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Protein

T-cell activation inhibitor, mitochondrial

Gene

TCAIM

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May regulate T-cell apoptosis.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
T-cell activation inhibitor, mitochondrial
Alternative name(s):
Tolerance associated gene-1 protein
Short name:
TOAG-1
Gene namesi
Name:TCAIM
Synonyms:C3orf23, TOAG1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000179152.19
HGNCiHGNC:25241 TCAIM
neXtProtiNX_Q8N3R3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

DisGeNETi285343
OpenTargetsiENSG00000179152
PharmGKBiPA142672384

Polymorphism and mutation databases

BioMutaiTCAIM
DMDMi116241286

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002353401 – 496T-cell activation inhibitor, mitochondrialAdd BLAST496

Proteomic databases

EPDiQ8N3R3
MaxQBiQ8N3R3
PaxDbiQ8N3R3
PeptideAtlasiQ8N3R3
PRIDEiQ8N3R3
ProteomicsDBi71823
71824 [Q8N3R3-2]
71825 [Q8N3R3-3]
71826 [Q8N3R3-4]

PTM databases

iPTMnetiQ8N3R3
PhosphoSitePlusiQ8N3R3

Expressioni

Gene expression databases

BgeeiENSG00000179152 Expressed in 194 organ(s), highest expression level in kidney
CleanExiHS_C3orf23
ExpressionAtlasiQ8N3R3 baseline and differential
GenevisibleiQ8N3R3 HS

Interactioni

Protein-protein interaction databases

IntActiQ8N3R3, 1 interactor

Structurei

3D structure databases

ProteinModelPortaliQ8N3R3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili404 – 437Sequence analysisAdd BLAST34

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IIUQ Eukaryota
ENOG410XQCT LUCA
GeneTreeiENSGT00390000012832
HOVERGENiHBG056981
InParanoidiQ8N3R3
OMAiEGHVMLF
OrthoDBiEOG091G0AOF
PhylomeDBiQ8N3R3
TreeFamiTF315619

Family and domain databases

InterProiView protein in InterPro
IPR028031 DUF4460
IPR027989 DUF4461
IPR027986 TCAIM
PANTHERiPTHR31596 PTHR31596, 1 hit
PfamiView protein in Pfam
PF14687 DUF4460, 1 hit
PF14688 DUF4461, 1 hit

Sequences (4+)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8N3R3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MFCHLRPMRR LCLEKIFPHW FPFSRALSGA EAVNALRPFY FAVHPDFFGQ
60 70 80 90 100
HPVEREINEN SLKRLSVYLE NLQKPGFKSL KPTQLTFYVR ETDQSSSDGQ
110 120 130 140 150
EPFSTSGFRA VKFTLHTRDL LSTVLYILNS CSLSVEHIQS LNTNMHTQPL
160 170 180 190 200
KEAKRMPDRP IKWDKSYYSF TGFKDPDEDL EQVSRVETTL TSWLDNNGKS
210 220 230 240 250
AVKKLKNSLP LRKELDRLKD ELSHQLQLSD IRWQRSWGIA HRCSQLHSLS
260 270 280 290 300
RLAQQNLETL KKAKGCTIIF TDRSGMSAVG HVMLGTMDVH HHWTKLFERL
310 320 330 340 350
PSYFDLQRRL MILEDQISYL LGGIQVVYIE ELQPVLTLEE YYSLLDVFYN
360 370 380 390 400
RLLKSRILFH PRSLRGLQMI LNSDRYAPSL HELGHFNIPT LCDPANLQWF
410 420 430 440 450
ILTKAQQARE NMKRKEELKV IENELIQAST KKFSLEKLYK EPSISSIQMV
460 470 480 490
DCCKRLLEQS LPYLHGMHLC ISHFYSVMQD GDLCIPWNWK NGEAIK
Length:496
Mass (Da):57,925
Last modified:October 17, 2006 - v2
Checksum:iA4D60B8606F58251
GO
Isoform 2 (identifier: Q8N3R3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     107-115: GFRAVKFTL → VYLLNISKA
     116-496: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. No experimental confirmation available.
Show »
Length:115
Mass (Da):13,397
Checksum:i82C015AF923964A4
GO
Isoform 3 (identifier: Q8N3R3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     56-70: EINENSLKRLSVYLE → DDTWKSFQCPSDFSL
     71-496: Missing.

Show »
Length:70
Mass (Da):8,333
Checksum:i2C5508E53A2045F3
GO
Isoform 4 (identifier: Q8N3R3-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-144: Missing.

Show »
Length:352
Mass (Da):41,274
Checksum:i7D25CC5D48D18F3E
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0U1RQT4A0A0U1RQT4_HUMAN
T-cell activation inhibitor, mitoch...
TCAIM
115Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti3C → Y in BAF85445 (PubMed:14702039).Curated1
Sequence conflicti244S → G in CAD38627 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0507204H → P. Corresponds to variant dbSNP:rs35830741Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0384211 – 144Missing in isoform 4. 2 PublicationsAdd BLAST144
Alternative sequenceiVSP_01846956 – 70EINEN…SVYLE → DDTWKSFQCPSDFSL in isoform 3. 2 PublicationsAdd BLAST15
Alternative sequenceiVSP_01847071 – 496Missing in isoform 3. 2 PublicationsAdd BLAST426
Alternative sequenceiVSP_018471107 – 115GFRAVKFTL → VYLLNISKA in isoform 2. 1 Publication9
Alternative sequenceiVSP_018472116 – 496Missing in isoform 2. 1 PublicationAdd BLAST381

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK292756 mRNA Translation: BAF85445.1
AK056593 mRNA Translation: BAG51758.1
AK124087 mRNA Translation: BAG54004.1
AL832473 mRNA Translation: CAD38627.1
AC104187 Genomic DNA No translation available.
AC134943 Genomic DNA No translation available.
CH471055 Genomic DNA Translation: EAW64703.1
CH471055 Genomic DNA Translation: EAW64704.1
BC009400 mRNA Translation: AAH09400.2
BC038420 mRNA Translation: AAH38420.1
BC047231 mRNA Translation: AAH47231.1
BC062587 mRNA Translation: AAH62587.1
BC073829 mRNA Translation: AAH73829.1
BC101059 mRNA Translation: AAI01060.1
BC101061 mRNA Translation: AAI01062.1
BC101058 mRNA No translation available.
BC101060 mRNA Translation: AAI01061.1
CCDSiCCDS2712.1 [Q8N3R3-1]
CCDS43076.1 [Q8N3R3-3]
RefSeqiNP_001025010.1, NM_001029839.2 [Q8N3R3-3]
NP_001025011.1, NM_001029840.2 [Q8N3R3-3]
NP_001269842.1, NM_001282913.1 [Q8N3R3-1]
NP_001269843.1, NM_001282914.1 [Q8N3R3-4]
NP_001269844.1, NM_001282915.1 [Q8N3R3-4]
NP_776187.2, NM_173826.3 [Q8N3R3-1]
XP_016861740.1, XM_017006251.1
UniGeneiHs.55131

Genome annotation databases

EnsembliENST00000342649; ENSP00000341539; ENSG00000179152 [Q8N3R3-1]
ENST00000383746; ENSP00000373252; ENSG00000179152 [Q8N3R3-3]
ENST00000396078; ENSP00000379388; ENSG00000179152 [Q8N3R3-3]
ENST00000412611; ENSP00000392032; ENSG00000179152 [Q8N3R3-2]
ENST00000417237; ENSP00000402581; ENSG00000179152 [Q8N3R3-1]
ENST00000417768; ENSP00000402604; ENSG00000179152 [Q8N3R3-2]
ENST00000431657; ENSP00000387842; ENSG00000179152 [Q8N3R3-2]
GeneIDi285343
KEGGihsa:285343
UCSCiuc003cnb.5 human [Q8N3R3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK292756 mRNA Translation: BAF85445.1
AK056593 mRNA Translation: BAG51758.1
AK124087 mRNA Translation: BAG54004.1
AL832473 mRNA Translation: CAD38627.1
AC104187 Genomic DNA No translation available.
AC134943 Genomic DNA No translation available.
CH471055 Genomic DNA Translation: EAW64703.1
CH471055 Genomic DNA Translation: EAW64704.1
BC009400 mRNA Translation: AAH09400.2
BC038420 mRNA Translation: AAH38420.1
BC047231 mRNA Translation: AAH47231.1
BC062587 mRNA Translation: AAH62587.1
BC073829 mRNA Translation: AAH73829.1
BC101059 mRNA Translation: AAI01060.1
BC101061 mRNA Translation: AAI01062.1
BC101058 mRNA No translation available.
BC101060 mRNA Translation: AAI01061.1
CCDSiCCDS2712.1 [Q8N3R3-1]
CCDS43076.1 [Q8N3R3-3]
RefSeqiNP_001025010.1, NM_001029839.2 [Q8N3R3-3]
NP_001025011.1, NM_001029840.2 [Q8N3R3-3]
NP_001269842.1, NM_001282913.1 [Q8N3R3-1]
NP_001269843.1, NM_001282914.1 [Q8N3R3-4]
NP_001269844.1, NM_001282915.1 [Q8N3R3-4]
NP_776187.2, NM_173826.3 [Q8N3R3-1]
XP_016861740.1, XM_017006251.1
UniGeneiHs.55131

3D structure databases

ProteinModelPortaliQ8N3R3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8N3R3, 1 interactor

PTM databases

iPTMnetiQ8N3R3
PhosphoSitePlusiQ8N3R3

Polymorphism and mutation databases

BioMutaiTCAIM
DMDMi116241286

Proteomic databases

EPDiQ8N3R3
MaxQBiQ8N3R3
PaxDbiQ8N3R3
PeptideAtlasiQ8N3R3
PRIDEiQ8N3R3
ProteomicsDBi71823
71824 [Q8N3R3-2]
71825 [Q8N3R3-3]
71826 [Q8N3R3-4]

Protocols and materials databases

DNASUi285343
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000342649; ENSP00000341539; ENSG00000179152 [Q8N3R3-1]
ENST00000383746; ENSP00000373252; ENSG00000179152 [Q8N3R3-3]
ENST00000396078; ENSP00000379388; ENSG00000179152 [Q8N3R3-3]
ENST00000412611; ENSP00000392032; ENSG00000179152 [Q8N3R3-2]
ENST00000417237; ENSP00000402581; ENSG00000179152 [Q8N3R3-1]
ENST00000417768; ENSP00000402604; ENSG00000179152 [Q8N3R3-2]
ENST00000431657; ENSP00000387842; ENSG00000179152 [Q8N3R3-2]
GeneIDi285343
KEGGihsa:285343
UCSCiuc003cnb.5 human [Q8N3R3-1]

Organism-specific databases

CTDi285343
DisGeNETi285343
EuPathDBiHostDB:ENSG00000179152.19
GeneCardsiTCAIM
H-InvDBiHIX0021651
HGNCiHGNC:25241 TCAIM
neXtProtiNX_Q8N3R3
OpenTargetsiENSG00000179152
PharmGKBiPA142672384
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIUQ Eukaryota
ENOG410XQCT LUCA
GeneTreeiENSGT00390000012832
HOVERGENiHBG056981
InParanoidiQ8N3R3
OMAiEGHVMLF
OrthoDBiEOG091G0AOF
PhylomeDBiQ8N3R3
TreeFamiTF315619

Miscellaneous databases

ChiTaRSiTCAIM human
GeneWikiiC3orf23
GenomeRNAii285343
PROiPR:Q8N3R3

Gene expression databases

BgeeiENSG00000179152 Expressed in 194 organ(s), highest expression level in kidney
CleanExiHS_C3orf23
ExpressionAtlasiQ8N3R3 baseline and differential
GenevisibleiQ8N3R3 HS

Family and domain databases

InterProiView protein in InterPro
IPR028031 DUF4460
IPR027989 DUF4461
IPR027986 TCAIM
PANTHERiPTHR31596 PTHR31596, 1 hit
PfamiView protein in Pfam
PF14687 DUF4460, 1 hit
PF14688 DUF4461, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTCAIM_HUMAN
AccessioniPrimary (citable) accession number: Q8N3R3
Secondary accession number(s): A8K9P1
, Q0P5T9, Q495R1, Q495R3, Q4G0M4, Q6GMU8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: October 17, 2006
Last modified: November 7, 2018
This is version 98 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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Main funding by: National Institutes of Health

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