Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 106 (11 Dec 2019)
Sequence version 3 (12 Sep 2018)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

von Willebrand factor A domain-containing protein 5B2

Gene

VWA5B2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
von Willebrand factor A domain-containing protein 5B2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:VWA5B2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000145198.14

Human Gene Nomenclature Database

More...
HGNCi
HGNC:25144 VWA5B2

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8N398

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000145198

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162409079

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8N398 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
VWA5B2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
190461810

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003393021 – 1242von Willebrand factor A domain-containing protein 5B2Add BLAST1242

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8N398

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8N398

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8N398

PeptideAtlas

More...
PeptideAtlasi
Q8N398

PRoteomics IDEntifications database

More...
PRIDEi
Q8N398

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8N398

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8N398

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000145198 Expressed in 85 organ(s), highest expression level in right adrenal gland

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8N398 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8N398 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA036823
HPA036824
HPA061412

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
124663, 2 interactors

Protein interaction database and analysis system

More...
IntActi
Q8N398, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000398688

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8N398 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 138VITPROSITE-ProRule annotationAdd BLAST138
Domaini354 – 527VWFAAdd BLAST174

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IFPF Eukaryota
COG2304 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157096

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000049261

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8N398

Identification of Orthologs from Complete Genome Data

More...
OMAi
CYSPANM

Database of Orthologous Groups

More...
OrthoDBi
955432at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8N398

TreeFam database of animal gene trees

More...
TreeFami
TF329720

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.410, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013694 VIT
IPR002035 VWF_A
IPR036465 vWFA_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13757 VIT_2, 1 hit
PF13768 VWA_3, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53300 SSF53300, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51468 VIT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8N398-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPGLYCPSSW TPLPLTDSWV RACANGPCLS VRARLTYRNP QPQPVDGVFV
60 70 80 90 100
YPLAEAEVVS GFEAEAAGRR VSFQLQSRRR SQAACCRALG PGLGTPTPRR
110 120 130 140 150
CAQGHLVLDL AQARSTLVLP TGIIAAAGTM TVTLHSSREL PSRPDGVLHV
160 170 180 190 200
ALPTVLTPLA PPGPPGPPRP PGLCDDSPTS CFGVGSLQEE GLAWEELAAP
210 220 230 240 250
RDVFSGPARC PAPYTFSFEM LVTGPCLLAG LESPSHALRA DAPPHASSAA
260 270 280 290 300
TICVTLAEGH HCDRALEILL HPSEPHQPHL MLEGGSLSSA EYEARVRARR
310 320 330 340 350
DFQRLQRRDS DGDRQVWFLQ RRFHKDILLN PVLALSFCPD LSSKPGHLGT
360 370 380 390 400
ATRELLFLLD SSSVAHKDAI VLAVKSLPPQ TLINLAVFGT LVQPLFPESR
410 420 430 440 450
PCSDDAVQLI CESIETLQVP SGPPDVLAAL DWAVGQPQHR AYPRQLFLLT
460 470 480 490 500
AASPMAATTH RTLELMRWHR GTARCFSFGL GPTCHQLLQG LSALSRGQAY
510 520 530 540 550
FLRPGQRLQP MLVQALRKAL EPALSDISVD WFVPDTVEAL LTPREIPALY
560 570 580 590 600
PGDQLLGYCS LFRVDGFRSR PPGGQEPGWQ SSGGSVFPSP EEAPSAASPG
610 620 630 640 650
TEPTGTSEPL GTGTVSAELS SPWAARDSEQ STDALTDPVT DPGPNPSDTA
660 670 680 690 700
IWRRIFQSSY IREQYVLTHC SASPEPGPGS TGSSESPGSQ GPGSPEGSAP
710 720 730 740 750
LEPPSQQGCR SLAWGEPAGS RSCPLPAPTP APFKVGALST EVLGRQHRAA
760 770 780 790 800
LAGRSLSSPP GRANQVPGRP RKPSLGAILD GPSPEPGQQL GQGLDDSGNL
810 820 830 840 850
LSPAPMDWDM LMEPPFLFTA VPPSGELAPP AVPPQAPRCH VVIRGLCGEQ
860 870 880 890 900
PMCWEVGVGL ETLWGPGDGS QPPSPPVREA AWDQALHRLT AASVVRDNEQ
910 920 930 940 950
LALRGGAETT ADRGHARRCW LRALQTSKVS SAPSCFTCPV AVDATTREVL
960 970 980 990 1000
PGALQVCSSE PAEPPGTPPA SHSHLDAAPL PTVVYSKGLQ RGSPAGAWDS
1010 1020 1030 1040 1050
DQNGNSKRAL GDPATPTEGP RRPPPRPPCR LSMGRRHKLC SPDPGQANNS
1060 1070 1080 1090 1100
EGSDHDYLPL VRLQEAPGSF RLDAPFCAAV RISQERLCRA SPFAVHRASL
1110 1120 1130 1140 1150
SPTSASLPWA LLGPGVGQGD SATASCSPSP SSGSEGPGQV DSGRGSDTEA
1160 1170 1180 1190 1200
SEGAEGLGGT DLRGRTWATA VALAWLEHRC AAAFDEWELT AAKADCWLRA
1210 1220 1230 1240
QHLPDGLDLA ALKAAARGLF LLLRHWDQNL QLHLLCYSPA NV
Length:1,242
Mass (Da):131,668
Last modified:September 12, 2018 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB0E6EB4039B2AFA5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PF42E9PF42_HUMAN
von Willebrand factor A domain-cont...
VWA5B2
1,024Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_043939200P → S. Corresponds to variant dbSNP:rs902417Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC061705 Genomic DNA No translation available.
BC136609 mRNA Translation: AAI36610.1
AL834499 mRNA Translation: CAD39157.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS54686.1

NCBI Reference Sequences

More...
RefSeqi
NP_001307302.1, NM_001320373.1
NP_612354.1, NM_138345.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000426955; ENSP00000398688; ENSG00000145198

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
90113

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:90113

UCSC genome browser

More...
UCSCi
uc011bra.3 human

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC061705 Genomic DNA No translation available.
BC136609 mRNA Translation: AAI36610.1
AL834499 mRNA Translation: CAD39157.1
CCDSiCCDS54686.1
RefSeqiNP_001307302.1, NM_001320373.1
NP_612354.1, NM_138345.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi124663, 2 interactors
IntActiQ8N398, 2 interactors
STRINGi9606.ENSP00000398688

PTM databases

iPTMnetiQ8N398
PhosphoSitePlusiQ8N398

Polymorphism and mutation databases

BioMutaiVWA5B2
DMDMi190461810

Proteomic databases

jPOSTiQ8N398
MassIVEiQ8N398
PaxDbiQ8N398
PeptideAtlasiQ8N398
PRIDEiQ8N398

Genome annotation databases

EnsembliENST00000426955; ENSP00000398688; ENSG00000145198
GeneIDi90113
KEGGihsa:90113
UCSCiuc011bra.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
90113
EuPathDBiHostDB:ENSG00000145198.14

GeneCards: human genes, protein and diseases

More...
GeneCardsi
VWA5B2
HGNCiHGNC:25144 VWA5B2
HPAiHPA036823
HPA036824
HPA061412
neXtProtiNX_Q8N398
OpenTargetsiENSG00000145198
PharmGKBiPA162409079

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IFPF Eukaryota
COG2304 LUCA
GeneTreeiENSGT00940000157096
HOGENOMiHOG000049261
InParanoidiQ8N398
OMAiCYSPANM
OrthoDBi955432at2759
PhylomeDBiQ8N398
TreeFamiTF329720

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
90113
PharosiQ8N398 Tdark

Protein Ontology

More...
PROi
PR:Q8N398
RNActiQ8N398 protein

Gene expression databases

BgeeiENSG00000145198 Expressed in 85 organ(s), highest expression level in right adrenal gland
ExpressionAtlasiQ8N398 baseline and differential
GenevisibleiQ8N398 HS

Family and domain databases

Gene3Di3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR013694 VIT
IPR002035 VWF_A
IPR036465 vWFA_dom_sf
PfamiView protein in Pfam
PF13757 VIT_2, 1 hit
PF13768 VWA_3, 1 hit
SUPFAMiSSF53300 SSF53300, 1 hit
PROSITEiView protein in PROSITE
PS51468 VIT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiVW5B2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8N398
Secondary accession number(s): B9EGN7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: September 12, 2018
Last modified: December 11, 2019
This is version 106 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again