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UniProtKB - Q8N3R9 (PALS1_HUMAN)

Entry version 194 (02 Jun 2021)
Sequence version 3 (17 Oct 2006)
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Protein

Protein PALS1

Gene

PALS1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role in tight junction biogenesis and in the establishment of cell polarity in epithelial cells (PubMed:16678097, PubMed:25385611).

Also involved in adherens junction biogenesis by ensuring correct localization of the exocyst complex protein EXOC4/SEC8 which allows trafficking of adherens junction structural component CDH1 to the cell surface (By similarity).

Plays a role through its interaction with CDH5 in vascular lumen formation and endothelial membrane polarity (PubMed:27466317).

Required during embryonic and postnatal retinal development (By similarity).

Required for the maintenance of cerebellar progenitor cells in an undifferentiated proliferative state, preventing premature differentiation, and is required for cerebellar histogenesis, fissure formation, cerebellar layer organization and cortical development (By similarity).

Plays a role in neuronal progenitor cell survival, potentially via promotion of mTOR signaling (By similarity).

Plays a role in the radial and longitudinal extension of the myelin sheath in Schwann cells (By similarity).

May modulate SC6A1/GAT1-mediated GABA uptake by stabilizing the transporter (By similarity).

Plays a role in the T-cell receptor-mediated activation of NF-kappa-B (PubMed:21479189).

Required for localization of EZR to the apical membrane of parietal cells and may play a role in the dynamic remodeling of the apical cytoskeleton (By similarity).

Required for the normal polarized localization of the vesicular marker STX4 (By similarity).

Required for the correct trafficking of the myelin proteins PMP22 and MAG (By similarity).

Involved in promoting phosphorylation and cytoplasmic retention of transcriptional coactivators YAP1 and WWTR1/TAZ which leads to suppression of TGFB1-dependent transcription of target genes such as CCN2/CTGF, SERPINE1/PAI1, SNAI1/SNAIL1 and SMAD7 (By similarity).

By similarity4 Publications

(Microbial infection) Acts as an interaction partner for human coronaviruses SARS-CoV and, probably, SARS-CoV-2 envelope protein E which results in delayed formation of tight junctions and disregulation of cell polarity.

1 Publication1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi486 – 493ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processHost-virus interaction
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q8N3R9

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-420029, Tight junction interactions

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q8N3R9

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein PALS1Curated
Alternative name(s):
MAGUK p55 subfamily member 5
Membrane protein, palmitoylated 51 Publication
Protein associated with Lin-7 11 PublicationImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PALS11 PublicationImported
Synonyms:MPP51 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:18669, PALS1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		606958, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8N3R9

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000072415.8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Golgi apparatus, Membrane, Tight junction

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi318F → A or C: Increases interaction with CRB1. 1 Publication1
Mutagenesisi386D → K: Reduces binding to Drosophila crb and causes incorrect PALS1 localization and cell polarity. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		64398

Open Targets

More...OpenTargetsi		ENSG00000072415

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA38631

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q8N3R9, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		MPP5

Domain mapping of disease mutations (DMDM)

More...DMDMi		116242632

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000945801 – 675Protein PALS1Add BLAST675

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei14PhosphoserineCombined sources1
Modified residuei25PhosphoserineCombined sources1
Modified residuei83PhosphoserineCombined sources1
Modified residuei84PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q8N3R9

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q8N3R9

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q8N3R9

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q8N3R9

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8N3R9

PeptideAtlas

More...PeptideAtlasi		Q8N3R9

PRoteomics IDEntifications database

More...PRIDEi		Q8N3R9

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		71827 [Q8N3R9-1]
71828 [Q8N3R9-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8N3R9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8N3R9

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q8N3R9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed at the outer limiting membrane in the retina (at protein level) (PubMed:15914641, PubMed:15558731, PubMed:16519681, PubMed:17584769). Expressed in T lymphocytes (at protein level) (PubMed:21479189). Expressed in the kidney (at protein level) (PubMed:17584769).5 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000072415, Expressed in metanephros and 221 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q8N3R9, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8N3R9, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000072415, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer with MPP1 (PubMed:17584769).

Forms a heterotrimeric complex composed of PALS1, LIN7B and PATJ; the N-terminal L27 domain of PALS1 interacts with the L27 domain of PATJ and the C-terminal L27 domain of PALS1 interacts with the L27 domain of LIN7B (PubMed:22337881).

Component of a complex composed of PALS1, CRB1 and MPP4 (PubMed:15914641).

Component of a complex whose core is composed of ARHGAP17, AMOT, PALS1, PATJ and PARD3/PAR3 (PubMed:16678097).

Component of a complex composed of PALS1, CRB1 and EPB41L5 (PubMed:17920587). Within the complex, interacts (via HOOK domain) with EPB41L5 (via FERM domain), and interacts with CRB1 (via intracellular domain) (PubMed:17920587).

Component of a complex composed of PALS1, MPP3 and CRB1; PALS1 acts as a bridging protein between MPP3 (via guanylate kinase-like domain) and CRB1 (PubMed:16519681).

Component of a complex composed of CRB3, PALS1 and PATJ (By similarity).

Interacts (via PDZ domain) with PATJ (via N-terminus) (PubMed:12527193).

Interacts with EZR (By similarity).

Interacts (via PDZ domain) with CRB1 (via C-terminal ERLI motif) (PubMed:25385611, PubMed:25760605). While the PDZ domain is sufficient for interaction with CRB1, the adjacent SH3 and guanylate kinase-like domains are likely to contribute to a high affinity interaction (PubMed:25385611).

Interacts with WWTR1/TAZ (via WW domain) (PubMed:21145499).

Interacts with MPP7 (PubMed:16678097, PubMed:17332497).

Interacts (via PDZ domain) with CRB3 (via C-terminus) (By similarity).

Interacts with LIN7C (By similarity).

Interacts with MPDZ (By similarity).

Interacts with PARD6B (By similarity).

Interacts with SC6A1 (By similarity).

Interacts with CDH5; the interaction promotes PALS1 localization to cell junctions and is required for CDH5-mediated vascular lumen formation and endothelial cell (PubMed:27466317).

Interacts with NPHP1 (via coiled coil and SH3 domains) (PubMed:19755384).

Interacts with NPHP4 (PubMed:19755384).

Interacts with CRB2 (By similarity).

By similarity13 Publications

(Microbial infection) Interacts (via PDZ domain) with human coronaviruses SARS-CoV and, probably, SARS-CoV-2 envelope small membrane protein E (via C-terminus); this inhibits the interaction between PALS1 and CRB3.

1 Publication1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		122155, 53 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-6166, CRUMBS3-PALS1-PATJ cell polarity complex
CPX-6167, CRUMBS1-PALS1-PATJ cell polarity complex
CPX-6180, CRUMBS2-PALS1-PATJ cell polarity complex

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q8N3R9

Protein interaction database and analysis system

More...IntActi		Q8N3R9, 70 interactors

Molecular INTeraction database

More...MINTi		Q8N3R9

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000261681

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8N3R9, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1675
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Biological Magnetic Resonance Data Bank

More...BMRBi		Q8N3R9

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8N3R9

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q8N3R9

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini120 – 177L27 1PROSITE-ProRule annotationAdd BLAST58
Domaini179 – 235L27 2PROSITE-ProRule annotationAdd BLAST57
Domaini256 – 336PDZPROSITE-ProRule annotationAdd BLAST81
Domaini345 – 417SH3PROSITE-ProRule annotationAdd BLAST73
Domaini479 – 660Guanylate kinase-likePROSITE-ProRule annotationAdd BLAST182

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 345Required for the correct localization of PALS1 and PATJ at cell-cell contacts and the normal formation of tight junctions and adherens junctionsBy similarityAdd BLAST345
Regioni1 – 34DisorderedSequence analysisAdd BLAST34
Regioni21 – 140Interaction with PARD6BBy similarityAdd BLAST120
Regioni51 – 78DisorderedSequence analysisAdd BLAST28
Regioni181 – 243Interaction with LIN7CBy similarityAdd BLAST63

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi10 – 34Basic and acidic residuesSequence analysisAdd BLAST25
Compositional biasi57 – 78Basic and acidic residuesSequence analysisAdd BLAST22

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The L27 domain 1 functions in targeting to the tight junctions by binding to and stabilizing PATJ.By similarity
The PDZ domain binds to the C-terminus of SC6A1.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the MAGUK family.Curated

Keywords - Domaini

Repeat, SH3 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0609, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000156087

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_001715_5_4_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8N3R9

Identification of Orthologs from Complete Genome Data

More...OMAi		MMPMRRS

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8N3R9

TreeFam database of animal gene trees

More...TreeFami		TF314263

Family and domain databases

Conserved Domains Database

More...CDDi		cd12036, SH3_MPP5, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.30.42.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR008145, GK/Ca_channel_bsu
IPR008144, Guanylate_kin-like_dom
IPR020590, Guanylate_kinase_CS
IPR014775, L27_C
IPR004172, L27_dom
IPR036892, L27_dom_sf
IPR015145, L27_N
IPR035601, MPP5_SH3
IPR027417, P-loop_NTPase
IPR001478, PDZ
IPR036034, PDZ_sf
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00625, Guanylate_kin, 1 hit
PF02828, L27, 1 hit
PF09060, L27_N, 1 hit
PF00595, PDZ, 1 hit
PF07653, SH3_2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00072, GuKc, 1 hit
SM00569, L27, 2 hits
SM00228, PDZ, 1 hit
SM00326, SH3, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF101288, SSF101288, 2 hits
SSF50044, SSF50044, 1 hit
SSF50156, SSF50156, 1 hit
SSF52540, SSF52540, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00856, GUANYLATE_KINASE_1, 1 hit
PS50052, GUANYLATE_KINASE_2, 1 hit
PS51022, L27, 2 hits
PS50106, PDZ, 1 hit
PS50002, SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8N3R9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTTSHMNGHV TEESDSEVKN VDLASPEEHQ KHREMAVDCP GDLGTRMMPI 
        60         70         80         90        100
RRSAQLERIR QQQEDMRRRR EEEGKKQELD LNSSMRLKKL AQIPPKTGID 
       110        120        130        140        150
NPMFDTEEGI VLESPHYAVK ILEIEDLFSS LKHIQHTLVD SQSQEDISLL 
       160        170        180        190        200
LQLVQNKDFQ NAFKIHNAIT VHMNKASPPF PLISNAQDLA QEVQTVLKPV 
       210        220        230        240        250
HHKEGQELTA LLNTPHIQAL LLAHDKVAEQ EMQLEPITDE RVYESIGQYG 
       260        270        280        290        300
GETVKIVRIE KARDIPLGAT VRNEMDSVII SRIVKGGAAE KSGLLHEGDE 
       310        320        330        340        350
VLEINGIEIR GKDVNEVFDL LSDMHGTLTF VLIPSQQIKP PPAKETVIHV 
       360        370        380        390        400
KAHFDYDPSD DPYVPCRELG LSFQKGDILH VISQEDPNWW QAYREGDEDN 
       410        420        430        440        450
QPLAGLVPGK SFQQQREAMK QTIEEDKEPE KSGKLWCAKK NKKKRKKVLY 
       460        470        480        490        500
NANKNDDYDN EEILTYEEMS LYHQPANRKR PIILIGPQNC GQNELRQRLM 
       510        520        530        540        550
NKEKDRFASA VPHTTRSRRD QEVAGRDYHF VSRQAFEADI AAGKFIEHGE 
       560        570        580        590        600
FEKNLYGTSI DSVRQVINSG KICLLSLRTQ SLKTLRNSDL KPYIIFIAPP 
       610        620        630        640        650
SQERLRALLA KEGKNPKPEE LREIIEKTRE MEQNNGHYFD TAIVNSDLDK 
       660        670 
AYQELLRLIN KLDTEPQWVP STWLR
Length:675
Mass (Da):77,294
Last modified:October 17, 2006 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA3B2CB594E0908CA
GO
Isoform 2 (identifier: Q8N3R9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-34: Missing.

Show »
Length:641
Mass (Da):73,421
Checksum:iAD604D26B3580FDB
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V2H1G3V2H1_HUMAN
Protein-associated with LIN7 1, MAG...
PALS1
149Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V2B0G3V2B0_HUMAN
Protein-associated with LIN7 1, MAG...
PALS1
124Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH53366 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence BAB14172 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti100D → G in CAD38620 (PubMed:17974005).Curated1
Sequence conflicti141S → Y in CAD89937 (PubMed:17974005).Curated1
Sequence conflicti161N → S in BAC05295 (PubMed:14702039).Curated1
Sequence conflicti324M → L in BAC05295 (PubMed:14702039).Curated1
Sequence conflicti401Q → H in CAD89937 (PubMed:17974005).Curated1
Sequence conflicti460N → H in CAD89937 (PubMed:17974005).Curated1
Sequence conflicti490C → F in BAB14172 (PubMed:14702039).Curated1
Sequence conflicti613G → V in CAD38620 (PubMed:17974005).Curated1
Sequence conflicti634N → S in CAD38620 (PubMed:17974005).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0140021 – 34Missing in isoform 2. 1 PublicationAdd BLAST34

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AL832326 mRNA Translation: CAD38620.1
AL832578 mRNA Translation: CAD89937.1
CH471061 Genomic DNA Translation: EAW80930.1
BC053366 mRNA Translation: AAH53366.1 Sequence problems.
BC129933 mRNA Translation: AAI29934.1
AK022677 mRNA Translation: BAB14172.1 Different initiation.
AK098373 mRNA Translation: BAC05295.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS58325.1 [Q8N3R9-2]
CCDS9779.1 [Q8N3R9-1]

NCBI Reference Sequences

More...RefSeqi		NP_001243479.1, NM_001256550.1 [Q8N3R9-2]
NP_071919.2, NM_022474.3 [Q8N3R9-1]
XP_005268060.1, XM_005268003.1 [Q8N3R9-2]
XP_011535388.1, XM_011537086.2 [Q8N3R9-1]
XP_011535389.1, XM_011537087.2 [Q8N3R9-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000261681; ENSP00000261681; ENSG00000072415 [Q8N3R9-1]
ENST00000555925; ENSP00000451488; ENSG00000072415 [Q8N3R9-2]
ENST00000676464; ENSP00000503713; ENSG00000072415 [Q8N3R9-1]
ENST00000677382; ENSP00000503322; ENSG00000072415 [Q8N3R9-1]
ENST00000677835; ENSP00000503517; ENSG00000072415 [Q8N3R9-1]
ENST00000678380; ENSP00000503321; ENSG00000072415 [Q8N3R9-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		64398

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:64398

UCSC genome browser

More...UCSCi		uc001xjc.5, human [Q8N3R9-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL832326 mRNA Translation: CAD38620.1
AL832578 mRNA Translation: CAD89937.1
CH471061 Genomic DNA Translation: EAW80930.1
BC053366 mRNA Translation: AAH53366.1 Sequence problems.
BC129933 mRNA Translation: AAI29934.1
AK022677 mRNA Translation: BAB14172.1 Different initiation.
AK098373 mRNA Translation: BAC05295.1
CCDSiCCDS58325.1 [Q8N3R9-2]
CCDS9779.1 [Q8N3R9-1]
RefSeqiNP_001243479.1, NM_001256550.1 [Q8N3R9-2]
NP_071919.2, NM_022474.3 [Q8N3R9-1]
XP_005268060.1, XM_005268003.1 [Q8N3R9-2]
XP_011535388.1, XM_011537086.2 [Q8N3R9-1]
XP_011535389.1, XM_011537087.2 [Q8N3R9-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1Y76NMR-B/D118-177[»]
3UITX-ray2.05A/B/C/D119-232[»]
4UU5X-ray1.23A251-335[»]
4UU6X-ray1.80A251-335[»]
4WSIX-ray2.95A/B236-675[»]
BMRBiQ8N3R9
SMRiQ8N3R9
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi122155, 53 interactors
ComplexPortaliCPX-6166, CRUMBS3-PALS1-PATJ cell polarity complex
CPX-6167, CRUMBS1-PALS1-PATJ cell polarity complex
CPX-6180, CRUMBS2-PALS1-PATJ cell polarity complex
CORUMiQ8N3R9
IntActiQ8N3R9, 70 interactors
MINTiQ8N3R9
STRINGi9606.ENSP00000261681

PTM databases

iPTMnetiQ8N3R9
PhosphoSitePlusiQ8N3R9
SwissPalmiQ8N3R9

Genetic variation databases

BioMutaiMPP5
DMDMi116242632

Proteomic databases

EPDiQ8N3R9
jPOSTiQ8N3R9
MassIVEiQ8N3R9
MaxQBiQ8N3R9
PaxDbiQ8N3R9
PeptideAtlasiQ8N3R9
PRIDEiQ8N3R9
ProteomicsDBi71827 [Q8N3R9-1]
71828 [Q8N3R9-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		20, 335 antibodies

The DNASU plasmid repository

More...DNASUi		64398

Genome annotation databases

EnsembliENST00000261681; ENSP00000261681; ENSG00000072415 [Q8N3R9-1]
ENST00000555925; ENSP00000451488; ENSG00000072415 [Q8N3R9-2]
ENST00000676464; ENSP00000503713; ENSG00000072415 [Q8N3R9-1]
ENST00000677382; ENSP00000503322; ENSG00000072415 [Q8N3R9-1]
ENST00000677835; ENSP00000503517; ENSG00000072415 [Q8N3R9-1]
ENST00000678380; ENSP00000503321; ENSG00000072415 [Q8N3R9-1]
GeneIDi64398
KEGGihsa:64398
UCSCiuc001xjc.5, human [Q8N3R9-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		64398
DisGeNETi64398

GeneCards: human genes, protein and diseases

More...GeneCardsi		MPP5
HGNCiHGNC:18669, PALS1
HPAiENSG00000072415, Low tissue specificity
MIMi606958, gene
neXtProtiNX_Q8N3R9
OpenTargetsiENSG00000072415
PharmGKBiPA38631
VEuPathDBiHostDB:ENSG00000072415.8

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0609, Eukaryota
GeneTreeiENSGT00940000156087
HOGENOMiCLU_001715_5_4_1
InParanoidiQ8N3R9
OMAiMMPMRRS
PhylomeDBiQ8N3R9
TreeFamiTF314263

Enzyme and pathway databases

PathwayCommonsiQ8N3R9
ReactomeiR-HSA-420029, Tight junction interactions
SIGNORiQ8N3R9

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		64398, 11 hits in 996 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		MPP5, human
EvolutionaryTraceiQ8N3R9

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		MPP5

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		64398
PharosiQ8N3R9, Tbio

Protein Ontology

More...PROi		PR:Q8N3R9
RNActiQ8N3R9, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000072415, Expressed in metanephros and 221 other tissues
ExpressionAtlasiQ8N3R9, baseline and differential
GenevisibleiQ8N3R9, HS

Family and domain databases

CDDicd12036, SH3_MPP5, 1 hit
Gene3Di2.30.42.10, 1 hit
InterProiView protein in InterPro
IPR008145, GK/Ca_channel_bsu
IPR008144, Guanylate_kin-like_dom
IPR020590, Guanylate_kinase_CS
IPR014775, L27_C
IPR004172, L27_dom
IPR036892, L27_dom_sf
IPR015145, L27_N
IPR035601, MPP5_SH3
IPR027417, P-loop_NTPase
IPR001478, PDZ
IPR036034, PDZ_sf
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain
PfamiView protein in Pfam
PF00625, Guanylate_kin, 1 hit
PF02828, L27, 1 hit
PF09060, L27_N, 1 hit
PF00595, PDZ, 1 hit
PF07653, SH3_2, 1 hit
SMARTiView protein in SMART
SM00072, GuKc, 1 hit
SM00569, L27, 2 hits
SM00228, PDZ, 1 hit
SM00326, SH3, 1 hit
SUPFAMiSSF101288, SSF101288, 2 hits
SSF50044, SSF50044, 1 hit
SSF50156, SSF50156, 1 hit
SSF52540, SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00856, GUANYLATE_KINASE_1, 1 hit
PS50052, GUANYLATE_KINASE_2, 1 hit
PS51022, L27, 2 hits
PS50106, PDZ, 1 hit
PS50002, SH3, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPALS1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8N3R9
Secondary accession number(s): A1L380
, Q7Z631, Q86T98, Q8N7I5, Q9H9Q0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: October 17, 2006
Last modified: June 2, 2021
This is version 194 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
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