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Protein

CAP-Gly domain-containing linker protein 4

Gene

CLIP4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
CAP-Gly domain-containing linker protein 4
Alternative name(s):
Restin-like protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CLIP4
Synonyms:RSNL2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000115295.19

Human Gene Nomenclature Database

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HGNCi
HGNC:26108 CLIP4

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8N3C7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

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OpenTargetsi
ENSG00000115295

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162382440

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CLIP4

Domain mapping of disease mutations (DMDM)

More...
DMDMi
60390950

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000835291 – 705CAP-Gly domain-containing linker protein 4Add BLAST705

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei557PhosphoserineBy similarity1
Modified residuei609PhosphoserineBy similarity1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q8N3C7

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8N3C7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8N3C7

PeptideAtlas

More...
PeptideAtlasi
Q8N3C7

PRoteomics IDEntifications database

More...
PRIDEi
Q8N3C7

ProteomicsDB human proteome resource

More...
ProteomicsDBi
71789
71790 [Q8N3C7-2]
71791 [Q8N3C7-3]
71792 [Q8N3C7-4]

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
Q8N3C7-4 [Q8N3C7-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q8N3C7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8N3C7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000115295 Expressed in 209 organ(s), highest expression level in left lobe of thyroid gland

CleanEx database of gene expression profiles

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CleanExi
HS_CLIP4

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q8N3C7 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q8N3C7 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA043366
HPA056246

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
122857, 11 interactors

Protein interaction database and analysis system

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IntActi
Q8N3C7, 30 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000327009

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1705
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q8N3C7

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q8N3C7

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q8N3C7

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati65 – 101ANK 1Add BLAST37
Repeati149 – 180ANK 2Add BLAST32
Repeati186 – 215ANK 3Add BLAST30
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini303 – 345CAP-Gly 1PROSITE-ProRule annotationAdd BLAST43
Domaini505 – 547CAP-Gly 2PROSITE-ProRule annotationAdd BLAST43
Domaini644 – 686CAP-Gly 3PROSITE-ProRule annotationAdd BLAST43

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi424 – 474Ser-richAdd BLAST51

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0241 Eukaryota
KOG4568 Eukaryota
COG5244 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157706

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG057079

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q8N3C7

KEGG Orthology (KO)

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KOi
K10423

Identification of Orthologs from Complete Genome Data

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OMAi
IGTIKFF

Database of Orthologous Groups

More...
OrthoDBi
EOG091G04NK

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8N3C7

TreeFam database of animal gene trees

More...
TreeFami
TF326096

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00204 ANK, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.20, 1 hit
2.30.30.190, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR036859 CAP-Gly_dom_sf
IPR000938 CAP-Gly_domain
IPR028397 CLIP4

The PANTHER Classification System

More...
PANTHERi
PTHR18916:SF32 PTHR18916:SF32, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF12796 Ank_2, 1 hit
PF01302 CAP_GLY, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248 ANK, 3 hits
SM01052 CAP_GLY, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48403 SSF48403, 1 hit
SSF74924 SSF74924, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 1 hit
PS00845 CAP_GLY_1, 2 hits
PS50245 CAP_GLY_2, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8N3C7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTIEDLPDFP LEGNPLFGRY PFIFSASDTP VIFSISAAPM PSDCEFSFFD
60 70 80 90 100
PNDASCQEIL FDPKTSVSEL FAILRQWVPQ VQQNIDIIGN EILKRGCNVN
110 120 130 140 150
DRDGLTDMTL LHYTCKSGAH GIGDVETAVK FATQLIDLGA DISLRSRWTN
160 170 180 190 200
MNALHYAAYF DVPELIRVIL KTSKPKDVDA TCSDFNFGTA LHIAAYNLCA
210 220 230 240 250
GAVKCLLEQG ANPAFRNDKG QIPADVVPDP VDMPLEMADA AATAKEIKQM
260 270 280 290 300
LLDAVPLSCN ISKAMLPNYD HVTGKAMLTS LGLKLGDRVV IAGQKVGTLR
310 320 330 340 350
FCGTTEFASG QWAGIELDEP EGKNNGSVGK VQYFKCAPKY GIFAPLSKIS
360 370 380 390 400
KAKGRRKNIT HTPSTKAAVP LIRSQKIDVA HVTSKVNTGL MTSKKDSASE
410 420 430 440 450
STLSLPPGEE LKTVTEKDVA LLGSVSSCSS TSSLEHRQSY PKKQNAISSN
460 470 480 490 500
KKTMSKSPSL SSRASAGLNS SATSTANNSR CEGELRLGER VLVVGQRLGT
510 520 530 540 550
IRFFGTTNFA PGYWYGIELE KPHGKNDGSV GGVQYFSCSP RYGIFAPPSR
560 570 580 590 600
VQRVTDSLDT LSEISSNKQN HSYPGFRRSF STTSASSQKE INRRNAFSKS
610 620 630 640 650
KAALRRSWSS TPTAGGIEGS VKLHEGSQVL LTSSNEMGTV RYVGPTDFAS
660 670 680 690 700
GIWLGLELRS AKGKNDGSVG DKRYFTCKPN HGVLVRPSRV TYRGINGSKL

VDENC
Length:705
Mass (Da):76,317
Last modified:October 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2BE72B2DD2206F12
GO
Isoform 2 (identifier: Q8N3C7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     511-511: P → PVL
     600-705: Missing.

Note: No experimental confirmation available.
Show »
Length:601
Mass (Da):65,177
Checksum:i9400F09A54FE036E
GO
Isoform 3 (identifier: Q8N3C7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     600-705: Missing.

Note: No experimental confirmation available.
Show »
Length:599
Mass (Da):64,965
Checksum:i9628032387B737F4
GO
Isoform 4 (identifier: Q8N3C7-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-150: Missing.
     468-705: LNSSATSTAN...NGSKLVDENC → IYGFFNQAFLVFFILVCLFEFLSNIYSK

Note: No experimental confirmation available.
Show »
Length:345
Mass (Da):37,113
Checksum:i71412DDD803F8983
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3XAK3G3XAK3_HUMAN
CAP-Gly domain-containing linker pr...
CLIP4 RSNL2, hCG_1783765
495Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B5MCH3B5MCH3_HUMAN
CAP-Gly domain-containing linker pr...
CLIP4
571Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EW06E7EW06_HUMAN
CAP-Gly domain-containing linker pr...
CLIP4
214Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9IYE4C9IYE4_HUMAN
CAP-Gly domain-containing linker pr...
CLIP4
93Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PBB1E9PBB1_HUMAN
CAP-Gly domain-containing linker pr...
CLIP4
97Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB14974 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti321E → G in BAB14974 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_048675486R → L. Corresponds to variant dbSNP:rs3100246Ensembl.1
Natural variantiVAR_048676613T → P. Corresponds to variant dbSNP:rs34327508Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0129691 – 150Missing in isoform 4. 1 PublicationAdd BLAST150
Alternative sequenceiVSP_012970468 – 705LNSSA…VDENC → IYGFFNQAFLVFFILVCLFE FLSNIYSK in isoform 4. 1 PublicationAdd BLAST238
Alternative sequenceiVSP_012971511P → PVL in isoform 2. 2 Publications1
Alternative sequenceiVSP_012972600 – 705Missing in isoform 2 and isoform 3. 3 PublicationsAdd BLAST106

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF433661 mRNA Translation: AAP97312.1
AK024722 mRNA Translation: BAB14974.1 Different initiation.
AK057267 mRNA Translation: BAB71403.1
AK302325 mRNA Translation: BAH13674.1
AL834443 mRNA Translation: CAD39103.1
CH471053 Genomic DNA Translation: EAX00510.1
BC015310 mRNA Translation: AAH15310.2
BC126167 mRNA Translation: AAI26168.1
BC136331 mRNA Translation: AAI36332.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS1770.1 [Q8N3C7-1]
CCDS74502.1 [Q8N3C7-3]

NCBI Reference Sequences

More...
RefSeqi
NP_001274456.1, NM_001287527.1 [Q8N3C7-1]
NP_001274457.1, NM_001287528.1 [Q8N3C7-3]
NP_078968.3, NM_024692.5 [Q8N3C7-1]
XP_005264619.1, XM_005264562.2 [Q8N3C7-1]
XP_005264620.1, XM_005264563.1 [Q8N3C7-1]
XP_006712167.1, XM_006712104.2 [Q8N3C7-1]
XP_011531411.1, XM_011533109.1 [Q8N3C7-1]
XP_016860447.1, XM_017004958.1 [Q8N3C7-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.122927

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000320081; ENSP00000327009; ENSG00000115295 [Q8N3C7-1]
ENST00000401605; ENSP00000384242; ENSG00000115295 [Q8N3C7-3]
ENST00000404424; ENSP00000385594; ENSG00000115295 [Q8N3C7-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
79745

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:79745

UCSC genome browser

More...
UCSCi
uc002rmu.5 human [Q8N3C7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF433661 mRNA Translation: AAP97312.1
AK024722 mRNA Translation: BAB14974.1 Different initiation.
AK057267 mRNA Translation: BAB71403.1
AK302325 mRNA Translation: BAH13674.1
AL834443 mRNA Translation: CAD39103.1
CH471053 Genomic DNA Translation: EAX00510.1
BC015310 mRNA Translation: AAH15310.2
BC126167 mRNA Translation: AAI26168.1
BC136331 mRNA Translation: AAI36332.1
CCDSiCCDS1770.1 [Q8N3C7-1]
CCDS74502.1 [Q8N3C7-3]
RefSeqiNP_001274456.1, NM_001287527.1 [Q8N3C7-1]
NP_001274457.1, NM_001287528.1 [Q8N3C7-3]
NP_078968.3, NM_024692.5 [Q8N3C7-1]
XP_005264619.1, XM_005264562.2 [Q8N3C7-1]
XP_005264620.1, XM_005264563.1 [Q8N3C7-1]
XP_006712167.1, XM_006712104.2 [Q8N3C7-1]
XP_011531411.1, XM_011533109.1 [Q8N3C7-1]
XP_016860447.1, XM_017004958.1 [Q8N3C7-1]
UniGeneiHs.122927

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2Z0WX-ray2.50A482-564[»]
ProteinModelPortaliQ8N3C7
SMRiQ8N3C7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122857, 11 interactors
IntActiQ8N3C7, 30 interactors
STRINGi9606.ENSP00000327009

PTM databases

iPTMnetiQ8N3C7
PhosphoSitePlusiQ8N3C7

Polymorphism and mutation databases

BioMutaiCLIP4
DMDMi60390950

Proteomic databases

EPDiQ8N3C7
MaxQBiQ8N3C7
PaxDbiQ8N3C7
PeptideAtlasiQ8N3C7
PRIDEiQ8N3C7
ProteomicsDBi71789
71790 [Q8N3C7-2]
71791 [Q8N3C7-3]
71792 [Q8N3C7-4]
TopDownProteomicsiQ8N3C7-4 [Q8N3C7-4]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
79745
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000320081; ENSP00000327009; ENSG00000115295 [Q8N3C7-1]
ENST00000401605; ENSP00000384242; ENSG00000115295 [Q8N3C7-3]
ENST00000404424; ENSP00000385594; ENSG00000115295 [Q8N3C7-1]
GeneIDi79745
KEGGihsa:79745
UCSCiuc002rmu.5 human [Q8N3C7-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
79745
EuPathDBiHostDB:ENSG00000115295.19

GeneCards: human genes, protein and diseases

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GeneCardsi
CLIP4

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0001941
HGNCiHGNC:26108 CLIP4
HPAiHPA043366
HPA056246
neXtProtiNX_Q8N3C7
OpenTargetsiENSG00000115295
PharmGKBiPA162382440

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0241 Eukaryota
KOG4568 Eukaryota
COG5244 LUCA
GeneTreeiENSGT00940000157706
HOVERGENiHBG057079
InParanoidiQ8N3C7
KOiK10423
OMAiIGTIKFF
OrthoDBiEOG091G04NK
PhylomeDBiQ8N3C7
TreeFamiTF326096

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
CLIP4 human
EvolutionaryTraceiQ8N3C7

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
79745

Protein Ontology

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PROi
PR:Q8N3C7

Gene expression databases

BgeeiENSG00000115295 Expressed in 209 organ(s), highest expression level in left lobe of thyroid gland
CleanExiHS_CLIP4
ExpressionAtlasiQ8N3C7 baseline and differential
GenevisibleiQ8N3C7 HS

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 1 hit
2.30.30.190, 3 hits
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR036859 CAP-Gly_dom_sf
IPR000938 CAP-Gly_domain
IPR028397 CLIP4
PANTHERiPTHR18916:SF32 PTHR18916:SF32, 1 hit
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
PF01302 CAP_GLY, 3 hits
SMARTiView protein in SMART
SM00248 ANK, 3 hits
SM01052 CAP_GLY, 3 hits
SUPFAMiSSF48403 SSF48403, 1 hit
SSF74924 SSF74924, 3 hits
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 1 hit
PS00845 CAP_GLY_1, 2 hits
PS50245 CAP_GLY_2, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCLIP4_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8N3C7
Secondary accession number(s): A0AV10
, B2RMQ3, B7Z7N8, Q7Z4U3, Q96BR7, Q96MA5, Q9H7C0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: October 1, 2002
Last modified: December 5, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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