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Entry version 165 (02 Jun 2021)
Sequence version 2 (07 Jun 2004)
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Protein

Synaptopodin

Gene

SYNPO

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Actin-associated protein that may play a role in modulating actin-based shape and motility of dendritic spines and renal podocyte foot processes. Seems to be essential for the formation of spine apparatuses in spines of telencephalic neurons, which is involved in synaptic plasticity (By similarity).

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

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PathwayCommonsi
Q8N3V7

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Synaptopodin
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SYNPO
Synonyms:KIAA1029
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:30672, SYNPO

Online Mendelian Inheritance in Man (OMIM)

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MIMi
608155, gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q8N3V7

Eukaryotic Pathogen, Vector and Host Database Resources

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VEuPathDBi
HostDB:ENSG00000171992.12

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell junction, Cell projection, Cytoplasm, Cytoskeleton, Synapse, Tight junction

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
11346

Open Targets

More...
OpenTargetsi
ENSG00000171992

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134863299

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8N3V7, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
SYNPO

Domain mapping of disease mutations (DMDM)

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DMDMi
48428650

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001876701 – 929SynaptopodinAdd BLAST929

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei140PhosphoserineBy similarity1
Modified residuei207PhosphoserineBy similarity1
Modified residuei263PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi330N-linked (GlcNAc...) asparagine1 Publication1
Modified residuei501PhosphoserineBy similarity1
Modified residuei525PhosphoserineCombined sources1
Modified residuei560PhosphothreonineBy similarity1
Modified residuei580PhosphoserineCombined sources1
Modified residuei685PhosphoserineCombined sources1
Modified residuei702PhosphoserineCombined sources1
Modified residuei746PhosphothreonineCombined sources1
Modified residuei754PhosphoserineCombined sources1
Modified residuei758PhosphoserineBy similarity1
Modified residuei779PhosphoserineBy similarity1
Modified residuei783PhosphothreonineBy similarity1
Modified residuei833PhosphoserineCombined sources1
Modified residuei854PhosphoserineCombined sources1
Isoform 2 (identifier: Q8N3V7-2)
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei738PhosphoserineCombined sources1
Modified residuei784PhosphoserineCombined sources1
Modified residuei804PhosphoserineCombined sources1
Modified residuei812PhosphoserineCombined sources1
Modified residuei826PhosphoserineCombined sources1
Modified residuei854PhosphoserineCombined sources1
Modified residuei871PhosphoserineCombined sources1
Modified residuei894PhosphoserineCombined sources1
Isoform 3 (identifier: Q8N3V7-3)
Modified residuei1N-acetylmethionineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

O-glycosylated.By similarity

Keywords - PTMi

Acetylation, Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q8N3V7

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q8N3V7

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q8N3V7

MaxQB - The MaxQuant DataBase

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MaxQBi
Q8N3V7

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q8N3V7

PeptideAtlas

More...
PeptideAtlasi
Q8N3V7

PRoteomics IDEntifications database

More...
PRIDEi
Q8N3V7

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
71838 [Q8N3V7-1]
71839 [Q8N3V7-2]
71840 [Q8N3V7-3]

PTM databases

GlyConnect protein glycosylation platform

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GlyConnecti
2889, 1 O-Linked glycan (1 site)

GlyGen: Computational and Informatics Resources for Glycoscience

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GlyGeni
Q8N3V7, 1 site

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q8N3V7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q8N3V7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in cerebral cortex.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000171992, Expressed in metanephric glomerulus and 239 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q8N3V7, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000171992, Group enriched (heart muscle, placenta, skeletal muscle)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with BAIAP1.

Interacts with actin (By similarity).

Interacts (via PPxY motifs) with WWC1 (via WW domains).

By similarity2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
116474, 183 interactors

Protein interaction database and analysis system

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IntActi
Q8N3V7, 174 interactors

Molecular INTeraction database

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MINTi
Q8N3V7

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000377789

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

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RNActi
Q8N3V7, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 260DisorderedSequence analysisAdd BLAST260
Regioni285 – 389DisorderedSequence analysisAdd BLAST105
Regioni509 – 558DisorderedSequence analysisAdd BLAST50
Regioni589 – 610DisorderedSequence analysisAdd BLAST22
Regioni630 – 726DisorderedSequence analysisAdd BLAST97
Regioni740 – 763DisorderedSequence analysisAdd BLAST24
Regioni826 – 916DisorderedSequence analysisAdd BLAST91

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi562 – 565PPxY motif4
Motifi581 – 584PPxY motif4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 16Pro residuesSequence analysisAdd BLAST16
Compositional biasi154 – 179Polar residuesSequence analysisAdd BLAST26
Compositional biasi186 – 204Polar residuesSequence analysisAdd BLAST19
Compositional biasi312 – 383Polar residuesSequence analysisAdd BLAST72
Compositional biasi643 – 660Basic and acidic residuesSequence analysisAdd BLAST18
Compositional biasi747 – 763Polar residuesSequence analysisAdd BLAST17
Compositional biasi863 – 880Polar residuesSequence analysisAdd BLAST18

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the synaptopodin family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502R7RM, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00950000183054

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_013103_0_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q8N3V7

Identification of Orthologs from Complete Genome Data

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OMAi
CAGGQPQ

Database of Orthologous Groups

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OrthoDBi
691538at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q8N3V7

TreeFam database of animal gene trees

More...
TreeFami
TF330867

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR028753, Synpo

The PANTHER Classification System

More...
PANTHERi
PTHR24217:SF13, PTHR24217:SF13, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8N3V7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLGPHLPPPP LAPSEGRPTP CAFQIPDGSY RCLALEAEES SGEEGLQGEV
60 70 80 90 100
GPTDLEEDEG VSRSGDDSAC RVTQGTPQLP KALGIQPPSC SREEQGASQH
110 120 130 140 150
DDRASQDWDV VKAGQMMTAS PSPGPGPRVA QKPALGRSTS LTEKDLKEAK
160 170 180 190 200
ARSQQIAAQL TTPPSSNSRG VQLFNRRRQR VNEFTLESHG QRGQKPSQES
210 220 230 240 250
LRVLPSSLPG HAPGLSLSST SLPEPGPPRH PSPQSPDRGV PGHSMEGYSE
260 270 280 290 300
EASLLRHLEK VASEEEEVPL VVYLKENAAL LTANGLHLSQ NREAQQSSPA
310 320 330 340 350
PPPAEVHSPA ADVNQNLASP SATLTTPTSN SSHNPPATDV NQNPPATVVP
360 370 380 390 400
QSLPLSSIQQ NSSEAQLPSN GTGPASKPST LCADGQPQAP AEEVRCSTLL
410 420 430 440 450
IDKVSTPATT TSTFSREATL IPSSRPPASD FMSSSLLIDI QPNTLVVSAD
460 470 480 490 500
QEMSGRAAAT TPTKVYSEVH FTLAKPPSVV NRTARPFGIQ APGGTSQMER
510 520 530 540 550
SPMLERRHFG EKAPAPQPPS LPDRSPRPQR HIMSRSPMVE RRMMGQRSPA
560 570 580 590 600
SERRPLGNFT APPTYTETLS TAPLASWVRS PPSYSVLYPS SDPKSSHLKG
610 620 630 640 650
QAVPASKTGI LEESMARRGS RKSMFTFVEK PKVTPNPDLL DLVQTADEKR
660 670 680 690 700
RQRDQGEVGV EEEPFALGAE ASNFQQEPAP RDRASPAAAE EVVPEWASCL
710 720 730 740 750
KSPRIQAKPK PKPNQNLSEA SGKGAELYAR RQSRMEKYVI ESSSHTPELA
760 770 780 790 800
RCPSPTMSLP SSWKYPTNAP GAFRVASRSP ARTPPASLYH GYLPENGVLR
810 820 830 840 850
PEPTKQPPYQ LRPSLFVLSP IKEPAKVSPR AASPAKPSSL DLVPNLPKGA
860 870 880 890 900
LPPSPALPRP SRSSPGLYTS PGQDSLQPTA VSPPYGGDIS PVSPSRAWSP
910 920
RAKQAPRPSF STRNAGIEAQ VWKPSFCFK
Length:929
Mass (Da):99,463
Last modified:June 7, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i38723B6FDD046F15
GO
Isoform 2 (identifier: Q8N3V7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-244: Missing.
     921-929: VWKPSFCFK → DRRESLPTSP...SLPAEASCTT

Show »
Length:903
Mass (Da):96,397
Checksum:i5F0C0A39635750E4
GO
Isoform 3 (identifier: Q8N3V7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-244: Missing.

Show »
Length:685
Mass (Da):73,667
Checksum:iBE102B27B2C0BCC8
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA82981 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti95Q → R in CAD38532 (PubMed:17974005).Curated1
Sequence conflicti417E → G (PubMed:14702039).Curated1
Sequence conflicti428A → V in CAA71955 (PubMed:9314539).Curated1
Sequence conflicti744S → G in CAA71955 (PubMed:9314539).Curated1
Sequence conflicti836K → R (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0104761 – 244Missing in isoform 2 and isoform 3. 5 PublicationsAdd BLAST244
Alternative sequenceiVSP_010477921 – 929VWKPSFCFK → DRRESLPTSPPWTPGASRPP SSLDGWVSPGPWEPGRGSSM SSPPPLPPPPPMSPSWSERS VSPLRPETEARPPSRQLQAL LARNIINAARRKSASPRSAG AENPRPFSPPRAPPPPPPPP PPPPRMRSPQPARPGSAAVP GAAFAPIPRSPLPAGPSSCT SPRSPLPAPPRPFLYRRSPT DSDVSLDSEDSGAKSPGILG YNICPRGWNGSLRLKRGSLP AEASCTT in isoform 2. 2 Publications9

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
Y11072 mRNA Translation: CAA71955.1
AF499136 mRNA Translation: AAQ07402.1
AF499137 mRNA Translation: AAQ07403.1
AB028952 mRNA Translation: BAA82981.2 Different initiation.
AK127049 mRNA No translation available.
AK290178 mRNA Translation: BAF82867.1
AL831818 mRNA Translation: CAD38532.1
CH471062 Genomic DNA Translation: EAW61715.1
CH471062 Genomic DNA Translation: EAW61716.1
BC142683 mRNA Translation: AAI42684.1
BC146665 mRNA Translation: AAI46666.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS4308.1 [Q8N3V7-2]
CCDS54937.1 [Q8N3V7-1]
CCDS54938.1 [Q8N3V7-3]

NCBI Reference Sequences

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RefSeqi
NP_001103444.1, NM_001109974.2 [Q8N3V7-3]
NP_001159680.1, NM_001166208.1 [Q8N3V7-1]
NP_001159681.1, NM_001166209.1 [Q8N3V7-1]
NP_009217.3, NM_007286.5 [Q8N3V7-2]
XP_005268427.1, XM_005268370.1 [Q8N3V7-2]
XP_005268428.1, XM_005268371.1 [Q8N3V7-2]
XP_011535854.1, XM_011537552.2 [Q8N3V7-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000307662; ENSP00000302139; ENSG00000171992 [Q8N3V7-2]
ENST00000394243; ENSP00000377789; ENSG00000171992 [Q8N3V7-1]
ENST00000519664; ENSP00000429268; ENSG00000171992 [Q8N3V7-3]
ENST00000522122; ENSP00000428378; ENSG00000171992 [Q8N3V7-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
11346

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:11346

UCSC genome browser

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UCSCi
uc003lsn.4, human [Q8N3V7-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y11072 mRNA Translation: CAA71955.1
AF499136 mRNA Translation: AAQ07402.1
AF499137 mRNA Translation: AAQ07403.1
AB028952 mRNA Translation: BAA82981.2 Different initiation.
AK127049 mRNA No translation available.
AK290178 mRNA Translation: BAF82867.1
AL831818 mRNA Translation: CAD38532.1
CH471062 Genomic DNA Translation: EAW61715.1
CH471062 Genomic DNA Translation: EAW61716.1
BC142683 mRNA Translation: AAI42684.1
BC146665 mRNA Translation: AAI46666.1
CCDSiCCDS4308.1 [Q8N3V7-2]
CCDS54937.1 [Q8N3V7-1]
CCDS54938.1 [Q8N3V7-3]
RefSeqiNP_001103444.1, NM_001109974.2 [Q8N3V7-3]
NP_001159680.1, NM_001166208.1 [Q8N3V7-1]
NP_001159681.1, NM_001166209.1 [Q8N3V7-1]
NP_009217.3, NM_007286.5 [Q8N3V7-2]
XP_005268427.1, XM_005268370.1 [Q8N3V7-2]
XP_005268428.1, XM_005268371.1 [Q8N3V7-2]
XP_011535854.1, XM_011537552.2 [Q8N3V7-1]

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi116474, 183 interactors
IntActiQ8N3V7, 174 interactors
MINTiQ8N3V7
STRINGi9606.ENSP00000377789

PTM databases

GlyConnecti2889, 1 O-Linked glycan (1 site)
GlyGeniQ8N3V7, 1 site
iPTMnetiQ8N3V7
PhosphoSitePlusiQ8N3V7

Genetic variation databases

BioMutaiSYNPO
DMDMi48428650

Proteomic databases

EPDiQ8N3V7
jPOSTiQ8N3V7
MassIVEiQ8N3V7
MaxQBiQ8N3V7
PaxDbiQ8N3V7
PeptideAtlasiQ8N3V7
PRIDEiQ8N3V7
ProteomicsDBi71838 [Q8N3V7-1]
71839 [Q8N3V7-2]
71840 [Q8N3V7-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
16210, 300 antibodies

The DNASU plasmid repository

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DNASUi
11346

Genome annotation databases

EnsembliENST00000307662; ENSP00000302139; ENSG00000171992 [Q8N3V7-2]
ENST00000394243; ENSP00000377789; ENSG00000171992 [Q8N3V7-1]
ENST00000519664; ENSP00000429268; ENSG00000171992 [Q8N3V7-3]
ENST00000522122; ENSP00000428378; ENSG00000171992 [Q8N3V7-1]
GeneIDi11346
KEGGihsa:11346
UCSCiuc003lsn.4, human [Q8N3V7-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
11346
DisGeNETi11346

GeneCards: human genes, protein and diseases

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GeneCardsi
SYNPO
HGNCiHGNC:30672, SYNPO
HPAiENSG00000171992, Group enriched (heart muscle, placenta, skeletal muscle)
MIMi608155, gene
neXtProtiNX_Q8N3V7
OpenTargetsiENSG00000171992
PharmGKBiPA134863299
VEuPathDBiHostDB:ENSG00000171992.12

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502R7RM, Eukaryota
GeneTreeiENSGT00950000183054
HOGENOMiCLU_013103_0_0_1
InParanoidiQ8N3V7
OMAiCAGGQPQ
OrthoDBi691538at2759
PhylomeDBiQ8N3V7
TreeFamiTF330867

Enzyme and pathway databases

PathwayCommonsiQ8N3V7

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
11346, 4 hits in 986 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
SYNPO, human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
SYNPO

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
11346
PharosiQ8N3V7, Tbio

Protein Ontology

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PROi
PR:Q8N3V7
RNActiQ8N3V7, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000171992, Expressed in metanephric glomerulus and 239 other tissues
GenevisibleiQ8N3V7, HS

Family and domain databases

InterProiView protein in InterPro
IPR028753, Synpo
PANTHERiPTHR24217:SF13, PTHR24217:SF13, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSYNPO_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8N3V7
Secondary accession number(s): A5PKZ8
, D3DQG8, O15271, Q9UPX1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 7, 2004
Last modified: June 2, 2021
This is version 165 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
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