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Protein

Beta-taxilin

Gene

TXLNB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Promotes motor nerve regeneration (By similarity). May be involved in intracellular vesicle traffic.By similarity

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-taxilin
Alternative name(s):
Muscle-derived protein 77
Short name:
hMDP77
Gene namesi
Name:TXLNB
Synonyms:C6orf198, MDP77
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000164440.14
HGNCiHGNC:21617 TXLNB
MIMi611438 gene
neXtProtiNX_Q8N3L3

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

DisGeNETi167838
OpenTargetsiENSG00000164440
PharmGKBiPA134878600

Polymorphism and mutation databases

BioMutaiTXLNB
DMDMi55583953

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001894231 – 684Beta-taxilinAdd BLAST684

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei474PhosphoserineBy similarity1
Modified residuei483PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8N3L3
PaxDbiQ8N3L3
PeptideAtlasiQ8N3L3
PRIDEiQ8N3L3
ProteomicsDBi71819

PTM databases

iPTMnetiQ8N3L3
PhosphoSitePlusiQ8N3L3

Expressioni

Tissue specificityi

Expressed in skeletal muscle.

Gene expression databases

BgeeiENSG00000164440 Expressed in 140 organ(s), highest expression level in quadriceps femoris
CleanExiHS_TXLNB
ExpressionAtlasiQ8N3L3 baseline and differential
GenevisibleiQ8N3L3 HS

Organism-specific databases

HPAiHPA030401
HPA030402
HPA030403

Interactioni

Subunit structurei

Binds to the C-terminal coiled coil region of syntaxin family members STX1A, STX3A and STX4A. Has a preference for STX1A.

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi127952, 42 interactors
IntActiQ8N3L3, 70 interactors
STRINGi9606.ENSP00000351206

Structurei

3D structure databases

ProteinModelPortaliQ8N3L3
SMRiQ8N3L3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili135 – 351Sequence analysisAdd BLAST217
Coiled coili378 – 467Sequence analysisAdd BLAST90

Sequence similaritiesi

Belongs to the taxilin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG1850 Eukaryota
ENOG410XQH1 LUCA
GeneTreeiENSGT00390000001482
HOGENOMiHOG000231384
HOVERGENiHBG104385
InParanoidiQ8N3L3
OMAiTAFMIIH
OrthoDBiEOG091G0GVB
PhylomeDBiQ8N3L3
TreeFamiTF318595

Family and domain databases

InterProiView protein in InterPro
IPR026183 Taxilin_fam
PANTHERiPTHR16127 PTHR16127, 1 hit
PfamiView protein in Pfam
PF09728 Taxilin, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8N3L3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEANHSEQLS AERQSTPPGD SSSLPSHNGL EKEDGQDSPT PVQPPEKEAS
60 70 80 90 100
VHPDISEELN RQLEDIINTY GSAASTAGKE GSARASEQPE NAESPDNEDG
110 120 130 140 150
DCEETTEEAG REPVASGEPP TVKEPVSNKE QKLEKKILKG LGKEANLLMQ
160 170 180 190 200
NLNKLQTPEE KFDFLFKKYA ELLDEHRTEQ KKLKLLQKKQ VQIQKEKDQL
210 220 230 240 250
QGEHSRAILA RSKLESLCRE LQRHNKTLKE EALQRAREEE EKRKEITSHF
260 270 280 290 300
QSTLTDIQGQ IEQQSERNMK LCQENTELAE KLKSIIDQYE LREEHLDKIF
310 320 330 340 350
KHRELQQKLV DAKLEQAQEM MKEAEERHKR EKEYLLNQAA EWKLQAKVLK
360 370 380 390 400
EQETVLQAQL TLYSGRFEEF QSTLTKSNEV FATFKQEMDK TTKKMKKLEK
410 420 430 440 450
DTATWKARFE NCNKALLDMI EEKALRAKEY ECFVMKIGRL ENLCRALQEE
460 470 480 490 500
RNELHKKIRD AEISEKDDQS QHNSDEEPES NVSVDQEIDA EEVNSVQTAV
510 520 530 540 550
KNLATAFMII HHPESTPHQS KETQPEIGSS QESADAALKE PEQPPLIPSR
560 570 580 590 600
DSESPLPPLT PQAEAEGGSD AEPPSKASNS PAGLGAETQC EGLPVGAQAD
610 620 630 640 650
QASWKPEAEA SGQAPQAPTE ASLQKMEADV PAPACAAEEH VAAMVPACEP
660 670 680
SRQPPRAAAE ELPVGASAGP QPRNVADTNL EGVD
Length:684
Mass (Da):76,519
Last modified:November 9, 2004 - v3
Checksum:i5C40DF4B3085C590
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7BY59H7BY59_HUMAN
Beta-taxilin
TXLNB
133Annotation score:

Sequence cautioni

The sequence CAD38924 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAD91140 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti270K → E in CAD38617 (PubMed:17974005).Curated1
Sequence conflicti597A → T in CAD91140 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01980711A → T. Corresponds to variant dbSNP:rs9321712Ensembl.1
Natural variantiVAR_057729348V → M2 PublicationsCorresponds to variant dbSNP:rs17068451Ensembl.1
Natural variantiVAR_057730527I → T. Corresponds to variant dbSNP:rs9495392Ensembl.1
Natural variantiVAR_057731602A → P2 PublicationsCorresponds to variant dbSNP:rs9495391Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB085905 mRNA Translation: BAC92688.1
AL832322 mRNA Translation: CAD38617.1
AL834248 mRNA Translation: CAD38924.2 Different initiation.
AL831988 mRNA Translation: CAD91140.1 Different initiation.
BX647633 mRNA Translation: CAI45978.1
AL592434 Genomic DNA No translation available.
AL158850 Genomic DNA No translation available.
BC115383 mRNA Translation: AAI15384.1
BC115384 mRNA Translation: AAI15385.1
CCDSiCCDS34545.1
RefSeqiNP_694967.3, NM_153235.3
XP_005266893.1, XM_005266836.1
XP_011533807.1, XM_011535505.2
XP_016865811.1, XM_017010322.1
UniGeneiHs.535820

Genome annotation databases

EnsembliENST00000358430; ENSP00000351206; ENSG00000164440
GeneIDi167838
KEGGihsa:167838
UCSCiuc063rxd.1 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB085905 mRNA Translation: BAC92688.1
AL832322 mRNA Translation: CAD38617.1
AL834248 mRNA Translation: CAD38924.2 Different initiation.
AL831988 mRNA Translation: CAD91140.1 Different initiation.
BX647633 mRNA Translation: CAI45978.1
AL592434 Genomic DNA No translation available.
AL158850 Genomic DNA No translation available.
BC115383 mRNA Translation: AAI15384.1
BC115384 mRNA Translation: AAI15385.1
CCDSiCCDS34545.1
RefSeqiNP_694967.3, NM_153235.3
XP_005266893.1, XM_005266836.1
XP_011533807.1, XM_011535505.2
XP_016865811.1, XM_017010322.1
UniGeneiHs.535820

3D structure databases

ProteinModelPortaliQ8N3L3
SMRiQ8N3L3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127952, 42 interactors
IntActiQ8N3L3, 70 interactors
STRINGi9606.ENSP00000351206

PTM databases

iPTMnetiQ8N3L3
PhosphoSitePlusiQ8N3L3

Polymorphism and mutation databases

BioMutaiTXLNB
DMDMi55583953

Proteomic databases

MaxQBiQ8N3L3
PaxDbiQ8N3L3
PeptideAtlasiQ8N3L3
PRIDEiQ8N3L3
ProteomicsDBi71819

Protocols and materials databases

DNASUi167838
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000358430; ENSP00000351206; ENSG00000164440
GeneIDi167838
KEGGihsa:167838
UCSCiuc063rxd.1 human

Organism-specific databases

CTDi167838
DisGeNETi167838
EuPathDBiHostDB:ENSG00000164440.14
GeneCardsiTXLNB
HGNCiHGNC:21617 TXLNB
HPAiHPA030401
HPA030402
HPA030403
MIMi611438 gene
neXtProtiNX_Q8N3L3
OpenTargetsiENSG00000164440
PharmGKBiPA134878600
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1850 Eukaryota
ENOG410XQH1 LUCA
GeneTreeiENSGT00390000001482
HOGENOMiHOG000231384
HOVERGENiHBG104385
InParanoidiQ8N3L3
OMAiTAFMIIH
OrthoDBiEOG091G0GVB
PhylomeDBiQ8N3L3
TreeFamiTF318595

Miscellaneous databases

ChiTaRSiTXLNB human
GeneWikiiTXLNB
GenomeRNAii167838
PROiPR:Q8N3L3
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000164440 Expressed in 140 organ(s), highest expression level in quadriceps femoris
CleanExiHS_TXLNB
ExpressionAtlasiQ8N3L3 baseline and differential
GenevisibleiQ8N3L3 HS

Family and domain databases

InterProiView protein in InterPro
IPR026183 Taxilin_fam
PANTHERiPTHR16127 PTHR16127, 1 hit
PfamiView protein in Pfam
PF09728 Taxilin, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTXLNB_HUMAN
AccessioniPrimary (citable) accession number: Q8N3L3
Secondary accession number(s): Q5HYH7
, Q5VTF3, Q76L25, Q86T52, Q8N3S2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 9, 2004
Last sequence update: November 9, 2004
Last modified: September 12, 2018
This is version 114 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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