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UniProtKB - Q8N3C0 (ASCC3_HUMAN)

>sp|Q8N3C0|ASCC3_HUMAN Activating signal cointegrator 1 complex subunit 3 OS=Homo sapiens OX=9606 GN=ASCC3 PE=1 SV=3
MALPRLTGALRSFSNVTKQDNYNEEVADLKIKRSKLHEQVLDLGLTWKKIIKFLNEKLEK
SKMQSINEDLKDILHAAKQIVGTDNGREAIESGAAFLFMTFHLKDSVGHKETKAIKQMFG
PFPSSSATAACNATNRIISHFSQDDLTALVQMTEKEHGDRVFFGKNLAFSFDMHDLDHFD
ELPINGETQKTISLDYKKFLNEHLQEACTPELKPVEKTNGSFLWCEVEKYLNSTLKEMTE
VPRVEDLCCTLYDMLASIKSGDELQDELFELLGPEGLELIEKLLQNRITIVDRFLNSSND
HRFQALQDNCKKILGENAKPNYGCQVTIQSEQEKQLMKQYRREEKRIARREKKAGEDLEV
SEGLMCFDPKELRIQREQALLNARSVPILSRQRDADVEKIHYPHVYDSQAEAMKTSAFIA
GAKMILPEGIQRENNKLYEEVRIPYSEPMPLSFEEKPVYIQDLDEIGQLAFKGMKRLNRI
QSIVFETAYNTNENMLICAPTGAGKTNIAMLTVLHEIRQHFQQGVIKKNEFKIVYVAPMK
ALAAEMTDYFSRRLEPLGIIVKELTGDMQLSKSEILRTQMLVTTPEKWDVVTRKSVGDVA
LSQIVRLLILDEVHLLHEDRGPVLESIVARTLRQVESTQSMIRILGLSATLPNYLDVATF
LHVNPYIGLFFFDGRFRPVPLGQTFLGIKCANKMQQLNNMDEVCYENVLKQVKAGHQVMV
FVHARNATVRTAMSLIERAKNCGHIPFFFPTQGHDYVLAEKQVQRSRNKQVRELFPDGFS
IHHAGMLRQDRNLVENLFSNGHIKVLVCTATLAWGVNLPAHAVIIKGTQIYAAKRGSFVD
LGILDVMQIFGRAGRPQFDKFGEGIIITTHDKLSHYLTLLTQRNPIESQFLESLADNLNA
EIALGTVTNVEEAVKWISYTYLYVRMRANPLAYGISHKAYQIDPTLRKHREQLVIEVGRK
LDKAQMIRFEERTGYFSSTDLGRTASHYYIKYNTIETFNELFDAHKTEGDIFAIVSKAEE
FDQIKVREEEIEELDTLLSNFCELSTPGGVENSYGKINILLQTYISRGEMDSFSLISDSA
YVAQNAARIVRALFEIALRKRWPTMTYRLLNLSKVIDKRLWGWASPLRQFSILPPHILTR
LEEKKLTVDKLKDMRKDEIGHILHHVNIGLKVKQCVHQIPSVMMEASIQPITRTVLRVTL
SIYADFTWNDQVHGTVGEPWWIWVEDPTNDHIYHSEYFLALKKQVISKEAQLLVFTIPIF
EPLPSQYYIRAVSDRWLGAEAVCIINFQHLILPERHPPHTELLDLQPLPITALGCKAYEA
LYNFSHFNPVQTQIFHTLYHTDCNVLLGAPTGSGKTVAAELAIFRVFNKYPTSKAVYIAP
LKALVRERMDDWKVRIEEKLGKKVIELTGDVTPDMKSIAKADLIVTTPEKWDGVSRSWQN
RNYVQQVTILIIDEIHLLGEERGPVLEVIVSRTNFISSHTEKPVRIVGLSTALANARDLA
DWLNIKQMGLFNFRPSVRPVPLEVHIQGFPGQHYCPRMASMNKPAFQAIRSHSPAKPVLI
FVSSRRQTRLTALELIAFLATEEDPKQWLNMDEREMENIIATVRDSNLKLTLAFGIGMHH
AGLHERDRKTVEELFVNCKVQVLIATSTLAWGVNFPAHLVIIKGTEYYDGKTRRYVDFPI
TDVLQMMGRAGRPQFDDQGKAVILVHDIKKDFYKKFLYEPFPVESSLLGVLSDHLNAEIA
GGTITSKQDALDYITWTYFFRRLIMNPSYYNLGDVSHDSVNKFLSHLIEKSLIELELSYC
IEIGEDNRSIEPLTYGRIASYYYLKHQTVKMFKDRLKPECSTEELLSILSDAEEYTDLPV
RHNEDHMNSELAKCLPIESNPHSFDSPHTKAHLLLQAHLSRAMLPCPDYDTDTKTVLDQA
LRVCQAMLDVAANQGWLVTVLNITNLIQMVIQGRWLKDSSLLTLPNIENHHLHLFKKWKP
IMKGPHARGRTSIESLPELIHACGGKDHVFSSMVESELHAAKTKQAWNFLSHLPVINVGI
SVKGSWDDLVEGHNELSVSTLTADKRDDNKWIKLHADQEYVLQVSLQRVHFGFHKGKPES
CAVTPRFPKSKDEGWFLILGEVDKRELIALKRVGYIRNHHVASLSFYTPEIPGRYIYTLY
FMSDCYLGLDQQYDIYLNVTQASLSAQVNTKVSDSLTDLALK

Entry version 181 (23 Feb 2022)
Sequence version 3 (11 Sep 2007)
Previous versions | rss

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Protein

Activating signal cointegrator 1 complex subunit 3

Gene

ASCC3

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

3'-5' DNA helicase involved in repair of alkylated DNA (PubMed:22055184).

Promotes DNA unwinding to generate single-stranded substrate needed for ALKBH3, enabling ALKBH3 to process alkylated N3-methylcytosine (3mC) within double-stranded regions (PubMed:22055184).

Also involved in activation of the ribosome quality control (RQC) pathway, a pathway that degrades nascent peptide chains during problematic translation (PubMed:28757607, PubMed:32099016).

Drives the splitting of stalled ribosomes, as part of the ribosome quality control trigger (RQT) complex (PubMed:28757607, PubMed:32099016).

Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation (PubMed:12077347).

4 Publications

Catalytic activityⁱ

ATP
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
+
H₂O
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Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
=
ADP
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Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
+
H⁺
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Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
+
phosphate
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Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
1 Publication
Manual assertion based on experiment inⁱ
- Ref.11
  "DNA unwinding by ASCC3 helicase is coupled to ALKBH3-dependent DNA alkylation repair and cancer cell proliferation."
  Dango S., Mosammaparast N., Sowa M.E., Xiong L.J., Wu F., Park K., Rubin M., Gygi S., Harper J.W., Shi Y.
  Mol. Cell 44:373-384(2011) [PubMed] [Europe PMC] [Abstract]
  Cited for: FUNCTION, CATALYTIC ACTIVITY, INTERACTION WITH ALKBH3, MUTAGENESIS OF GLY-1354.
EC:
3.6.4.12
- Search proteins in UniProtKB for this EC number.
- See the description of this EC number in ENZYME.
- Search reactions for this EC number in Rhea.
1 Publication
Manual assertion based on experiment inⁱ
- Ref.11
  "DNA unwinding by ASCC3 helicase is coupled to ALKBH3-dependent DNA alkylation repair and cancer cell proliferation."
  Dango S., Mosammaparast N., Sowa M.E., Xiong L.J., Wu F., Park K., Rubin M., Gygi S., Harper J.W., Shi Y.
  Mol. Cell 44:373-384(2011) [PubMed] [Europe PMC] [Abstract]
  Cited for: FUNCTION, CATALYTIC ACTIVITY, INTERACTION WITH ALKBH3, MUTAGENESIS OF GLY-1354.
Source:
Rhea
Search for this reaction in UniProtKB.
See the description of this reaction in Rhea.
. Show »« Hide
ATP
+
H₂O
=
ADP
+
H⁺
+
phosphate
zoom

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	499 – 506	ATPPROSITE-ProRule annotation		8
Nucleotide bindingⁱ	1349 – 1356	ATPPROSITE-ProRule annotation		8

GO - Molecular functionⁱ

Complete GO annotation on QuickGO ...

GO - Biological processⁱ

Complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Helicase, Hydrolase
Biological process	DNA damage, DNA repair, Transcription, Transcription regulation
Ligand	ATP-binding, Nucleotide-binding

Enzyme and pathway databases

PathwayCommonsⁱ	Q8N3C0
Reactomeⁱ	R-HSA-112126, ALKBH3 mediated reversal of alkylation damage
SignaLinkⁱ	Q8N3C0

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Activating signal cointegrator 1 complex subunit 3 (EC:3.6.4.121 Publication) Alternative name(s): ASC-1 complex subunit p2001 Publication Short name: ASC1p200 Helicase, ATP binding 1 Trip4 complex subunit p2001 Publication
Gene namesⁱ	Name:ASCC3 Synonyms:HELIC1, RQT21 Publication
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:18697, ASCC3
MIMⁱ	614217, gene
neXtProtⁱ	NX_Q8N3C0
VEuPathDBⁱ	HostDB:ENSG00000112249

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	505	K → R: Defective activation of the ribosome quality control (RQC) pathway. Impairs its association with ribosomes. 1 Publication		1
Mutagenesisⁱ	1354	G → D: Abolishes 3'-5' DNA helicase activity and ability to promote DNA repair. 1 Publication		1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	10973
Open Targets More...OpenTargetsⁱ	ENSG00000112249
PharmGKBⁱ	PA134890913

Miscellaneous databases

Pharosⁱ	Q8N3C0, Tbio

Pharosⁱ

Q8N3C0, Tbio

Genetic variation databases

BioMutaⁱ	ASCC3
DMDMⁱ	158518649

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000102093	1 – 2202	Activating signal cointegrator 1 complex subunit 3Add BLAST		2202

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	12	PhosphoserineCombined sources	1
Modified residueⁱ	572	N6-acetyllysineCombined sources	1
Modified residueⁱ	2195	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

EPDⁱ	Q8N3C0
jPOSTⁱ	Q8N3C0
MassIVEⁱ	Q8N3C0
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q8N3C0
PaxDbⁱ	Q8N3C0
PeptideAtlas More...PeptideAtlasⁱ	Q8N3C0
PRIDEⁱ	Q8N3C0
ProteomicsDBⁱ	71786 [Q8N3C0-1] 71787 [Q8N3C0-3] 71788 [Q8N3C0-4]

PTM databases

CarbonylDBⁱ	Q8N3C0
iPTMnetⁱ	Q8N3C0
MetOSiteⁱ	Q8N3C0
PhosphoSitePlusⁱ	Q8N3C0

Expressionⁱ

Tissue specificityⁱ

Ubiquitous.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000112249, Expressed in decidua and 223 other tissues
ExpressionAtlasⁱ	Q8N3C0, baseline and differential
Genevisibleⁱ	Q8N3C0, HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	ENSG00000112249, Low tissue specificity

HPAⁱ

ENSG00000112249, Low tissue specificity

Interactionⁱ

Subunit structureⁱ

Identified in the ASCC complex that contains ASCC1, ASCC2 and ASCC3 (PubMed:12077347, PubMed:29144457, PubMed:29997253). Functions as scaffolding subunit that interacts directly with both ASCC1 and ASCC2 (PubMed:29144457, PubMed:29997253).

Interacts directly with ALKBH3, and thereby recruits ALKBH3 to the ASCC complex (PubMed:22055184, PubMed:29144457). Part of the ASC-1/TRIP4 complex, that contains TRIP4, ASCC1, ASCC2 and ASCC3 (PubMed:12077347). Identified in the RQT (ribosome quality control trigger) complex, that contains ASCC2, ASCC3 and TRIP4 (PubMed:32099016).

Interacts with ASCC2 (PubMed:32099016).

Interacts with TRIP4 (PubMed:32099016).

Interacts with ZCCHC4 (PubMed:31799605).

Interacts with ZNF598 (PubMed:28757607).

Interacts with RPS3 (PubMed:28757607). Associates with ribosomes (PubMed:32099016).

6 Publications

Binary interactionsⁱ

Hide details

Q8N3C0

With	#Exp.	IntAct
ASCC1 - isoform 2 [Q8N9N2-2]	4	EBI-1210710,EBI-10962548
ASCC2 [Q9H1I8]	6	EBI-1210710,EBI-711197

Protein-protein interaction databases

BioGRIDⁱ	116170, 144 interactors
CORUMⁱ	Q8N3C0
IntActⁱ	Q8N3C0, 39 interactors
Molecular INTeraction database More...MINTⁱ	Q8N3C0
STRINGⁱ	9606.ENSP00000358159

Miscellaneous databases

RNActⁱ	Q8N3C0, protein

RNActⁱ

Q8N3C0, protein

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	6 – 14	Combined sources	9
Helixⁱ	16 – 19	Combined sources	4
Helixⁱ	20 – 22	Combined sources	3
Helixⁱ	26 – 35	Combined sources	10
Turnⁱ	36 – 39	Combined sources	4
Helixⁱ	47 – 57	Combined sources	11
Helixⁱ	60 – 81	Combined sources	22
Beta strandⁱ	83 – 85	Combined sources	3
Helixⁱ	87 – 101	Combined sources	15
Helixⁱ	109 – 119	Combined sources	11
Helixⁱ	124 – 138	Combined sources	15
Helixⁱ	143 – 159	Combined sources	17
Turnⁱ	163 – 166	Combined sources	4

Show more details

3D structure databases

SMRⁱ	Q8N3C0
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	486 – 669	Helicase ATP-binding 1PROSITE-ProRule annotationAdd BLAST	184
Domainⁱ	728 – 914	Helicase C-terminal 1PROSITE-ProRule annotationAdd BLAST	187
Domainⁱ	978 – 1287	SEC63 1Add BLAST	310
Domainⁱ	1336 – 1511	Helicase ATP-binding 2PROSITE-ProRule annotationAdd BLAST	176
Domainⁱ	1544 – 1739	Helicase C-terminal 2PROSITE-ProRule annotationAdd BLAST	196
Domainⁱ	1812 – 2176	SEC63 2Add BLAST	365

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	1 – 400	Required for interaction with ASCC21 PublicationAdd BLAST		400

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	18 – 79	Sequence analysisAdd BLAST		62
Coiled coilⁱ	328 – 356	Sequence analysisAdd BLAST		29

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	611 – 614	DEVH box		4
Motifⁱ	1453 – 1456	DEIH box		4

Sequence similaritiesⁱ

Belongs to the helicase family.Curated

Keywords - Domainⁱ

Coiled coil, Repeat

Phylogenomic databases

eggNOGⁱ	KOG0952, Eukaryota
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00940000155377
HOGENOMⁱ	CLU_000335_2_1_1
InParanoidⁱ	Q8N3C0
OMAⁱ	DTRTIRD
Database of Orthologous Groups More...OrthoDBⁱ	154891at2759
PhylomeDBⁱ	Q8N3C0
TreeFamⁱ	TF105778

Family and domain databases

Gene3Dⁱ	1.10.10.10, 2 hits 2.60.40.150, 2 hits 3.40.50.300, 4 hits
InterProⁱ	View protein in InterPro IPR003593, AAA+_ATPase IPR035892, C2_domain_sf IPR011545, DEAD/DEAH_box_helicase_dom IPR014001, Helicase_ATP-bd IPR001650, Helicase_C IPR014756, Ig_E-set IPR027417, P-loop_NTPase IPR004179, Sec63-dom IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00270, DEAD, 2 hits PF00271, Helicase_C, 2 hits PF02889, Sec63, 2 hits
SMARTⁱ	View protein in SMART SM00382, AAA, 2 hits SM00487, DEXDc, 2 hits SM00490, HELICc, 2 hits SM00973, Sec63, 2 hits
SUPFAMⁱ	SSF46785, SSF46785, 2 hits SSF52540, SSF52540, 4 hits SSF81296, SSF81296, 1 hit
PROSITEⁱ	View protein in PROSITE PS51192, HELICASE_ATP_BIND_1, 2 hits PS51194, HELICASE_CTER, 2 hits

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q8N3C0-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the canonicalⁱ sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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        10         20         30         40         50
MALPRLTGAL RSFSNVTKQD NYNEEVADLK IKRSKLHEQV LDLGLTWKKI 
        60         70         80         90        100
IKFLNEKLEK SKMQSINEDL KDILHAAKQI VGTDNGREAI ESGAAFLFMT 
       110        120        130        140        150
FHLKDSVGHK ETKAIKQMFG PFPSSSATAA CNATNRIISH FSQDDLTALV 
       160        170        180        190        200
QMTEKEHGDR VFFGKNLAFS FDMHDLDHFD ELPINGETQK TISLDYKKFL 
       210        220        230        240        250
NEHLQEACTP ELKPVEKTNG SFLWCEVEKY LNSTLKEMTE VPRVEDLCCT 
       260        270        280        290        300
LYDMLASIKS GDELQDELFE LLGPEGLELI EKLLQNRITI VDRFLNSSND 
       310        320        330        340        350
HRFQALQDNC KKILGENAKP NYGCQVTIQS EQEKQLMKQY RREEKRIARR 
       360        370        380        390        400
EKKAGEDLEV SEGLMCFDPK ELRIQREQAL LNARSVPILS RQRDADVEKI 
       410        420        430        440        450
HYPHVYDSQA EAMKTSAFIA GAKMILPEGI QRENNKLYEE VRIPYSEPMP 
       460        470        480        490        500
LSFEEKPVYI QDLDEIGQLA FKGMKRLNRI QSIVFETAYN TNENMLICAP 
       510        520        530        540        550
TGAGKTNIAM LTVLHEIRQH FQQGVIKKNE FKIVYVAPMK ALAAEMTDYF 
       560        570        580        590        600
SRRLEPLGII VKELTGDMQL SKSEILRTQM LVTTPEKWDV VTRKSVGDVA 
       610        620        630        640        650
LSQIVRLLIL DEVHLLHEDR GPVLESIVAR TLRQVESTQS MIRILGLSAT 
       660        670        680        690        700
LPNYLDVATF LHVNPYIGLF FFDGRFRPVP LGQTFLGIKC ANKMQQLNNM 
       710        720        730        740        750
DEVCYENVLK QVKAGHQVMV FVHARNATVR TAMSLIERAK NCGHIPFFFP 
       760        770        780        790        800
TQGHDYVLAE KQVQRSRNKQ VRELFPDGFS IHHAGMLRQD RNLVENLFSN 
       810        820        830        840        850
GHIKVLVCTA TLAWGVNLPA HAVIIKGTQI YAAKRGSFVD LGILDVMQIF 
       860        870        880        890        900
GRAGRPQFDK FGEGIIITTH DKLSHYLTLL TQRNPIESQF LESLADNLNA 
       910        920        930        940        950
EIALGTVTNV EEAVKWISYT YLYVRMRANP LAYGISHKAY QIDPTLRKHR 
       960        970        980        990       1000
EQLVIEVGRK LDKAQMIRFE ERTGYFSSTD LGRTASHYYI KYNTIETFNE 
      1010       1020       1030       1040       1050
LFDAHKTEGD IFAIVSKAEE FDQIKVREEE IEELDTLLSN FCELSTPGGV 
      1060       1070       1080       1090       1100
ENSYGKINIL LQTYISRGEM DSFSLISDSA YVAQNAARIV RALFEIALRK 
      1110       1120       1130       1140       1150
RWPTMTYRLL NLSKVIDKRL WGWASPLRQF SILPPHILTR LEEKKLTVDK 
      1160       1170       1180       1190       1200
LKDMRKDEIG HILHHVNIGL KVKQCVHQIP SVMMEASIQP ITRTVLRVTL 
      1210       1220       1230       1240       1250
SIYADFTWND QVHGTVGEPW WIWVEDPTND HIYHSEYFLA LKKQVISKEA 
      1260       1270       1280       1290       1300
QLLVFTIPIF EPLPSQYYIR AVSDRWLGAE AVCIINFQHL ILPERHPPHT 
      1310       1320       1330       1340       1350
ELLDLQPLPI TALGCKAYEA LYNFSHFNPV QTQIFHTLYH TDCNVLLGAP 
      1360       1370       1380       1390       1400
TGSGKTVAAE LAIFRVFNKY PTSKAVYIAP LKALVRERMD DWKVRIEEKL 
      1410       1420       1430       1440       1450
GKKVIELTGD VTPDMKSIAK ADLIVTTPEK WDGVSRSWQN RNYVQQVTIL 
      1460       1470       1480       1490       1500
IIDEIHLLGE ERGPVLEVIV SRTNFISSHT EKPVRIVGLS TALANARDLA 
      1510       1520       1530       1540       1550
DWLNIKQMGL FNFRPSVRPV PLEVHIQGFP GQHYCPRMAS MNKPAFQAIR 
      1560       1570       1580       1590       1600
SHSPAKPVLI FVSSRRQTRL TALELIAFLA TEEDPKQWLN MDEREMENII 
      1610       1620       1630       1640       1650
ATVRDSNLKL TLAFGIGMHH AGLHERDRKT VEELFVNCKV QVLIATSTLA 
      1660       1670       1680       1690       1700
WGVNFPAHLV IIKGTEYYDG KTRRYVDFPI TDVLQMMGRA GRPQFDDQGK 
      1710       1720       1730       1740       1750
AVILVHDIKK DFYKKFLYEP FPVESSLLGV LSDHLNAEIA GGTITSKQDA 
      1760       1770       1780       1790       1800
LDYITWTYFF RRLIMNPSYY NLGDVSHDSV NKFLSHLIEK SLIELELSYC 
      1810       1820       1830       1840       1850
IEIGEDNRSI EPLTYGRIAS YYYLKHQTVK MFKDRLKPEC STEELLSILS 
      1860       1870       1880       1890       1900
DAEEYTDLPV RHNEDHMNSE LAKCLPIESN PHSFDSPHTK AHLLLQAHLS 
      1910       1920       1930       1940       1950
RAMLPCPDYD TDTKTVLDQA LRVCQAMLDV AANQGWLVTV LNITNLIQMV 
      1960       1970       1980       1990       2000
IQGRWLKDSS LLTLPNIENH HLHLFKKWKP IMKGPHARGR TSIESLPELI 
      2010       2020       2030       2040       2050
HACGGKDHVF SSMVESELHA AKTKQAWNFL SHLPVINVGI SVKGSWDDLV 
      2060       2070       2080       2090       2100
EGHNELSVST LTADKRDDNK WIKLHADQEY VLQVSLQRVH FGFHKGKPES 
      2110       2120       2130       2140       2150
CAVTPRFPKS KDEGWFLILG EVDKRELIAL KRVGYIRNHH VASLSFYTPE 
      2160       2170       2180       2190       2200
IPGRYIYTLY FMSDCYLGLD QQYDIYLNVT QASLSAQVNT KVSDSLTDLA 

LK

Length:2,202

Mass (Da):251,460

Last modified:September 11, 2007 - v3

Checksum:ⁱ9F074E6E5853399C

Isoform 2 (identifier: Q8N3C0-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
81-111: VGTDNGREAIESGAAFLFMTFHLKDSVGHKE → EVNCPFQKRRLDGKEEDEKMSRASDRFRGLR
112-2202: Missing.

« Hide

        10         20         30         40         50
MALPRLTGAL RSFSNVTKQD NYNEEVADLK IKRSKLHEQV LDLGLTWKKI 
        60         70         80         90        100
IKFLNEKLEK SKMQSINEDL KDILHAAKQI EVNCPFQKRR LDGKEEDEKM 
       110 
SRASDRFRGL R

Show »

Length:111

Mass (Da):13,014

Checksum:ⁱF3D84693464682F3

Isoform 3 (identifier: Q8N3C0-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
719-731: MVFVHARNATVRT → HLFYLLLHLFICF
732-2202: Missing.

« Hide

        10         20         30         40         50
MALPRLTGAL RSFSNVTKQD NYNEEVADLK IKRSKLHEQV LDLGLTWKKI 
        60         70         80         90        100
IKFLNEKLEK SKMQSINEDL KDILHAAKQI VGTDNGREAI ESGAAFLFMT 
       110        120        130        140        150
FHLKDSVGHK ETKAIKQMFG PFPSSSATAA CNATNRIISH FSQDDLTALV 
       160        170        180        190        200
QMTEKEHGDR VFFGKNLAFS FDMHDLDHFD ELPINGETQK TISLDYKKFL 
       210        220        230        240        250
NEHLQEACTP ELKPVEKTNG SFLWCEVEKY LNSTLKEMTE VPRVEDLCCT 
       260        270        280        290        300
LYDMLASIKS GDELQDELFE LLGPEGLELI EKLLQNRITI VDRFLNSSND 
       310        320        330        340        350
HRFQALQDNC KKILGENAKP NYGCQVTIQS EQEKQLMKQY RREEKRIARR 
       360        370        380        390        400
EKKAGEDLEV SEGLMCFDPK ELRIQREQAL LNARSVPILS RQRDADVEKI 
       410        420        430        440        450
HYPHVYDSQA EAMKTSAFIA GAKMILPEGI QRENNKLYEE VRIPYSEPMP 
       460        470        480        490        500
LSFEEKPVYI QDLDEIGQLA FKGMKRLNRI QSIVFETAYN TNENMLICAP 
       510        520        530        540        550
TGAGKTNIAM LTVLHEIRQH FQQGVIKKNE FKIVYVAPMK ALAAEMTDYF 
       560        570        580        590        600
SRRLEPLGII VKELTGDMQL SKSEILRTQM LVTTPEKWDV VTRKSVGDVA 
       610        620        630        640        650
LSQIVRLLIL DEVHLLHEDR GPVLESIVAR TLRQVESTQS MIRILGLSAT 
       660        670        680        690        700
LPNYLDVATF LHVNPYIGLF FFDGRFRPVP LGQTFLGIKC ANKMQQLNNM 
       710        720        730 
DEVCYENVLK QVKAGHQVHL FYLLLHLFIC F

Show »

Length:731

Mass (Da):83,675

Checksum:ⁱE82CDB32BEC21AF3

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

E5RFZ0	E5RFZ0_HUMAN	Activating signal cointegrator 1 co... Activating signal cointegrator 1 complex subunit 3	ASCC3	176	Annotation score:
J3KNJ4	J3KNJ4_HUMAN	Activating signal cointegrator 1 co... Activating signal cointegrator 1 complex subunit 3	ASCC3	48	Annotation score:

Sequence cautionⁱ

The sequence AAG45474 differs from that shown. Reason: Frameshift.Curated

The sequence CAA11679 differs from that shown. Reason: Frameshift.Curated

The sequence CAA11679 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	86	G → E in AAH26066 (PubMed:15489334).Curated	1
Sequence conflictⁱ	444	P → S in CAD39122 (PubMed:17974005).Curated	1
Sequence conflictⁱ	582	V → A in AAH26066 (PubMed:15489334).Curated	1
Sequence conflictⁱ	750	P → S in CAD39122 (PubMed:17974005).Curated	1
Sequence conflictⁱ	1187	S → F in CAA11679 (Ref. 7) Curated	1
Sequence conflictⁱ	1343	C → S in CAA11679 (Ref. 7) Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_034859	146	L → F1 PublicationCorresponds to variant dbSNP:rs9390698Ensembl.	1
Natural variantⁱVAR_049339	344	E → K. Corresponds to variant dbSNP:rs6918004Ensembl.	1
Natural variantⁱVAR_049340	478	N → S. Corresponds to variant dbSNP:rs7750940Ensembl.	1
Natural variantⁱVAR_061212	1016	S → C. Corresponds to variant dbSNP:rs57534235Ensembl.	1
Natural variantⁱVAR_034860	1050	V → I. Corresponds to variant dbSNP:rs9497983EnsemblClinVar.	1
Natural variantⁱVAR_049341	1425	V → A. Corresponds to variant dbSNP:rs17246013Ensembl.	1
Natural variantⁱVAR_049342	1497	R → T. Corresponds to variant dbSNP:rs17305382Ensembl.	1
Natural variantⁱVAR_034861	1800	C → W. Corresponds to variant dbSNP:rs35011147Ensembl.	1
Natural variantⁱVAR_034862	1930	V → M. Corresponds to variant dbSNP:rs3213542Ensembl.	1
Natural variantⁱVAR_034863	1995	S → C2 PublicationsCorresponds to variant dbSNP:rs240780Ensembl.	1
Natural variantⁱVAR_034864	2176	Y → C. Corresponds to variant dbSNP:rs240768Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_042955	81 – 111	VGTDN…VGHKE → EVNCPFQKRRLDGKEEDEKM SRASDRFRGLR in isoform 2. 2 PublicationsAdd BLAST	31
Alternative sequenceⁱVSP_042956	112 – 2202	Missing in isoform 2. 2 PublicationsAdd BLAST	2091
Alternative sequenceⁱVSP_042957	719 – 731	MVFVH…ATVRT → HLFYLLLHLFICF in isoform 3. 1 PublicationAdd BLAST	13
Alternative sequenceⁱVSP_042958	732 – 2202	Missing in isoform 3. 1 PublicationAdd BLAST	1471

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL834463 mRNA Translation: CAD39122.1 AK315197 mRNA Translation: BAG37637.1 AL121965 Genomic DNA No translation available. AL133338 Genomic DNA No translation available. AL356122 Genomic DNA No translation available. AL591585 Genomic DNA No translation available. Z86062 Genomic DNA No translation available. CH471051 Genomic DNA Translation: EAW48449.1 BC050681 mRNA Translation: AAH50681.1 BC125211 mRNA Translation: AAI25212.1 BC125212 mRNA Translation: AAI25213.1 BC026066 mRNA Translation: AAH26066.1 AY013288 mRNA Translation: AAG45474.1 Frameshift. AJ223948 mRNA Translation: CAA11679.1 Sequence problems.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS5046.1 [Q8N3C0-1] CCDS5047.1 [Q8N3C0-3] CCDS75497.1 [Q8N3C0-4]
NCBI Reference Sequences More...RefSeqⁱ	NP_001271200.1, NM_001284271.1 [Q8N3C0-4] NP_006819.2, NM_006828.3 [Q8N3C0-1] NP_071374.1, NM_022091.4 [Q8N3C0-3]

Genome annotation databases

Ensemblⁱ	ENST00000369143; ENSP00000358139; ENSG00000112249 [Q8N3C0-3] ENST00000369162; ENSP00000358159; ENSG00000112249 ENST00000522650; ENSP00000430769; ENSG00000112249 [Q8N3C0-4]
GeneIDⁱ	10973
KEGGⁱ	hsa:10973
MANE-Selectⁱ	ENST00000369162.7; ENSP00000358159.2; NM_006828.4; NP_006819.2
UCSC genome browser More...UCSCⁱ	uc003pqk.5, human [Q8N3C0-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q8N3C0	Activating signal cointegrator 1 complex subunit 3 (Fragment)		HUMAN		176	UniRef100_Q8N3C0
ASCC3 isoform 7 (Fragment)		PONAB		176
ASCC3 isoform 4 (Fragment)		PANTR		176
Q8N3C0-3	Activating signal cointegrator 1 complex subunit 3		PANTR		111	UniRef100_K7CW09
ASCC3 isoform 8		PONAB		111
Activating signal cointegrator 1 complex subunit 3		PANPA		111
ASCC3 isoform 5		PANTR		111

Protein	Similar proteins		Species	Score	Length	Source
Q8N3C0	Activating signal cointegrator 1 complex subunit 3		MOUSE		2198	UniRef90_Q8N3C0
Activating signal cointegrator 1 complex subunit 3		RAT		2197
Activating signal cointegrator 1 complex subunit 3 (Fragment)		HUMAN		176
ASCC3 isoform 7 (Fragment)		PONAB		176
ASCC3 isoform 4 (Fragment)		PANTR		176
+197
Q8N3C0-3	Activating signal cointegrator 1 complex subunit 3		PANTR		111	UniRef90_K7CW09
ASCC3 isoform 8		PONAB		111
Activating signal cointegrator 1 complex subunit 3		PANPA		111
Activating signal cointegrator 1 complex subunit 3		COLAP		111
Uncharacterized protein		NOMLE		111
+19
Q8N3C0-4	ASCC3 isoform 4		PONAB		770	UniRef90_Q8N3C0-4
ASCC3 isoform 3		PANTR		731
ASCC3 isoform 5		PONAB		736

Protein	Similar proteins		Species	Score	Length	Source
Q8N3C0	Activating signal cointegrator 1 complex subunit 3		MOUSE		2198	UniRef50_Q8N3C0
Activating signal cointegrator 1 complex subunit 3		RAT		2197
Activating signal cointegrator 1 complex subunit 3 (Fragment)		HUMAN		176
ASCC3 isoform 7 (Fragment)		PONAB		176
ASCC3 isoform 4 (Fragment)		PANTR		176
+541
Q8N3C0-3	activating signal cointegrator 1 complex subunit 3-like		CARSF		124	UniRef50_A0A3Q0EKQ5
Activating signal cointegrator 1 complex subunit 3		NEOVI		109
Activating signal cointegrator 1 complex subunit 3		SURSU		110
activating signal cointegrator 1 complex subunit 3 isoform X2		PUMCO		111
Uncharacterized protein		LYNCA		110
+41
Q8N3C0-4	ASCC3 isoform 4		PONAB		770	UniRef50_Q8N3C0-4
ASCC3 isoform 3		PANTR		731
Helicase ATP-binding domain-containing protein		SCYTO		721
Helicase ATP-binding domain-containing protein		BIOGL		720
Activating signal cointegrator 1 complex subunit 3-like (Fragment)		COLLI		643
+13

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL834463 mRNA Translation: CAD39122.1 AK315197 mRNA Translation: BAG37637.1 AL121965 Genomic DNA No translation available. AL133338 Genomic DNA No translation available. AL356122 Genomic DNA No translation available. AL591585 Genomic DNA No translation available. Z86062 Genomic DNA No translation available. CH471051 Genomic DNA Translation: EAW48449.1 BC050681 mRNA Translation: AAH50681.1 BC125211 mRNA Translation: AAI25212.1 BC125212 mRNA Translation: AAI25213.1 BC026066 mRNA Translation: AAH26066.1 AY013288 mRNA Translation: AAG45474.1 Frameshift. AJ223948 mRNA Translation: CAA11679.1 Sequence problems.
CCDSⁱ	CCDS5046.1 [Q8N3C0-1] CCDS5047.1 [Q8N3C0-3] CCDS75497.1 [Q8N3C0-4]
RefSeqⁱ	NP_001271200.1, NM_001284271.1 [Q8N3C0-4] NP_006819.2, NM_006828.3 [Q8N3C0-1] NP_071374.1, NM_022091.4 [Q8N3C0-3]

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	6YXQ	X-ray	2.70	A	1-207	[»]
SMRⁱ	Q8N3C0
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Protein-protein interaction databases

BioGRIDⁱ	116170, 144 interactors
CORUMⁱ	Q8N3C0
IntActⁱ	Q8N3C0, 39 interactors
MINTⁱ	Q8N3C0
STRINGⁱ	9606.ENSP00000358159

PTM databases

CarbonylDBⁱ	Q8N3C0
iPTMnetⁱ	Q8N3C0
MetOSiteⁱ	Q8N3C0
PhosphoSitePlusⁱ	Q8N3C0

Genetic variation databases

BioMutaⁱ	ASCC3
DMDMⁱ	158518649

Proteomic databases

EPDⁱ	Q8N3C0
jPOSTⁱ	Q8N3C0
MassIVEⁱ	Q8N3C0
MaxQBⁱ	Q8N3C0
PaxDbⁱ	Q8N3C0
PeptideAtlasⁱ	Q8N3C0
PRIDEⁱ	Q8N3C0
ProteomicsDBⁱ	71786 [Q8N3C0-1] 71787 [Q8N3C0-3] 71788 [Q8N3C0-4]

Protocols and materials databases

Antibodypediaⁱ	32044, 88 antibodies from 19 providers
The DNASU plasmid repository More...DNASUⁱ	10973

Genome annotation databases

Ensemblⁱ	ENST00000369143; ENSP00000358139; ENSG00000112249 [Q8N3C0-3] ENST00000369162; ENSP00000358159; ENSG00000112249 ENST00000522650; ENSP00000430769; ENSG00000112249 [Q8N3C0-4]
GeneIDⁱ	10973
KEGGⁱ	hsa:10973
MANE-Selectⁱ	ENST00000369162.7; ENSP00000358159.2; NM_006828.4; NP_006819.2
UCSCⁱ	uc003pqk.5, human [Q8N3C0-1]

Organism-specific databases

CTDⁱ	10973
DisGeNETⁱ	10973
GeneCardsⁱ	ASCC3
HGNCⁱ	HGNC:18697, ASCC3
HPAⁱ	ENSG00000112249, Low tissue specificity
MIMⁱ	614217, gene
neXtProtⁱ	NX_Q8N3C0
OpenTargetsⁱ	ENSG00000112249
PharmGKBⁱ	PA134890913
VEuPathDBⁱ	HostDB:ENSG00000112249
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0952, Eukaryota
GeneTreeⁱ	ENSGT00940000155377
HOGENOMⁱ	CLU_000335_2_1_1
InParanoidⁱ	Q8N3C0
OMAⁱ	DTRTIRD
OrthoDBⁱ	154891at2759
PhylomeDBⁱ	Q8N3C0
TreeFamⁱ	TF105778

Enzyme and pathway databases

PathwayCommonsⁱ	Q8N3C0
Reactomeⁱ	R-HSA-112126, ALKBH3 mediated reversal of alkylation damage
SignaLinkⁱ	Q8N3C0

Miscellaneous databases

BioGRID-ORCSⁱ	10973, 183 hits in 1055 CRISPR screens
ChiTaRSⁱ	ASCC3, human
GeneWikiⁱ	ASCC3
GenomeRNAiⁱ	10973
Pharosⁱ	Q8N3C0, Tbio
Protein Ontology More...PROⁱ	PR:Q8N3C0
RNActⁱ	Q8N3C0, protein
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000112249, Expressed in decidua and 223 other tissues
ExpressionAtlasⁱ	Q8N3C0, baseline and differential
Genevisibleⁱ	Q8N3C0, HS

Family and domain databases

Gene3Dⁱ	1.10.10.10, 2 hits 2.60.40.150, 2 hits 3.40.50.300, 4 hits
InterProⁱ	View protein in InterPro IPR003593, AAA+_ATPase IPR035892, C2_domain_sf IPR011545, DEAD/DEAH_box_helicase_dom IPR014001, Helicase_ATP-bd IPR001650, Helicase_C IPR014756, Ig_E-set IPR027417, P-loop_NTPase IPR004179, Sec63-dom IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf
Pfamⁱ	View protein in Pfam PF00270, DEAD, 2 hits PF00271, Helicase_C, 2 hits PF02889, Sec63, 2 hits
SMARTⁱ	View protein in SMART SM00382, AAA, 2 hits SM00487, DEXDc, 2 hits SM00490, HELICc, 2 hits SM00973, Sec63, 2 hits
SUPFAMⁱ	SSF46785, SSF46785, 2 hits SSF52540, SSF52540, 4 hits SSF81296, SSF81296, 1 hit
PROSITEⁱ	View protein in PROSITE PS51192, HELICASE_ATP_BIND_1, 2 hits PS51194, HELICASE_CTER, 2 hits
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ASCC3_HUMAN
Accessionⁱ	Q8N3C0Primary (citable) accession number: Q8N3C0 Secondary accession number(s): E7EW23 Q9NTR0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 19, 2004
	Last sequence update:	September 11, 2007
	Last modified:	February 23, 2022
	This is version 181 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Direct protein sequencing, Reference proteome

Documents

Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM
Human entries with genetic variants
List of human entries with genetic variants
Human variants curated from literature reports
Index of human variants curated from literature reports
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families

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UniProtKB - Q8N3C0 (ASCC3_HUMAN)

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Activating signal cointegrator 1 complex subunit 3

ASCC3

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytoplasm and Cytosol

Nucleus

Cytosol

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Miscellaneous databases

Genetic variation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Q8N3C0

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Coiled coil

Motif

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Genetic variation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

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Functionⁱ

Catalytic activityⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ