UniProtKB - Q8N3R9 (MPP5_HUMAN)

BLAST

>sp|Q8N3R9|MPP5_HUMAN MAGUK p55 subfamily member 5 OS=Homo sapiens OX=9606 GN=MPP5 PE=1 SV=3
MTTSHMNGHVTEESDSEVKNVDLASPEEHQKHREMAVDCPGDLGTRMMPIRRSAQLERIR
QQQEDMRRRREEEGKKQELDLNSSMRLKKLAQIPPKTGIDNPMFDTEEGIVLESPHYAVK
ILEIEDLFSSLKHIQHTLVDSQSQEDISLLLQLVQNKDFQNAFKIHNAITVHMNKASPPF
PLISNAQDLAQEVQTVLKPVHHKEGQELTALLNTPHIQALLLAHDKVAEQEMQLEPITDE
RVYESIGQYGGETVKIVRIEKARDIPLGATVRNEMDSVIISRIVKGGAAEKSGLLHEGDE
VLEINGIEIRGKDVNEVFDLLSDMHGTLTFVLIPSQQIKPPPAKETVIHVKAHFDYDPSD
DPYVPCRELGLSFQKGDILHVISQEDPNWWQAYREGDEDNQPLAGLVPGKSFQQQREAMK
QTIEEDKEPEKSGKLWCAKKNKKKRKKVLYNANKNDDYDNEEILTYEEMSLYHQPANRKR
PIILIGPQNCGQNELRQRLMNKEKDRFASAVPHTTRSRRDQEVAGRDYHFVSRQAFEADI
AAGKFIEHGEFEKNLYGTSIDSVRQVINSGKICLLSLRTQSLKTLRNSDLKPYIIFIAPP
SQERLRALLAKEGKNPKPEELREIIEKTREMEQNNGHYFDTAIVNSDLDKAYQELLRLIN
KLDTEPQWVPSTWLR

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History
Entry version 175 (07 Nov 2018)
Sequence version 3 (17 Oct 2006)
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Protein

MAGUK p55 subfamily member 5

Gene

MPP5

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

May play a role in tight junctions biogenesis and in the establishment of cell polarity in epithelial cells. May modulate SC6A1/GAT1-mediated GABA uptake by stabilizing the transporter. Required for localization of EZR to the apical membrane of parietal cells and may play a role in the dynamic remodeling of the apical cytoskeleton (By similarity).By similarity

GO - Molecular functionⁱ

protein domain specific binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 17332497

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

bicellular tight junction assembly Source: Reactome
establishment of epithelial cell polarity Source: InterPro
morphogenesis of an epithelial sheet
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 23201090
myelin assembly Source: Ensembl
peripheral nervous system myelin maintenance Source: Ensembl
protein localization to myelin sheath abaxonal region Source: Ensembl
protein localization to plasma membrane Source: Ensembl

View the complete GO annotation on QuickGO ...

Enzyme and pathway databases

Reactomeⁱ	R-HSA-420029 Tight junction interactions
SIGNORⁱ	Q8N3R9

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: MAGUK p55 subfamily member 5
Gene namesⁱ	Name:MPP5
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 14

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000072415.8
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:18669 MPP5
MIMⁱ	606958 gene
neXtProtⁱ	NX_Q8N3R9

Keywords - Cellular componentⁱ

Cell junction, Cell membrane, Membrane, Tight junction

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	64398
Open Targets More...OpenTargetsⁱ	ENSG00000072415
PharmGKBⁱ	PA38631

Polymorphism and mutation databases

BioMutaⁱ	MPP5
DMDMⁱ	116242632

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000094580	1 – 675	MAGUK p55 subfamily member 5Add BLAST		675

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	14	PhosphoserineCombined sources	1
Modified residueⁱ	25	PhosphoserineCombined sources	1
Modified residueⁱ	83	PhosphoserineCombined sources	1
Modified residueⁱ	84	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q8N3R9
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q8N3R9
PaxDbⁱ	Q8N3R9
PeptideAtlas More...PeptideAtlasⁱ	Q8N3R9
PRIDEⁱ	Q8N3R9
ProteomicsDBⁱ	71827 71828 [Q8N3R9-2]

PTM databases

iPTMnetⁱ	Q8N3R9
PhosphoSitePlusⁱ	Q8N3R9
SwissPalmⁱ	Q8N3R9

Expressionⁱ

Tissue specificityⁱ

Expressed in the retina (at protein level).2 Publications

Gene expression databases

Bgeeⁱ	ENSG00000072415 Expressed in 208 organ(s), highest expression level in metanephros
CleanExⁱ	HS_MPP5
ExpressionAtlasⁱ	Q8N3R9 baseline and differential
Genevisibleⁱ	Q8N3R9 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA000993 HPA063890

HPAⁱ

HPA000993
HPA063890

Interactionⁱ

Subunit structureⁱ

Interacts with CRB3, LIN7C and MPDZ. Interacts with PATJ, PARD6B, SC6A1 and EZR (By similarity). Forms a complex with CRB1 and MPP4. Component of a complex whose core is composed of ARHGAP17, AMOT, MPP5/PALS1, PATJ and PARD3/PAR3. Heterodimer with MPP1. Interacts with MPP7.By similarity4 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
LIN7A	O14910	7	EBI-2513978,EBI-2513988
PATJ	Q8NI35	4	EBI-2513978,EBI-724390

GO - Molecular functionⁱ

protein domain specific binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 17332497

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	122155, 32 interactors
CORUMⁱ	Q8N3R9
IntActⁱ	Q8N3R9, 33 interactors
Molecular INTeraction database More...MINTⁱ	Q8N3R9
STRINGⁱ	9606.ENSP00000261681

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	124 – 137	Combined sources	14
Helixⁱ	141 – 155	Combined sources	15
Helixⁱ	157 – 173	Combined sources	17
Helixⁱ	186 – 197	Combined sources	12
Turnⁱ	198 – 200	Combined sources	3
Helixⁱ	203 – 213	Combined sources	11
Helixⁱ	215 – 229	Combined sources	15
Beta strandⁱ	230 – 232	Combined sources	3
Beta strandⁱ	249 – 251	Combined sources	3
Beta strandⁱ	255 – 261	Combined sources	7
Beta strandⁱ	268 – 274	Combined sources	7
Beta strandⁱ	277 – 283	Combined sources	7
Helixⁱ	288 – 292	Combined sources	5
Beta strandⁱ	300 – 304	Combined sources	5
Helixⁱ	314 – 322	Combined sources	9
Beta strandⁱ	326 – 333	Combined sources	8
Beta strandⁱ	348 – 352	Combined sources	5
Helixⁱ	358 – 360	Combined sources	3
Helixⁱ	367 – 369	Combined sources	3
Beta strandⁱ	378 – 383	Combined sources	6
Beta strandⁱ	389 – 394	Combined sources	6
Beta strandⁱ	405 – 408	Combined sources	4
Beta strandⁱ	464 – 472	Combined sources	9
Beta strandⁱ	482 – 486	Combined sources	5
Turnⁱ	488 – 491	Combined sources	4
Helixⁱ	492 – 502	Combined sources	11
Turnⁱ	503 – 506	Combined sources	4
Turnⁱ	524 – 527	Combined sources	4
Helixⁱ	533 – 541	Combined sources	9
Beta strandⁱ	545 – 551	Combined sources	7
Beta strandⁱ	554 – 559	Combined sources	6
Helixⁱ	560 – 567	Combined sources	8
Turnⁱ	568 – 570	Combined sources	3
Beta strandⁱ	571 – 576	Combined sources	6
Helixⁱ	579 – 581	Combined sources	3
Helixⁱ	582 – 586	Combined sources	5
Beta strandⁱ	593 – 598	Combined sources	6
Helixⁱ	602 – 608	Combined sources	7
Helixⁱ	621 – 631	Combined sources	11
Helixⁱ	634 – 636	Combined sources	3
Beta strandⁱ	639 – 644	Combined sources	6
Helixⁱ	648 – 660	Combined sources	13
Turnⁱ	661 – 664	Combined sources	4
Beta strandⁱ	667 – 670	Combined sources	4
Helixⁱ	671 – 673	Combined sources	3

Show more details

3D structure databases

ProteinModelPortalⁱ	Q8N3R9
SMRⁱ	Q8N3R9
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q8N3R9

EvolutionaryTraceⁱ

Q8N3R9

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	120 – 177	L27 1PROSITE-ProRule annotationAdd BLAST	58
Domainⁱ	179 – 235	L27 2PROSITE-ProRule annotationAdd BLAST	57
Domainⁱ	256 – 336	PDZPROSITE-ProRule annotationAdd BLAST	81
Domainⁱ	345 – 417	SH3PROSITE-ProRule annotationAdd BLAST	73
Domainⁱ	479 – 660	Guanylate kinase-likePROSITE-ProRule annotationAdd BLAST	182

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	21 – 140	Interaction with PARD6BBy similarityAdd BLAST		120
Regionⁱ	181 – 243	Interaction with LIN7CBy similarityAdd BLAST		63

Domainⁱ

The L27 domain 1 functions in targeting to the tight junctions by binding to PATJ.By similarity

The PDZ domain binds to the C-terminus of SC6A1.By similarity

Sequence similaritiesⁱ

Belongs to the MAGUK family.Curated

Keywords - Domainⁱ

Repeat, SH3 domain

Phylogenomic databases

eggNOGⁱ	KOG0609 Eukaryota COG0194 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118866
HOGENOMⁱ	HOG000233034
HOVERGENⁱ	HBG001858
InParanoidⁱ	Q8N3R9
KEGG Orthology (KO) More...KOⁱ	K06091
OMAⁱ	ILADMHG
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G065I
PhylomeDBⁱ	Q8N3R9
TreeFamⁱ	TF314263

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd12036 SH3_MPP5, 1 hit
InterProⁱ	View protein in InterPro IPR008145 GK/Ca_channel_bsu IPR008144 Guanylate_kin-like_dom IPR020590 Guanylate_kinase_CS IPR014775 L27_C IPR004172 L27_dom IPR036892 L27_dom_sf IPR015145 L27_N IPR031185 MPP5 IPR035601 MPP5_SH3 IPR027417 P-loop_NTPase IPR001478 PDZ IPR036034 PDZ_sf IPR036028 SH3-like_dom_sf IPR001452 SH3_domain
PANTHERⁱ	PTHR23122:SF61 PTHR23122:SF61, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00625 Guanylate_kin, 1 hit PF02828 L27, 1 hit PF09060 L27_N, 1 hit PF00595 PDZ, 1 hit PF07653 SH3_2, 1 hit
SMARTⁱ	View protein in SMART SM00072 GuKc, 1 hit SM00569 L27, 2 hits SM00228 PDZ, 1 hit SM00326 SH3, 1 hit
SUPFAMⁱ	SSF101288 SSF101288, 2 hits SSF50044 SSF50044, 1 hit SSF50156 SSF50156, 1 hit SSF52540 SSF52540, 1 hit
PROSITEⁱ	View protein in PROSITE PS00856 GUANYLATE_KINASE_1, 1 hit PS50052 GUANYLATE_KINASE_2, 1 hit PS51022 L27, 2 hits PS50106 PDZ, 1 hit PS50002 SH3, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q8N3R9-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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        10         20         30         40         50
MTTSHMNGHV TEESDSEVKN VDLASPEEHQ KHREMAVDCP GDLGTRMMPI 
        60         70         80         90        100
RRSAQLERIR QQQEDMRRRR EEEGKKQELD LNSSMRLKKL AQIPPKTGID 
       110        120        130        140        150
NPMFDTEEGI VLESPHYAVK ILEIEDLFSS LKHIQHTLVD SQSQEDISLL 
       160        170        180        190        200
LQLVQNKDFQ NAFKIHNAIT VHMNKASPPF PLISNAQDLA QEVQTVLKPV 
       210        220        230        240        250
HHKEGQELTA LLNTPHIQAL LLAHDKVAEQ EMQLEPITDE RVYESIGQYG 
       260        270        280        290        300
GETVKIVRIE KARDIPLGAT VRNEMDSVII SRIVKGGAAE KSGLLHEGDE 
       310        320        330        340        350
VLEINGIEIR GKDVNEVFDL LSDMHGTLTF VLIPSQQIKP PPAKETVIHV 
       360        370        380        390        400
KAHFDYDPSD DPYVPCRELG LSFQKGDILH VISQEDPNWW QAYREGDEDN 
       410        420        430        440        450
QPLAGLVPGK SFQQQREAMK QTIEEDKEPE KSGKLWCAKK NKKKRKKVLY 
       460        470        480        490        500
NANKNDDYDN EEILTYEEMS LYHQPANRKR PIILIGPQNC GQNELRQRLM 
       510        520        530        540        550
NKEKDRFASA VPHTTRSRRD QEVAGRDYHF VSRQAFEADI AAGKFIEHGE 
       560        570        580        590        600
FEKNLYGTSI DSVRQVINSG KICLLSLRTQ SLKTLRNSDL KPYIIFIAPP 
       610        620        630        640        650
SQERLRALLA KEGKNPKPEE LREIIEKTRE MEQNNGHYFD TAIVNSDLDK 
       660        670 
AYQELLRLIN KLDTEPQWVP STWLR

Length:675

Mass (Da):77,294

Last modified:October 17, 2006 - v3

Checksum:ⁱA3B2CB594E0908CA

Isoform 2 (identifier: Q8N3R9-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-34: Missing.

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        10         20         30         40         50
MAVDCPGDLG TRMMPIRRSA QLERIRQQQE DMRRRREEEG KKQELDLNSS 
        60         70         80         90        100
MRLKKLAQIP PKTGIDNPMF DTEEGIVLES PHYAVKILEI EDLFSSLKHI 
       110        120        130        140        150
QHTLVDSQSQ EDISLLLQLV QNKDFQNAFK IHNAITVHMN KASPPFPLIS 
       160        170        180        190        200
NAQDLAQEVQ TVLKPVHHKE GQELTALLNT PHIQALLLAH DKVAEQEMQL 
       210        220        230        240        250
EPITDERVYE SIGQYGGETV KIVRIEKARD IPLGATVRNE MDSVIISRIV 
       260        270        280        290        300
KGGAAEKSGL LHEGDEVLEI NGIEIRGKDV NEVFDLLSDM HGTLTFVLIP 
       310        320        330        340        350
SQQIKPPPAK ETVIHVKAHF DYDPSDDPYV PCRELGLSFQ KGDILHVISQ 
       360        370        380        390        400
EDPNWWQAYR EGDEDNQPLA GLVPGKSFQQ QREAMKQTIE EDKEPEKSGK 
       410        420        430        440        450
LWCAKKNKKK RKKVLYNANK NDDYDNEEIL TYEEMSLYHQ PANRKRPIIL 
       460        470        480        490        500
IGPQNCGQNE LRQRLMNKEK DRFASAVPHT TRSRRDQEVA GRDYHFVSRQ 
       510        520        530        540        550
AFEADIAAGK FIEHGEFEKN LYGTSIDSVR QVINSGKICL LSLRTQSLKT 
       560        570        580        590        600
LRNSDLKPYI IFIAPPSQER LRALLAKEGK NPKPEELREI IEKTREMEQN 
       610        620        630        640 
NGHYFDTAIV NSDLDKAYQE LLRLINKLDT EPQWVPSTWL R

Show »

Length:641

Mass (Da):73,421

Checksum:ⁱAD604D26B3580FDB

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

G3V2H1	G3V2H1_HUMAN	MAGUK p55 subfamily member 5 MAGUK p55 subfamily member 5	MPP5	149	Annotation score:
G3V2B0	G3V2B0_HUMAN	MAGUK p55 subfamily member 5 MAGUK p55 subfamily member 5	MPP5	124	Annotation score:

Sequence cautionⁱ

The sequence AAH53366 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

The sequence BAB14172 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	100	D → G in CAD38620 (PubMed:17974005).Curated	1
Sequence conflictⁱ	141	S → Y in CAD89937 (PubMed:17974005).Curated	1
Sequence conflictⁱ	161	N → S in BAC05295 (PubMed:14702039).Curated	1
Sequence conflictⁱ	324	M → L in BAC05295 (PubMed:14702039).Curated	1
Sequence conflictⁱ	401	Q → H in CAD89937 (PubMed:17974005).Curated	1
Sequence conflictⁱ	460	N → H in CAD89937 (PubMed:17974005).Curated	1
Sequence conflictⁱ	490	C → F in BAB14172 (PubMed:14702039).Curated	1
Sequence conflictⁱ	613	G → V in CAD38620 (PubMed:17974005).Curated	1
Sequence conflictⁱ	634	N → S in CAD38620 (PubMed:17974005).Curated	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_014002	1 – 34	Missing in isoform 2. 1 PublicationAdd BLAST		34

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL832326 mRNA Translation: CAD38620.1 AL832578 mRNA Translation: CAD89937.1 CH471061 Genomic DNA Translation: EAW80930.1 BC053366 mRNA Translation: AAH53366.1 Sequence problems. BC129933 mRNA Translation: AAI29934.1 AK022677 mRNA Translation: BAB14172.1 Different initiation. AK098373 mRNA Translation: BAC05295.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS58325.1 [Q8N3R9-2] CCDS9779.1 [Q8N3R9-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001243479.1, NM_001256550.1 [Q8N3R9-2] NP_071919.2, NM_022474.3 [Q8N3R9-1] XP_005268060.1, XM_005268003.1 [Q8N3R9-2] XP_011535388.1, XM_011537086.2 [Q8N3R9-1] XP_011535389.1, XM_011537087.2 [Q8N3R9-1]
UniGeneⁱ	Hs.652312 Hs.740524

Genome annotation databases

Ensemblⁱ	ENST00000261681; ENSP00000261681; ENSG00000072415 [Q8N3R9-1] ENST00000555925; ENSP00000451488; ENSG00000072415 [Q8N3R9-2]
GeneIDⁱ	64398
KEGGⁱ	hsa:64398
UCSC genome browser More...UCSCⁱ	uc001xjc.5 human [Q8N3R9-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q8N3R9	MPP5 isoform 1		PANTR		675	UniRef100_Q8N3R9
Uncharacterized protein		PANPA		675
Isoform 2 of MAGUK p55 subfamily member 5		HUMAN		641
MPP5 isoform 6 (Fragment)		PONAB		149
UPI000013D1DB		MACFA		503
+3

Protein	Similar proteins		Species	Score	Length	Source
Q8N3R9	MAGUK p55 subfamily member 5	)	MOUSE		675	UniRef90_Q9JLB2
MAGUK p55 subfamily member 5		PONAB		675
Membrane palmitoylated protein 5		MONDO		698
Membrane palmitoylated protein 5		FICAL		679
Uncharacterized protein		MACMU		678
+280

Protein	Similar proteins		Species	Score	Length	Source
Q8N3R9	MAGUK p55 subfamily member 5	)	MOUSE		675	UniRef50_Q9JLB2
MAGUK p55 subfamily member 5		PONAB		675
MAGUK p55 subfamily member 5-A		DANRE		677
Membrane palmitoylated protein 5		MONDO		698
Membrane palmitoylated protein 5		FICAL		679
+504

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL832326 mRNA Translation: CAD38620.1 AL832578 mRNA Translation: CAD89937.1 CH471061 Genomic DNA Translation: EAW80930.1 BC053366 mRNA Translation: AAH53366.1 Sequence problems. BC129933 mRNA Translation: AAI29934.1 AK022677 mRNA Translation: BAB14172.1 Different initiation. AK098373 mRNA Translation: BAC05295.1
CCDSⁱ	CCDS58325.1 [Q8N3R9-2] CCDS9779.1 [Q8N3R9-1]
RefSeqⁱ	NP_001243479.1, NM_001256550.1 [Q8N3R9-2] NP_071919.2, NM_022474.3 [Q8N3R9-1] XP_005268060.1, XM_005268003.1 [Q8N3R9-2] XP_011535388.1, XM_011537086.2 [Q8N3R9-1] XP_011535389.1, XM_011537087.2 [Q8N3R9-1]
UniGeneⁱ	Hs.652312 Hs.740524

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1Y76	NMR	-	B/D	118-177	[»]
	3UIT	X-ray	2.05	A/B/C/D	119-232	[»]
	4UU5	X-ray	1.23	A	251-335	[»]
	4UU6	X-ray	1.80	A	251-335	[»]
	4WSI	X-ray	2.95	A/B	236-675	[»]
ProteinModelPortalⁱ	Q8N3R9
SMRⁱ	Q8N3R9
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	122155, 32 interactors
CORUMⁱ	Q8N3R9
IntActⁱ	Q8N3R9, 33 interactors
MINTⁱ	Q8N3R9
STRINGⁱ	9606.ENSP00000261681

PTM databases

iPTMnetⁱ	Q8N3R9
PhosphoSitePlusⁱ	Q8N3R9
SwissPalmⁱ	Q8N3R9

Polymorphism and mutation databases

BioMutaⁱ	MPP5
DMDMⁱ	116242632

Proteomic databases

EPDⁱ	Q8N3R9
MaxQBⁱ	Q8N3R9
PaxDbⁱ	Q8N3R9
PeptideAtlasⁱ	Q8N3R9
PRIDEⁱ	Q8N3R9
ProteomicsDBⁱ	71827 71828 [Q8N3R9-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	64398
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000261681; ENSP00000261681; ENSG00000072415 [Q8N3R9-1] ENST00000555925; ENSP00000451488; ENSG00000072415 [Q8N3R9-2]
GeneIDⁱ	64398
KEGGⁱ	hsa:64398
UCSCⁱ	uc001xjc.5 human [Q8N3R9-1]

Organism-specific databases

CTDⁱ	64398
DisGeNETⁱ	64398
EuPathDBⁱ	HostDB:ENSG00000072415.8
GeneCardsⁱ	MPP5
HGNCⁱ	HGNC:18669 MPP5
HPAⁱ	HPA000993 HPA063890
MIMⁱ	606958 gene
neXtProtⁱ	NX_Q8N3R9
OpenTargetsⁱ	ENSG00000072415
PharmGKBⁱ	PA38631
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0609 Eukaryota COG0194 LUCA
GeneTreeⁱ	ENSGT00760000118866
HOGENOMⁱ	HOG000233034
HOVERGENⁱ	HBG001858
InParanoidⁱ	Q8N3R9
KOⁱ	K06091
OMAⁱ	ILADMHG
OrthoDBⁱ	EOG091G065I
PhylomeDBⁱ	Q8N3R9
TreeFamⁱ	TF314263

Enzyme and pathway databases

Reactomeⁱ	R-HSA-420029 Tight junction interactions
SIGNORⁱ	Q8N3R9

Miscellaneous databases

ChiTaRSⁱ	MPP5 human
EvolutionaryTraceⁱ	Q8N3R9
GeneWikiⁱ	MPP5
GenomeRNAiⁱ	64398
Protein Ontology More...PROⁱ	PR:Q8N3R9
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000072415 Expressed in 208 organ(s), highest expression level in metanephros
CleanExⁱ	HS_MPP5
ExpressionAtlasⁱ	Q8N3R9 baseline and differential
Genevisibleⁱ	Q8N3R9 HS

Family and domain databases

CDDⁱ	cd12036 SH3_MPP5, 1 hit
InterProⁱ	View protein in InterPro IPR008145 GK/Ca_channel_bsu IPR008144 Guanylate_kin-like_dom IPR020590 Guanylate_kinase_CS IPR014775 L27_C IPR004172 L27_dom IPR036892 L27_dom_sf IPR015145 L27_N IPR031185 MPP5 IPR035601 MPP5_SH3 IPR027417 P-loop_NTPase IPR001478 PDZ IPR036034 PDZ_sf IPR036028 SH3-like_dom_sf IPR001452 SH3_domain
PANTHERⁱ	PTHR23122:SF61 PTHR23122:SF61, 1 hit
Pfamⁱ	View protein in Pfam PF00625 Guanylate_kin, 1 hit PF02828 L27, 1 hit PF09060 L27_N, 1 hit PF00595 PDZ, 1 hit PF07653 SH3_2, 1 hit
SMARTⁱ	View protein in SMART SM00072 GuKc, 1 hit SM00569 L27, 2 hits SM00228 PDZ, 1 hit SM00326 SH3, 1 hit
SUPFAMⁱ	SSF101288 SSF101288, 2 hits SSF50044 SSF50044, 1 hit SSF50156 SSF50156, 1 hit SSF52540 SSF52540, 1 hit
PROSITEⁱ	View protein in PROSITE PS00856 GUANYLATE_KINASE_1, 1 hit PS50052 GUANYLATE_KINASE_2, 1 hit PS51022 L27, 2 hits PS50106 PDZ, 1 hit PS50002 SH3, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	MPP5_HUMAN
Accessionⁱ	Q8N3R9Primary (citable) accession number: Q8N3R9 Secondary accession number(s): A1L380 , Q7Z631, Q86T98, Q8N7I5, Q9H9Q0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 10, 2003
	Last sequence update:	October 17, 2006
	Last modified:	November 7, 2018
	This is version 175 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 14
Human chromosome 14: entries, gene names and cross-references to MIM

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UniProtKB - Q8N3R9 (MPP5_HUMAN)

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MAGUK p55 subfamily member 5

MPP5

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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GO - Biological processi

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Gene expression databases

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Secondary structure

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<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ