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UniProtKB - Q8N386 (LRC25_HUMAN)

Entry version 140 (02 Dec 2020)
Sequence version 2 (24 May 2004)
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Protein

Leucine-rich repeat-containing protein 25

Gene

LRRC25

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role in the inhibition of RLR-mediated type I interferon signaling pathway by targeting DDX58/RIG-I for autophagic degradation. Interacts specifically with ISG15-associated DDX58 to promote interaction between DDX58 and the autophagic cargo receptor p62/SQSTM1 to mediate DDX58 degradation via selective autophagy (PubMed:29288164). Plays also a role in the inhibition of NF-kappa-B signaling pathway and inflammatory response by promoting the degradation of p65/RELA.3 Publications

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q8N386

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Leucine-rich repeat-containing protein 25
Alternative name(s):
Monocyte and plasmacytoid-activated protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LRRC25
Synonyms:MAPA
ORF Names:UNQ6169/PRO20174
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000175489.9

Human Gene Nomenclature Database

More...HGNCi		HGNC:29806, LRRC25

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		607518, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8N386

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini21 – 165ExtracellularSequence analysisAdd BLAST145
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei166 – 186HelicalSequence analysisAdd BLAST21
Topological domaini187 – 305CytoplasmicSequence analysisAdd BLAST119

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		126364

Open Targets

More...OpenTargetsi		ENSG00000175489

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134957834

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q8N386, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		LRRC25

Domain mapping of disease mutations (DMDM)

More...DMDMi		47605902

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 20Sequence analysisAdd BLAST20
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002161321 – 305Leucine-rich repeat-containing protein 25Add BLAST285

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi44N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi55N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi130N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi148N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei284PhosphotyrosineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q8N386

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q8N386

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8N386

PeptideAtlas

More...PeptideAtlasi		Q8N386

PRoteomics IDEntifications database

More...PRIDEi		Q8N386

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		71776

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q8N386, 4 sites

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8N386

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q8N386

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in plasmacytoid dendritic cells (PDC), monocyte-derived dendritic cells (MDDC), granulocytes, monocytes, B-lymphocytes, peripheral blood leukocytes, spleen, bone marrow, and, to a lesser extent, lymph nodes, fetal liver, and appendix but not in thymus.1 Publication

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Down-regulated in CD40-activated monocyte-derived dendritic cells.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000175489, Expressed in blood and 127 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8N386, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000175489, Tissue enhanced (blood, lymphoid tissue)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with DDX58 (PubMed:29288164).

Interacts with SQSTM1 (PubMed:29288164).

Interacts with p65/RELA; this interaction promotes the degradation of RELA through autophagy (PubMed:29044191).

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details
Q8N386
With#Exp.IntAct
ACD [Q96AP0]2EBI-11304917,EBI-717666
AGPAT4 [Q9NRZ5]3EBI-11304917,EBI-1754287
ANKRD46 - isoform 1 [Q86W74-2]3EBI-11304917,EBI-12109402
APOL3 - isoform 2 [O95236-2]3EBI-11304917,EBI-11976321
ATP6V0C [P27449]3EBI-11304917,EBI-721179
BMP10 [O95393]3EBI-11304917,EBI-3922513
BRICD5 - isoform 2 [Q6PL45-2]3EBI-11304917,EBI-12244618
CD72 [P21854]3EBI-11304917,EBI-307924
CLDN19 - isoform 2 [Q8N6F1-2]3EBI-11304917,EBI-12256978
CLEC1A [Q8NC01]3EBI-11304917,EBI-11996768
CLN6 [Q9NWW5]3EBI-11304917,EBI-6165897
CLRN2 [A0PK11]3EBI-11304917,EBI-12813623
CNIH3 [Q8TBE1]3EBI-11304917,EBI-12208021
CXCL9 [Q07325]3EBI-11304917,EBI-3911467
DEFB121 [Q5J5C9]3EBI-11304917,EBI-10244198
DNAJC30 [Q96LL9]3EBI-11304917,EBI-8639143
EDDM3B [P56851]3EBI-11304917,EBI-10215665
FAM3C [Q92520]3EBI-11304917,EBI-2876774
FATE1 [Q969F0]3EBI-11304917,EBI-743099
FPR2 [P25090]3EBI-11304917,EBI-17291771
GPRC5D [Q9NZD1]3EBI-11304917,EBI-13067820
LHFPL5 [Q8TAF8]3EBI-11304917,EBI-2820517
MAL [P21145]3EBI-11304917,EBI-3932027
OPRM1 - isoform 10 [P35372-10]3EBI-11304917,EBI-12807478
PKMYT1 - isoform 2 [Q99640-2]3EBI-11304917,EBI-12257782
PNLIPRP1 [P54315]3EBI-11304917,EBI-8652812
SEC22A [Q96IW7]3EBI-11304917,EBI-8652744
SEC61G [P60059]3EBI-11304917,EBI-4402709
SMCO4 [Q9NRQ5]3EBI-11304917,EBI-8640191
SPNS3 - isoform 2 [Q6ZMD2-2]3EBI-11304917,EBI-17848320
TMEM120A [Q9BXJ8]3EBI-11304917,EBI-727322
TMEM201 - isoform 2 [Q5SNT2-2]3EBI-11304917,EBI-11994282
TNF [P01375]3EBI-11304917,EBI-359977
TRAF3IP3 [Q9Y228]3EBI-11304917,EBI-765817
TSPAN4 [O14817]3EBI-11304917,EBI-8652667
TTMP [Q5BVD1]3EBI-11304917,EBI-10243654
VAMP5 [O95183]3EBI-11304917,EBI-10191195
YIPF6 [Q96EC8]3EBI-11304917,EBI-751210

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		125983, 40 interactors

Protein interaction database and analysis system

More...IntActi		Q8N386, 38 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000340983

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8N386, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati39 – 59LRR 1Add BLAST21
Repeati62 – 83LRR 2Add BLAST22
Repeati86 – 107LRR 3Add BLAST22

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502S9V5, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000004001

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_906014_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8N386

Identification of Orthologs from Complete Genome Data

More...OMAi		YMNYEGP

Database of Orthologous Groups

More...OrthoDBi		1374271at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8N386

TreeFam database of animal gene trees

More...TreeFami		TF337414

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.80.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR032675, LRR_dom_sf
IPR039243, LRRC25

The PANTHER Classification System

More...PANTHERi		PTHR20878, PTHR20878, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q8N386-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGGTLAWTLL LPLLLRESDS LEPSCTVSSA DVDWNAEFSA TCLNFSGLSL 
        60         70         80         90        100
SLPHNQSLRA SNVILLDLSG NGLRELPVTF FAHLQKLEVL NVLRNPLSRV 
       110        120        130        140        150
DGALAARCDL DLQADCNCAL ESWHDIRRDN CSGQKPLLCW DTTSSQHNLS 
       160        170        180        190        200
AFLEVSCAPG LASATIGAVV VSGCLLLGLA IAGPVLAWRL WRCRVARSRE 
       210        220        230        240        250
LNKPWAAQDG PKPGLGLQPR YGSRSAPKPQ VAVPSCPSTP DYENMFVGQP 
       260        270        280        290        300
AAEHQWDEQG AHPSEDNDFY INYKDIDLAS QPVYCNLQSL GQAPMDEEEY 

VIPGH
Length:305
Mass (Da):33,179
Last modified:May 24, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA2851B3B8F160294
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti40A → V in BAC04548 (PubMed:14702039).Curated1
Sequence conflicti82A → G in CAD19531 (PubMed:12384430).Curated1
Sequence conflicti95N → S in BAC04548 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_061677234P → T. Corresponds to variant dbSNP:rs34439430EnsemblClinVar.1
Natural variantiVAR_051109294P → S2 PublicationsCorresponds to variant dbSNP:rs6512265Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AJ422148 mRNA Translation: CAD19531.1
AY358151 mRNA Translation: AAQ88518.1
AK095435 mRNA Translation: BAC04548.1
BC071640 mRNA Translation: AAH71640.1
BC093842 mRNA Translation: AAH93842.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS12377.1

NCBI Reference Sequences

More...RefSeqi		NP_660299.2, NM_145256.2
XP_005259796.1, XM_005259739.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000339007; ENSP00000340983; ENSG00000175489
ENST00000595840; ENSP00000472290; ENSG00000175489

Database of genes from NCBI RefSeq genomes

More...GeneIDi		126364

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:126364

UCSC genome browser

More...UCSCi		uc002niw.4, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ422148 mRNA Translation: CAD19531.1
AY358151 mRNA Translation: AAQ88518.1
AK095435 mRNA Translation: BAC04548.1
BC071640 mRNA Translation: AAH71640.1
BC093842 mRNA Translation: AAH93842.1
CCDSiCCDS12377.1
RefSeqiNP_660299.2, NM_145256.2
XP_005259796.1, XM_005259739.3

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi125983, 40 interactors
IntActiQ8N386, 38 interactors
STRINGi9606.ENSP00000340983

PTM databases

GlyGeniQ8N386, 4 sites
PhosphoSitePlusiQ8N386
SwissPalmiQ8N386

Polymorphism and mutation databases

BioMutaiLRRC25
DMDMi47605902

Proteomic databases

jPOSTiQ8N386
MassIVEiQ8N386
PaxDbiQ8N386
PeptideAtlasiQ8N386
PRIDEiQ8N386
ProteomicsDBi71776

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		28033, 326 antibodies

The DNASU plasmid repository

More...DNASUi		126364

Genome annotation databases

EnsembliENST00000339007; ENSP00000340983; ENSG00000175489
ENST00000595840; ENSP00000472290; ENSG00000175489
GeneIDi126364
KEGGihsa:126364
UCSCiuc002niw.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		126364
DisGeNETi126364
EuPathDBiHostDB:ENSG00000175489.9

GeneCards: human genes, protein and diseases

More...GeneCardsi		LRRC25
HGNCiHGNC:29806, LRRC25
HPAiENSG00000175489, Tissue enhanced (blood, lymphoid tissue)
MIMi607518, gene
neXtProtiNX_Q8N386
OpenTargetsiENSG00000175489
PharmGKBiPA134957834

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502S9V5, Eukaryota
GeneTreeiENSGT00390000004001
HOGENOMiCLU_906014_0_0_1
InParanoidiQ8N386
OMAiYMNYEGP
OrthoDBi1374271at2759
PhylomeDBiQ8N386
TreeFamiTF337414

Enzyme and pathway databases

PathwayCommonsiQ8N386

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		126364, 3 hits in 842 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		LRRC25, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		126364
PharosiQ8N386, Tbio

Protein Ontology

More...PROi		PR:Q8N386
RNActiQ8N386, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000175489, Expressed in blood and 127 other tissues
GenevisibleiQ8N386, HS

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR032675, LRR_dom_sf
IPR039243, LRRC25
PANTHERiPTHR20878, PTHR20878, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLRC25_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8N386
Secondary accession number(s): Q6IQ00, Q8N9A5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: May 24, 2004
Last modified: December 2, 2020
This is version 140 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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