UniProtKB - Q8N3R9 (MPP5_HUMAN)
MAGUK p55 subfamily member 5
MPP5
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 486 – 493 | ATPPROSITE-ProRule annotation | 8 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- protein domain specific binding Source: BHF-UCL
GO - Biological processi
- bicellular tight junction assembly Source: Reactome
- central nervous system neuron development Source: UniProtKB
- cerebral cortex development Source: UniProtKB
- gene expression Source: Ensembl
- morphogenesis of an epithelial sheet Source: UniProtKB
- myelin assembly Source: Ensembl
- peripheral nervous system myelin maintenance Source: Ensembl
- protein localization to myelin sheath abaxonal region Source: Ensembl
- protein localization to plasma membrane Source: Ensembl
- regulation of transforming growth factor beta receptor signaling pathway Source: UniProtKB
Keywordsi
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | Q8N3R9 |
Reactomei | R-HSA-420029, Tight junction interactions |
SIGNORi | Q8N3R9 |
Names & Taxonomyi
Protein namesi | Recommended name: MAGUK p55 subfamily member 5 |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:18669, MPP5 |
MIMi | 606958, gene |
neXtProti | NX_Q8N3R9 |
VEuPathDBi | HostDB:ENSG00000072415.8 |
Subcellular locationi
Plasma membrane
- Cell membrane ; Peripheral membrane protein
- Apical cell membrane 3 Publications
Golgi apparatus
- Golgi apparatus 1 Publication
Other locations
- Endomembrane system ; Peripheral membrane protein
- tight junction 1 Publication
- adherens junction 1 Publication
- axon By similarity
- Perikaryon By similarity
Note: Localized to the tight junctions of epithelial cells (By similarity). Localized to the Golgi apparatus in T lymphocytes (PubMed:21479189). Localized to a subset of intracellular vesicles (By similarity). Localized to the Purkinje cell body and axon (By similarity). Localized to intercellular junctions in vascular endothelial cells (PubMed:27466317). Localized to Schmidt-Lanterman incisures, the adaxonal domain, and the inner part of paranodal loops in myelinating Schwann cells of the sciatic nerve (By similarity). Localized to apical membrane domains of the outer limiting membrane (OLM) junctions in the retina (By similarity). Colocalizes with CRB1 at the OLM, apical to the adherens junction (PubMed:15914641). Colocalizes with MPP1 in the retina at the OLM (PubMed:17584769). Colocalizes with MPP3 to the subapical region of adherens junctions in the retina OLM (PubMed:16519681).By similarity5 Publications
Golgi apparatus
- Golgi apparatus 1 Publication
Other locations
- Endoplasmic reticulum-Golgi intermediate compartment 1 Publication
Note: (Microbial infection) Following infection by human SARS coronavirus, partially localized at the site of viral replication; the endoplasmic reticulum-Golgi intermediate compartment, reducing its levels at cell-cell contacts which results in delayed formation of tight junctions and affects establishment of cell polarity.1 Publication
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Golgi apparatus
- Golgi apparatus Source: UniProtKB-SubCell
Plasma Membrane
- apical plasma membrane Source: UniProtKB-SubCell
- plasma membrane Source: Reactome
Other locations
- adherens junction Source: UniProtKB
- axon Source: UniProtKB-SubCell
- bicellular tight junction Source: UniProtKB-SubCell
- cytoplasm Source: LIFEdb
- endoplasmic reticulum-Golgi intermediate compartment Source: UniProtKB-SubCell
- lateral loop Source: Ensembl
- myelin sheath adaxonal region Source: Ensembl
- perikaryon Source: UniProtKB-SubCell
- protein-containing complex Source: UniProtKB
- Schmidt-Lanterman incisure Source: Ensembl
Keywords - Cellular componenti
Cell junction, Cell membrane, Cell projection, Golgi apparatus, Membrane, Tight junctionPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 318 | F → A or C: Increases interaction with CRB1. 1 Publication | 1 | |
Mutagenesisi | 386 | D → K: Reduces binding to Drosophila crb and causes incorrect MPP5 localization and cell polarity. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 64398 |
OpenTargetsi | ENSG00000072415 |
PharmGKBi | PA38631 |
Miscellaneous databases
Pharosi | Q8N3R9, Tbio |
Genetic variation databases
BioMutai | MPP5 |
DMDMi | 116242632 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000094580 | 1 – 675 | MAGUK p55 subfamily member 5Add BLAST | 675 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 14 | PhosphoserineCombined sources | 1 | |
Modified residuei | 25 | PhosphoserineCombined sources | 1 | |
Modified residuei | 83 | PhosphoserineCombined sources | 1 | |
Modified residuei | 84 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q8N3R9 |
jPOSTi | Q8N3R9 |
MassIVEi | Q8N3R9 |
MaxQBi | Q8N3R9 |
PaxDbi | Q8N3R9 |
PeptideAtlasi | Q8N3R9 |
PRIDEi | Q8N3R9 |
ProteomicsDBi | 71827 [Q8N3R9-1] 71828 [Q8N3R9-2] |
PTM databases
iPTMneti | Q8N3R9 |
PhosphoSitePlusi | Q8N3R9 |
SwissPalmi | Q8N3R9 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000072415, Expressed in metanephros and 220 other tissues |
ExpressionAtlasi | Q8N3R9, baseline and differential |
Genevisiblei | Q8N3R9, HS |
Organism-specific databases
HPAi | ENSG00000072415, Low tissue specificity |
Interactioni
Subunit structurei
Heterodimer with MPP1 (PubMed:17584769).
Forms a heterotrimeric complex composed of MMP5, LIN7B and PATJ; the N-terminal L27 domain of MPP5 interacts with the L27 domain of PATJ and the C-terminal L27 domain of MPP5 interacts with the L27 domain of LIN7B (PubMed:22337881).
Component of a complex composed of MPP5, CRB1 and MPP4 (PubMed:15914641).
Component of a complex whose core is composed of ARHGAP17, AMOT, MPP5/PALS1, PATJ and PARD3/PAR3 (PubMed:16678097).
Component of a complex composed of MPP5, CRB1 and EPB41L5 (PubMed:17920587). Within the complex, interacts (via HOOK domain) with EPB41L5 (via FERM domain), and interacts with CRB1 (via intracellular domain) (PubMed:17920587).
Component of a complex composed of MPP5, MPP3 and CRB1; MPP5 acts as a bridging protein between MPP3 (via guanylate kinase-like domain) and CRB1 (PubMed:16519681).
Component of a complex composed of CRB3, MPP5/PALS1 and PATJ (By similarity).
Interacts (via PDZ domain) with PATJ (via N-terminus) (PubMed:12527193).
Interacts with EZR (By similarity).
Interacts (via PDZ domain) with CRB1 (via C-terminal ERLI motif) (PubMed:25385611, PubMed:25760605). While the PDZ domain is sufficient for interaction with CRB1, the adjacent SH3 and guanylate kinase-like domains are likely to contribute to a high affinity interaction (PubMed:25385611).
Interacts with WWTR1/TAZ (via WW domain) (PubMed:21145499).
Interacts with MPP7 (PubMed:16678097, PubMed:17332497).
Interacts (via PDZ domain) with CRB3 (via C-terminus) (By similarity).
Interacts with LIN7C (By similarity).
Interacts with MPDZ (By similarity).
Interacts with PARD6B (By similarity).
Interacts with SC6A1 (By similarity).
Interacts with CDH5; the interaction promotes MPP5 localization to cell junctions and is required for CDH5-mediated vascular lumen formation and endothelial cell (PubMed:27466317).
Interacts with NPHP1 (via coiled coil and SH3 domains) (PubMed:19755384).
Interacts with NPHP4 (PubMed:19755384).
Interacts with CRB2 (By similarity).
By similarity13 Publications(Microbial infection) Interacts (via PDZ domain) with human SARS coronavirus envelope small membrane protein E (via C-terminus); this inhibits the interaction between MPP5 and CRB3.
1 PublicationBinary interactionsi
Hide detailsQ8N3R9
Isoform 1 [Q8N3R9-1]
With | #Exp. | IntAct |
---|---|---|
Protein crumbs homolog 3 (PRO_0000021005) | 3 | EBI-8231026,EBI-25611611 |
E [P59637] from Severe acute respiratory syndrome coronavirus. | 9 | EBI-8231026,EBI-25487741 |
GO - Molecular functioni
- protein domain specific binding Source: BHF-UCL
Protein-protein interaction databases
BioGRIDi | 122155, 49 interactors |
ComplexPortali | CPX-6166, CRUMBS3-PALS1-PATJ cell polarity complex CPX-6167, CRUMBS1-PALS1-PATJ cell polarity complex CPX-6180, CRUMBS2-PALS1-PATJ cell polarity complex |
CORUMi | Q8N3R9 |
IntActi | Q8N3R9, 69 interactors |
MINTi | Q8N3R9 |
STRINGi | 9606.ENSP00000261681 |
Miscellaneous databases
RNActi | Q8N3R9, protein |
Structurei
Secondary structure
3D structure databases
BMRBi | Q8N3R9 |
SMRi | Q8N3R9 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q8N3R9 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 120 – 177 | L27 1PROSITE-ProRule annotationAdd BLAST | 58 | |
Domaini | 179 – 235 | L27 2PROSITE-ProRule annotationAdd BLAST | 57 | |
Domaini | 256 – 336 | PDZPROSITE-ProRule annotationAdd BLAST | 81 | |
Domaini | 345 – 417 | SH3PROSITE-ProRule annotationAdd BLAST | 73 | |
Domaini | 479 – 660 | Guanylate kinase-likePROSITE-ProRule annotationAdd BLAST | 182 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 345 | Required for the correct localization of MPP5 and PATJ at cell-cell contacts and the normal formation of tight junctions and adherens junctionsBy similarityAdd BLAST | 345 | |
Regioni | 21 – 140 | Interaction with PARD6BBy similarityAdd BLAST | 120 | |
Regioni | 181 – 243 | Interaction with LIN7CBy similarityAdd BLAST | 63 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Repeat, SH3 domainPhylogenomic databases
eggNOGi | KOG0609, Eukaryota |
GeneTreei | ENSGT00940000156087 |
HOGENOMi | CLU_001715_5_4_1 |
InParanoidi | Q8N3R9 |
OMAi | MMPMRRS |
PhylomeDBi | Q8N3R9 |
TreeFami | TF314263 |
Family and domain databases
CDDi | cd12036, SH3_MPP5, 1 hit |
Gene3Di | 2.30.42.10, 1 hit |
InterProi | View protein in InterPro IPR008145, GK/Ca_channel_bsu IPR008144, Guanylate_kin-like_dom IPR020590, Guanylate_kinase_CS IPR014775, L27_C IPR004172, L27_dom IPR036892, L27_dom_sf IPR015145, L27_N IPR035601, MPP5_SH3 IPR027417, P-loop_NTPase IPR001478, PDZ IPR036034, PDZ_sf IPR036028, SH3-like_dom_sf IPR001452, SH3_domain |
Pfami | View protein in Pfam PF00625, Guanylate_kin, 1 hit PF02828, L27, 1 hit PF09060, L27_N, 1 hit PF00595, PDZ, 1 hit PF07653, SH3_2, 1 hit |
SMARTi | View protein in SMART SM00072, GuKc, 1 hit SM00569, L27, 2 hits SM00228, PDZ, 1 hit SM00326, SH3, 1 hit |
SUPFAMi | SSF101288, SSF101288, 2 hits SSF50044, SSF50044, 1 hit SSF50156, SSF50156, 1 hit SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS00856, GUANYLATE_KINASE_1, 1 hit PS50052, GUANYLATE_KINASE_2, 1 hit PS51022, L27, 2 hits PS50106, PDZ, 1 hit PS50002, SH3, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MTTSHMNGHV TEESDSEVKN VDLASPEEHQ KHREMAVDCP GDLGTRMMPI
60 70 80 90 100
RRSAQLERIR QQQEDMRRRR EEEGKKQELD LNSSMRLKKL AQIPPKTGID
110 120 130 140 150
NPMFDTEEGI VLESPHYAVK ILEIEDLFSS LKHIQHTLVD SQSQEDISLL
160 170 180 190 200
LQLVQNKDFQ NAFKIHNAIT VHMNKASPPF PLISNAQDLA QEVQTVLKPV
210 220 230 240 250
HHKEGQELTA LLNTPHIQAL LLAHDKVAEQ EMQLEPITDE RVYESIGQYG
260 270 280 290 300
GETVKIVRIE KARDIPLGAT VRNEMDSVII SRIVKGGAAE KSGLLHEGDE
310 320 330 340 350
VLEINGIEIR GKDVNEVFDL LSDMHGTLTF VLIPSQQIKP PPAKETVIHV
360 370 380 390 400
KAHFDYDPSD DPYVPCRELG LSFQKGDILH VISQEDPNWW QAYREGDEDN
410 420 430 440 450
QPLAGLVPGK SFQQQREAMK QTIEEDKEPE KSGKLWCAKK NKKKRKKVLY
460 470 480 490 500
NANKNDDYDN EEILTYEEMS LYHQPANRKR PIILIGPQNC GQNELRQRLM
510 520 530 540 550
NKEKDRFASA VPHTTRSRRD QEVAGRDYHF VSRQAFEADI AAGKFIEHGE
560 570 580 590 600
FEKNLYGTSI DSVRQVINSG KICLLSLRTQ SLKTLRNSDL KPYIIFIAPP
610 620 630 640 650
SQERLRALLA KEGKNPKPEE LREIIEKTRE MEQNNGHYFD TAIVNSDLDK
660 670
AYQELLRLIN KLDTEPQWVP STWLR
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketG3V2H1 | G3V2H1_HUMAN | MAGUK p55 subfamily member 5 | MPP5 | 149 | Annotation score: | ||
G3V2B0 | G3V2B0_HUMAN | MAGUK p55 subfamily member 5 | MPP5 | 124 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 100 | D → G in CAD38620 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 141 | S → Y in CAD89937 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 161 | N → S in BAC05295 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 324 | M → L in BAC05295 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 401 | Q → H in CAD89937 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 460 | N → H in CAD89937 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 490 | C → F in BAB14172 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 613 | G → V in CAD38620 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 634 | N → S in CAD38620 (PubMed:17974005).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_014002 | 1 – 34 | Missing in isoform 2. 1 PublicationAdd BLAST | 34 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL832326 mRNA Translation: CAD38620.1 AL832578 mRNA Translation: CAD89937.1 CH471061 Genomic DNA Translation: EAW80930.1 BC053366 mRNA Translation: AAH53366.1 Sequence problems. BC129933 mRNA Translation: AAI29934.1 AK022677 mRNA Translation: BAB14172.1 Different initiation. AK098373 mRNA Translation: BAC05295.1 |
CCDSi | CCDS58325.1 [Q8N3R9-2] CCDS9779.1 [Q8N3R9-1] |
RefSeqi | NP_001243479.1, NM_001256550.1 [Q8N3R9-2] NP_071919.2, NM_022474.3 [Q8N3R9-1] XP_005268060.1, XM_005268003.1 [Q8N3R9-2] XP_011535388.1, XM_011537086.2 [Q8N3R9-1] XP_011535389.1, XM_011537087.2 [Q8N3R9-1] |
Genome annotation databases
Ensembli | ENST00000261681; ENSP00000261681; ENSG00000072415 [Q8N3R9-1] ENST00000555925; ENSP00000451488; ENSG00000072415 [Q8N3R9-2] |
GeneIDi | 64398 |
KEGGi | hsa:64398 |
UCSCi | uc001xjc.5, human [Q8N3R9-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL832326 mRNA Translation: CAD38620.1 AL832578 mRNA Translation: CAD89937.1 CH471061 Genomic DNA Translation: EAW80930.1 BC053366 mRNA Translation: AAH53366.1 Sequence problems. BC129933 mRNA Translation: AAI29934.1 AK022677 mRNA Translation: BAB14172.1 Different initiation. AK098373 mRNA Translation: BAC05295.1 |
CCDSi | CCDS58325.1 [Q8N3R9-2] CCDS9779.1 [Q8N3R9-1] |
RefSeqi | NP_001243479.1, NM_001256550.1 [Q8N3R9-2] NP_071919.2, NM_022474.3 [Q8N3R9-1] XP_005268060.1, XM_005268003.1 [Q8N3R9-2] XP_011535388.1, XM_011537086.2 [Q8N3R9-1] XP_011535389.1, XM_011537087.2 [Q8N3R9-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1Y76 | NMR | - | B/D | 118-177 | [»] | |
3UIT | X-ray | 2.05 | A/B/C/D | 119-232 | [»] | |
4UU5 | X-ray | 1.23 | A | 251-335 | [»] | |
4UU6 | X-ray | 1.80 | A | 251-335 | [»] | |
4WSI | X-ray | 2.95 | A/B | 236-675 | [»] | |
BMRBi | Q8N3R9 | |||||
SMRi | Q8N3R9 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 122155, 49 interactors |
ComplexPortali | CPX-6166, CRUMBS3-PALS1-PATJ cell polarity complex CPX-6167, CRUMBS1-PALS1-PATJ cell polarity complex CPX-6180, CRUMBS2-PALS1-PATJ cell polarity complex |
CORUMi | Q8N3R9 |
IntActi | Q8N3R9, 69 interactors |
MINTi | Q8N3R9 |
STRINGi | 9606.ENSP00000261681 |
PTM databases
iPTMneti | Q8N3R9 |
PhosphoSitePlusi | Q8N3R9 |
SwissPalmi | Q8N3R9 |
Genetic variation databases
BioMutai | MPP5 |
DMDMi | 116242632 |
Proteomic databases
EPDi | Q8N3R9 |
jPOSTi | Q8N3R9 |
MassIVEi | Q8N3R9 |
MaxQBi | Q8N3R9 |
PaxDbi | Q8N3R9 |
PeptideAtlasi | Q8N3R9 |
PRIDEi | Q8N3R9 |
ProteomicsDBi | 71827 [Q8N3R9-1] 71828 [Q8N3R9-2] |
Protocols and materials databases
Antibodypediai | 20, 330 antibodies |
DNASUi | 64398 |
Genome annotation databases
Ensembli | ENST00000261681; ENSP00000261681; ENSG00000072415 [Q8N3R9-1] ENST00000555925; ENSP00000451488; ENSG00000072415 [Q8N3R9-2] |
GeneIDi | 64398 |
KEGGi | hsa:64398 |
UCSCi | uc001xjc.5, human [Q8N3R9-1] |
Organism-specific databases
CTDi | 64398 |
DisGeNETi | 64398 |
GeneCardsi | MPP5 |
HGNCi | HGNC:18669, MPP5 |
HPAi | ENSG00000072415, Low tissue specificity |
MIMi | 606958, gene |
neXtProti | NX_Q8N3R9 |
OpenTargetsi | ENSG00000072415 |
PharmGKBi | PA38631 |
VEuPathDBi | HostDB:ENSG00000072415.8 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0609, Eukaryota |
GeneTreei | ENSGT00940000156087 |
HOGENOMi | CLU_001715_5_4_1 |
InParanoidi | Q8N3R9 |
OMAi | MMPMRRS |
PhylomeDBi | Q8N3R9 |
TreeFami | TF314263 |
Enzyme and pathway databases
PathwayCommonsi | Q8N3R9 |
Reactomei | R-HSA-420029, Tight junction interactions |
SIGNORi | Q8N3R9 |
Miscellaneous databases
BioGRID-ORCSi | 64398, 7 hits in 876 CRISPR screens |
ChiTaRSi | MPP5, human |
EvolutionaryTracei | Q8N3R9 |
GeneWikii | MPP5 |
GenomeRNAii | 64398 |
Pharosi | Q8N3R9, Tbio |
PROi | PR:Q8N3R9 |
RNActi | Q8N3R9, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000072415, Expressed in metanephros and 220 other tissues |
ExpressionAtlasi | Q8N3R9, baseline and differential |
Genevisiblei | Q8N3R9, HS |
Family and domain databases
CDDi | cd12036, SH3_MPP5, 1 hit |
Gene3Di | 2.30.42.10, 1 hit |
InterProi | View protein in InterPro IPR008145, GK/Ca_channel_bsu IPR008144, Guanylate_kin-like_dom IPR020590, Guanylate_kinase_CS IPR014775, L27_C IPR004172, L27_dom IPR036892, L27_dom_sf IPR015145, L27_N IPR035601, MPP5_SH3 IPR027417, P-loop_NTPase IPR001478, PDZ IPR036034, PDZ_sf IPR036028, SH3-like_dom_sf IPR001452, SH3_domain |
Pfami | View protein in Pfam PF00625, Guanylate_kin, 1 hit PF02828, L27, 1 hit PF09060, L27_N, 1 hit PF00595, PDZ, 1 hit PF07653, SH3_2, 1 hit |
SMARTi | View protein in SMART SM00072, GuKc, 1 hit SM00569, L27, 2 hits SM00228, PDZ, 1 hit SM00326, SH3, 1 hit |
SUPFAMi | SSF101288, SSF101288, 2 hits SSF50044, SSF50044, 1 hit SSF50156, SSF50156, 1 hit SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS00856, GUANYLATE_KINASE_1, 1 hit PS50052, GUANYLATE_KINASE_2, 1 hit PS51022, L27, 2 hits PS50106, PDZ, 1 hit PS50002, SH3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MPP5_HUMAN | |
Accessioni | Q8N3R9Primary (citable) accession number: Q8N3R9 Secondary accession number(s): A1L380 Q9H9Q0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 10, 2003 |
Last sequence update: | October 17, 2006 | |
Last modified: | February 10, 2021 | |
This is version 192 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 14
Human chromosome 14: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families