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UniProtKB - Q8N3C0 (ASCC3_HUMAN)

Protein

Activating signal cointegrator 1 complex subunit 3

Gene

ASCC3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

3'-5' DNA helicase involved in repair of alkylated DNA. Promotes DNA unwinding to generate single-stranded substrate needed for ALKBH3, enabling ALKBH3 to process alkylated N3-methylcytosine (3mC) within double-stranded regions (PubMed:22055184). Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation (PubMed:12077347).2 Publications

Catalytic activityi

ATP + H2O = ADP + phosphate.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi499 – 506ATPPROSITE-ProRule annotation8
Nucleotide bindingi1349 – 1356ATPPROSITE-ProRule annotation8

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • ATP-dependent 3'-5' DNA helicase activity Source: UniProtKB
  • ATP-dependent helicase activity Source: GO_Central
  • RNA binding Source: UniProtKB
View the complete GO annotation on QuickGO ...

GO - Biological processi

  • cell proliferation Source: UniProtKB
  • DNA dealkylation involved in DNA repair Source: UniProtKB
  • DNA duplex unwinding Source: UniProtKB
View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionHelicase, Hydrolase
Biological processDNA damage, DNA repair, Transcription, Transcription regulation
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-112126 ALKBH3 mediated reversal of alkylation damage

Names & Taxonomyi

Protein namesi
Recommended name:
Activating signal cointegrator 1 complex subunit 3 (EC:3.6.4.121 Publication)
Alternative name(s):
ASC-1 complex subunit p2001 Publication
Short name:
ASC1p200
Helicase, ATP binding 1
Trip4 complex subunit p2001 Publication
Gene namesi
Name:ASCC3
Synonyms:HELIC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000112249.13
HGNCiHGNC:18697 ASCC3
MIMi614217 gene
neXtProtiNX_Q8N3C0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi1354G → D: Abolishes 3'-5' DNA helicase activity and ability to promote DNA repair. 1 Publication1

Organism-specific databases

DisGeNETi10973
OpenTargetsiENSG00000112249
PharmGKBiPA134890913

Polymorphism and mutation databases

BioMutaiASCC3
DMDMi158518649

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001020931 – 2202Activating signal cointegrator 1 complex subunit 3Add BLAST2202

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei12PhosphoserineCombined sources1
Modified residuei572N6-acetyllysineCombined sources1
Modified residuei2195PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ8N3C0
MaxQBiQ8N3C0
PaxDbiQ8N3C0
PeptideAtlasiQ8N3C0
PRIDEiQ8N3C0
ProteomicsDBi71786
71787 [Q8N3C0-3]
71788 [Q8N3C0-4]

PTM databases

CarbonylDBiQ8N3C0
iPTMnetiQ8N3C0
PhosphoSitePlusiQ8N3C0

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

BgeeiENSG00000112249 Expressed in 213 organ(s), highest expression level in decidua
CleanExiHS_ASCC3
ExpressionAtlasiQ8N3C0 baseline and differential
GenevisibleiQ8N3C0 HS

Organism-specific databases

HPAiHPA031608
HPA031609
HPA031610

Interactioni

Subunit structurei

Identified in the ASCC complex that contains ASCC1, ASCC2 and ASCC3 (PubMed:12077347, PubMed:29144457, PubMed:29997253). Functions as scaffolding subunit that interacts directly with both ASCC1 and ASCC2 (PubMed:29144457, PubMed:29997253). Interacts directly with ALKBH3, and thereby recruits ALKBH3 to the ASCC complex (PubMed:22055184, PubMed:29144457). Part of the ASC-1/TRIP4 complex, that contains TRIP4, ASCC1, ASCC2 and ASCC3 (PubMed:12077347).4 Publications

Protein-protein interaction databases

BioGridi116170, 65 interactors
CORUMiQ8N3C0
IntActiQ8N3C0, 18 interactors
MINTiQ8N3C0
STRINGi9606.ENSP00000358159

Structurei

3D structure databases

ProteinModelPortaliQ8N3C0
SMRiQ8N3C0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini486 – 669Helicase ATP-binding 1PROSITE-ProRule annotationAdd BLAST184
Domaini728 – 914Helicase C-terminal 1PROSITE-ProRule annotationAdd BLAST187
Domaini978 – 1287SEC63 1Add BLAST310
Domaini1336 – 1511Helicase ATP-binding 2PROSITE-ProRule annotationAdd BLAST176
Domaini1544 – 1739Helicase C-terminal 2PROSITE-ProRule annotationAdd BLAST196
Domaini1812 – 2176SEC63 2Add BLAST365

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 400Required for interaction with ASCC21 PublicationAdd BLAST400

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili18 – 79Sequence analysisAdd BLAST62
Coiled coili328 – 356Sequence analysisAdd BLAST29

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi611 – 614DEVH box4
Motifi1453 – 1456DEIH box4

Sequence similaritiesi

Belongs to the helicase family.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG0952 Eukaryota
COG1204 LUCA
GeneTreeiENSGT00640000091272
HOGENOMiHOG000152625
HOVERGENiHBG051896
InParanoidiQ8N3C0
KOiK18663
OMAiYKTLNRM
OrthoDBiEOG091G0HE5
PhylomeDBiQ8N3C0
TreeFamiTF105778

Family and domain databases

CDDicd00079 HELICc, 2 hits
Gene3Di2.60.40.150, 2 hits
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR035892 C2_domain_sf
IPR011545 DEAD/DEAH_box_helicase_dom
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR014756 Ig_E-set
IPR027417 P-loop_NTPase
IPR004179 Sec63-dom
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00270 DEAD, 2 hits
PF00271 Helicase_C, 2 hits
PF02889 Sec63, 2 hits
SMARTiView protein in SMART
SM00382 AAA, 2 hits
SM00487 DEXDc, 2 hits
SM00490 HELICc, 2 hits
SM00973 Sec63, 2 hits
SUPFAMiSSF46785 SSF46785, 2 hits
SSF52540 SSF52540, 4 hits
SSF81296 SSF81296, 1 hit
PROSITEiView protein in PROSITE
PS51192 HELICASE_ATP_BIND_1, 2 hits
PS51194 HELICASE_CTER, 2 hits

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8N3C0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MALPRLTGAL RSFSNVTKQD NYNEEVADLK IKRSKLHEQV LDLGLTWKKI 
        60         70         80         90        100
IKFLNEKLEK SKMQSINEDL KDILHAAKQI VGTDNGREAI ESGAAFLFMT 
       110        120        130        140        150
FHLKDSVGHK ETKAIKQMFG PFPSSSATAA CNATNRIISH FSQDDLTALV 
       160        170        180        190        200
QMTEKEHGDR VFFGKNLAFS FDMHDLDHFD ELPINGETQK TISLDYKKFL 
       210        220        230        240        250
NEHLQEACTP ELKPVEKTNG SFLWCEVEKY LNSTLKEMTE VPRVEDLCCT 
       260        270        280        290        300
LYDMLASIKS GDELQDELFE LLGPEGLELI EKLLQNRITI VDRFLNSSND 
       310        320        330        340        350
HRFQALQDNC KKILGENAKP NYGCQVTIQS EQEKQLMKQY RREEKRIARR 
       360        370        380        390        400
EKKAGEDLEV SEGLMCFDPK ELRIQREQAL LNARSVPILS RQRDADVEKI 
       410        420        430        440        450
HYPHVYDSQA EAMKTSAFIA GAKMILPEGI QRENNKLYEE VRIPYSEPMP 
       460        470        480        490        500
LSFEEKPVYI QDLDEIGQLA FKGMKRLNRI QSIVFETAYN TNENMLICAP 
       510        520        530        540        550
TGAGKTNIAM LTVLHEIRQH FQQGVIKKNE FKIVYVAPMK ALAAEMTDYF 
       560        570        580        590        600
SRRLEPLGII VKELTGDMQL SKSEILRTQM LVTTPEKWDV VTRKSVGDVA 
       610        620        630        640        650
LSQIVRLLIL DEVHLLHEDR GPVLESIVAR TLRQVESTQS MIRILGLSAT 
       660        670        680        690        700
LPNYLDVATF LHVNPYIGLF FFDGRFRPVP LGQTFLGIKC ANKMQQLNNM 
       710        720        730        740        750
DEVCYENVLK QVKAGHQVMV FVHARNATVR TAMSLIERAK NCGHIPFFFP 
       760        770        780        790        800
TQGHDYVLAE KQVQRSRNKQ VRELFPDGFS IHHAGMLRQD RNLVENLFSN 
       810        820        830        840        850
GHIKVLVCTA TLAWGVNLPA HAVIIKGTQI YAAKRGSFVD LGILDVMQIF 
       860        870        880        890        900
GRAGRPQFDK FGEGIIITTH DKLSHYLTLL TQRNPIESQF LESLADNLNA 
       910        920        930        940        950
EIALGTVTNV EEAVKWISYT YLYVRMRANP LAYGISHKAY QIDPTLRKHR 
       960        970        980        990       1000
EQLVIEVGRK LDKAQMIRFE ERTGYFSSTD LGRTASHYYI KYNTIETFNE 
      1010       1020       1030       1040       1050
LFDAHKTEGD IFAIVSKAEE FDQIKVREEE IEELDTLLSN FCELSTPGGV 
      1060       1070       1080       1090       1100
ENSYGKINIL LQTYISRGEM DSFSLISDSA YVAQNAARIV RALFEIALRK 
      1110       1120       1130       1140       1150
RWPTMTYRLL NLSKVIDKRL WGWASPLRQF SILPPHILTR LEEKKLTVDK 
      1160       1170       1180       1190       1200
LKDMRKDEIG HILHHVNIGL KVKQCVHQIP SVMMEASIQP ITRTVLRVTL 
      1210       1220       1230       1240       1250
SIYADFTWND QVHGTVGEPW WIWVEDPTND HIYHSEYFLA LKKQVISKEA 
      1260       1270       1280       1290       1300
QLLVFTIPIF EPLPSQYYIR AVSDRWLGAE AVCIINFQHL ILPERHPPHT 
      1310       1320       1330       1340       1350
ELLDLQPLPI TALGCKAYEA LYNFSHFNPV QTQIFHTLYH TDCNVLLGAP 
      1360       1370       1380       1390       1400
TGSGKTVAAE LAIFRVFNKY PTSKAVYIAP LKALVRERMD DWKVRIEEKL 
      1410       1420       1430       1440       1450
GKKVIELTGD VTPDMKSIAK ADLIVTTPEK WDGVSRSWQN RNYVQQVTIL 
      1460       1470       1480       1490       1500
IIDEIHLLGE ERGPVLEVIV SRTNFISSHT EKPVRIVGLS TALANARDLA 
      1510       1520       1530       1540       1550
DWLNIKQMGL FNFRPSVRPV PLEVHIQGFP GQHYCPRMAS MNKPAFQAIR 
      1560       1570       1580       1590       1600
SHSPAKPVLI FVSSRRQTRL TALELIAFLA TEEDPKQWLN MDEREMENII 
      1610       1620       1630       1640       1650
ATVRDSNLKL TLAFGIGMHH AGLHERDRKT VEELFVNCKV QVLIATSTLA 
      1660       1670       1680       1690       1700
WGVNFPAHLV IIKGTEYYDG KTRRYVDFPI TDVLQMMGRA GRPQFDDQGK 
      1710       1720       1730       1740       1750
AVILVHDIKK DFYKKFLYEP FPVESSLLGV LSDHLNAEIA GGTITSKQDA 
      1760       1770       1780       1790       1800
LDYITWTYFF RRLIMNPSYY NLGDVSHDSV NKFLSHLIEK SLIELELSYC 
      1810       1820       1830       1840       1850
IEIGEDNRSI EPLTYGRIAS YYYLKHQTVK MFKDRLKPEC STEELLSILS 
      1860       1870       1880       1890       1900
DAEEYTDLPV RHNEDHMNSE LAKCLPIESN PHSFDSPHTK AHLLLQAHLS 
      1910       1920       1930       1940       1950
RAMLPCPDYD TDTKTVLDQA LRVCQAMLDV AANQGWLVTV LNITNLIQMV 
      1960       1970       1980       1990       2000
IQGRWLKDSS LLTLPNIENH HLHLFKKWKP IMKGPHARGR TSIESLPELI 
      2010       2020       2030       2040       2050
HACGGKDHVF SSMVESELHA AKTKQAWNFL SHLPVINVGI SVKGSWDDLV 
      2060       2070       2080       2090       2100
EGHNELSVST LTADKRDDNK WIKLHADQEY VLQVSLQRVH FGFHKGKPES 
      2110       2120       2130       2140       2150
CAVTPRFPKS KDEGWFLILG EVDKRELIAL KRVGYIRNHH VASLSFYTPE 
      2160       2170       2180       2190       2200
IPGRYIYTLY FMSDCYLGLD QQYDIYLNVT QASLSAQVNT KVSDSLTDLA 

LK
Length:2,202
Mass (Da):251,460
Last modified:September 11, 2007 - v3
Checksum:i9F074E6E5853399C
GO
Isoform 2 (identifier: Q8N3C0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     81-111: VGTDNGREAIESGAAFLFMTFHLKDSVGHKE → EVNCPFQKRRLDGKEEDEKMSRASDRFRGLR
     112-2202: Missing.

Show »
Length:111
Mass (Da):13,014
Checksum:iF3D84693464682F3
GO
Isoform 3 (identifier: Q8N3C0-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     719-731: MVFVHARNATVRT → HLFYLLLHLFICF
     732-2202: Missing.

Show »
Length:731
Mass (Da):83,675
Checksum:iE82CDB32BEC21AF3
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E5RFZ0E5RFZ0_HUMAN
Activating signal cointegrator 1 co...
ASCC3
176Annotation score:
J3KNJ4J3KNJ4_HUMAN
Activating signal cointegrator 1 co...
ASCC3
48Annotation score:

Sequence cautioni

The sequence AAG45474 differs from that shown. Reason: Frameshift at position 2175.Curated
The sequence CAA11679 differs from that shown. Reason: Frameshift at position 2175.Curated
The sequence CAA11679 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti86G → E in AAH26066 (PubMed:15489334).Curated1
Sequence conflicti269 – 277Missing in CAH73862 (PubMed:14702039).Curated9
Sequence conflicti269 – 277Missing in CAI16190 (PubMed:14702039).Curated9
Sequence conflicti269 – 277Missing in CAI19454 (PubMed:14702039).Curated9
Sequence conflicti269 – 277Missing in CAI19627 (PubMed:14702039).Curated9
Sequence conflicti269 – 277Missing in CAI21439 (PubMed:14702039).Curated9
Sequence conflicti444P → S in CAD39122 (PubMed:17974005).Curated1
Sequence conflicti582V → A in AAH26066 (PubMed:15489334).Curated1
Sequence conflicti750P → S in CAD39122 (PubMed:17974005).Curated1
Sequence conflicti1187S → F in CAA11679 (Ref. 7) Curated1
Sequence conflicti1343C → S in CAA11679 (Ref. 7) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_034859146L → F1 PublicationCorresponds to variant dbSNP:rs9390698Ensembl.1
Natural variantiVAR_049339344E → K. Corresponds to variant dbSNP:rs6918004Ensembl.1
Natural variantiVAR_049340478N → S. Corresponds to variant dbSNP:rs7750940Ensembl.1
Natural variantiVAR_0612121016S → C. Corresponds to variant dbSNP:rs57534235Ensembl.1
Natural variantiVAR_0348601050V → I. Corresponds to variant dbSNP:rs9497983Ensembl.1
Natural variantiVAR_0493411425V → A. Corresponds to variant dbSNP:rs17246013Ensembl.1
Natural variantiVAR_0493421497R → T. Corresponds to variant dbSNP:rs17305382Ensembl.1
Natural variantiVAR_0348611800C → W. Corresponds to variant dbSNP:rs35011147Ensembl.1
Natural variantiVAR_0348621930V → M. Corresponds to variant dbSNP:rs3213542Ensembl.1
Natural variantiVAR_0348631995S → C2 PublicationsCorresponds to variant dbSNP:rs240780Ensembl.1
Natural variantiVAR_0348642176Y → C. Corresponds to variant dbSNP:rs240768Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04295581 – 111VGTDN…VGHKE → EVNCPFQKRRLDGKEEDEKM SRASDRFRGLR in isoform 2. 2 PublicationsAdd BLAST31
Alternative sequenceiVSP_042956112 – 2202Missing in isoform 2. 2 PublicationsAdd BLAST2091
Alternative sequenceiVSP_042957719 – 731MVFVH…ATVRT → HLFYLLLHLFICF in isoform 3. 1 PublicationAdd BLAST13
Alternative sequenceiVSP_042958732 – 2202Missing in isoform 3. 1 PublicationAdd BLAST1471

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL834463 mRNA Translation: CAD39122.1
AK315197 mRNA Translation: BAG37637.1
AL591585
, AL121965, AL133338, AL356122, Z86062 Genomic DNA Translation: CAH73862.1
AL356122
, AL121965, AL133338, AL591585, Z86062 Genomic DNA Translation: CAI16190.1
Z86062
, AL121965, AL133338, AL356122, AL591585 Genomic DNA Translation: CAI19454.1
AL121965
, AL133338, AL356122, AL591585, Z86062 Genomic DNA Translation: CAI19627.1
AL133338
, AL121965, AL356122, AL591585, Z86062 Genomic DNA Translation: CAI21439.1
AL133338 Genomic DNA Translation: CAC07337.1
CH471051 Genomic DNA Translation: EAW48449.1
BC050681 mRNA Translation: AAH50681.1
BC125211 mRNA Translation: AAI25212.1
BC125212 mRNA Translation: AAI25213.1
BC026066 mRNA Translation: AAH26066.1
AY013288 mRNA Translation: AAG45474.1 Frameshift.
AJ223948 mRNA Translation: CAA11679.1 Sequence problems.
CCDSiCCDS5046.1 [Q8N3C0-1]
CCDS5047.1 [Q8N3C0-3]
CCDS75497.1 [Q8N3C0-4]
RefSeqiNP_001271200.1, NM_001284271.1 [Q8N3C0-4]
NP_006819.2, NM_006828.3 [Q8N3C0-1]
NP_071374.1, NM_022091.4 [Q8N3C0-3]
UniGeneiHs.486031
Hs.733060

Genome annotation databases

EnsembliENST00000369143; ENSP00000358139; ENSG00000112249 [Q8N3C0-3]
ENST00000369162; ENSP00000358159; ENSG00000112249 [Q8N3C0-1]
ENST00000522650; ENSP00000430769; ENSG00000112249 [Q8N3C0-4]
GeneIDi10973
KEGGihsa:10973
UCSCiuc003pqk.5 human [Q8N3C0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL834463 mRNA Translation: CAD39122.1
AK315197 mRNA Translation: BAG37637.1
AL591585
, AL121965, AL133338, AL356122, Z86062 Genomic DNA Translation: CAH73862.1
AL356122
, AL121965, AL133338, AL591585, Z86062 Genomic DNA Translation: CAI16190.1
Z86062
, AL121965, AL133338, AL356122, AL591585 Genomic DNA Translation: CAI19454.1
AL121965
, AL133338, AL356122, AL591585, Z86062 Genomic DNA Translation: CAI19627.1
AL133338
, AL121965, AL356122, AL591585, Z86062 Genomic DNA Translation: CAI21439.1
AL133338 Genomic DNA Translation: CAC07337.1
CH471051 Genomic DNA Translation: EAW48449.1
BC050681 mRNA Translation: AAH50681.1
BC125211 mRNA Translation: AAI25212.1
BC125212 mRNA Translation: AAI25213.1
BC026066 mRNA Translation: AAH26066.1
AY013288 mRNA Translation: AAG45474.1 Frameshift.
AJ223948 mRNA Translation: CAA11679.1 Sequence problems.
CCDSiCCDS5046.1 [Q8N3C0-1]
CCDS5047.1 [Q8N3C0-3]
CCDS75497.1 [Q8N3C0-4]
RefSeqiNP_001271200.1, NM_001284271.1 [Q8N3C0-4]
NP_006819.2, NM_006828.3 [Q8N3C0-1]
NP_071374.1, NM_022091.4 [Q8N3C0-3]
UniGeneiHs.486031
Hs.733060

3D structure databases

ProteinModelPortaliQ8N3C0
SMRiQ8N3C0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116170, 65 interactors
CORUMiQ8N3C0
IntActiQ8N3C0, 18 interactors
MINTiQ8N3C0
STRINGi9606.ENSP00000358159

PTM databases

CarbonylDBiQ8N3C0
iPTMnetiQ8N3C0
PhosphoSitePlusiQ8N3C0

Polymorphism and mutation databases

BioMutaiASCC3
DMDMi158518649

Proteomic databases

EPDiQ8N3C0
MaxQBiQ8N3C0
PaxDbiQ8N3C0
PeptideAtlasiQ8N3C0
PRIDEiQ8N3C0
ProteomicsDBi71786
71787 [Q8N3C0-3]
71788 [Q8N3C0-4]

Protocols and materials databases

DNASUi10973
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000369143; ENSP00000358139; ENSG00000112249 [Q8N3C0-3]
ENST00000369162; ENSP00000358159; ENSG00000112249 [Q8N3C0-1]
ENST00000522650; ENSP00000430769; ENSG00000112249 [Q8N3C0-4]
GeneIDi10973
KEGGihsa:10973
UCSCiuc003pqk.5 human [Q8N3C0-1]

Organism-specific databases

CTDi10973
DisGeNETi10973
EuPathDBiHostDB:ENSG00000112249.13
GeneCardsiASCC3
H-InvDBiHIX0021958
HGNCiHGNC:18697 ASCC3
HPAiHPA031608
HPA031609
HPA031610
MIMi614217 gene
neXtProtiNX_Q8N3C0
OpenTargetsiENSG00000112249
PharmGKBiPA134890913
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0952 Eukaryota
COG1204 LUCA
GeneTreeiENSGT00640000091272
HOGENOMiHOG000152625
HOVERGENiHBG051896
InParanoidiQ8N3C0
KOiK18663
OMAiYKTLNRM
OrthoDBiEOG091G0HE5
PhylomeDBiQ8N3C0
TreeFamiTF105778

Enzyme and pathway databases

ReactomeiR-HSA-112126 ALKBH3 mediated reversal of alkylation damage

Miscellaneous databases

ChiTaRSiASCC3 human
GeneWikiiASCC3
GenomeRNAii10973
PROiPR:Q8N3C0
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000112249 Expressed in 213 organ(s), highest expression level in decidua
CleanExiHS_ASCC3
ExpressionAtlasiQ8N3C0 baseline and differential
GenevisibleiQ8N3C0 HS

Family and domain databases

CDDicd00079 HELICc, 2 hits
Gene3Di2.60.40.150, 2 hits
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR035892 C2_domain_sf
IPR011545 DEAD/DEAH_box_helicase_dom
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR014756 Ig_E-set
IPR027417 P-loop_NTPase
IPR004179 Sec63-dom
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00270 DEAD, 2 hits
PF00271 Helicase_C, 2 hits
PF02889 Sec63, 2 hits
SMARTiView protein in SMART
SM00382 AAA, 2 hits
SM00487 DEXDc, 2 hits
SM00490 HELICc, 2 hits
SM00973 Sec63, 2 hits
SUPFAMiSSF46785 SSF46785, 2 hits
SSF52540 SSF52540, 4 hits
SSF81296 SSF81296, 1 hit
PROSITEiView protein in PROSITE
PS51192 HELICASE_ATP_BIND_1, 2 hits
PS51194 HELICASE_CTER, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiASCC3_HUMAN
AccessioniPrimary (citable) accession number: Q8N3C0
Secondary accession number(s): E7EW23
, O43738, Q4G1A0, Q5VTN2, Q9H1I9, Q9H5A2, Q9NTR0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: September 11, 2007
Last modified: November 7, 2018
This is version 159 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
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