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Entry version 155 (08 May 2019)
Sequence version 2 (23 Apr 2003)
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Protein

MICAL-like protein 1

Gene

MICALL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probable lipid-binding protein with higher affinity for phosphatidic acid, a lipid enriched in recycling endosome membranes. On endosome membranes, may act as a downstream effector of Rab proteins recruiting cytosolic proteins to regulate membrane tubulation. May be involved in a late step of receptor-mediated endocytosis regulating for instance endocytosed-EGF receptor trafficking. Alternatively, may regulate slow endocytic recycling of endocytosed proteins back to the plasma membrane. May indirectly play a role in neurite outgrowth.4 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processEndocytosis, Protein transport, Transport
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
MICAL-like protein 1
Alternative name(s):
Molecule interacting with Rab13
Short name:
MIRab13
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MICALL1
Synonyms:KIAA1668, MIRAB13
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 22

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:29804 MICALL1

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8N3F8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Endosome, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi385 – 387PLP → ALA: No effect on interaction with PACSIN2. Loss of interaction with PACSIN2; when associated with 480-A--A-483. 1 Publication3
Mutagenesisi425 – 427NPF → APA: Partial loss of interaction with EHD1. Complete loss of interaction with EHD1; when associated with 633-A--A-635. 1 Publication3
Mutagenesisi428 – 430EEE → AAA: Strongly reduces interaction with EHD1. 1 Publication3
Mutagenesisi480 – 483PRAP → ARAA: No effect on interaction with PACSIN2. Loss of interaction with PACSIN2; when associated with 385-A--A-387. 1 Publication4
Mutagenesisi633 – 635NPF → APA: No effect on interaction with EHD1. Complete loss of interaction with EHD1; when associated with 425-A--A-427. 1 Publication3
Mutagenesisi721 – 726MLVDWF → AAAAAA: Altered association with membranes. 1 Publication6

Organism-specific databases

DisGeNET

More...
DisGeNETi
85377

Open Targets

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OpenTargetsi
ENSG00000100139

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162395891

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MICALL1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
30173085

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000758481 – 863MICAL-like protein 1Add BLAST863

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei295PhosphoserineCombined sources1
Modified residuei309PhosphoserineCombined sources1
Modified residuei318PhosphothreonineCombined sources1
Modified residuei391PhosphoserineCombined sources1
Modified residuei467PhosphothreonineCombined sources1
Modified residuei469PhosphothreonineCombined sources1
Modified residuei470PhosphoserineCombined sources1
Modified residuei471PhosphoserineCombined sources1
Modified residuei484PhosphoserineCombined sources1
Modified residuei486PhosphoserineCombined sources1
Modified residuei578PhosphoserineCombined sources1
Modified residuei621PhosphoserineCombined sources1
Modified residuei740PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q8N3F8

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q8N3F8

MaxQB - The MaxQuant DataBase

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MaxQBi
Q8N3F8

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q8N3F8

PeptideAtlas

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PeptideAtlasi
Q8N3F8

PRoteomics IDEntifications database

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PRIDEi
Q8N3F8

ProteomicsDB human proteome resource

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ProteomicsDBi
71798

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q8N3F8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q8N3F8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000100139 Expressed in 195 organ(s), highest expression level in cervix squamous epithelium

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q8N3F8 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q8N3F8 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA043480
HPA051956

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homooligomer (Probable).

Interacts (via NPF1 motif) with EHD1 (via EH domain); the interaction is direct and probably recruits EHD1 to membranes.

Interacts with EHD3 (via EH domain).

Interacts with RAB35 (GTP-bound form); the interaction is direct and probably recruits MICALL1 to membranes.

Interacts with ACAP2; the interaction is indirect through RAB35.

Interacts with RAB8A (GTP-bound form); regulates RAB8A association with recycling endosomes.

Interacts with RAB13 (GTP-bound form).

Interacts with ARF6 (GTP-bound form).

Interacts with PACSIN2 (via the SH3 domain).

Interacts with DPYSL2.

Curated6 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
124504, 30 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q8N3F8

Protein interaction database and analysis system

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IntActi
Q8N3F8, 21 interactors

Molecular INTeraction database

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MINTi
Q8N3F8

STRING: functional protein association networks

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STRINGi
9606.ENSP00000215957

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q8N3F8

Database of comparative protein structure models

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ModBasei
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
Q8N3F8

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini2 – 108Calponin-homology (CH)PROSITE-ProRule annotationAdd BLAST107
Domaini162 – 225LIM zinc-bindingPROSITE-ProRule annotationAdd BLAST64
Domaini671 – 818bMERBPROSITE-ProRule annotationAdd BLAST148

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni652 – 863Mediates the interaction with RAB13 and RAB35 and intramolecular interaction with the CH domain2 PublicationsAdd BLAST212
Regioni700 – 863Necessary and sufficient to associate with tubular recycling endosome membranes, mediate phosphatidic acid-binding and membrane tubulationAdd BLAST164

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili682 – 711Sequence analysisAdd BLAST30
Coiled coili785 – 830Sequence analysisAdd BLAST46

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi425 – 427NPF13
Motifi633 – 635NPF23

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi253 – 667Pro-richAdd BLAST415

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Probably exists in a closed and an opened conformation due to interaction of the C-terminal RAB-binding domain (RBD), also described as bivalent Mical/EHBP Rab binding (bMERB) domain, with the N-terminal calponin-homology (CH) domain. The conformational change is regulated by RAB13 and may modulate MICALL1 interactions with functional partners.1 Publication

Keywords - Domaini

Coiled coil, LIM domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IG9K Eukaryota
COG5069 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000156057

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q8N3F8

KEGG Orthology (KO)

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KOi
K19948

Identification of Orthologs from Complete Genome Data

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OMAi
AYHRTCL

Database of Orthologous Groups

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OrthoDBi
377701at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q8N3F8

TreeFam database of animal gene trees

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TreeFami
TF328311

Family and domain databases

Conserved Domains Database

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CDDi
cd00014 CH, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.10.418.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR022735 bMERB_dom
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR028563 MICAL-L
IPR001781 Znf_LIM

The PANTHER Classification System

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PANTHERi
PTHR23167:SF44 PTHR23167:SF44, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00307 CH, 1 hit
PF12130 DUF3585, 1 hit
PF00412 LIM, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00033 CH, 1 hit
SM00132 LIM, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47576 SSF47576, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS51848 BMERB, 1 hit
PS50021 CH, 1 hit
PS00478 LIM_DOMAIN_1, 1 hit
PS50023 LIM_DOMAIN_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q8N3F8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGPRGALLA WCRRQCEGYR GVEIRDLSSS FRDGLAFCAI LHRHRPDLLD
60 70 80 90 100
FDSLSKDNVF ENNRLAFEVA EKELGIPALL DPNDMVSMSV PDCLSIMTYV
110 120 130 140 150
SQYYNHFCSP GQAGVSPPRK GLAPCSPPSV APTPVEPEDV AQGEELSSGS
160 170 180 190 200
LSEQGTGQTP SSTCAACQQH VHLVQRYLAD GRLYHRHCFR CRRCSSTLLP
210 220 230 240 250
GAYENGPEEG TFVCAEHCAR LGPGTRSGTR PGPFSQPKQQ HQQQLAEDAK
260 270 280 290 300
DVPGGGPSSS APAGAEADGP KASPEARPQI PTKPRVPGKL QELASPPAGR
310 320 330 340 350
PTPAPRKASE STTPAPPTPR PRSSLQQENL VEQAGSSSLV NGRLHELPVP
360 370 380 390 400
KPRGTPKPSE GTPAPRKDPP WITLVQAEPK KKPAPLPPSS SPGPPSQDSR
410 420 430 440 450
QVENGGTEEV AQPSPTASLE SKPYNPFEEE EEDKEEEAPA APSLATSPAL
460 470 480 490 500
GHPESTPKSL HPWYGITPTS SPKTKKRPAP RAPSASPLAL HASRLSHSEP
510 520 530 540 550
PSATPSPALS VESLSSESAS QTAGAELLEP PAVPKSSSEP AVHAPGTPGN
560 570 580 590 600
PVSLSTNSSL ASSGELVEPR VEQMPQASPG LAPRTRGSSG PQPAKPCSGA
610 620 630 640 650
TPTPLLLVGD RSPVPSPGSS SPQLQVKSSC KENPFNRKPS PAASPATKKA
660 670 680 690 700
TKGSKPVRPP APGHGFPLIK RKVQADQYIP EEDIHGEMDT IERRLDALEH
710 720 730 740 750
RGVLLEEKLR GGLNEGREDD MLVDWFKLIH EKHLLVRRES ELIYVFKQQN
760 770 780 790 800
LEQRQADVEY ELRCLLNKPE KDWTEEDRAR EKVLMQELVT LIEQRNAIIN
810 820 830 840 850
CLDEDRQREE EEDKMLEAMI KKKEFQREAE PEGKKKGKFK TMKMLKLLGN
860
KRDAKSKSPR DKS
Length:863
Mass (Da):93,441
Last modified:April 23, 2003 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i755E3B57C6037292
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B0QY91B0QY91_HUMAN
MICAL-like protein 1
MICALL1
186Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y6J8H0Y6J8_HUMAN
MICAL-like protein 1
MICALL1
370Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B0QY86B0QY86_HUMAN
MICAL-like protein 1
MICALL1
210Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAD39036 differs from that shown. Reason: Frameshift at positions 486 and 507.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti137P → S in BAB33338 (PubMed:11258795).Curated1
Sequence conflicti212F → Y in CAD39036 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_018262519A → S1 PublicationCorresponds to variant dbSNP:rs9610875Ensembl.1
Natural variantiVAR_020258583P → L. Corresponds to variant dbSNP:rs2272829Ensembl.1
Natural variantiVAR_050158685H → R. Corresponds to variant dbSNP:rs34834842Ensembl.1
Natural variantiVAR_036192817E → K in a breast cancer sample; somatic mutation. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AJ496196 mRNA Translation: CAD42713.1
CR456437 mRNA Translation: CAG30323.1
AL022311 Genomic DNA No translation available.
AL834373 mRNA Translation: CAD39036.1 Frameshift.
AL833860 mRNA Translation: CAD38718.1
AB051455 mRNA Translation: BAB33338.1
BC001090 mRNA Translation: AAH01090.2
BK000466 mRNA Translation: DAA01345.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS13961.1

NCBI Reference Sequences

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RefSeqi
NP_203744.1, NM_033386.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000215957; ENSP00000215957; ENSG00000100139

Database of genes from NCBI RefSeq genomes

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GeneIDi
85377

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:85377

UCSC genome browser

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UCSCi
uc003aui.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ496196 mRNA Translation: CAD42713.1
CR456437 mRNA Translation: CAG30323.1
AL022311 Genomic DNA No translation available.
AL834373 mRNA Translation: CAD39036.1 Frameshift.
AL833860 mRNA Translation: CAD38718.1
AB051455 mRNA Translation: BAB33338.1
BC001090 mRNA Translation: AAH01090.2
BK000466 mRNA Translation: DAA01345.1
CCDSiCCDS13961.1
RefSeqiNP_203744.1, NM_033386.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2KSPNMR-B419-433[»]
SMRiQ8N3F8
ModBaseiSearch...

Protein-protein interaction databases

BioGridi124504, 30 interactors
CORUMiQ8N3F8
IntActiQ8N3F8, 21 interactors
MINTiQ8N3F8
STRINGi9606.ENSP00000215957

PTM databases

iPTMnetiQ8N3F8
PhosphoSitePlusiQ8N3F8

Polymorphism and mutation databases

BioMutaiMICALL1
DMDMi30173085

Proteomic databases

EPDiQ8N3F8
jPOSTiQ8N3F8
MaxQBiQ8N3F8
PaxDbiQ8N3F8
PeptideAtlasiQ8N3F8
PRIDEiQ8N3F8
ProteomicsDBi71798

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
85377
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000215957; ENSP00000215957; ENSG00000100139
GeneIDi85377
KEGGihsa:85377
UCSCiuc003aui.4 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
85377
DisGeNETi85377

GeneCards: human genes, protein and diseases

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GeneCardsi
MICALL1
HGNCiHGNC:29804 MICALL1
HPAiHPA043480
HPA051956
neXtProtiNX_Q8N3F8
OpenTargetsiENSG00000100139
PharmGKBiPA162395891

Human Unidentified Gene-Encoded large proteins database

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HUGEi
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GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410IG9K Eukaryota
COG5069 LUCA
GeneTreeiENSGT00940000156057
InParanoidiQ8N3F8
KOiK19948
OMAiAYHRTCL
OrthoDBi377701at2759
PhylomeDBiQ8N3F8
TreeFamiTF328311

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
MICALL1 human
EvolutionaryTraceiQ8N3F8

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
MICALL1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
85377

Protein Ontology

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PROi
PR:Q8N3F8

Gene expression databases

BgeeiENSG00000100139 Expressed in 195 organ(s), highest expression level in cervix squamous epithelium
ExpressionAtlasiQ8N3F8 baseline and differential
GenevisibleiQ8N3F8 HS

Family and domain databases

CDDicd00014 CH, 1 hit
Gene3Di1.10.418.10, 1 hit
InterProiView protein in InterPro
IPR022735 bMERB_dom
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR028563 MICAL-L
IPR001781 Znf_LIM
PANTHERiPTHR23167:SF44 PTHR23167:SF44, 1 hit
PfamiView protein in Pfam
PF00307 CH, 1 hit
PF12130 DUF3585, 1 hit
PF00412 LIM, 1 hit
SMARTiView protein in SMART
SM00033 CH, 1 hit
SM00132 LIM, 1 hit
SUPFAMiSSF47576 SSF47576, 1 hit
PROSITEiView protein in PROSITE
PS51848 BMERB, 1 hit
PS50021 CH, 1 hit
PS00478 LIM_DOMAIN_1, 1 hit
PS50023 LIM_DOMAIN_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMILK1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8N3F8
Secondary accession number(s): Q5TI16
, Q7RTP5, Q8N3N8, Q9BVL9, Q9BY92, Q9UH43, Q9UH44, Q9UH45
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: April 23, 2003
Last modified: May 8, 2019
This is version 155 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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