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Protein

MAGUK p55 subfamily member 5

Gene

MPP5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in tight junctions biogenesis and in the establishment of cell polarity in epithelial cells. May modulate SC6A1/GAT1-mediated GABA uptake by stabilizing the transporter. Required for localization of EZR to the apical membrane of parietal cells and may play a role in the dynamic remodeling of the apical cytoskeleton (By similarity).By similarity

GO - Molecular functioni

  • protein domain specific binding Source: BHF-UCL

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-420029 Tight junction interactions
SIGNORiQ8N3R9

Names & Taxonomyi

Protein namesi
Recommended name:
MAGUK p55 subfamily member 5
Gene namesi
Name:MPP5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000072415.8
HGNCiHGNC:18669 MPP5
MIMi606958 gene
neXtProtiNX_Q8N3R9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Tight junction

Pathology & Biotechi

Organism-specific databases

DisGeNETi64398
OpenTargetsiENSG00000072415
PharmGKBiPA38631

Polymorphism and mutation databases

BioMutaiMPP5
DMDMi116242632

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000945801 – 675MAGUK p55 subfamily member 5Add BLAST675

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei14PhosphoserineCombined sources1
Modified residuei25PhosphoserineCombined sources1
Modified residuei83PhosphoserineCombined sources1
Modified residuei84PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8N3R9
MaxQBiQ8N3R9
PaxDbiQ8N3R9
PeptideAtlasiQ8N3R9
PRIDEiQ8N3R9
ProteomicsDBi71827
71828 [Q8N3R9-2]

PTM databases

iPTMnetiQ8N3R9
PhosphoSitePlusiQ8N3R9
SwissPalmiQ8N3R9

Expressioni

Tissue specificityi

Expressed in the retina (at protein level).2 Publications

Gene expression databases

BgeeiENSG00000072415 Expressed in 208 organ(s), highest expression level in metanephros
CleanExiHS_MPP5
ExpressionAtlasiQ8N3R9 baseline and differential
GenevisibleiQ8N3R9 HS

Organism-specific databases

HPAiHPA000993
HPA063890

Interactioni

Subunit structurei

Interacts with CRB3, LIN7C and MPDZ. Interacts with PATJ, PARD6B, SC6A1 and EZR (By similarity). Forms a complex with CRB1 and MPP4. Component of a complex whose core is composed of ARHGAP17, AMOT, MPP5/PALS1, PATJ and PARD3/PAR3. Heterodimer with MPP1. Interacts with MPP7.By similarity4 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi122155, 32 interactors
CORUMiQ8N3R9
IntActiQ8N3R9, 33 interactors
MINTiQ8N3R9
STRINGi9606.ENSP00000261681

Structurei

Secondary structure

1675
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ8N3R9
SMRiQ8N3R9
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8N3R9

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini120 – 177L27 1PROSITE-ProRule annotationAdd BLAST58
Domaini179 – 235L27 2PROSITE-ProRule annotationAdd BLAST57
Domaini256 – 336PDZPROSITE-ProRule annotationAdd BLAST81
Domaini345 – 417SH3PROSITE-ProRule annotationAdd BLAST73
Domaini479 – 660Guanylate kinase-likePROSITE-ProRule annotationAdd BLAST182

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni21 – 140Interaction with PARD6BBy similarityAdd BLAST120
Regioni181 – 243Interaction with LIN7CBy similarityAdd BLAST63

Domaini

The L27 domain 1 functions in targeting to the tight junctions by binding to PATJ.By similarity
The PDZ domain binds to the C-terminus of SC6A1.By similarity

Sequence similaritiesi

Belongs to the MAGUK family.Curated

Keywords - Domaini

Repeat, SH3 domain

Phylogenomic databases

eggNOGiKOG0609 Eukaryota
COG0194 LUCA
GeneTreeiENSGT00760000118866
HOGENOMiHOG000233034
HOVERGENiHBG001858
InParanoidiQ8N3R9
KOiK06091
OMAiILADMHG
OrthoDBiEOG091G065I
PhylomeDBiQ8N3R9
TreeFamiTF314263

Family and domain databases

CDDicd12036 SH3_MPP5, 1 hit
InterProiView protein in InterPro
IPR008145 GK/Ca_channel_bsu
IPR008144 Guanylate_kin-like_dom
IPR020590 Guanylate_kinase_CS
IPR014775 L27_C
IPR004172 L27_dom
IPR036892 L27_dom_sf
IPR015145 L27_N
IPR031185 MPP5
IPR035601 MPP5_SH3
IPR027417 P-loop_NTPase
IPR001478 PDZ
IPR036034 PDZ_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PANTHERiPTHR23122:SF61 PTHR23122:SF61, 1 hit
PfamiView protein in Pfam
PF00625 Guanylate_kin, 1 hit
PF02828 L27, 1 hit
PF09060 L27_N, 1 hit
PF00595 PDZ, 1 hit
PF07653 SH3_2, 1 hit
SMARTiView protein in SMART
SM00072 GuKc, 1 hit
SM00569 L27, 2 hits
SM00228 PDZ, 1 hit
SM00326 SH3, 1 hit
SUPFAMiSSF101288 SSF101288, 2 hits
SSF50044 SSF50044, 1 hit
SSF50156 SSF50156, 1 hit
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00856 GUANYLATE_KINASE_1, 1 hit
PS50052 GUANYLATE_KINASE_2, 1 hit
PS51022 L27, 2 hits
PS50106 PDZ, 1 hit
PS50002 SH3, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8N3R9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTTSHMNGHV TEESDSEVKN VDLASPEEHQ KHREMAVDCP GDLGTRMMPI
60 70 80 90 100
RRSAQLERIR QQQEDMRRRR EEEGKKQELD LNSSMRLKKL AQIPPKTGID
110 120 130 140 150
NPMFDTEEGI VLESPHYAVK ILEIEDLFSS LKHIQHTLVD SQSQEDISLL
160 170 180 190 200
LQLVQNKDFQ NAFKIHNAIT VHMNKASPPF PLISNAQDLA QEVQTVLKPV
210 220 230 240 250
HHKEGQELTA LLNTPHIQAL LLAHDKVAEQ EMQLEPITDE RVYESIGQYG
260 270 280 290 300
GETVKIVRIE KARDIPLGAT VRNEMDSVII SRIVKGGAAE KSGLLHEGDE
310 320 330 340 350
VLEINGIEIR GKDVNEVFDL LSDMHGTLTF VLIPSQQIKP PPAKETVIHV
360 370 380 390 400
KAHFDYDPSD DPYVPCRELG LSFQKGDILH VISQEDPNWW QAYREGDEDN
410 420 430 440 450
QPLAGLVPGK SFQQQREAMK QTIEEDKEPE KSGKLWCAKK NKKKRKKVLY
460 470 480 490 500
NANKNDDYDN EEILTYEEMS LYHQPANRKR PIILIGPQNC GQNELRQRLM
510 520 530 540 550
NKEKDRFASA VPHTTRSRRD QEVAGRDYHF VSRQAFEADI AAGKFIEHGE
560 570 580 590 600
FEKNLYGTSI DSVRQVINSG KICLLSLRTQ SLKTLRNSDL KPYIIFIAPP
610 620 630 640 650
SQERLRALLA KEGKNPKPEE LREIIEKTRE MEQNNGHYFD TAIVNSDLDK
660 670
AYQELLRLIN KLDTEPQWVP STWLR
Length:675
Mass (Da):77,294
Last modified:October 17, 2006 - v3
Checksum:iA3B2CB594E0908CA
GO
Isoform 2 (identifier: Q8N3R9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-34: Missing.

Show »
Length:641
Mass (Da):73,421
Checksum:iAD604D26B3580FDB
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V2H1G3V2H1_HUMAN
MAGUK p55 subfamily member 5
MPP5
149Annotation score:
G3V2B0G3V2B0_HUMAN
MAGUK p55 subfamily member 5
MPP5
124Annotation score:

Sequence cautioni

The sequence AAH53366 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence BAB14172 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti100D → G in CAD38620 (PubMed:17974005).Curated1
Sequence conflicti141S → Y in CAD89937 (PubMed:17974005).Curated1
Sequence conflicti161N → S in BAC05295 (PubMed:14702039).Curated1
Sequence conflicti324M → L in BAC05295 (PubMed:14702039).Curated1
Sequence conflicti401Q → H in CAD89937 (PubMed:17974005).Curated1
Sequence conflicti460N → H in CAD89937 (PubMed:17974005).Curated1
Sequence conflicti490C → F in BAB14172 (PubMed:14702039).Curated1
Sequence conflicti613G → V in CAD38620 (PubMed:17974005).Curated1
Sequence conflicti634N → S in CAD38620 (PubMed:17974005).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0140021 – 34Missing in isoform 2. 1 PublicationAdd BLAST34

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL832326 mRNA Translation: CAD38620.1
AL832578 mRNA Translation: CAD89937.1
CH471061 Genomic DNA Translation: EAW80930.1
BC053366 mRNA Translation: AAH53366.1 Sequence problems.
BC129933 mRNA Translation: AAI29934.1
AK022677 mRNA Translation: BAB14172.1 Different initiation.
AK098373 mRNA Translation: BAC05295.1
CCDSiCCDS58325.1 [Q8N3R9-2]
CCDS9779.1 [Q8N3R9-1]
RefSeqiNP_001243479.1, NM_001256550.1 [Q8N3R9-2]
NP_071919.2, NM_022474.3 [Q8N3R9-1]
XP_005268060.1, XM_005268003.1 [Q8N3R9-2]
XP_011535388.1, XM_011537086.2 [Q8N3R9-1]
XP_011535389.1, XM_011537087.2 [Q8N3R9-1]
UniGeneiHs.652312
Hs.740524

Genome annotation databases

EnsembliENST00000261681; ENSP00000261681; ENSG00000072415 [Q8N3R9-1]
ENST00000555925; ENSP00000451488; ENSG00000072415 [Q8N3R9-2]
GeneIDi64398
KEGGihsa:64398
UCSCiuc001xjc.5 human [Q8N3R9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL832326 mRNA Translation: CAD38620.1
AL832578 mRNA Translation: CAD89937.1
CH471061 Genomic DNA Translation: EAW80930.1
BC053366 mRNA Translation: AAH53366.1 Sequence problems.
BC129933 mRNA Translation: AAI29934.1
AK022677 mRNA Translation: BAB14172.1 Different initiation.
AK098373 mRNA Translation: BAC05295.1
CCDSiCCDS58325.1 [Q8N3R9-2]
CCDS9779.1 [Q8N3R9-1]
RefSeqiNP_001243479.1, NM_001256550.1 [Q8N3R9-2]
NP_071919.2, NM_022474.3 [Q8N3R9-1]
XP_005268060.1, XM_005268003.1 [Q8N3R9-2]
XP_011535388.1, XM_011537086.2 [Q8N3R9-1]
XP_011535389.1, XM_011537087.2 [Q8N3R9-1]
UniGeneiHs.652312
Hs.740524

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1Y76NMR-B/D118-177[»]
3UITX-ray2.05A/B/C/D119-232[»]
4UU5X-ray1.23A251-335[»]
4UU6X-ray1.80A251-335[»]
4WSIX-ray2.95A/B236-675[»]
ProteinModelPortaliQ8N3R9
SMRiQ8N3R9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122155, 32 interactors
CORUMiQ8N3R9
IntActiQ8N3R9, 33 interactors
MINTiQ8N3R9
STRINGi9606.ENSP00000261681

PTM databases

iPTMnetiQ8N3R9
PhosphoSitePlusiQ8N3R9
SwissPalmiQ8N3R9

Polymorphism and mutation databases

BioMutaiMPP5
DMDMi116242632

Proteomic databases

EPDiQ8N3R9
MaxQBiQ8N3R9
PaxDbiQ8N3R9
PeptideAtlasiQ8N3R9
PRIDEiQ8N3R9
ProteomicsDBi71827
71828 [Q8N3R9-2]

Protocols and materials databases

DNASUi64398
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000261681; ENSP00000261681; ENSG00000072415 [Q8N3R9-1]
ENST00000555925; ENSP00000451488; ENSG00000072415 [Q8N3R9-2]
GeneIDi64398
KEGGihsa:64398
UCSCiuc001xjc.5 human [Q8N3R9-1]

Organism-specific databases

CTDi64398
DisGeNETi64398
EuPathDBiHostDB:ENSG00000072415.8
GeneCardsiMPP5
HGNCiHGNC:18669 MPP5
HPAiHPA000993
HPA063890
MIMi606958 gene
neXtProtiNX_Q8N3R9
OpenTargetsiENSG00000072415
PharmGKBiPA38631
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0609 Eukaryota
COG0194 LUCA
GeneTreeiENSGT00760000118866
HOGENOMiHOG000233034
HOVERGENiHBG001858
InParanoidiQ8N3R9
KOiK06091
OMAiILADMHG
OrthoDBiEOG091G065I
PhylomeDBiQ8N3R9
TreeFamiTF314263

Enzyme and pathway databases

ReactomeiR-HSA-420029 Tight junction interactions
SIGNORiQ8N3R9

Miscellaneous databases

ChiTaRSiMPP5 human
EvolutionaryTraceiQ8N3R9
GeneWikiiMPP5
GenomeRNAii64398
PROiPR:Q8N3R9
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000072415 Expressed in 208 organ(s), highest expression level in metanephros
CleanExiHS_MPP5
ExpressionAtlasiQ8N3R9 baseline and differential
GenevisibleiQ8N3R9 HS

Family and domain databases

CDDicd12036 SH3_MPP5, 1 hit
InterProiView protein in InterPro
IPR008145 GK/Ca_channel_bsu
IPR008144 Guanylate_kin-like_dom
IPR020590 Guanylate_kinase_CS
IPR014775 L27_C
IPR004172 L27_dom
IPR036892 L27_dom_sf
IPR015145 L27_N
IPR031185 MPP5
IPR035601 MPP5_SH3
IPR027417 P-loop_NTPase
IPR001478 PDZ
IPR036034 PDZ_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PANTHERiPTHR23122:SF61 PTHR23122:SF61, 1 hit
PfamiView protein in Pfam
PF00625 Guanylate_kin, 1 hit
PF02828 L27, 1 hit
PF09060 L27_N, 1 hit
PF00595 PDZ, 1 hit
PF07653 SH3_2, 1 hit
SMARTiView protein in SMART
SM00072 GuKc, 1 hit
SM00569 L27, 2 hits
SM00228 PDZ, 1 hit
SM00326 SH3, 1 hit
SUPFAMiSSF101288 SSF101288, 2 hits
SSF50044 SSF50044, 1 hit
SSF50156 SSF50156, 1 hit
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00856 GUANYLATE_KINASE_1, 1 hit
PS50052 GUANYLATE_KINASE_2, 1 hit
PS51022 L27, 2 hits
PS50106 PDZ, 1 hit
PS50002 SH3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMPP5_HUMAN
AccessioniPrimary (citable) accession number: Q8N3R9
Secondary accession number(s): A1L380
, Q7Z631, Q86T98, Q8N7I5, Q9H9Q0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: October 17, 2006
Last modified: November 7, 2018
This is version 175 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
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