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Entry version 151 (12 Aug 2020)
Sequence version 3 (18 May 2010)
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Protein

Rho GTPase-activating protein 18

Gene

ARHGAP18

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Rho GTPase activating protein that suppresses F-actin polymerization by inhibiting Rho. Rho GTPase activating proteins act by converting Rho-type GTPases to an inactive GDP-bound state (PubMed:21865595). Plays a key role in tissue tension and 3D tissue shape by regulating cortical actomyosin network formation. Acts downstream of YAP1 and inhibits actin polymerization, which in turn reduces nuclear localization of YAP1 (PubMed:25778702). Regulates cell shape, spreading, and migration (PubMed:21865595).2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGTPase activation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q8N392

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-194840, Rho GTPase cycle

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Rho GTPase-activating protein 18
Alternative name(s):
MacGAP1 Publication
Rho-type GTPase-activating protein 18
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ARHGAP18Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000146376.10

Human Gene Nomenclature Database

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HGNCi
HGNC:21035, ARHGAP18

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
613351, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8N392

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi365R → A: Abolishes GTPase activation activity. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
93663

Open Targets

More...
OpenTargetsi
ENSG00000146376

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134884487

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8N392, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ARHGAP18

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296452981

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002457891 – 663Rho GTPase-activating protein 18Add BLAST663

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei66PhosphoserineBy similarity1
Modified residuei69PhosphoserineBy similarity1
Modified residuei158PhosphothreonineCombined sources1
Modified residuei263PhosphoserineCombined sources1
Modified residuei610PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q8N392

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q8N392

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q8N392

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8N392

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8N392

PeptideAtlas

More...
PeptideAtlasi
Q8N392

PRoteomics IDEntifications database

More...
PRIDEi
Q8N392

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
71779 [Q8N392-1]
71780 [Q8N392-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8N392

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8N392

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q8N392

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000146376, Expressed in germinal epithelium of ovary and 215 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8N392, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000146376, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with MPHOSPH6.

1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
125050, 5 interactors

Protein interaction database and analysis system

More...
IntActi
Q8N392, 6 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000357131

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8N392, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q8N392

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini324 – 523Rho-GAPPROSITE-ProRule annotationAdd BLAST200

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2200, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157142

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_023268_2_1_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q8N392

KEGG Orthology (KO)

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KOi
K20639

Identification of Orthologs from Complete Genome Data

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OMAi
TYMKDLF

Database of Orthologous Groups

More...
OrthoDBi
700544at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8N392

TreeFam database of animal gene trees

More...
TreeFami
TF314044

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.10.555.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR008936, Rho_GTPase_activation_prot
IPR000198, RhoGAP_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00620, RhoGAP, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00324, RhoGAP, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF48350, SSF48350, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50238, RHOGAP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8N392-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSWLSSSQGV VLTAYHPSGK DQTVGNSHAK AGEEATSSRR YGQYTMNQES
60 70 80 90 100
TTIKVMEKPP FDRSISQDSL DELSMEDYWI ELENIKKSSE NSQEDQEVVV
110 120 130 140 150
VKEPDEGELE EEWLKEAGLS NLFGESAGDP QESIVFLSTL TRTQAAAVQK
160 170 180 190 200
RVETVSQTLR KKNKQYQIPD VRDIFAQQRE SKETAPGGTE SQSLRTNENK
210 220 230 240 250
YQGRDDEASN LVGEEKLIPP EETPAPETDI NLEVSFAEQA LNQKESSKEK
260 270 280 290 300
IQKSKGDDAT LPSFRLPKDK TGTTRIGDLA PQDMKKVCHL ALIELTALYD
310 320 330 340 350
VLGIELKQQK AVKIKTKDSG LFCVPLTALL EQDQRKVPGM RIPLIFQKLI
360 370 380 390 400
SRIEERGLET EGLLRIPGAA IRIKNLCQEL EAKFYEGTFN WESVKQHDAA
410 420 430 440 450
SLLKLFIREL PQPLLSVEYL KAFQAVQNLP TKKQQLQALN LLVILLPDAN
460 470 480 490 500
RDTLKALLEF LQRVIDNKEK NKMTVMNVAM VMAPNLFMCH ALGLKSSEQR
510 520 530 540 550
EFVMAAGTAN TMHLLIKYQK LLWTIPKFIV NQVRKQNTEN HKKDKRAMKK
560 570 580 590 600
LLKKMAYDRE KYEKQDKSTN DADVPQGVIR VQAPHLSKVS MAIQLTEELK
610 620 630 640 650
ASDVLARFLS QESGVAQTLK KGEVFLYEIG GNIGERCLDD DTYMKDLYQL
660
NPNAEWVIKS KPL
Length:663
Mass (Da):74,977
Last modified:May 18, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2DD127301026928D
GO
Isoform 2 (identifier: Q8N392-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-45: Missing.

Show »
Length:618
Mass (Da):70,164
Checksum:i12A738DABAFE2ABB
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH17223 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAH39611 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAH62417 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence BAB61887 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti307K → E in AAH17223 (PubMed:15489334).Curated1
Sequence conflicti467N → K in AAH62417 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_06046023T → A3 PublicationsCorresponds to variant dbSNP:rs3752536Ensembl.1
Natural variantiVAR_06046191N → S. Corresponds to variant dbSNP:rs11544371Ensembl.1
Natural variantiVAR_060462165Q → H. Corresponds to variant dbSNP:rs11544372Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0520921 – 45Missing in isoform 2. 1 PublicationAdd BLAST45

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL834511 mRNA Translation: CAD39167.2
AL450310 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48076.1
CH471051 Genomic DNA Translation: EAW48077.1
BC017223 mRNA Translation: AAH17223.1 Sequence problems.
BC039611 mRNA Translation: AAH39611.1 Sequence problems.
BC062417 mRNA Translation: AAH62417.1 Sequence problems.
BC101708 mRNA Translation: AAI01709.1
BC107416 mRNA Translation: AAI07417.1
BC111940 mRNA Translation: AAI11941.1
AB053293 mRNA Translation: BAB61887.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS34535.1 [Q8N392-1]

Protein sequence database of the Protein Information Resource

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PIRi
G59432

NCBI Reference Sequences

More...
RefSeqi
NP_277050.2, NM_033515.2 [Q8N392-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000368149; ENSP00000357131; ENSG00000146376 [Q8N392-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
93663

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:93663

UCSC genome browser

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UCSCi
uc003qbr.4, human [Q8N392-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL834511 mRNA Translation: CAD39167.2
AL450310 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48076.1
CH471051 Genomic DNA Translation: EAW48077.1
BC017223 mRNA Translation: AAH17223.1 Sequence problems.
BC039611 mRNA Translation: AAH39611.1 Sequence problems.
BC062417 mRNA Translation: AAH62417.1 Sequence problems.
BC101708 mRNA Translation: AAI01709.1
BC107416 mRNA Translation: AAI07417.1
BC111940 mRNA Translation: AAI11941.1
AB053293 mRNA Translation: BAB61887.1 Different initiation.
CCDSiCCDS34535.1 [Q8N392-1]
PIRiG59432
RefSeqiNP_277050.2, NM_033515.2 [Q8N392-1]

3D structure databases

SMRiQ8N392
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi125050, 5 interactors
IntActiQ8N392, 6 interactors
STRINGi9606.ENSP00000357131

PTM databases

iPTMnetiQ8N392
PhosphoSitePlusiQ8N392
SwissPalmiQ8N392

Polymorphism and mutation databases

BioMutaiARHGAP18
DMDMi296452981

Proteomic databases

EPDiQ8N392
jPOSTiQ8N392
MassIVEiQ8N392
MaxQBiQ8N392
PaxDbiQ8N392
PeptideAtlasiQ8N392
PRIDEiQ8N392
ProteomicsDBi71779 [Q8N392-1]
71780 [Q8N392-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
46605, 167 antibodies

Genome annotation databases

EnsembliENST00000368149; ENSP00000357131; ENSG00000146376 [Q8N392-1]
GeneIDi93663
KEGGihsa:93663
UCSCiuc003qbr.4, human [Q8N392-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
93663
DisGeNETi93663
EuPathDBiHostDB:ENSG00000146376.10

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ARHGAP18
HGNCiHGNC:21035, ARHGAP18
HPAiENSG00000146376, Low tissue specificity
MIMi613351, gene
neXtProtiNX_Q8N392
OpenTargetsiENSG00000146376
PharmGKBiPA134884487

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2200, Eukaryota
GeneTreeiENSGT00940000157142
HOGENOMiCLU_023268_2_1_1
InParanoidiQ8N392
KOiK20639
OMAiTYMKDLF
OrthoDBi700544at2759
PhylomeDBiQ8N392
TreeFamiTF314044

Enzyme and pathway databases

PathwayCommonsiQ8N392
ReactomeiR-HSA-194840, Rho GTPase cycle

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
93663, 5 hits in 872 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ARHGAP18, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
93663
PharosiQ8N392, Tbio

Protein Ontology

More...
PROi
PR:Q8N392
RNActiQ8N392, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000146376, Expressed in germinal epithelium of ovary and 215 other tissues
GenevisibleiQ8N392, HS

Family and domain databases

Gene3Di1.10.555.10, 1 hit
InterProiView protein in InterPro
IPR008936, Rho_GTPase_activation_prot
IPR000198, RhoGAP_dom
PfamiView protein in Pfam
PF00620, RhoGAP, 1 hit
SMARTiView protein in SMART
SM00324, RhoGAP, 1 hit
SUPFAMiSSF48350, SSF48350, 1 hit
PROSITEiView protein in PROSITE
PS50238, RHOGAP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRHG18_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8N392
Secondary accession number(s): E1P575
, Q58EZ3, Q6P679, Q6PJD7, Q96S64
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: May 18, 2010
Last modified: August 12, 2020
This is version 151 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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