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UniProtKB - Q8N3P4 (VPS8_HUMAN)

Entry version 158 (07 Apr 2021)
Sequence version 3 (18 May 2010)
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Protein

Vacuolar protein sorting-associated protein 8 homolog

Gene

VPS8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role in vesicle-mediated protein trafficking of the endocytic membrane transport pathway. Believed to act as a component of the putative CORVET endosomal tethering complexes which is proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (PubMed:25266290). Functions predominantly in APPL1-containing endosomes (PubMed:25266290).1 Publication1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri1258 – 1310RING-type; atypicalPROSITE-ProRule annotationAdd BLAST53

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

  • endosomal vesicle fusion Source: UniProtKB
  • protein transport Source: UniProtKB-KW
Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processProtein transport, Transport
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q8N3P4

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Vacuolar protein sorting-associated protein 8 homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:VPS8
Synonyms:KIAA0804
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:29122, VPS8

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		618366, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8N3P4

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000156931.15

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Endosome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		23355

Open Targets

More...OpenTargetsi		ENSG00000156931

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA142671617
PA142671888

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q8N3P4, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		VPS8

Domain mapping of disease mutations (DMDM)

More...DMDMi		296452997

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002782671 – 1428Vacuolar protein sorting-associated protein 8 homologAdd BLAST1428

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei26PhosphoserineCombined sources1
Modified residuei32PhosphoserineCombined sources1
Modified residuei127PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q8N3P4

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q8N3P4

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q8N3P4

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q8N3P4

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8N3P4

PeptideAtlas

More...PeptideAtlasi		Q8N3P4

PRoteomics IDEntifications database

More...PRIDEi		Q8N3P4

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		71820 [Q8N3P4-1]
71821 [Q8N3P4-2]
71822 [Q8N3P4-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8N3P4

MetOSite database of methionine sulfoxide sites

More...MetOSitei		Q8N3P4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8N3P4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000156931, Expressed in corpus callosum and 229 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q8N3P4, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8N3P4, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000156931, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with RAB5C (By similarity).

Interacts with TGFBRAP1 (PubMed:25266290).

Component of the putative class C core vacuole/endosome tethering (CORVET) complex; the core of which composed of the class C Vps proteins VPS11, VPS16, VPS18 and VPS33A, is associated with VPS8 and TGFBRAP1 (PubMed:25266290).

By similarity1 Publication1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		116937, 28 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-6213, CORVET tethering complex

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q8N3P4

Protein interaction database and analysis system

More...IntActi		Q8N3P4, 23 interactors

Molecular INTeraction database

More...MINTi		Q8N3P4

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000404704

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8N3P4, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati195 – 236WDAdd BLAST42

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the VPS8 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1258 – 1310RING-type; atypicalPROSITE-ProRule annotationAdd BLAST53

Keywords - Domaini

WD repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2079, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000010672

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_000917_1_2_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8N3P4

Database of Orthologous Groups

More...OrthoDBi		22166at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8N3P4

TreeFam database of animal gene trees

More...TreeFami		TF314244

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.130.10.10, 1 hit
3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011044, Quino_amine_DH_bsu
IPR025941, Vps8_central_dom
IPR015943, WD40/YVTN_repeat-like_dom_sf
IPR001680, WD40_repeat
IPR017986, WD40_repeat_dom
IPR036322, WD40_repeat_dom_sf
IPR001841, Znf_RING
IPR013083, Znf_RING/FYVE/PHD

Pfam protein domain database

More...Pfami		View protein in Pfam
PF12816, Vps8, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00184, RING, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF50969, SSF50969, 1 hit
SSF50978, SSF50978, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50082, WD_REPEATS_2, 1 hit
PS50294, WD_REPEATS_REGION, 1 hit
PS50089, ZF_RING_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 11 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8N3P4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MENEPDHENV EQSLCAKTSE EELNKSFNLE ASLSKFSYID MDKELEFKND 
        60         70         80         90        100
LIDDKEFDIP QVDTPPTLES ILNETDDEDE SFILEDPTLL NIDTIDSHSY 
       110        120        130        140        150
DTSSVASSDS GDRTNLKRKK KLPDSFSLHG SVMRHSLLKG ISAQIVSAAD 
       160        170        180        190        200
KVDAGLPTAI AVSSLIAVGT SHGLALIFGK DQNQALRLCL GSTSVGGQYG 
       210        220        230        240        250
AISALSINND CSRLLCGFAK GQITMWDLAS GKLLRSITDA HPPGTAILHI 
       260        270        280        290        300
KFTDDPTLAI CNDSGGSVFE LTFKRVMGVR TCESRCLFSG SKGEVCCIEP 
       310        320        330        340        350
LHSKPELKDH PITQFSLLAM ASLTKILVIG LKPSLKVWMT FPYGRMDPSS 
       360        370        380        390        400
VPLLAWHFVA VQNYVNPMLA FCRGDVVHFL LVKRDESGAI HVTKQKHLHL 
       410        420        430        440        450
YYDLINFTWI NSRTVVLLDS VEKLHVIDRQ TQEELETVEI SEVQLVYNSS 
       460        470        480        490        500
HFKSLATGGN VSQALALVGE KACYQSISSY GGQIFYLGTK SVYVMMLRSW 
       510        520        530        540        550
RERVDHLLKQ DCLTEALALA WSFHEGKAKA VVGLSGDASK RKAIVADRMV 
       560        570        580        590        600
EILFHYADRA LKKCPDQGKI QVMEQHFQDM VPVIVDYCLL LQRKDLLFSQ 
       610        620        630        640        650
MYDKLSENSV AKGVFLECLE PYILSDKLVG ITPQVMKDLI VHFQDKKLME 
       660        670        680        690        700
NVEALIVHMD ITSLDIQQVV LMCWENRLYD AMIYVYNRGM NEFISPMEKL 
       710        720        730        740        750
FRVIAPPLNA GKTLTDEQVV MGNKLLVYIS CCLAGRAYPL GDIPEDLVPL 
       760        770        780        790        800
VKNQVFEFLI RLHSAEASPE EEIYPYIRTL LHFDTREFLN VLALTFEDFK 
       810        820        830        840        850
NDKQAVEYQQ RIVDILLKVM VENSDFTPSQ VGCLFTFLAR QLAKPDNTLF 
       860        870        880        890        900
VNRTLFDQVL EFLCSPDDDS RHSERQQVLL ELLQAGGIVQ FEESRLIRMA 
       910        920        930        940        950
EKAEFYQICE FMYEREHQYD KIIDCYLRDP LREEEVFNYI HNILSIPGHS 
       960        970        980        990       1000
AEEKQSVWQK AMDHIEELVS LKPCKAAELV ATHFSGHIET VIKKLQNQVL 
      1010       1020       1030       1040       1050
LFKFLRSLLD PREGIHVNQE LLQISPCITE QFIELLCQFN PTQVIETLQV 
      1060       1070       1080       1090       1100
LECYRLEETI QITQKYQLHE VTAYLLEKKG DIHGAFLIML ERLQSKLQEV 
      1110       1120       1130       1140       1150
THQGENTKED PSLKDVEDTM VETIALCQRN SHNLNQQQRE ALWFPLLEAM 
      1160       1170       1180       1190       1200
MAPQKLSSSA IPHLHSEALK SLTMQVLNSM AAFIALPSIL QRILQDPVYG 
      1210       1220       1230       1240       1250
KGKLGEIQGL ILGMLDTFNY EQTLLETTTS LLNQDLHWSL CNLRASVTRG 
      1260       1270       1280       1290       1300
LNPKQDYCSI CLQQYKRRQE MADEIIVFSC GHLYHSFCLQ NKECTVEFEG 
      1310       1320       1330       1340       1350
QTRWTCYKCS SSNKVGKLSE NSSEIKKGRI TPSQVKMSPS YHQSKGDPTA 
      1360       1370       1380       1390       1400
KKGTSEPVLD PQQIQAFDQL CRLYRGSSRL ALLTELSQNR SSESYRPFSG 
      1410       1420 
SQSAPAFNSI FQNENFQLQL IPPPVTED
Length:1,428
Mass (Da):161,754
Last modified:May 18, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i97FB5E8D453BBCB6
GO
Isoform 2 (identifier: Q8N3P4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     179-180: Missing.
     578-667: Missing.

Show »
Length:1,336
Mass (Da):151,216
Checksum:i67DBD2AE6D4FBEE6
GO
Isoform 3 (identifier: Q8N3P4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     179-180: Missing.

Show »
Length:1,426
Mass (Da):161,568
Checksum:iECF6DAC303CC7B16
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JJN9C9JJN9_HUMAN
Vacuolar protein sorting-associated...
VPS8
1,428Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JIA0C9JIA0_HUMAN
Vacuolar protein sorting-associated...
VPS8
121Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JPI1C9JPI1_HUMAN
Vacuolar protein sorting-associated...
VPS8
140Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C058H7C058_HUMAN
Vacuolar protein sorting-associated...
VPS8
57Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JG07C9JG07_HUMAN
Vacuolar protein sorting-associated...
VPS8
202Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JKL0C9JKL0_HUMAN
Vacuolar protein sorting-associated...
VPS8
74Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JP71C9JP71_HUMAN
Vacuolar protein sorting-associated...
VPS8
164Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C1G7H7C1G7_HUMAN
Vacuolar protein sorting-associated...
VPS8
59Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C322H7C322_HUMAN
Vacuolar protein sorting-associated...
VPS8
108Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WB24F8WB24_HUMAN
Vacuolar protein sorting-associated...
VPS8
68Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There is more potential isoformShow all

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB14322 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence CAH56195 differs from that shown. Reason: Frameshift.Curated
The sequence CAH56195 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti433E → G in CAH56195 (PubMed:17974005).Curated1
Sequence conflicti471K → N in CAH56195 (PubMed:17974005).Curated1
Sequence conflicti765A → S in BAB14322 (PubMed:14702039).Curated1
Sequence conflicti932Missing in CAH56195 (PubMed:17974005).Curated1
Sequence conflicti1042T → A in BAB14322 (PubMed:14702039).Curated1
Sequence conflicti1043Q → L in CAH56195 (PubMed:17974005).Curated1
Sequence conflicti1167E → G in BAB14322 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03073083I → V1 PublicationCorresponds to variant dbSNP:rs9830734Ensembl.1
Natural variantiVAR_0307311165H → Y1 PublicationCorresponds to variant dbSNP:rs11555405Ensembl.1
Natural variantiVAR_0307321364I → T. Corresponds to variant dbSNP:rs3821750Ensembl.1
Natural variantiVAR_0307331372R → H. Corresponds to variant dbSNP:rs16859527EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_023249179 – 180Missing in isoform 2 and isoform 3. 2 Publications2
Alternative sequenceiVSP_023250578 – 667Missing in isoform 2. 1 PublicationAdd BLAST90

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK022945 mRNA Translation: BAB14322.1 Different initiation.
AK292423 mRNA Translation: BAF85112.1
AL833838 mRNA Translation: CAD38698.1
BX647915 mRNA Translation: CAH56195.1 Frameshift.
AC025573 Genomic DNA No translation available.
AC107294 Genomic DNA No translation available.
AC117436 Genomic DNA No translation available.
BC001001 mRNA Translation: AAH01001.2
BC140768 mRNA Translation: AAI40769.1
AB018347 mRNA Translation: BAA34524.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS46971.1 [Q8N3P4-1]
CCDS46972.1 [Q8N3P4-3]

NCBI Reference Sequences

More...RefSeqi		NP_001009921.1, NM_001009921.2 [Q8N3P4-1]
NP_056118.2, NM_015303.3 [Q8N3P4-3]
XP_005247308.1, XM_005247251.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000436792; ENSP00000404704; ENSG00000156931 [Q8N3P4-3]
ENST00000446204; ENSP00000405483; ENSG00000156931 [Q8N3P4-2]
ENST00000625842; ENSP00000487164; ENSG00000156931 [Q8N3P4-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		23355

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:23355

UCSC genome browser

More...UCSCi		uc003fpb.2, human [Q8N3P4-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK022945 mRNA Translation: BAB14322.1 Different initiation.
AK292423 mRNA Translation: BAF85112.1
AL833838 mRNA Translation: CAD38698.1
BX647915 mRNA Translation: CAH56195.1 Frameshift.
AC025573 Genomic DNA No translation available.
AC107294 Genomic DNA No translation available.
AC117436 Genomic DNA No translation available.
BC001001 mRNA Translation: AAH01001.2
BC140768 mRNA Translation: AAI40769.1
AB018347 mRNA Translation: BAA34524.1
CCDSiCCDS46971.1 [Q8N3P4-1]
CCDS46972.1 [Q8N3P4-3]
RefSeqiNP_001009921.1, NM_001009921.2 [Q8N3P4-1]
NP_056118.2, NM_015303.3 [Q8N3P4-3]
XP_005247308.1, XM_005247251.3

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi116937, 28 interactors
ComplexPortaliCPX-6213, CORVET tethering complex
CORUMiQ8N3P4
IntActiQ8N3P4, 23 interactors
MINTiQ8N3P4
STRINGi9606.ENSP00000404704

PTM databases

iPTMnetiQ8N3P4
MetOSiteiQ8N3P4
PhosphoSitePlusiQ8N3P4

Genetic variation databases

BioMutaiVPS8
DMDMi296452997

Proteomic databases

EPDiQ8N3P4
jPOSTiQ8N3P4
MassIVEiQ8N3P4
MaxQBiQ8N3P4
PaxDbiQ8N3P4
PeptideAtlasiQ8N3P4
PRIDEiQ8N3P4
ProteomicsDBi71820 [Q8N3P4-1]
71821 [Q8N3P4-2]
71822 [Q8N3P4-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		33827, 76 antibodies

Genome annotation databases

EnsembliENST00000436792; ENSP00000404704; ENSG00000156931 [Q8N3P4-3]
ENST00000446204; ENSP00000405483; ENSG00000156931 [Q8N3P4-2]
ENST00000625842; ENSP00000487164; ENSG00000156931 [Q8N3P4-1]
GeneIDi23355
KEGGihsa:23355
UCSCiuc003fpb.2, human [Q8N3P4-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		23355
DisGeNETi23355

GeneCards: human genes, protein and diseases

More...GeneCardsi		VPS8
HGNCiHGNC:29122, VPS8
HPAiENSG00000156931, Low tissue specificity
MIMi618366, gene
neXtProtiNX_Q8N3P4
OpenTargetsiENSG00000156931
PharmGKBiPA142671617
PA142671888
VEuPathDBiHostDB:ENSG00000156931.15

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2079, Eukaryota
GeneTreeiENSGT00390000010672
HOGENOMiCLU_000917_1_2_1
InParanoidiQ8N3P4
OrthoDBi22166at2759
PhylomeDBiQ8N3P4
TreeFamiTF314244

Enzyme and pathway databases

PathwayCommonsiQ8N3P4

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		23355, 36 hits in 1006 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		VPS8, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		23355
PharosiQ8N3P4, Tbio

Protein Ontology

More...PROi		PR:Q8N3P4
RNActiQ8N3P4, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000156931, Expressed in corpus callosum and 229 other tissues
ExpressionAtlasiQ8N3P4, baseline and differential
GenevisibleiQ8N3P4, HS

Family and domain databases

Gene3Di2.130.10.10, 1 hit
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR011044, Quino_amine_DH_bsu
IPR025941, Vps8_central_dom
IPR015943, WD40/YVTN_repeat-like_dom_sf
IPR001680, WD40_repeat
IPR017986, WD40_repeat_dom
IPR036322, WD40_repeat_dom_sf
IPR001841, Znf_RING
IPR013083, Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF12816, Vps8, 1 hit
SMARTiView protein in SMART
SM00184, RING, 1 hit
SUPFAMiSSF50969, SSF50969, 1 hit
SSF50978, SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS50082, WD_REPEATS_2, 1 hit
PS50294, WD_REPEATS_REGION, 1 hit
PS50089, ZF_RING_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiVPS8_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8N3P4
Secondary accession number(s): A8K8Q8
, B9EIQ1, C9JB61, O94896, Q63HP2, Q9BVP9, Q9H9B0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: May 18, 2010
Last modified: April 7, 2021
This is version 158 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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