Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

CAP-Gly domain-containing linker protein 4

Gene

CLIP4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
CAP-Gly domain-containing linker protein 4
Alternative name(s):
Restin-like protein 2
Gene namesi
Name:CLIP4
Synonyms:RSNL2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000115295.19
HGNCiHGNC:26108 CLIP4
neXtProtiNX_Q8N3C7

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000115295
PharmGKBiPA162382440

Polymorphism and mutation databases

BioMutaiCLIP4
DMDMi60390950

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000835291 – 705CAP-Gly domain-containing linker protein 4Add BLAST705

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei557PhosphoserineBy similarity1
Modified residuei609PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8N3C7
MaxQBiQ8N3C7
PaxDbiQ8N3C7
PeptideAtlasiQ8N3C7
PRIDEiQ8N3C7
ProteomicsDBi71789
71790 [Q8N3C7-2]
71791 [Q8N3C7-3]
71792 [Q8N3C7-4]
TopDownProteomicsiQ8N3C7-4 [Q8N3C7-4]

PTM databases

iPTMnetiQ8N3C7
PhosphoSitePlusiQ8N3C7

Expressioni

Gene expression databases

BgeeiENSG00000115295 Expressed in 209 organ(s), highest expression level in left lobe of thyroid gland
CleanExiHS_CLIP4
ExpressionAtlasiQ8N3C7 baseline and differential
GenevisibleiQ8N3C7 HS

Organism-specific databases

HPAiHPA043366
HPA056246

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi122857, 11 interactors
IntActiQ8N3C7, 30 interactors
STRINGi9606.ENSP00000327009

Structurei

Secondary structure

1705
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ8N3C7
SMRiQ8N3C7
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8N3C7

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati65 – 101ANK 1Add BLAST37
Repeati149 – 180ANK 2Add BLAST32
Repeati186 – 215ANK 3Add BLAST30
Domaini303 – 345CAP-Gly 1PROSITE-ProRule annotationAdd BLAST43
Domaini505 – 547CAP-Gly 2PROSITE-ProRule annotationAdd BLAST43
Domaini644 – 686CAP-Gly 3PROSITE-ProRule annotationAdd BLAST43

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi424 – 474Ser-richAdd BLAST51

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG0241 Eukaryota
KOG4568 Eukaryota
COG5244 LUCA
GeneTreeiENSGT00760000119173
HOVERGENiHBG057079
InParanoidiQ8N3C7
KOiK10423
OMAiILKRGCN
OrthoDBiEOG091G04NK
PhylomeDBiQ8N3C7
TreeFamiTF326096

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 1 hit
2.30.30.190, 3 hits
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR036859 CAP-Gly_dom_sf
IPR000938 CAP-Gly_domain
IPR028397 CLIP4
PANTHERiPTHR18916:SF32 PTHR18916:SF32, 1 hit
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
PF01302 CAP_GLY, 3 hits
SMARTiView protein in SMART
SM00248 ANK, 3 hits
SM01052 CAP_GLY, 3 hits
SUPFAMiSSF48403 SSF48403, 1 hit
SSF74924 SSF74924, 3 hits
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 1 hit
PS00845 CAP_GLY_1, 2 hits
PS50245 CAP_GLY_2, 3 hits

Sequences (4+)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 5 potential isoforms that are computationally mapped.iShow all

Isoform 1 (identifier: Q8N3C7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTIEDLPDFP LEGNPLFGRY PFIFSASDTP VIFSISAAPM PSDCEFSFFD
60 70 80 90 100
PNDASCQEIL FDPKTSVSEL FAILRQWVPQ VQQNIDIIGN EILKRGCNVN
110 120 130 140 150
DRDGLTDMTL LHYTCKSGAH GIGDVETAVK FATQLIDLGA DISLRSRWTN
160 170 180 190 200
MNALHYAAYF DVPELIRVIL KTSKPKDVDA TCSDFNFGTA LHIAAYNLCA
210 220 230 240 250
GAVKCLLEQG ANPAFRNDKG QIPADVVPDP VDMPLEMADA AATAKEIKQM
260 270 280 290 300
LLDAVPLSCN ISKAMLPNYD HVTGKAMLTS LGLKLGDRVV IAGQKVGTLR
310 320 330 340 350
FCGTTEFASG QWAGIELDEP EGKNNGSVGK VQYFKCAPKY GIFAPLSKIS
360 370 380 390 400
KAKGRRKNIT HTPSTKAAVP LIRSQKIDVA HVTSKVNTGL MTSKKDSASE
410 420 430 440 450
STLSLPPGEE LKTVTEKDVA LLGSVSSCSS TSSLEHRQSY PKKQNAISSN
460 470 480 490 500
KKTMSKSPSL SSRASAGLNS SATSTANNSR CEGELRLGER VLVVGQRLGT
510 520 530 540 550
IRFFGTTNFA PGYWYGIELE KPHGKNDGSV GGVQYFSCSP RYGIFAPPSR
560 570 580 590 600
VQRVTDSLDT LSEISSNKQN HSYPGFRRSF STTSASSQKE INRRNAFSKS
610 620 630 640 650
KAALRRSWSS TPTAGGIEGS VKLHEGSQVL LTSSNEMGTV RYVGPTDFAS
660 670 680 690 700
GIWLGLELRS AKGKNDGSVG DKRYFTCKPN HGVLVRPSRV TYRGINGSKL

VDENC
Length:705
Mass (Da):76,317
Last modified:October 1, 2002 - v1
Checksum:i2BE72B2DD2206F12
GO
Isoform 2 (identifier: Q8N3C7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     511-511: P → PVL
     600-705: Missing.

Note: No experimental confirmation available.
Show »
Length:601
Mass (Da):65,177
Checksum:i9400F09A54FE036E
GO
Isoform 3 (identifier: Q8N3C7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     600-705: Missing.

Note: No experimental confirmation available.
Show »
Length:599
Mass (Da):64,965
Checksum:i9628032387B737F4
GO
Isoform 4 (identifier: Q8N3C7-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-150: Missing.
     468-705: LNSSATSTAN...NGSKLVDENC → IYGFFNQAFLVFFILVCLFEFLSNIYSK

Note: No experimental confirmation available.
Show »
Length:345
Mass (Da):37,113
Checksum:i71412DDD803F8983
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3XAK3G3XAK3_HUMAN
CAP-Gly domain-containing linker pr...
CLIP4 RSNL2, hCG_1783765
495Annotation score:
B5MCH3B5MCH3_HUMAN
CAP-Gly domain-containing linker pr...
CLIP4
571Annotation score:
E7EW06E7EW06_HUMAN
CAP-Gly domain-containing linker pr...
CLIP4
214Annotation score:
C9IYE4C9IYE4_HUMAN
CAP-Gly domain-containing linker pr...
CLIP4
93Annotation score:
E9PBB1E9PBB1_HUMAN
CAP-Gly domain-containing linker pr...
CLIP4
97Annotation score:

Sequence cautioni

The sequence BAB14974 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti321E → G in BAB14974 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_048675486R → L. Corresponds to variant dbSNP:rs3100246Ensembl.1
Natural variantiVAR_048676613T → P. Corresponds to variant dbSNP:rs34327508Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0129691 – 150Missing in isoform 4. 1 PublicationAdd BLAST150
Alternative sequenceiVSP_012970468 – 705LNSSA…VDENC → IYGFFNQAFLVFFILVCLFE FLSNIYSK in isoform 4. 1 PublicationAdd BLAST238
Alternative sequenceiVSP_012971511P → PVL in isoform 2. 2 Publications1
Alternative sequenceiVSP_012972600 – 705Missing in isoform 2 and isoform 3. 3 PublicationsAdd BLAST106

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF433661 mRNA Translation: AAP97312.1
AK024722 mRNA Translation: BAB14974.1 Different initiation.
AK057267 mRNA Translation: BAB71403.1
AK302325 mRNA Translation: BAH13674.1
AL834443 mRNA Translation: CAD39103.1
CH471053 Genomic DNA Translation: EAX00510.1
BC015310 mRNA Translation: AAH15310.2
BC126167 mRNA Translation: AAI26168.1
BC136331 mRNA Translation: AAI36332.1
CCDSiCCDS1770.1 [Q8N3C7-1]
CCDS74502.1 [Q8N3C7-3]
RefSeqiNP_001274456.1, NM_001287527.1 [Q8N3C7-1]
NP_001274457.1, NM_001287528.1 [Q8N3C7-3]
NP_078968.3, NM_024692.5 [Q8N3C7-1]
XP_005264619.1, XM_005264562.2 [Q8N3C7-1]
XP_005264620.1, XM_005264563.1 [Q8N3C7-1]
XP_006712167.1, XM_006712104.2 [Q8N3C7-1]
XP_011531411.1, XM_011533109.1 [Q8N3C7-1]
XP_016860447.1, XM_017004958.1 [Q8N3C7-1]
UniGeneiHs.122927

Genome annotation databases

EnsembliENST00000320081; ENSP00000327009; ENSG00000115295 [Q8N3C7-1]
ENST00000401605; ENSP00000384242; ENSG00000115295 [Q8N3C7-3]
ENST00000404424; ENSP00000385594; ENSG00000115295 [Q8N3C7-1]
GeneIDi79745
KEGGihsa:79745
UCSCiuc002rmu.5 human [Q8N3C7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCLIP4_HUMAN
AccessioniPrimary (citable) accession number: Q8N3C7
Secondary accession number(s): A0AV10
, B2RMQ3, B7Z7N8, Q7Z4U3, Q96BR7, Q96MA5, Q9H7C0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: October 1, 2002
Last modified: September 12, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again