of thyroid gland
CleanExⁱ	HS_FNBP4
ExpressionAtlasⁱ	Q8N3X1 baseline and differential
Genevisibleⁱ	Q8N3X1 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA039485 HPA040029

HPAⁱ

HPA039485
HPA040029

Interactionⁱ

Subunit structureⁱ

Binds FMN1. Interacts with the Arg/Gly-rich-flanked Pro-rich of KHDRBS1/SAM68. Arginine methylation in these regions has no effect on this binding.1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
HTT	P42858	6	EBI-310600,EBI-466029

With

Entry

#Exp.

IntAct

Notes

HTT

P42858

EBI-310600,EBI-466029

Protein-protein interaction databases

BioGridⁱ	116941, 19 interactors
Database of interacting proteins More...DIPⁱ	DIP-31674N
IntActⁱ	Q8N3X1, 8 interactors
Molecular INTeraction database More...MINTⁱ	Q8N3X1
STRINGⁱ	9606.ENSP00000263773

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8N3X1
SMRⁱ	Q8N3X1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	214 – 248	WW 1PROSITE-ProRule annotationAdd BLAST		35
Domainⁱ	595 – 629	WW 2PROSITE-ProRule annotationAdd BLAST		35

Compositional bias

Feature key	Position(s)	DescriptionActions	Length
Compositional biasⁱ	630 – 635	Poly-Glu	6
Compositional biasⁱ	701 – 731	Pro-richAdd BLAST	31
Compositional biasⁱ	905 – 925	Pro-richAdd BLAST	21

Domainⁱ

These WW domains interact with Arg/Gly-rich-flanked Pro-rich domains found in several WW domain-binding proteins (WBPs). The N-terminal WW domain has the greater ligand-binding ability (By similarity).By similarity

Keywords - Domainⁱ

Repeat

Phylogenomic databases

eggNOGⁱ	ENOG410IIQY Eukaryota ENOG4111F8J LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000003450
HOGENOMⁱ	HOG000168238
HOVERGENⁱ	HBG066308
InParanoidⁱ	Q8N3X1
OMAⁱ	VEMGDWQ
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0KMM
PhylomeDBⁱ	Q8N3X1
TreeFamⁱ	TF331046

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00201 WW, 2 hits
InterProⁱ	View protein in InterPro IPR001202 WW_dom IPR036020 WW_dom_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00397 WW, 2 hits
SMARTⁱ	View protein in SMART SM00456 WW, 2 hits
SUPFAMⁱ	SSF51045 SSF51045, 2 hits
PROSITEⁱ	View protein in PROSITE PS01159 WW_DOMAIN_1, 1 hit PS50020 WW_DOMAIN_2, 2 hits

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform 1 (identifier: Q8N3X1-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGKKSRAVPG RRPILQLSPP GPRGSTPGRD PEPEPDTEPD STAAVPSQPA 
        60         70         80         90        100
PSAATTTTTA VTAAAASDDS PSEDEQEAVQ EVPRVVQNPP KPVMTTRPTA 
       110        120        130        140        150
VKATGGLCLL GAYADSDDDD NDVSEKLAQS KETNGNQSTD IDSTLANFLA 
       160        170        180        190        200
EIDAITAPQP AAPVGASAPP PTPPRPEPKE AATSTLSSST SNGTDSTQTS 
       210        220        230        240        250
GWQYDTQCSL AGVGIEMGDW QEVWDENTGC YYYWNTQTNE VTWELPQYLA 
       260        270        280        290        300
TQVQGLQHYQ PSSVPGAETS FVVNTDIYSK EKTISVSSSK SGPVIAKREV 
       310        320        330        340        350
KKEVNEGIQA LSNSEEEKKG VAASLLAPLL PEGIKEEEER WRRKVICKEE 
       360        370        380        390        400
PVSEVKETST TVEEATTIVK PQEIMLDNIE DPSQEDLCSV VQSGESEEEE 
       410        420        430        440        450
EQDTLELELV LERKKAELRA LEEGDGSVSG SSPRSDISQP ASQDGMRRLM 
       460        470        480        490        500
SKRGKWKMFV RATSPESTSR SSSKTGRDTP ENGETAIGAE NSEKIDENSD 
       510        520        530        540        550
KEMEVEESPE KIKVQTTPKV EEEQDLKFQI GELANTLTSK FEFLGINRQS 
       560        570        580        590        600
ISNFHVLLLQ TETRIADWRE GALNGNYLKR KLQDAAEQLK QYEINATPKG 
       610        620        630        640        650
WSCHWDRDHR RYFYVNEQSG ESQWEFPDGE EEEEESQAQE NRDETLAKQT 
       660        670        680        690        700
LKDKTGTDSN STESSETSTG SLCKESFSGQ VSSSSLMPLT PFWTLLQSNV 
       710        720        730        740        750
PVLQPPLPLE MPPPPPPPPE SPPPPPPPPP PAEDGEIQEV EMEDEGSEEP 
       760        770        780        790        800
PAPGTEEDTP LKPSAQTTVV TSQSSVDSTI SSSSSTKGIK RKATEISTAV 
       810        820        830        840        850
VQRSATIGSS PVLYSQSAIA TGHQAAGIGN QATGIGHQTI PVSLPAAGMG 
       860        870        880        890        900
HQARGMSLQS NYLGLAAAPA IMSYAECSVP IGVTAPSLQP VQARGAVPTA 
       910        920        930        940        950
TIIEPPPPPP PPPPPPPPAP KMPPPEKTKK GRKDKAKKSK TKMPSLVKKW 
       960        970        980        990       1000
QSIQRELDEE DNSSSSEEDR ESTAQKRIEE WKQQQLVSGM AERNANFEAL 
      1010 
PEDWRARLKR RKMAPNT

Length:1,017

Mass (Da):110,266

Last modified:November 30, 2010 - v3

Checksum:ⁱ510DC8011B5973AD

Isoform 2 (identifier: Q8N3X1-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
73-73: E → EGK

« Hide

        10         20         30         40         50
MGKKSRAVPG RRPILQLSPP GPRGSTPGRD PEPEPDTEPD STAAVPSQPA 
        60         70         80         90        100
PSAATTTTTA VTAAAASDDS PSEGKDEQEA VQEVPRVVQN PPKPVMTTRP 
       110        120        130        140        150
TAVKATGGLC LLGAYADSDD DDNDVSEKLA QSKETNGNQS TDIDSTLANF 
       160        170        180        190        200
LAEIDAITAP QPAAPVGASA PPPTPPRPEP KEAATSTLSS STSNGTDSTQ 
       210        220        230        240        250
TSGWQYDTQC SLAGVGIEMG DWQEVWDENT GCYYYWNTQT NEVTWELPQY 
       260        270        280        290        300
LATQVQGLQH YQPSSVPGAE TSFVVNTDIY SKEKTISVSS SKSGPVIAKR 
       310        320        330        340        350
EVKKEVNEGI QALSNSEEEK KGVAASLLAP LLPEGIKEEE ERWRRKVICK 
       360        370        380        390        400
EEPVSEVKET STTVEEATTI VKPQEIMLDN IEDPSQEDLC SVVQSGESEE 
       410        420        430        440        450
EEEQDTLELE LVLERKKAEL RALEEGDGSV SGSSPRSDIS QPASQDGMRR 
       460        470        480        490        500
LMSKRGKWKM FVRATSPEST SRSSSKTGRD TPENGETAIG AENSEKIDEN 
       510        520        530        540        550
SDKEMEVEES PEKIKVQTTP KVEEEQDLKF QIGELANTLT SKFEFLGINR 
       560        570        580        590        600
QSISNFHVLL LQTETRIADW REGALNGNYL KRKLQDAAEQ LKQYEINATP 
       610        620        630        640        650
KGWSCHWDRD HRRYFYVNEQ SGESQWEFPD GEEEEEESQA QENRDETLAK 
       660        670        680        690        700
QTLKDKTGTD SNSTESSETS TGSLCKESFS GQVSSSSLMP LTPFWTLLQS 
       710        720        730        740        750
NVPVLQPPLP LEMPPPPPPP PESPPPPPPP PPPAEDGEIQ EVEMEDEGSE 
       760        770        780        790        800
EPPAPGTEED TPLKPSAQTT VVTSQSSVDS TISSSSSTKG IKRKATEIST 
       810        820        830        840        850
AVVQRSATIG SSPVLYSQSA IATGHQAAGI GNQATGIGHQ TIPVSLPAAG 
       860        870        880        890        900
MGHQARGMSL QSNYLGLAAA PAIMSYAECS VPIGVTAPSL QPVQARGAVP 
       910        920        930        940        950
TATIIEPPPP PPPPPPPPPP APKMPPPEKT KKGRKDKAKK SKTKMPSLVK 
       960        970        980        990       1000
KWQSIQRELD EEDNSSSSEE DRESTAQKRI EEWKQQQLVS GMAERNANFE 
      1010 
ALPEDWRARL KRRKMAPNT

Show »

Length:1,019

Mass (Da):110,451

Checksum:ⁱ2D60B6B14CC4CE16

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	F5GXL1	F5GXL1_HUMAN		Formin-binding protein 4 Formin-binding protein 4	FNBP4	143	Annotation score:

Sequence cautionⁱ

The sequence BAA76858 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	55 – 56	Missing in BAA76858 (PubMed:10231032).Curated	2
Sequence conflictⁱ	55 – 56	Missing in AAH37404 (PubMed:15489334).Curated	2
Sequence conflictⁱ	55 – 56	Missing in CAB70761 (PubMed:17974005).Curated	2

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_032623	125	E → G. Corresponds to variant dbSNP:rs34962598Ensembl.	1
Natural variantⁱVAR_075345	228	T → M Rare variant found in a patient with microphthalmia with limb anomalies; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs780064080EnsemblClinVar.	1
Natural variantⁱVAR_032624	794	T → A. Corresponds to variant dbSNP:rs35040940Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_040292	73	E → EGK in isoform 2. 1 Publication		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB023231 mRNA Translation: BAA76858.2 Different initiation. AC021443 Genomic DNA No translation available. BC037404 mRNA Translation: AAH37404.1 AL137480 mRNA Translation: CAB70761.1 AK022987 mRNA Translation: BAB14348.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS41644.1 [Q8N3X1-1]
PIRⁱ	T46422
NCBI Reference Sequences More...RefSeqⁱ	NP_001305268.1, NM_001318339.1 [Q8N3X1-2] NP_056123.2, NM_015308.3 [Q8N3X1-1]
UniGeneⁱ	Hs.6834

Genome annotation databases

Ensemblⁱ	ENST00000263773; ENSP00000263773; ENSG00000109920 [Q8N3X1-1] ENST00000646180; ENSP00000494562; ENSG00000285182 [Q8N3X1-1]
GeneIDⁱ	23360
KEGGⁱ	hsa:23360
UCSC genome browser More...UCSCⁱ	uc009ylv.4 human [Q8N3X1-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Protein	Similar proteins		Species	Score	Length	Source
Q8N3X1	Uncharacterized protein		RABIT		1075	UniRef90_Q8N3X1
Uncharacterized protein		ICTTR		1071
Uncharacterized protein		MUSPF		1028
Formin binding protein 4		CANLF		1022
Formin binding protein 4		CALJA		1021
+85

Protein	Similar proteins		Species	Score	Length	Source
Q8N3X1	Uncharacterized protein		RABIT		1075	UniRef50_Q8N3X1
Uncharacterized protein		ICTTR		1071
Uncharacterized protein		MUSPF		1028
Formin binding protein 4		CANLF		1022
Formin binding protein 4		CALJA		1021
+228

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB023231 mRNA Translation: BAA76858.2 Different initiation. AC021443 Genomic DNA No translation available. BC037404 mRNA Translation: AAH37404.1 AL137480 mRNA Translation: CAB70761.1 AK022987 mRNA Translation: BAB14348.1
CCDSⁱ	CCDS41644.1 [Q8N3X1-1]
PIRⁱ	T46422
RefSeqⁱ	NP_001305268.1, NM_001318339.1 [Q8N3X1-2] NP_056123.2, NM_015308.3 [Q8N3X1-1]
UniGeneⁱ	Hs.6834

3D structure databases

ProteinModelPortalⁱ	Q8N3X1
SMRⁱ	Q8N3X1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	116941, 19 interactors
DIPⁱ	DIP-31674N
IntActⁱ	Q8N3X1, 8 interactors
MINTⁱ	Q8N3X1
STRINGⁱ	9606.ENSP00000263773

PTM databases

iPTMnetⁱ	Q8N3X1
PhosphoSitePlusⁱ	Q8N3X1

Polymorphism and mutation databases

BioMutaⁱ	FNBP4
DMDMⁱ	313104235

Proteomic databases

EPDⁱ	Q8N3X1
MaxQBⁱ	Q8N3X1
PaxDbⁱ	Q8N3X1
PeptideAtlasⁱ	Q8N3X1
PRIDEⁱ	Q8N3X1
ProteomicsDBⁱ	71841 71842 [Q8N3X1-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	23360
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000263773; ENSP00000263773; ENSG00000109920 [Q8N3X1-1] ENST00000646180; ENSP00000494562; ENSG00000285182 [Q8N3X1-1]
GeneIDⁱ	23360
KEGGⁱ	hsa:23360
UCSCⁱ	uc009ylv.4 human [Q8N3X1-1]

Organism-specific databases

CTDⁱ	23360
EuPathDBⁱ	HostDB:ENSG00000109920.12
GeneCardsⁱ	FNBP4
H-InvDBⁱ	HIX0201592
HGNCⁱ	HGNC:19752 FNBP4
HPAⁱ	HPA039485 HPA040029
MIMⁱ	615265 gene
neXtProtⁱ	NX_Q8N3X1
OpenTargetsⁱ	ENSG00000109920
PharmGKBⁱ	PA134971679
HUGEⁱ	Search...
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IIQY Eukaryota ENOG4111F8J LUCA
GeneTreeⁱ	ENSGT00390000003450
HOGENOMⁱ	HOG000168238
HOVERGENⁱ	HBG066308
InParanoidⁱ	Q8N3X1
OMAⁱ	VEMGDWQ
OrthoDBⁱ	EOG091G0KMM
PhylomeDBⁱ	Q8N3X1
TreeFamⁱ	TF331046

Enzyme and pathway databases

SignaLinkⁱ	Q8N3X1

SignaLinkⁱ

Q8N3X1

Miscellaneous databases

ChiTaRSⁱ	FNBP4 human
GeneWikiⁱ	FNBP4
GenomeRNAiⁱ	23360
PMAP-CutDBⁱ	Q8N3X1
Protein Ontology More...PROⁱ	PR:Q8N3X1
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000109920 Expressed in 226 organ(s), highest expression level in left lobe of thyroid gland
CleanExⁱ	HS_FNBP4
ExpressionAtlasⁱ	Q8N3X1 baseline and differential
Genevisibleⁱ	Q8N3X1 HS

Family and domain databases

CDDⁱ	cd00201 WW, 2 hits
InterProⁱ	View protein in InterPro IPR001202 WW_dom IPR036020 WW_dom_sf
Pfamⁱ	View protein in Pfam PF00397 WW, 2 hits
SMARTⁱ	View protein in SMART SM00456 WW, 2 hits
SUPFAMⁱ	SSF51045 SSF51045, 2 hits
PROSITEⁱ	View protein in PROSITE PS01159 WW_DOMAIN_1, 1 hit PS50020 WW_DOMAIN_2, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	FNBP4_HUMAN
Accessionⁱ	Q8N3X1Primary (citable) accession number: Q8N3X1 Secondary accession number(s): Q9H985, Q9NT81, Q9Y2L7
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 29, 2007
	Last sequence update:	November 30, 2010
	Last modified:	November 7, 2018
	This is version 134 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM

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UniRef

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Supporting data

UniProtKB - Q8N3X1 (FNBP4_HUMAN)

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Formin-binding protein 4

FNBP4

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

Miscellaneous databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Compositional bias

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ