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Protein

Cell adhesion molecule 2

Gene

CADM2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Adhesion molecule that engages in homo- and heterophilic interactions with the other nectin-like family members, leading to cell aggregation. Important for synapse organization, providing regulated trans-synaptic adhesion. Preferentially binds to oligodendrocytes.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-418990 Adherens junctions interactions

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cell adhesion molecule 2
Alternative name(s):
Immunoglobulin superfamily member 4D
Short name:
IgSF4D
Nectin-like protein 3
Short name:
NECL-3
Synaptic cell adhesion molecule 2
Short name:
SynCAM 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CADM2
Synonyms:IGSF4D, NECL3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000175161.13

Human Gene Nomenclature Database

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HGNCi
HGNC:29849 CADM2

Online Mendelian Inheritance in Man (OMIM)

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MIMi
609938 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8N3J6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini25 – 367ExtracellularSequence analysisAdd BLAST343
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei368 – 388HelicalSequence analysisAdd BLAST21
Topological domaini389 – 435CytoplasmicSequence analysisAdd BLAST47

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Membrane, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
253559

Open Targets

More...
OpenTargetsi
ENSG00000175161

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162380882

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CADM2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74759850

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 24Sequence analysisAdd BLAST24
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000029197025 – 435Cell adhesion molecule 2Add BLAST411

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi31N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi44 ↔ 104PROSITE-ProRule annotation
Glycosylationi51N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi146 ↔ 203PROSITE-ProRule annotation
Disulfide bondi248 ↔ 296PROSITE-ProRule annotation
Glycosylationi291N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei423PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8N3J6

PeptideAtlas

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PeptideAtlasi
Q8N3J6

PRoteomics IDEntifications database

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PRIDEi
Q8N3J6

ProteomicsDB human proteome resource

More...
ProteomicsDBi
71814
71815 [Q8N3J6-2]
71816 [Q8N3J6-3]

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
Q8N3J6-3 [Q8N3J6-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8N3J6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8N3J6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000175161 Expressed in 142 organ(s), highest expression level in endothelial cell

CleanEx database of gene expression profiles

More...
CleanExi
HS_CADM2

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8N3J6 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8N3J6 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA010024

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
128973, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000384193

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q8N3J6

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8N3J6

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini27 – 119Ig-like V-typeAdd BLAST93
Domaini127 – 219Ig-like C2-type 1Add BLAST93
Domaini227 – 312Ig-like C2-type 2Add BLAST86

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi319 – 350Thr-richAdd BLAST32

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the nectin family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IFCE Eukaryota
ENOG411017U LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000155947

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000036057

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG057086

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q8N3J6

KEGG Orthology (KO)

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KOi
K06782

Identification of Orthologs from Complete Genome Data

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OMAi
XPNALAG

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0BHE

Database for complete collections of gene phylogenies

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PhylomeDBi
Q8N3J6

TreeFam database of animal gene trees

More...
TreeFami
TF326804

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013162 CD80_C2-set
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013106 Ig_V-set
IPR003585 Neurexin-like

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08205 C2-set_2, 1 hit
PF07686 V-set, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00294 4.1m, 1 hit
SM00409 IG, 2 hits
SM00408 IGc2, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726 SSF48726, 3 hits

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS50835 IG_LIKE, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8N3J6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MIWKRSAVLR FYSVCGLLLQ GSQGQFPLTQ NVTVVEGGTA ILTCRVDQND
60 70 80 90 100
NTSLQWSNPA QQTLYFDDKK ALRDNRIELV RASWHELSIS VSDVSLSDEG
110 120 130 140 150
QYTCSLFTMP VKTSKAYLTV LGVPEKPQIS GFSSPVMEGD LMQLTCKTSG
160 170 180 190 200
SKPAADIRWF KNDKEIKDVK YLKEEDANRK TFTVSSTLDF RVDRSDDGVA
210 220 230 240 250
VICRVDHESL NATPQVAMQV LEIHYTPSVK IIPSTPFPQE GQPLILTCES
260 270 280 290 300
KGKPLPEPVL WTKDGGELPD PDRMVVSGRE LNILFLNKTD NGTYRCEATN
310 320 330 340 350
TIGQSSAEYV LIVHDVPNTL LPTTIIPSLT TATVTTTVAI TTSPTTSATT
360 370 380 390 400
SSIRDPNALA GQNGPDHALI GGIVAVVVFV TLCSIFLLGR YLARHKGTYL
410 420 430
TNEAKGAEDA PDADTAIINA EGSQVNAEEK KEYFI
Length:435
Mass (Da):47,554
Last modified:October 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i59DDD41B7F34D446
GO
Isoform 2 (identifier: Q8N3J6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     20-20: Q → QAAASKNKVK
     316-355: Missing.

Show »
Length:404
Mass (Da):44,423
Checksum:i736AC87C03FDE1B7
GO
Isoform 3 (identifier: Q8N3J6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-20: MIWKRSAVLRFYSVCGLLLQ → MFVLFLCNLSLVPAAASKNKVK

Show »
Length:437
Mass (Da):47,564
Checksum:iE94A18403F9B774C
GO
Isoform 5 (identifier: Q8N3J6-4) [UniParc]FASTAAdd to basket
Also known as: 7

The sequence of this isoform differs from the canonical sequence as follows:
     1-108: Missing.
     315-354: Missing.

Show »
Length:287
Mass (Da):31,382
Checksum:iBC731D7DAE4DCC7F
GO
Isoform 6 (identifier: Q8N3J6-5) [UniParc]FASTAAdd to basket
Also known as: 8

The sequence of this isoform differs from the canonical sequence as follows:
     1-108: Missing.

Show »
Length:327
Mass (Da):35,410
Checksum:i5F453DC33C818100
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti174E → K in AAN16368 (Ref. 2) Curated1
Sequence conflicti212A → T in AAN16368 (Ref. 2) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0553551 – 108Missing in isoform 5 and isoform 6. 1 PublicationAdd BLAST108
Alternative sequenceiVSP_0263331 – 20MIWKR…GLLLQ → MFVLFLCNLSLVPAAASKNK VK in isoform 3. 1 PublicationAdd BLAST20
Alternative sequenceiVSP_02633420Q → QAAASKNKVK in isoform 2. 2 Publications1
Alternative sequenceiVSP_055356315 – 354Missing in isoform 5. 1 PublicationAdd BLAST40
Alternative sequenceiVSP_026335316 – 355Missing in isoform 2. 2 PublicationsAdd BLAST40

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB646740 mRNA Translation: BAK93303.1
AB646741 mRNA Translation: BAK93304.1
AB646742 mRNA Translation: BAK93305.1
AB646743 mRNA Translation: BAK93306.1
AF538973 mRNA Translation: AAN16368.1
AL833049 mRNA Translation: CAH56314.1
AL834270 mRNA Translation: CAD38945.1
BC105999 mRNA Translation: AAI06000.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS33792.1 [Q8N3J6-3]
CCDS54613.1 [Q8N3J6-2]
CCDS54614.1 [Q8N3J6-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001161146.1, NM_001167674.1 [Q8N3J6-1]
NP_001161147.1, NM_001167675.1 [Q8N3J6-2]
NP_001243431.1, NM_001256502.1 [Q8N3J6-5]
NP_001243432.1, NM_001256503.1 [Q8N3J6-5]
NP_001243433.1, NM_001256504.1 [Q8N3J6-4]
NP_001243434.1, NM_001256505.1 [Q8N3J6-4]
NP_694854.2, NM_153184.3 [Q8N3J6-3]
XP_006713144.1, XM_006713081.3 [Q8N3J6-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.164578

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000383699; ENSP00000373200; ENSG00000175161 [Q8N3J6-2]
ENST00000405615; ENSP00000384193; ENSG00000175161 [Q8N3J6-3]
ENST00000407528; ENSP00000384575; ENSG00000175161 [Q8N3J6-1]
ENST00000644573; ENSP00000496096; ENSG00000284780 [Q8N3J6-2]
ENST00000644749; ENSP00000495354; ENSG00000284780 [Q8N3J6-3]
ENST00000647099; ENSP00000494084; ENSG00000284780 [Q8N3J6-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
253559

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:253559

UCSC genome browser

More...
UCSCi
uc003dqj.4 human [Q8N3J6-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB646740 mRNA Translation: BAK93303.1
AB646741 mRNA Translation: BAK93304.1
AB646742 mRNA Translation: BAK93305.1
AB646743 mRNA Translation: BAK93306.1
AF538973 mRNA Translation: AAN16368.1
AL833049 mRNA Translation: CAH56314.1
AL834270 mRNA Translation: CAD38945.1
BC105999 mRNA Translation: AAI06000.1
CCDSiCCDS33792.1 [Q8N3J6-3]
CCDS54613.1 [Q8N3J6-2]
CCDS54614.1 [Q8N3J6-1]
RefSeqiNP_001161146.1, NM_001167674.1 [Q8N3J6-1]
NP_001161147.1, NM_001167675.1 [Q8N3J6-2]
NP_001243431.1, NM_001256502.1 [Q8N3J6-5]
NP_001243432.1, NM_001256503.1 [Q8N3J6-5]
NP_001243433.1, NM_001256504.1 [Q8N3J6-4]
NP_001243434.1, NM_001256505.1 [Q8N3J6-4]
NP_694854.2, NM_153184.3 [Q8N3J6-3]
XP_006713144.1, XM_006713081.3 [Q8N3J6-1]
UniGeneiHs.164578

3D structure databases

ProteinModelPortaliQ8N3J6
SMRiQ8N3J6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128973, 1 interactor
STRINGi9606.ENSP00000384193

PTM databases

iPTMnetiQ8N3J6
PhosphoSitePlusiQ8N3J6

Polymorphism and mutation databases

BioMutaiCADM2
DMDMi74759850

Proteomic databases

PaxDbiQ8N3J6
PeptideAtlasiQ8N3J6
PRIDEiQ8N3J6
ProteomicsDBi71814
71815 [Q8N3J6-2]
71816 [Q8N3J6-3]
TopDownProteomicsiQ8N3J6-3 [Q8N3J6-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000383699; ENSP00000373200; ENSG00000175161 [Q8N3J6-2]
ENST00000405615; ENSP00000384193; ENSG00000175161 [Q8N3J6-3]
ENST00000407528; ENSP00000384575; ENSG00000175161 [Q8N3J6-1]
ENST00000644573; ENSP00000496096; ENSG00000284780 [Q8N3J6-2]
ENST00000644749; ENSP00000495354; ENSG00000284780 [Q8N3J6-3]
ENST00000647099; ENSP00000494084; ENSG00000284780 [Q8N3J6-1]
GeneIDi253559
KEGGihsa:253559
UCSCiuc003dqj.4 human [Q8N3J6-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
253559
DisGeNETi253559
EuPathDBiHostDB:ENSG00000175161.13

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CADM2
HGNCiHGNC:29849 CADM2
HPAiHPA010024
MIMi609938 gene
neXtProtiNX_Q8N3J6
OpenTargetsiENSG00000175161
PharmGKBiPA162380882

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IFCE Eukaryota
ENOG411017U LUCA
GeneTreeiENSGT00940000155947
HOGENOMiHOG000036057
HOVERGENiHBG057086
InParanoidiQ8N3J6
KOiK06782
OMAiXPNALAG
OrthoDBiEOG091G0BHE
PhylomeDBiQ8N3J6
TreeFamiTF326804

Enzyme and pathway databases

ReactomeiR-HSA-418990 Adherens junctions interactions

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
CADM2 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
253559

Protein Ontology

More...
PROi
PR:Q8N3J6

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000175161 Expressed in 142 organ(s), highest expression level in endothelial cell
CleanExiHS_CADM2
ExpressionAtlasiQ8N3J6 baseline and differential
GenevisibleiQ8N3J6 HS

Family and domain databases

Gene3Di2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR013162 CD80_C2-set
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013106 Ig_V-set
IPR003585 Neurexin-like
PfamiView protein in Pfam
PF08205 C2-set_2, 1 hit
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00294 4.1m, 1 hit
SM00409 IG, 2 hits
SM00408 IGc2, 2 hits
SUPFAMiSSF48726 SSF48726, 3 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCADM2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8N3J6
Secondary accession number(s): G3XHN7
, G3XHN8, Q3KQY9, Q658Q7, Q8IZP8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: October 1, 2002
Last modified: December 5, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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