UniProtKB - Q8N3C0 (ASCC3_HUMAN)
Activating signal cointegrator 1 complex subunit 3
ASCC3
Functioni
3'-5' DNA helicase involved in repair of alkylated DNA (PubMed:22055184).
Promotes DNA unwinding to generate single-stranded substrate needed for ALKBH3, enabling ALKBH3 to process alkylated N3-methylcytosine (3mC) within double-stranded regions (PubMed:22055184).
Also involved in activation of the ribosome quality control (RQC) pathway, a pathway that degrades nascent peptide chains during problematic translation (PubMed:28757607, PubMed:32099016).
Drives the splitting of stalled ribosomes, as part of the ribosome quality control trigger (RQT) complex (PubMed:28757607, PubMed:32099016).
Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation (PubMed:12077347).
4 PublicationsCatalytic activityi
- EC:3.6.4.121 Publication
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 499 – 506 | ATPPROSITE-ProRule annotation | 8 | |
Nucleotide bindingi | 1349 – 1356 | ATPPROSITE-ProRule annotation | 8 |
GO - Molecular functioni
- 3'-5' DNA helicase activity Source: UniProtKB
- ATP binding Source: UniProtKB-KW
- ATP hydrolysis activity Source: RHEA
- RNA binding Source: UniProtKB
GO - Biological processi
- cell population proliferation Source: UniProtKB
- DNA dealkylation involved in DNA repair Source: UniProtKB
- DNA duplex unwinding Source: UniProtKB
- rescue of stalled ribosome Source: UniProtKB
- ribosome-associated ubiquitin-dependent protein catabolic process Source: UniProtKB
Keywordsi
Molecular function | Helicase, Hydrolase |
Biological process | DNA damage, DNA repair, Transcription, Transcription regulation |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | Q8N3C0 |
Reactomei | R-HSA-112126, ALKBH3 mediated reversal of alkylation damage |
SignaLinki | Q8N3C0 |
Names & Taxonomyi
Protein namesi | Recommended name: Activating signal cointegrator 1 complex subunit 3 (EC:3.6.4.121 Publication)Alternative name(s): ASC-1 complex subunit p2001 Publication Short name: ASC1p200 Helicase, ATP binding 1 Trip4 complex subunit p2001 Publication |
Gene namesi | Name:ASCC3 Synonyms:HELIC1, RQT21 Publication |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:18697, ASCC3 |
MIMi | 614217, gene |
neXtProti | NX_Q8N3C0 |
VEuPathDBi | HostDB:ENSG00000112249 |
Subcellular locationi
Cytoplasm and Cytosol
- cytosol 1 Publication
Nucleus
- Nucleus 2 Publications
- Nucleus speckle 2 Publications
Note: Colocalizes with ALKBH3 and ASCC2 in nuclear foci when cells have been exposed to alkylating agents that cause DNA damage.1 Publication
Cytosol
- cytosol Source: UniProtKB
Nucleus
- activating signal cointegrator 1 complex Source: UniProtKB
- nuclear speck Source: UniProtKB-SubCell
- nucleoplasm Source: Reactome
- nucleus Source: UniProtKB
Other locations
- membrane Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 505 | K → R: Defective activation of the ribosome quality control (RQC) pathway. Impairs its association with ribosomes. 1 Publication | 1 | |
Mutagenesisi | 1354 | G → D: Abolishes 3'-5' DNA helicase activity and ability to promote DNA repair. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 10973 |
OpenTargetsi | ENSG00000112249 |
PharmGKBi | PA134890913 |
Miscellaneous databases
Pharosi | Q8N3C0, Tbio |
Genetic variation databases
BioMutai | ASCC3 |
DMDMi | 158518649 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000102093 | 1 – 2202 | Activating signal cointegrator 1 complex subunit 3Add BLAST | 2202 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 12 | PhosphoserineCombined sources | 1 | |
Modified residuei | 572 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 2195 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q8N3C0 |
jPOSTi | Q8N3C0 |
MassIVEi | Q8N3C0 |
MaxQBi | Q8N3C0 |
PaxDbi | Q8N3C0 |
PeptideAtlasi | Q8N3C0 |
PRIDEi | Q8N3C0 |
ProteomicsDBi | 71786 [Q8N3C0-1] 71787 [Q8N3C0-3] 71788 [Q8N3C0-4] |
PTM databases
CarbonylDBi | Q8N3C0 |
iPTMneti | Q8N3C0 |
MetOSitei | Q8N3C0 |
PhosphoSitePlusi | Q8N3C0 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000112249, Expressed in decidua and 223 other tissues |
ExpressionAtlasi | Q8N3C0, baseline and differential |
Genevisiblei | Q8N3C0, HS |
Organism-specific databases
HPAi | ENSG00000112249, Low tissue specificity |
Interactioni
Subunit structurei
Identified in the ASCC complex that contains ASCC1, ASCC2 and ASCC3 (PubMed:12077347, PubMed:29144457, PubMed:29997253). Functions as scaffolding subunit that interacts directly with both ASCC1 and ASCC2 (PubMed:29144457, PubMed:29997253).
Interacts directly with ALKBH3, and thereby recruits ALKBH3 to the ASCC complex (PubMed:22055184, PubMed:29144457). Part of the ASC-1/TRIP4 complex, that contains TRIP4, ASCC1, ASCC2 and ASCC3 (PubMed:12077347). Identified in the RQT (ribosome quality control trigger) complex, that contains ASCC2, ASCC3 and TRIP4 (PubMed:32099016).
Interacts with ASCC2 (PubMed:32099016).
Interacts with TRIP4 (PubMed:32099016).
Interacts with ZCCHC4 (PubMed:31799605).
Interacts with ZNF598 (PubMed:28757607).
Interacts with RPS3 (PubMed:28757607). Associates with ribosomes (PubMed:32099016).
6 PublicationsBinary interactionsi
Q8N3C0
With | #Exp. | IntAct |
---|---|---|
ASCC1 - isoform 2 [Q8N9N2-2] | 4 | EBI-1210710,EBI-10962548 |
ASCC2 [Q9H1I8] | 6 | EBI-1210710,EBI-711197 |
Protein-protein interaction databases
BioGRIDi | 116170, 144 interactors |
CORUMi | Q8N3C0 |
IntActi | Q8N3C0, 39 interactors |
MINTi | Q8N3C0 |
STRINGi | 9606.ENSP00000358159 |
Miscellaneous databases
RNActi | Q8N3C0, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q8N3C0 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 486 – 669 | Helicase ATP-binding 1PROSITE-ProRule annotationAdd BLAST | 184 | |
Domaini | 728 – 914 | Helicase C-terminal 1PROSITE-ProRule annotationAdd BLAST | 187 | |
Domaini | 978 – 1287 | SEC63 1Add BLAST | 310 | |
Domaini | 1336 – 1511 | Helicase ATP-binding 2PROSITE-ProRule annotationAdd BLAST | 176 | |
Domaini | 1544 – 1739 | Helicase C-terminal 2PROSITE-ProRule annotationAdd BLAST | 196 | |
Domaini | 1812 – 2176 | SEC63 2Add BLAST | 365 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 400 | Required for interaction with ASCC21 PublicationAdd BLAST | 400 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 18 – 79 | Sequence analysisAdd BLAST | 62 | |
Coiled coili | 328 – 356 | Sequence analysisAdd BLAST | 29 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 611 – 614 | DEVH box | 4 | |
Motifi | 1453 – 1456 | DEIH box | 4 |
Sequence similaritiesi
Keywords - Domaini
Coiled coil, RepeatPhylogenomic databases
eggNOGi | KOG0952, Eukaryota |
GeneTreei | ENSGT00940000155377 |
HOGENOMi | CLU_000335_2_1_1 |
InParanoidi | Q8N3C0 |
OMAi | DTRTIRD |
OrthoDBi | 154891at2759 |
PhylomeDBi | Q8N3C0 |
TreeFami | TF105778 |
Family and domain databases
Gene3Di | 1.10.10.10, 2 hits 2.60.40.150, 2 hits 3.40.50.300, 4 hits |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR035892, C2_domain_sf IPR011545, DEAD/DEAH_box_helicase_dom IPR014001, Helicase_ATP-bd IPR001650, Helicase_C IPR014756, Ig_E-set IPR027417, P-loop_NTPase IPR004179, Sec63-dom IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
Pfami | View protein in Pfam PF00270, DEAD, 2 hits PF00271, Helicase_C, 2 hits PF02889, Sec63, 2 hits |
SMARTi | View protein in SMART SM00382, AAA, 2 hits SM00487, DEXDc, 2 hits SM00490, HELICc, 2 hits SM00973, Sec63, 2 hits |
SUPFAMi | SSF46785, SSF46785, 2 hits SSF52540, SSF52540, 4 hits SSF81296, SSF81296, 1 hit |
PROSITEi | View protein in PROSITE PS51192, HELICASE_ATP_BIND_1, 2 hits PS51194, HELICASE_CTER, 2 hits |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MALPRLTGAL RSFSNVTKQD NYNEEVADLK IKRSKLHEQV LDLGLTWKKI
60 70 80 90 100
IKFLNEKLEK SKMQSINEDL KDILHAAKQI VGTDNGREAI ESGAAFLFMT
110 120 130 140 150
FHLKDSVGHK ETKAIKQMFG PFPSSSATAA CNATNRIISH FSQDDLTALV
160 170 180 190 200
QMTEKEHGDR VFFGKNLAFS FDMHDLDHFD ELPINGETQK TISLDYKKFL
210 220 230 240 250
NEHLQEACTP ELKPVEKTNG SFLWCEVEKY LNSTLKEMTE VPRVEDLCCT
260 270 280 290 300
LYDMLASIKS GDELQDELFE LLGPEGLELI EKLLQNRITI VDRFLNSSND
310 320 330 340 350
HRFQALQDNC KKILGENAKP NYGCQVTIQS EQEKQLMKQY RREEKRIARR
360 370 380 390 400
EKKAGEDLEV SEGLMCFDPK ELRIQREQAL LNARSVPILS RQRDADVEKI
410 420 430 440 450
HYPHVYDSQA EAMKTSAFIA GAKMILPEGI QRENNKLYEE VRIPYSEPMP
460 470 480 490 500
LSFEEKPVYI QDLDEIGQLA FKGMKRLNRI QSIVFETAYN TNENMLICAP
510 520 530 540 550
TGAGKTNIAM LTVLHEIRQH FQQGVIKKNE FKIVYVAPMK ALAAEMTDYF
560 570 580 590 600
SRRLEPLGII VKELTGDMQL SKSEILRTQM LVTTPEKWDV VTRKSVGDVA
610 620 630 640 650
LSQIVRLLIL DEVHLLHEDR GPVLESIVAR TLRQVESTQS MIRILGLSAT
660 670 680 690 700
LPNYLDVATF LHVNPYIGLF FFDGRFRPVP LGQTFLGIKC ANKMQQLNNM
710 720 730 740 750
DEVCYENVLK QVKAGHQVMV FVHARNATVR TAMSLIERAK NCGHIPFFFP
760 770 780 790 800
TQGHDYVLAE KQVQRSRNKQ VRELFPDGFS IHHAGMLRQD RNLVENLFSN
810 820 830 840 850
GHIKVLVCTA TLAWGVNLPA HAVIIKGTQI YAAKRGSFVD LGILDVMQIF
860 870 880 890 900
GRAGRPQFDK FGEGIIITTH DKLSHYLTLL TQRNPIESQF LESLADNLNA
910 920 930 940 950
EIALGTVTNV EEAVKWISYT YLYVRMRANP LAYGISHKAY QIDPTLRKHR
960 970 980 990 1000
EQLVIEVGRK LDKAQMIRFE ERTGYFSSTD LGRTASHYYI KYNTIETFNE
1010 1020 1030 1040 1050
LFDAHKTEGD IFAIVSKAEE FDQIKVREEE IEELDTLLSN FCELSTPGGV
1060 1070 1080 1090 1100
ENSYGKINIL LQTYISRGEM DSFSLISDSA YVAQNAARIV RALFEIALRK
1110 1120 1130 1140 1150
RWPTMTYRLL NLSKVIDKRL WGWASPLRQF SILPPHILTR LEEKKLTVDK
1160 1170 1180 1190 1200
LKDMRKDEIG HILHHVNIGL KVKQCVHQIP SVMMEASIQP ITRTVLRVTL
1210 1220 1230 1240 1250
SIYADFTWND QVHGTVGEPW WIWVEDPTND HIYHSEYFLA LKKQVISKEA
1260 1270 1280 1290 1300
QLLVFTIPIF EPLPSQYYIR AVSDRWLGAE AVCIINFQHL ILPERHPPHT
1310 1320 1330 1340 1350
ELLDLQPLPI TALGCKAYEA LYNFSHFNPV QTQIFHTLYH TDCNVLLGAP
1360 1370 1380 1390 1400
TGSGKTVAAE LAIFRVFNKY PTSKAVYIAP LKALVRERMD DWKVRIEEKL
1410 1420 1430 1440 1450
GKKVIELTGD VTPDMKSIAK ADLIVTTPEK WDGVSRSWQN RNYVQQVTIL
1460 1470 1480 1490 1500
IIDEIHLLGE ERGPVLEVIV SRTNFISSHT EKPVRIVGLS TALANARDLA
1510 1520 1530 1540 1550
DWLNIKQMGL FNFRPSVRPV PLEVHIQGFP GQHYCPRMAS MNKPAFQAIR
1560 1570 1580 1590 1600
SHSPAKPVLI FVSSRRQTRL TALELIAFLA TEEDPKQWLN MDEREMENII
1610 1620 1630 1640 1650
ATVRDSNLKL TLAFGIGMHH AGLHERDRKT VEELFVNCKV QVLIATSTLA
1660 1670 1680 1690 1700
WGVNFPAHLV IIKGTEYYDG KTRRYVDFPI TDVLQMMGRA GRPQFDDQGK
1710 1720 1730 1740 1750
AVILVHDIKK DFYKKFLYEP FPVESSLLGV LSDHLNAEIA GGTITSKQDA
1760 1770 1780 1790 1800
LDYITWTYFF RRLIMNPSYY NLGDVSHDSV NKFLSHLIEK SLIELELSYC
1810 1820 1830 1840 1850
IEIGEDNRSI EPLTYGRIAS YYYLKHQTVK MFKDRLKPEC STEELLSILS
1860 1870 1880 1890 1900
DAEEYTDLPV RHNEDHMNSE LAKCLPIESN PHSFDSPHTK AHLLLQAHLS
1910 1920 1930 1940 1950
RAMLPCPDYD TDTKTVLDQA LRVCQAMLDV AANQGWLVTV LNITNLIQMV
1960 1970 1980 1990 2000
IQGRWLKDSS LLTLPNIENH HLHLFKKWKP IMKGPHARGR TSIESLPELI
2010 2020 2030 2040 2050
HACGGKDHVF SSMVESELHA AKTKQAWNFL SHLPVINVGI SVKGSWDDLV
2060 2070 2080 2090 2100
EGHNELSVST LTADKRDDNK WIKLHADQEY VLQVSLQRVH FGFHKGKPES
2110 2120 2130 2140 2150
CAVTPRFPKS KDEGWFLILG EVDKRELIAL KRVGYIRNHH VASLSFYTPE
2160 2170 2180 2190 2200
IPGRYIYTLY FMSDCYLGLD QQYDIYLNVT QASLSAQVNT KVSDSLTDLA
LK
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE5RFZ0 | E5RFZ0_HUMAN | Activating signal cointegrator 1 co... | ASCC3 | 176 | Annotation score: | ||
J3KNJ4 | J3KNJ4_HUMAN | Activating signal cointegrator 1 co... | ASCC3 | 48 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 86 | G → E in AAH26066 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 444 | P → S in CAD39122 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 582 | V → A in AAH26066 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 750 | P → S in CAD39122 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 1187 | S → F in CAA11679 (Ref. 7) Curated | 1 | |
Sequence conflicti | 1343 | C → S in CAA11679 (Ref. 7) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_034859 | 146 | L → F1 PublicationCorresponds to variant dbSNP:rs9390698Ensembl. | 1 | |
Natural variantiVAR_049339 | 344 | E → K. Corresponds to variant dbSNP:rs6918004Ensembl. | 1 | |
Natural variantiVAR_049340 | 478 | N → S. Corresponds to variant dbSNP:rs7750940Ensembl. | 1 | |
Natural variantiVAR_061212 | 1016 | S → C. Corresponds to variant dbSNP:rs57534235Ensembl. | 1 | |
Natural variantiVAR_034860 | 1050 | V → I. Corresponds to variant dbSNP:rs9497983EnsemblClinVar. | 1 | |
Natural variantiVAR_049341 | 1425 | V → A. Corresponds to variant dbSNP:rs17246013Ensembl. | 1 | |
Natural variantiVAR_049342 | 1497 | R → T. Corresponds to variant dbSNP:rs17305382Ensembl. | 1 | |
Natural variantiVAR_034861 | 1800 | C → W. Corresponds to variant dbSNP:rs35011147Ensembl. | 1 | |
Natural variantiVAR_034862 | 1930 | V → M. Corresponds to variant dbSNP:rs3213542Ensembl. | 1 | |
Natural variantiVAR_034863 | 1995 | S → C2 PublicationsCorresponds to variant dbSNP:rs240780Ensembl. | 1 | |
Natural variantiVAR_034864 | 2176 | Y → C. Corresponds to variant dbSNP:rs240768Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_042955 | 81 – 111 | VGTDN…VGHKE → EVNCPFQKRRLDGKEEDEKM SRASDRFRGLR in isoform 2. 2 PublicationsAdd BLAST | 31 | |
Alternative sequenceiVSP_042956 | 112 – 2202 | Missing in isoform 2. 2 PublicationsAdd BLAST | 2091 | |
Alternative sequenceiVSP_042957 | 719 – 731 | MVFVH…ATVRT → HLFYLLLHLFICF in isoform 3. 1 PublicationAdd BLAST | 13 | |
Alternative sequenceiVSP_042958 | 732 – 2202 | Missing in isoform 3. 1 PublicationAdd BLAST | 1471 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL834463 mRNA Translation: CAD39122.1 AK315197 mRNA Translation: BAG37637.1 AL121965 Genomic DNA No translation available. AL133338 Genomic DNA No translation available. AL356122 Genomic DNA No translation available. AL591585 Genomic DNA No translation available. Z86062 Genomic DNA No translation available. CH471051 Genomic DNA Translation: EAW48449.1 BC050681 mRNA Translation: AAH50681.1 BC125211 mRNA Translation: AAI25212.1 BC125212 mRNA Translation: AAI25213.1 BC026066 mRNA Translation: AAH26066.1 AY013288 mRNA Translation: AAG45474.1 Frameshift. AJ223948 mRNA Translation: CAA11679.1 Sequence problems. |
CCDSi | CCDS5046.1 [Q8N3C0-1] CCDS5047.1 [Q8N3C0-3] CCDS75497.1 [Q8N3C0-4] |
RefSeqi | NP_001271200.1, NM_001284271.1 [Q8N3C0-4] NP_006819.2, NM_006828.3 [Q8N3C0-1] NP_071374.1, NM_022091.4 [Q8N3C0-3] |
Genome annotation databases
Ensembli | ENST00000369143; ENSP00000358139; ENSG00000112249 [Q8N3C0-3] ENST00000369162; ENSP00000358159; ENSG00000112249 ENST00000522650; ENSP00000430769; ENSG00000112249 [Q8N3C0-4] |
GeneIDi | 10973 |
KEGGi | hsa:10973 |
MANE-Selecti | ENST00000369162.7; ENSP00000358159.2; NM_006828.4; NP_006819.2 |
UCSCi | uc003pqk.5, human [Q8N3C0-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL834463 mRNA Translation: CAD39122.1 AK315197 mRNA Translation: BAG37637.1 AL121965 Genomic DNA No translation available. AL133338 Genomic DNA No translation available. AL356122 Genomic DNA No translation available. AL591585 Genomic DNA No translation available. Z86062 Genomic DNA No translation available. CH471051 Genomic DNA Translation: EAW48449.1 BC050681 mRNA Translation: AAH50681.1 BC125211 mRNA Translation: AAI25212.1 BC125212 mRNA Translation: AAI25213.1 BC026066 mRNA Translation: AAH26066.1 AY013288 mRNA Translation: AAG45474.1 Frameshift. AJ223948 mRNA Translation: CAA11679.1 Sequence problems. |
CCDSi | CCDS5046.1 [Q8N3C0-1] CCDS5047.1 [Q8N3C0-3] CCDS75497.1 [Q8N3C0-4] |
RefSeqi | NP_001271200.1, NM_001284271.1 [Q8N3C0-4] NP_006819.2, NM_006828.3 [Q8N3C0-1] NP_071374.1, NM_022091.4 [Q8N3C0-3] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
6YXQ | X-ray | 2.70 | A | 1-207 | [»] | |
SMRi | Q8N3C0 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 116170, 144 interactors |
CORUMi | Q8N3C0 |
IntActi | Q8N3C0, 39 interactors |
MINTi | Q8N3C0 |
STRINGi | 9606.ENSP00000358159 |
PTM databases
CarbonylDBi | Q8N3C0 |
iPTMneti | Q8N3C0 |
MetOSitei | Q8N3C0 |
PhosphoSitePlusi | Q8N3C0 |
Genetic variation databases
BioMutai | ASCC3 |
DMDMi | 158518649 |
Proteomic databases
EPDi | Q8N3C0 |
jPOSTi | Q8N3C0 |
MassIVEi | Q8N3C0 |
MaxQBi | Q8N3C0 |
PaxDbi | Q8N3C0 |
PeptideAtlasi | Q8N3C0 |
PRIDEi | Q8N3C0 |
ProteomicsDBi | 71786 [Q8N3C0-1] 71787 [Q8N3C0-3] 71788 [Q8N3C0-4] |
Protocols and materials databases
Antibodypediai | 32044, 88 antibodies from 19 providers |
DNASUi | 10973 |
Genome annotation databases
Ensembli | ENST00000369143; ENSP00000358139; ENSG00000112249 [Q8N3C0-3] ENST00000369162; ENSP00000358159; ENSG00000112249 ENST00000522650; ENSP00000430769; ENSG00000112249 [Q8N3C0-4] |
GeneIDi | 10973 |
KEGGi | hsa:10973 |
MANE-Selecti | ENST00000369162.7; ENSP00000358159.2; NM_006828.4; NP_006819.2 |
UCSCi | uc003pqk.5, human [Q8N3C0-1] |
Organism-specific databases
CTDi | 10973 |
DisGeNETi | 10973 |
GeneCardsi | ASCC3 |
HGNCi | HGNC:18697, ASCC3 |
HPAi | ENSG00000112249, Low tissue specificity |
MIMi | 614217, gene |
neXtProti | NX_Q8N3C0 |
OpenTargetsi | ENSG00000112249 |
PharmGKBi | PA134890913 |
VEuPathDBi | HostDB:ENSG00000112249 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0952, Eukaryota |
GeneTreei | ENSGT00940000155377 |
HOGENOMi | CLU_000335_2_1_1 |
InParanoidi | Q8N3C0 |
OMAi | DTRTIRD |
OrthoDBi | 154891at2759 |
PhylomeDBi | Q8N3C0 |
TreeFami | TF105778 |
Enzyme and pathway databases
PathwayCommonsi | Q8N3C0 |
Reactomei | R-HSA-112126, ALKBH3 mediated reversal of alkylation damage |
SignaLinki | Q8N3C0 |
Miscellaneous databases
BioGRID-ORCSi | 10973, 183 hits in 1055 CRISPR screens |
ChiTaRSi | ASCC3, human |
GeneWikii | ASCC3 |
GenomeRNAii | 10973 |
Pharosi | Q8N3C0, Tbio |
PROi | PR:Q8N3C0 |
RNActi | Q8N3C0, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000112249, Expressed in decidua and 223 other tissues |
ExpressionAtlasi | Q8N3C0, baseline and differential |
Genevisiblei | Q8N3C0, HS |
Family and domain databases
Gene3Di | 1.10.10.10, 2 hits 2.60.40.150, 2 hits 3.40.50.300, 4 hits |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR035892, C2_domain_sf IPR011545, DEAD/DEAH_box_helicase_dom IPR014001, Helicase_ATP-bd IPR001650, Helicase_C IPR014756, Ig_E-set IPR027417, P-loop_NTPase IPR004179, Sec63-dom IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
Pfami | View protein in Pfam PF00270, DEAD, 2 hits PF00271, Helicase_C, 2 hits PF02889, Sec63, 2 hits |
SMARTi | View protein in SMART SM00382, AAA, 2 hits SM00487, DEXDc, 2 hits SM00490, HELICc, 2 hits SM00973, Sec63, 2 hits |
SUPFAMi | SSF46785, SSF46785, 2 hits SSF52540, SSF52540, 4 hits SSF81296, SSF81296, 1 hit |
PROSITEi | View protein in PROSITE PS51192, HELICASE_ATP_BIND_1, 2 hits PS51194, HELICASE_CTER, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | ASCC3_HUMAN | |
Accessioni | Q8N3C0Primary (citable) accession number: Q8N3C0 Secondary accession number(s): E7EW23 Q9NTR0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 19, 2004 |
Last sequence update: | September 11, 2007 | |
Last modified: | February 23, 2022 | |
This is version 181 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families