UniProtKB - Q8N3P4 (VPS8_HUMAN)
Vacuolar protein sorting-associated protein 8 homolog
VPS8
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 1258 – 1310 | RING-type; atypicalPROSITE-ProRule annotationAdd BLAST | 53 |
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- endosomal vesicle fusion Source: UniProtKB
- protein transport Source: UniProtKB-KW
Keywordsi
Biological process | Protein transport, Transport |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q8N3P4 |
Names & Taxonomyi
Protein namesi | Recommended name: Vacuolar protein sorting-associated protein 8 homolog |
Gene namesi | Name:VPS8 Synonyms:KIAA0804 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:29122, VPS8 |
MIMi | 618366, gene |
neXtProti | NX_Q8N3P4 |
VEuPathDBi | HostDB:ENSG00000156931.15 |
Subcellular locationi
Endosome
- Early endosome 1 Publication
Endosome
- CORVET complex Source: GO_Central
- early endosome Source: UniProtKB
Keywords - Cellular componenti
EndosomePathology & Biotechi
Organism-specific databases
DisGeNETi | 23355 |
OpenTargetsi | ENSG00000156931 |
PharmGKBi | PA142671617 PA142671888 |
Miscellaneous databases
Pharosi | Q8N3P4, Tbio |
Genetic variation databases
BioMutai | VPS8 |
DMDMi | 296452997 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000278267 | 1 – 1428 | Vacuolar protein sorting-associated protein 8 homologAdd BLAST | 1428 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 26 | PhosphoserineCombined sources | 1 | |
Modified residuei | 32 | PhosphoserineCombined sources | 1 | |
Modified residuei | 127 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q8N3P4 |
jPOSTi | Q8N3P4 |
MassIVEi | Q8N3P4 |
MaxQBi | Q8N3P4 |
PaxDbi | Q8N3P4 |
PeptideAtlasi | Q8N3P4 |
PRIDEi | Q8N3P4 |
ProteomicsDBi | 71820 [Q8N3P4-1] 71821 [Q8N3P4-2] 71822 [Q8N3P4-3] |
PTM databases
iPTMneti | Q8N3P4 |
MetOSitei | Q8N3P4 |
PhosphoSitePlusi | Q8N3P4 |
Expressioni
Gene expression databases
Bgeei | ENSG00000156931, Expressed in corpus callosum and 229 other tissues |
ExpressionAtlasi | Q8N3P4, baseline and differential |
Genevisiblei | Q8N3P4, HS |
Organism-specific databases
HPAi | ENSG00000156931, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with RAB5C (By similarity).
Interacts with TGFBRAP1 (PubMed:25266290).
Component of the putative class C core vacuole/endosome tethering (CORVET) complex; the core of which composed of the class C Vps proteins VPS11, VPS16, VPS18 and VPS33A, is associated with VPS8 and TGFBRAP1 (PubMed:25266290).
By similarity1 Publication1 PublicationBinary interactionsi
Q8N3P4
With | #Exp. | IntAct |
---|---|---|
TGFBRAP1 [Q8WUH2] | 2 | EBI-7261494,EBI-2954829 |
Protein-protein interaction databases
BioGRIDi | 116937, 27 interactors |
CORUMi | Q8N3P4 |
IntActi | Q8N3P4, 23 interactors |
MINTi | Q8N3P4 |
STRINGi | 9606.ENSP00000404704 |
Miscellaneous databases
RNActi | Q8N3P4, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 195 – 236 | WDAdd BLAST | 42 |
Sequence similaritiesi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 1258 – 1310 | RING-type; atypicalPROSITE-ProRule annotationAdd BLAST | 53 |
Keywords - Domaini
WD repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG2079, Eukaryota |
GeneTreei | ENSGT00390000010672 |
HOGENOMi | CLU_000917_1_2_1 |
InParanoidi | Q8N3P4 |
OrthoDBi | 22166at2759 |
PhylomeDBi | Q8N3P4 |
TreeFami | TF314244 |
Family and domain databases
Gene3Di | 2.130.10.10, 1 hit 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR011044, Quino_amine_DH_bsu IPR025941, Vps8_central_dom IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR017986, WD40_repeat_dom IPR036322, WD40_repeat_dom_sf IPR001841, Znf_RING IPR013083, Znf_RING/FYVE/PHD |
Pfami | View protein in Pfam PF12816, Vps8, 1 hit |
SMARTi | View protein in SMART SM00184, RING, 1 hit |
SUPFAMi | SSF50969, SSF50969, 1 hit SSF50978, SSF50978, 1 hit |
PROSITEi | View protein in PROSITE PS50082, WD_REPEATS_2, 1 hit PS50294, WD_REPEATS_REGION, 1 hit PS50089, ZF_RING_2, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 11 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MENEPDHENV EQSLCAKTSE EELNKSFNLE ASLSKFSYID MDKELEFKND
60 70 80 90 100
LIDDKEFDIP QVDTPPTLES ILNETDDEDE SFILEDPTLL NIDTIDSHSY
110 120 130 140 150
DTSSVASSDS GDRTNLKRKK KLPDSFSLHG SVMRHSLLKG ISAQIVSAAD
160 170 180 190 200
KVDAGLPTAI AVSSLIAVGT SHGLALIFGK DQNQALRLCL GSTSVGGQYG
210 220 230 240 250
AISALSINND CSRLLCGFAK GQITMWDLAS GKLLRSITDA HPPGTAILHI
260 270 280 290 300
KFTDDPTLAI CNDSGGSVFE LTFKRVMGVR TCESRCLFSG SKGEVCCIEP
310 320 330 340 350
LHSKPELKDH PITQFSLLAM ASLTKILVIG LKPSLKVWMT FPYGRMDPSS
360 370 380 390 400
VPLLAWHFVA VQNYVNPMLA FCRGDVVHFL LVKRDESGAI HVTKQKHLHL
410 420 430 440 450
YYDLINFTWI NSRTVVLLDS VEKLHVIDRQ TQEELETVEI SEVQLVYNSS
460 470 480 490 500
HFKSLATGGN VSQALALVGE KACYQSISSY GGQIFYLGTK SVYVMMLRSW
510 520 530 540 550
RERVDHLLKQ DCLTEALALA WSFHEGKAKA VVGLSGDASK RKAIVADRMV
560 570 580 590 600
EILFHYADRA LKKCPDQGKI QVMEQHFQDM VPVIVDYCLL LQRKDLLFSQ
610 620 630 640 650
MYDKLSENSV AKGVFLECLE PYILSDKLVG ITPQVMKDLI VHFQDKKLME
660 670 680 690 700
NVEALIVHMD ITSLDIQQVV LMCWENRLYD AMIYVYNRGM NEFISPMEKL
710 720 730 740 750
FRVIAPPLNA GKTLTDEQVV MGNKLLVYIS CCLAGRAYPL GDIPEDLVPL
760 770 780 790 800
VKNQVFEFLI RLHSAEASPE EEIYPYIRTL LHFDTREFLN VLALTFEDFK
810 820 830 840 850
NDKQAVEYQQ RIVDILLKVM VENSDFTPSQ VGCLFTFLAR QLAKPDNTLF
860 870 880 890 900
VNRTLFDQVL EFLCSPDDDS RHSERQQVLL ELLQAGGIVQ FEESRLIRMA
910 920 930 940 950
EKAEFYQICE FMYEREHQYD KIIDCYLRDP LREEEVFNYI HNILSIPGHS
960 970 980 990 1000
AEEKQSVWQK AMDHIEELVS LKPCKAAELV ATHFSGHIET VIKKLQNQVL
1010 1020 1030 1040 1050
LFKFLRSLLD PREGIHVNQE LLQISPCITE QFIELLCQFN PTQVIETLQV
1060 1070 1080 1090 1100
LECYRLEETI QITQKYQLHE VTAYLLEKKG DIHGAFLIML ERLQSKLQEV
1110 1120 1130 1140 1150
THQGENTKED PSLKDVEDTM VETIALCQRN SHNLNQQQRE ALWFPLLEAM
1160 1170 1180 1190 1200
MAPQKLSSSA IPHLHSEALK SLTMQVLNSM AAFIALPSIL QRILQDPVYG
1210 1220 1230 1240 1250
KGKLGEIQGL ILGMLDTFNY EQTLLETTTS LLNQDLHWSL CNLRASVTRG
1260 1270 1280 1290 1300
LNPKQDYCSI CLQQYKRRQE MADEIIVFSC GHLYHSFCLQ NKECTVEFEG
1310 1320 1330 1340 1350
QTRWTCYKCS SSNKVGKLSE NSSEIKKGRI TPSQVKMSPS YHQSKGDPTA
1360 1370 1380 1390 1400
KKGTSEPVLD PQQIQAFDQL CRLYRGSSRL ALLTELSQNR SSESYRPFSG
1410 1420
SQSAPAFNSI FQNENFQLQL IPPPVTED
Computationally mapped potential isoform sequencesi
There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketC9JJN9 | C9JJN9_HUMAN | Vacuolar protein sorting-associated... | VPS8 | 1,428 | Annotation score: | ||
C9JIA0 | C9JIA0_HUMAN | Vacuolar protein sorting-associated... | VPS8 | 121 | Annotation score: | ||
C9JPI1 | C9JPI1_HUMAN | Vacuolar protein sorting-associated... | VPS8 | 140 | Annotation score: | ||
H7C058 | H7C058_HUMAN | Vacuolar protein sorting-associated... | VPS8 | 57 | Annotation score: | ||
C9JG07 | C9JG07_HUMAN | Vacuolar protein sorting-associated... | VPS8 | 202 | Annotation score: | ||
C9JKL0 | C9JKL0_HUMAN | Vacuolar protein sorting-associated... | VPS8 | 74 | Annotation score: | ||
C9JP71 | C9JP71_HUMAN | Vacuolar protein sorting-associated... | VPS8 | 164 | Annotation score: | ||
F8WB24 | F8WB24_HUMAN | Vacuolar protein sorting-associated... | VPS8 | 68 | Annotation score: | ||
H7C1G7 | H7C1G7_HUMAN | Vacuolar protein sorting-associated... | VPS8 | 59 | Annotation score: | ||
H7C322 | H7C322_HUMAN | Vacuolar protein sorting-associated... | VPS8 | 108 | Annotation score: | ||
There is more potential isoformShow all |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 433 | E → G in CAH56195 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 471 | K → N in CAH56195 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 765 | A → S in BAB14322 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 932 | Missing in CAH56195 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 1042 | T → A in BAB14322 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 1043 | Q → L in CAH56195 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 1167 | E → G in BAB14322 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_030730 | 83 | I → V1 PublicationCorresponds to variant dbSNP:rs9830734Ensembl. | 1 | |
Natural variantiVAR_030731 | 1165 | H → Y1 PublicationCorresponds to variant dbSNP:rs11555405Ensembl. | 1 | |
Natural variantiVAR_030732 | 1364 | I → T. Corresponds to variant dbSNP:rs3821750Ensembl. | 1 | |
Natural variantiVAR_030733 | 1372 | R → H. Corresponds to variant dbSNP:rs16859527EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_023249 | 179 – 180 | Missing in isoform 2 and isoform 3. 2 Publications | 2 | |
Alternative sequenceiVSP_023250 | 578 – 667 | Missing in isoform 2. 1 PublicationAdd BLAST | 90 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK022945 mRNA Translation: BAB14322.1 Different initiation. AK292423 mRNA Translation: BAF85112.1 AL833838 mRNA Translation: CAD38698.1 BX647915 mRNA Translation: CAH56195.1 Frameshift. AC025573 Genomic DNA No translation available. AC107294 Genomic DNA No translation available. AC117436 Genomic DNA No translation available. BC001001 mRNA Translation: AAH01001.2 BC140768 mRNA Translation: AAI40769.1 AB018347 mRNA Translation: BAA34524.1 |
CCDSi | CCDS46971.1 [Q8N3P4-1] CCDS46972.1 [Q8N3P4-3] |
RefSeqi | NP_001009921.1, NM_001009921.2 [Q8N3P4-1] NP_056118.2, NM_015303.3 [Q8N3P4-3] XP_005247308.1, XM_005247251.3 |
Genome annotation databases
Ensembli | ENST00000436792; ENSP00000404704; ENSG00000156931 [Q8N3P4-3] ENST00000446204; ENSP00000405483; ENSG00000156931 [Q8N3P4-2] ENST00000625842; ENSP00000487164; ENSG00000156931 [Q8N3P4-1] |
GeneIDi | 23355 |
KEGGi | hsa:23355 |
UCSCi | uc003fpb.2, human [Q8N3P4-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK022945 mRNA Translation: BAB14322.1 Different initiation. AK292423 mRNA Translation: BAF85112.1 AL833838 mRNA Translation: CAD38698.1 BX647915 mRNA Translation: CAH56195.1 Frameshift. AC025573 Genomic DNA No translation available. AC107294 Genomic DNA No translation available. AC117436 Genomic DNA No translation available. BC001001 mRNA Translation: AAH01001.2 BC140768 mRNA Translation: AAI40769.1 AB018347 mRNA Translation: BAA34524.1 |
CCDSi | CCDS46971.1 [Q8N3P4-1] CCDS46972.1 [Q8N3P4-3] |
RefSeqi | NP_001009921.1, NM_001009921.2 [Q8N3P4-1] NP_056118.2, NM_015303.3 [Q8N3P4-3] XP_005247308.1, XM_005247251.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 116937, 27 interactors |
CORUMi | Q8N3P4 |
IntActi | Q8N3P4, 23 interactors |
MINTi | Q8N3P4 |
STRINGi | 9606.ENSP00000404704 |
PTM databases
iPTMneti | Q8N3P4 |
MetOSitei | Q8N3P4 |
PhosphoSitePlusi | Q8N3P4 |
Genetic variation databases
BioMutai | VPS8 |
DMDMi | 296452997 |
Proteomic databases
EPDi | Q8N3P4 |
jPOSTi | Q8N3P4 |
MassIVEi | Q8N3P4 |
MaxQBi | Q8N3P4 |
PaxDbi | Q8N3P4 |
PeptideAtlasi | Q8N3P4 |
PRIDEi | Q8N3P4 |
ProteomicsDBi | 71820 [Q8N3P4-1] 71821 [Q8N3P4-2] 71822 [Q8N3P4-3] |
Protocols and materials databases
Antibodypediai | 33827, 75 antibodies |
Genome annotation databases
Ensembli | ENST00000436792; ENSP00000404704; ENSG00000156931 [Q8N3P4-3] ENST00000446204; ENSP00000405483; ENSG00000156931 [Q8N3P4-2] ENST00000625842; ENSP00000487164; ENSG00000156931 [Q8N3P4-1] |
GeneIDi | 23355 |
KEGGi | hsa:23355 |
UCSCi | uc003fpb.2, human [Q8N3P4-1] |
Organism-specific databases
CTDi | 23355 |
DisGeNETi | 23355 |
GeneCardsi | VPS8 |
HGNCi | HGNC:29122, VPS8 |
HPAi | ENSG00000156931, Low tissue specificity |
MIMi | 618366, gene |
neXtProti | NX_Q8N3P4 |
OpenTargetsi | ENSG00000156931 |
PharmGKBi | PA142671617 PA142671888 |
VEuPathDBi | HostDB:ENSG00000156931.15 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2079, Eukaryota |
GeneTreei | ENSGT00390000010672 |
HOGENOMi | CLU_000917_1_2_1 |
InParanoidi | Q8N3P4 |
OrthoDBi | 22166at2759 |
PhylomeDBi | Q8N3P4 |
TreeFami | TF314244 |
Enzyme and pathway databases
PathwayCommonsi | Q8N3P4 |
Miscellaneous databases
BioGRID-ORCSi | 23355, 33 hits in 884 CRISPR screens |
ChiTaRSi | VPS8, human |
GenomeRNAii | 23355 |
Pharosi | Q8N3P4, Tbio |
PROi | PR:Q8N3P4 |
RNActi | Q8N3P4, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000156931, Expressed in corpus callosum and 229 other tissues |
ExpressionAtlasi | Q8N3P4, baseline and differential |
Genevisiblei | Q8N3P4, HS |
Family and domain databases
Gene3Di | 2.130.10.10, 1 hit 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR011044, Quino_amine_DH_bsu IPR025941, Vps8_central_dom IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR017986, WD40_repeat_dom IPR036322, WD40_repeat_dom_sf IPR001841, Znf_RING IPR013083, Znf_RING/FYVE/PHD |
Pfami | View protein in Pfam PF12816, Vps8, 1 hit |
SMARTi | View protein in SMART SM00184, RING, 1 hit |
SUPFAMi | SSF50969, SSF50969, 1 hit SSF50978, SSF50978, 1 hit |
PROSITEi | View protein in PROSITE PS50082, WD_REPEATS_2, 1 hit PS50294, WD_REPEATS_REGION, 1 hit PS50089, ZF_RING_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | VPS8_HUMAN | |
Accessioni | Q8N3P4Primary (citable) accession number: Q8N3P4 Secondary accession number(s): A8K8Q8 Q9H9B0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 20, 2007 |
Last sequence update: | May 18, 2010 | |
Last modified: | February 10, 2021 | |
This is version 157 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families