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Protein

Poly [ADP-ribose] polymerase 8

Gene

PARP8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.PROSITE-ProRule annotation EC:2.4.2.30

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • NAD+ ADP-ribosyltransferase activity Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGlycosyltransferase, Transferase
LigandNAD

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-197264 Nicotinamide salvaging

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Poly [ADP-ribose] polymerase 8 (EC:2.4.2.30)
Short name:
PARP-8
Alternative name(s):
ADP-ribosyltransferase diphtheria toxin-like 16
Short name:
ARTD16
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PARP8
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000151883.16

Human Gene Nomenclature Database

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HGNCi
HGNC:26124 PARP8

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8N3A8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000151883

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134903201

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3091262

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PARP8

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74714811

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002524331 – 854Poly [ADP-ribose] polymerase 8Add BLAST854

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8N3A8

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8N3A8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8N3A8

PeptideAtlas

More...
PeptideAtlasi
Q8N3A8

PRoteomics IDEntifications database

More...
PRIDEi
Q8N3A8

ProteomicsDB human proteome resource

More...
ProteomicsDBi
71784
71785 [Q8N3A8-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8N3A8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8N3A8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000151883 Expressed in 198 organ(s), highest expression level in small intestine Peyer's patch

CleanEx database of gene expression profiles

More...
CleanExi
HS_PARP8

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8N3A8 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8N3A8 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA049183

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
122793, 2 interactors

Protein interaction database and analysis system

More...
IntActi
Q8N3A8, 2 interactors

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q8N3A8

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini617 – 844PARP catalyticPROSITE-ProRule annotationAdd BLAST228

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi468 – 473Poly-Ser6

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IE5T Eukaryota
ENOG410ZI9J LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000017707

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000115451

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG057572

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8N3A8

KEGG Orthology (KO)

More...
KOi
K15258

Identification of Orthologs from Complete Genome Data

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OMAi
PRCEHNA

Database of Orthologous Groups

More...
OrthoDBi
EOG091G02PT

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8N3A8

TreeFam database of animal gene trees

More...
TreeFami
TF323413

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR012317 Poly(ADP-ribose)pol_cat_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00644 PARP, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51059 PARP_CATALYTIC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 13 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8N3A8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGMCSRQERI QKDIDVVIQK SRAEKDCLFA DFRYSDSTFT FTYVGGPRSV
60 70 80 90 100
SYSVHVSEDY PDNTYVSSSE NDEDVLVTTE PIPVIFHRIA TELRKTNDIN
110 120 130 140 150
CCLSIKSKLQ KENGEESRQN STVEEDSEGD NDSEEFYYGG QVNYDGELHK
160 170 180 190 200
HPQLEADLSA VREIYGPHAV SLREYGAIDD VDIDLHIDVS FLDEEIAVAW
210 220 230 240 250
EVIRTEPIIV RLHCSLTQYL NGPVPTVDVF QISTKERFGL GHQLKKIMQT
260 270 280 290 300
FVTQQWKQSK EKSNCLHNKK LSEKKVKSPL HLFSTLRRSP SYPPPGCGKS
310 320 330 340 350
KSKLKSEQDG ISKTHKLLRR TCSSTVKTDD VCVTKSHRTF GRSLSSDPRA
360 370 380 390 400
EQAMTAIKSH KLLNRPCPAA VKSEECLTLK SHRLLTRSCS GDPRCEHNTN
410 420 430 440 450
LKPHKLLSRS YSSNLRMEEL YGLKNHKLLS KSYSSAPKSS KTELFKEPNA
460 470 480 490 500
EGRRLSLTSG LIGILTPSSS SSSQLAPNGA KCIPVRDRGF LVQTIEFAEQ
510 520 530 540 550
RIPVLNEYCV VCDEPHVFQN GPMLRPTVCE RELCVFAFQT LGVMNEAADE
560 570 580 590 600
IATGAQVVDL LVSMCRSALE SPRKVVIFEP YPSVVDPNDP QMLAFNPRKK
610 620 630 640 650
NYDRVMKALD SITSIREMTQ APYLEIKKQM DKQDPLAHPL LQWVISSNRS
660 670 680 690 700
HIVKLPVNRQ LKFMHTPHQF LLLSSPPAKE SNFRAAKKLF GSTFAFHGSH
710 720 730 740 750
IENWHSILRN GLVVASNTRL QLHGAMYGSG IYLSPMSSIS FGYSGMNKKQ
760 770 780 790 800
KVSAKDEPAS SSKSSNTSQS QKKGQQSQFL QSRNLKCIAL CEVITSSDLH
810 820 830 840 850
KHGEIWVVPN TDHVCTRFFF VYEDGQVGDA NINTQEGGIH KEILRVIGNQ

TATG
Length:854
Mass (Da):95,871
Last modified:October 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD3287F5F46BA2B63
GO
Isoform 2 (identifier: Q8N3A8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     557-598: Missing.

Note: No experimental confirmation available.
Show »
Length:812
Mass (Da):91,158
Checksum:i968394B0E0897F42
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 13 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PFI7E9PFI7_HUMAN
Poly [ADP-ribose] polymerase
PARP8
833Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H3X8F5H3X8_HUMAN
Poly [ADP-ribose] polymerase
PARP8
494Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RB30D6RB30_HUMAN
Poly [ADP-ribose] polymerase 8
PARP8
253Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6R9T2D6R9T2_HUMAN
Poly [ADP-ribose] polymerase 8
PARP8
64Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RGZ9D6RGZ9_HUMAN
Poly [ADP-ribose] polymerase 8
PARP8
77Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RCA6D6RCA6_HUMAN
Poly [ADP-ribose] polymerase 8
PARP8
91Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RCN2D6RCN2_HUMAN
Poly [ADP-ribose] polymerase 8
PARP8
57Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RC81D6RC81_HUMAN
Poly [ADP-ribose] polymerase 8
PARP8
133Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6R914D6R914_HUMAN
Poly [ADP-ribose] polymerase 8
PARP8
49Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RAL6D6RAL6_HUMAN
Poly [ADP-ribose] polymerase 8
PARP8
116Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAI05790 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti849N → D in BAB15044 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_035853777S → A in a colorectal cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_020970557 – 598Missing in isoform 2. 1 PublicationAdd BLAST42

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL834477 mRNA Translation: CAD39136.1
BC075801 mRNA Translation: AAH75801.1
BC105789 mRNA Translation: AAI05790.1 Sequence problems.
AK024961 mRNA Translation: BAB15044.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS3954.1 [Q8N3A8-1]
CCDS54849.1 [Q8N3A8-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001171526.1, NM_001178055.1 [Q8N3A8-1]
NP_001171527.1, NM_001178056.1 [Q8N3A8-2]
NP_078891.2, NM_024615.3 [Q8N3A8-1]
XP_011541933.1, XM_011543631.2 [Q8N3A8-1]
XP_011541934.2, XM_011543632.2 [Q8N3A8-2]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.369581

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000281631; ENSP00000281631; ENSG00000151883 [Q8N3A8-1]
ENST00000505697; ENSP00000422217; ENSG00000151883 [Q8N3A8-1]
ENST00000514067; ENSP00000424814; ENSG00000151883 [Q8N3A8-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
79668

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:79668

UCSC genome browser

More...
UCSCi
uc003jon.5 human [Q8N3A8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL834477 mRNA Translation: CAD39136.1
BC075801 mRNA Translation: AAH75801.1
BC105789 mRNA Translation: AAI05790.1 Sequence problems.
AK024961 mRNA Translation: BAB15044.1
CCDSiCCDS3954.1 [Q8N3A8-1]
CCDS54849.1 [Q8N3A8-2]
RefSeqiNP_001171526.1, NM_001178055.1 [Q8N3A8-1]
NP_001171527.1, NM_001178056.1 [Q8N3A8-2]
NP_078891.2, NM_024615.3 [Q8N3A8-1]
XP_011541933.1, XM_011543631.2 [Q8N3A8-1]
XP_011541934.2, XM_011543632.2 [Q8N3A8-2]
UniGeneiHs.369581

3D structure databases

ProteinModelPortaliQ8N3A8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122793, 2 interactors
IntActiQ8N3A8, 2 interactors

Chemistry databases

ChEMBLiCHEMBL3091262

PTM databases

iPTMnetiQ8N3A8
PhosphoSitePlusiQ8N3A8

Polymorphism and mutation databases

BioMutaiPARP8
DMDMi74714811

Proteomic databases

EPDiQ8N3A8
MaxQBiQ8N3A8
PaxDbiQ8N3A8
PeptideAtlasiQ8N3A8
PRIDEiQ8N3A8
ProteomicsDBi71784
71785 [Q8N3A8-2]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
79668
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000281631; ENSP00000281631; ENSG00000151883 [Q8N3A8-1]
ENST00000505697; ENSP00000422217; ENSG00000151883 [Q8N3A8-1]
ENST00000514067; ENSP00000424814; ENSG00000151883 [Q8N3A8-2]
GeneIDi79668
KEGGihsa:79668
UCSCiuc003jon.5 human [Q8N3A8-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
79668
EuPathDBiHostDB:ENSG00000151883.16

GeneCards: human genes, protein and diseases

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GeneCardsi
PARP8

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0018354
HIX0121007
HIX0160161
HGNCiHGNC:26124 PARP8
HPAiHPA049183
neXtProtiNX_Q8N3A8
OpenTargetsiENSG00000151883
PharmGKBiPA134903201

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IE5T Eukaryota
ENOG410ZI9J LUCA
GeneTreeiENSGT00390000017707
HOGENOMiHOG000115451
HOVERGENiHBG057572
InParanoidiQ8N3A8
KOiK15258
OMAiPRCEHNA
OrthoDBiEOG091G02PT
PhylomeDBiQ8N3A8
TreeFamiTF323413

Enzyme and pathway databases

ReactomeiR-HSA-197264 Nicotinamide salvaging

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
PARP8 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
PARP8

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
79668

Protein Ontology

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PROi
PR:Q8N3A8

Gene expression databases

BgeeiENSG00000151883 Expressed in 198 organ(s), highest expression level in small intestine Peyer's patch
CleanExiHS_PARP8
ExpressionAtlasiQ8N3A8 baseline and differential
GenevisibleiQ8N3A8 HS

Family and domain databases

InterProiView protein in InterPro
IPR012317 Poly(ADP-ribose)pol_cat_dom
PfamiView protein in Pfam
PF00644 PARP, 1 hit
PROSITEiView protein in PROSITE
PS51059 PARP_CATALYTIC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPARP8_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8N3A8
Secondary accession number(s): Q3KRB7, Q6DHZ1, Q9H754
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: October 1, 2002
Last modified: December 5, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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