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Protein

Zinc finger protein 664

Gene

ZNF664

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri3 – 25C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri31 – 53C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri59 – 81C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri87 – 109C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri115 – 137C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri143 – 165C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri171 – 193C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri199 – 221C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri227 – 249C2H2-type 9PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 664
Alternative name(s):
Zinc finger protein 176Imported
Zinc finger protein from organ of Corti
Gene namesi
Name:ZNF664Imported
Synonyms:ZFOC1, ZNF176Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000179195.15
HGNCiHGNC:25406 ZNF664
MIMi617890 gene
neXtProtiNX_Q8N3J9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi144348
OpenTargetsiENSG00000179195
PharmGKBiPA37547

Polymorphism and mutation databases

BioMutaiZNF664
DMDMi74759851

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002962731 – 261Zinc finger protein 664Add BLAST261

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki257Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ8N3J9
MaxQBiQ8N3J9
PaxDbiQ8N3J9
PeptideAtlasiQ8N3J9
PRIDEiQ8N3J9
ProteomicsDBi71817

PTM databases

iPTMnetiQ8N3J9
PhosphoSitePlusiQ8N3J9

Expressioni

Gene expression databases

BgeeiENSG00000179195 Expressed in 206 organ(s), highest expression level in metanephros
CleanExiHS_ZNF664
ExpressionAtlasiQ8N3J9 baseline and differential
GenevisibleiQ8N3J9 HS

Organism-specific databases

HPAiHPA047846

Interactioni

Protein-protein interaction databases

BioGridi126844, 7 interactors
IntActiQ8N3J9, 4 interactors
STRINGi9606.ENSP00000337320

Structurei

3D structure databases

ProteinModelPortaliQ8N3J9
SMRiQ8N3J9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri3 – 25C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri31 – 53C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri59 – 81C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri87 – 109C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri115 – 137C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri143 – 165C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri171 – 193C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri199 – 221C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri227 – 249C2H2-type 9PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00870000136402
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ8N3J9
OMAiNNERPFT
OrthoDBiEOG091G02KC
PhylomeDBiQ8N3J9
TreeFamiTF337055

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 8 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 9 hits
SUPFAMiSSF57667 SSF57667, 5 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 9 hits
PS50157 ZINC_FINGER_C2H2_2, 9 hits

Sequencei

Sequence statusi: Complete.

Q8N3J9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIYKCPMCRE FFSERADLFM HQKIHTAEKP HKCDKCDKGF FHISELHIHW
60 70 80 90 100
RDHTGEKVYK CDDCGKDFST TTKLNRHKKI HTVEKPYKCY ECGKAFNWSS
110 120 130 140 150
HLQIHMRVHT GEKPYVCSEC GRGFSNSSNL CMHQRVHTGE KPFKCEECGK
160 170 180 190 200
AFRHTSSLCM HQRVHTGEKP YKCYECGKAF SQSSSLCIHQ RVHTGEKPYR
210 220 230 240 250
CCGCGKAFSQ SSSLCIHQRV HTGEKPFKCD ECGKAFSQST SLCIHQRVHT
260
KERNHLKISV I
Length:261
Mass (Da):30,284
Last modified:October 1, 2002 - v1
Checksum:i783FE11E5FBACAA5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti24I → V in AAC41997 (PubMed:8634327).Curated1
Sequence conflicti113K → E in AAC41997 (PubMed:8634327).Curated1
Sequence conflicti139G → R in AAH51696 (PubMed:15489334).Curated1
Sequence conflicti183S → R in AAC41997 (PubMed:8634327).Curated1
Sequence conflicti198P → H in AAH51696 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056034 mRNA Translation: BAG51609.1
AL834266 mRNA Translation: CAD38941.1
BX647762 mRNA Translation: CAH10567.1
CH471054 Genomic DNA Translation: EAW98441.1
BC051696 mRNA Translation: AAH51696.1
BC093848 mRNA Translation: AAH93848.1
BC101530 mRNA Translation: AAI01531.1
L41669 mRNA Translation: AAC41997.1
CCDSiCCDS9257.1
PIRiS70007
RefSeqiNP_001191227.1, NM_001204298.1
NP_689650.1, NM_152437.2
UniGeneiHs.524828

Genome annotation databases

EnsembliENST00000337815; ENSP00000337320; ENSG00000179195
ENST00000392404; ENSP00000376205; ENSG00000179195
ENST00000538932; ENSP00000440645; ENSG00000179195
ENST00000539644; ENSP00000441405; ENSG00000179195
GeneIDi144348
KEGGihsa:144348
UCSCiuc001uga.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056034 mRNA Translation: BAG51609.1
AL834266 mRNA Translation: CAD38941.1
BX647762 mRNA Translation: CAH10567.1
CH471054 Genomic DNA Translation: EAW98441.1
BC051696 mRNA Translation: AAH51696.1
BC093848 mRNA Translation: AAH93848.1
BC101530 mRNA Translation: AAI01531.1
L41669 mRNA Translation: AAC41997.1
CCDSiCCDS9257.1
PIRiS70007
RefSeqiNP_001191227.1, NM_001204298.1
NP_689650.1, NM_152437.2
UniGeneiHs.524828

3D structure databases

ProteinModelPortaliQ8N3J9
SMRiQ8N3J9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126844, 7 interactors
IntActiQ8N3J9, 4 interactors
STRINGi9606.ENSP00000337320

PTM databases

iPTMnetiQ8N3J9
PhosphoSitePlusiQ8N3J9

Polymorphism and mutation databases

BioMutaiZNF664
DMDMi74759851

Proteomic databases

EPDiQ8N3J9
MaxQBiQ8N3J9
PaxDbiQ8N3J9
PeptideAtlasiQ8N3J9
PRIDEiQ8N3J9
ProteomicsDBi71817

Protocols and materials databases

DNASUi144348
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000337815; ENSP00000337320; ENSG00000179195
ENST00000392404; ENSP00000376205; ENSG00000179195
ENST00000538932; ENSP00000440645; ENSG00000179195
ENST00000539644; ENSP00000441405; ENSG00000179195
GeneIDi144348
KEGGihsa:144348
UCSCiuc001uga.4 human

Organism-specific databases

CTDi144348
DisGeNETi144348
EuPathDBiHostDB:ENSG00000179195.15
GeneCardsiZNF664
HGNCiHGNC:25406 ZNF664
HPAiHPA047846
MIMi617890 gene
neXtProtiNX_Q8N3J9
OpenTargetsiENSG00000179195
PharmGKBiPA37547
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00870000136402
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ8N3J9
OMAiNNERPFT
OrthoDBiEOG091G02KC
PhylomeDBiQ8N3J9
TreeFamiTF337055

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Miscellaneous databases

ChiTaRSiZNF664 human
GeneWikiiZNF664
GenomeRNAii144348
PROiPR:Q8N3J9
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000179195 Expressed in 206 organ(s), highest expression level in metanephros
CleanExiHS_ZNF664
ExpressionAtlasiQ8N3J9 baseline and differential
GenevisibleiQ8N3J9 HS

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 8 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 9 hits
SUPFAMiSSF57667 SSF57667, 5 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 9 hits
PS50157 ZINC_FINGER_C2H2_2, 9 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZN664_HUMAN
AccessioniPrimary (citable) accession number: Q8N3J9
Secondary accession number(s): B3KP97, Q15914, Q3ZCQ7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: October 1, 2002
Last modified: November 7, 2018
This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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