UniProtKB - Q8N386 (LRC25_HUMAN)
Protein
Leucine-rich repeat-containing protein 25
Gene
LRRC25
Organism
Homo sapiens (Human)
Status
Functioni
Plays a role in the inhibition of RLR-mediated type I interferon signaling pathway by targeting DDX58/RIG-I for autophagic degradation. Interacts specifically with ISG15-associated DDX58 to promote interaction between DDX58 and the autophagic cargo receptor p62/SQSTM1 to mediate DDX58 degradation via selective autophagy (PubMed:29288164). Plays also a role in the inhibition of NF-kappa-B signaling pathway and inflammatory response by promoting the degradation of p65/RELA.3 Publications
Enzyme and pathway databases
PathwayCommonsi | Q8N386 |
Names & Taxonomyi
Protein namesi | Recommended name: Leucine-rich repeat-containing protein 25Alternative name(s): Monocyte and plasmacytoid-activated protein |
Gene namesi | Name:LRRC25 Synonyms:MAPA ORF Names:UNQ6169/PRO20174 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:29806, LRRC25 |
MIMi | 607518, gene |
neXtProti | NX_Q8N386 |
VEuPathDBi | HostDB:ENSG00000175489.9 |
Subcellular locationi
Other locations
- Membrane Curated; Single-pass type I membrane protein Curated
- Cytoplasm 1 Publication
Other locations
- cytoplasm Source: UniProtKB-SubCell
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 21 – 165 | ExtracellularSequence analysisAdd BLAST | 145 | |
Transmembranei | 166 – 186 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 187 – 305 | CytoplasmicSequence analysisAdd BLAST | 119 |
Keywords - Cellular componenti
Cytoplasm, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 126364 |
OpenTargetsi | ENSG00000175489 |
PharmGKBi | PA134957834 |
Miscellaneous databases
Pharosi | Q8N386, Tbio |
Genetic variation databases
BioMutai | LRRC25 |
DMDMi | 47605902 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 20 | Sequence analysisAdd BLAST | 20 | |
ChainiPRO_0000021613 | 21 – 305 | Leucine-rich repeat-containing protein 25Add BLAST | 285 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 44 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 55 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 130 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 148 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 284 | PhosphotyrosineBy similarity | 1 |
Keywords - PTMi
Glycoprotein, PhosphoproteinProteomic databases
jPOSTi | Q8N386 |
MassIVEi | Q8N386 |
PaxDbi | Q8N386 |
PeptideAtlasi | Q8N386 |
PRIDEi | Q8N386 |
ProteomicsDBi | 71776 |
PTM databases
GlyGeni | Q8N386, 4 sites |
PhosphoSitePlusi | Q8N386 |
SwissPalmi | Q8N386 |
Expressioni
Tissue specificityi
Expressed in plasmacytoid dendritic cells (PDC), monocyte-derived dendritic cells (MDDC), granulocytes, monocytes, B-lymphocytes, peripheral blood leukocytes, spleen, bone marrow, and, to a lesser extent, lymph nodes, fetal liver, and appendix but not in thymus.1 Publication
Inductioni
Down-regulated in CD40-activated monocyte-derived dendritic cells.1 Publication
Gene expression databases
Bgeei | ENSG00000175489, Expressed in blood and 127 other tissues |
Genevisiblei | Q8N386, HS |
Organism-specific databases
HPAi | ENSG00000175489, Tissue enhanced (blood, lymphoid tissue) |
Interactioni
Subunit structurei
Binary interactionsi
Hide detailsQ8N386
Protein-protein interaction databases
BioGRIDi | 125983, 40 interactors |
IntActi | Q8N386, 38 interactors |
STRINGi | 9606.ENSP00000340983 |
Miscellaneous databases
RNActi | Q8N386, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 39 – 59 | LRR 1Add BLAST | 21 | |
Repeati | 62 – 83 | LRR 2Add BLAST | 22 | |
Repeati | 86 – 107 | LRR 3Add BLAST | 22 |
Keywords - Domaini
Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502S9V5, Eukaryota |
GeneTreei | ENSGT00390000004001 |
HOGENOMi | CLU_906014_0_0_1 |
InParanoidi | Q8N386 |
OMAi | YMNYEGP |
OrthoDBi | 1374271at2759 |
PhylomeDBi | Q8N386 |
TreeFami | TF337414 |
Family and domain databases
Gene3Di | 3.80.10.10, 1 hit |
InterProi | View protein in InterPro IPR032675, LRR_dom_sf IPR039243, LRRC25 |
PANTHERi | PTHR20878, PTHR20878, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q8N386-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGGTLAWTLL LPLLLRESDS LEPSCTVSSA DVDWNAEFSA TCLNFSGLSL
60 70 80 90 100
SLPHNQSLRA SNVILLDLSG NGLRELPVTF FAHLQKLEVL NVLRNPLSRV
110 120 130 140 150
DGALAARCDL DLQADCNCAL ESWHDIRRDN CSGQKPLLCW DTTSSQHNLS
160 170 180 190 200
AFLEVSCAPG LASATIGAVV VSGCLLLGLA IAGPVLAWRL WRCRVARSRE
210 220 230 240 250
LNKPWAAQDG PKPGLGLQPR YGSRSAPKPQ VAVPSCPSTP DYENMFVGQP
260 270 280 290 300
AAEHQWDEQG AHPSEDNDFY INYKDIDLAS QPVYCNLQSL GQAPMDEEEY
VIPGH
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 40 | A → V in BAC04548 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 82 | A → G in CAD19531 (PubMed:12384430).Curated | 1 | |
Sequence conflicti | 95 | N → S in BAC04548 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_061677 | 234 | P → T. Corresponds to variant dbSNP:rs34439430EnsemblClinVar. | 1 | |
Natural variantiVAR_051109 | 294 | P → S2 PublicationsCorresponds to variant dbSNP:rs6512265Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ422148 mRNA Translation: CAD19531.1 AY358151 mRNA Translation: AAQ88518.1 AK095435 mRNA Translation: BAC04548.1 BC071640 mRNA Translation: AAH71640.1 BC093842 mRNA Translation: AAH93842.1 |
CCDSi | CCDS12377.1 |
RefSeqi | NP_660299.2, NM_145256.2 XP_005259796.1, XM_005259739.3 |
Genome annotation databases
Ensembli | ENST00000339007; ENSP00000340983; ENSG00000175489 ENST00000595840; ENSP00000472290; ENSG00000175489 |
GeneIDi | 126364 |
KEGGi | hsa:126364 |
UCSCi | uc002niw.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ422148 mRNA Translation: CAD19531.1 AY358151 mRNA Translation: AAQ88518.1 AK095435 mRNA Translation: BAC04548.1 BC071640 mRNA Translation: AAH71640.1 BC093842 mRNA Translation: AAH93842.1 |
CCDSi | CCDS12377.1 |
RefSeqi | NP_660299.2, NM_145256.2 XP_005259796.1, XM_005259739.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 125983, 40 interactors |
IntActi | Q8N386, 38 interactors |
STRINGi | 9606.ENSP00000340983 |
PTM databases
GlyGeni | Q8N386, 4 sites |
PhosphoSitePlusi | Q8N386 |
SwissPalmi | Q8N386 |
Genetic variation databases
BioMutai | LRRC25 |
DMDMi | 47605902 |
Proteomic databases
jPOSTi | Q8N386 |
MassIVEi | Q8N386 |
PaxDbi | Q8N386 |
PeptideAtlasi | Q8N386 |
PRIDEi | Q8N386 |
ProteomicsDBi | 71776 |
Protocols and materials databases
Antibodypediai | 28033, 326 antibodies |
DNASUi | 126364 |
Genome annotation databases
Ensembli | ENST00000339007; ENSP00000340983; ENSG00000175489 ENST00000595840; ENSP00000472290; ENSG00000175489 |
GeneIDi | 126364 |
KEGGi | hsa:126364 |
UCSCi | uc002niw.4, human |
Organism-specific databases
CTDi | 126364 |
DisGeNETi | 126364 |
GeneCardsi | LRRC25 |
HGNCi | HGNC:29806, LRRC25 |
HPAi | ENSG00000175489, Tissue enhanced (blood, lymphoid tissue) |
MIMi | 607518, gene |
neXtProti | NX_Q8N386 |
OpenTargetsi | ENSG00000175489 |
PharmGKBi | PA134957834 |
VEuPathDBi | HostDB:ENSG00000175489.9 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S9V5, Eukaryota |
GeneTreei | ENSGT00390000004001 |
HOGENOMi | CLU_906014_0_0_1 |
InParanoidi | Q8N386 |
OMAi | YMNYEGP |
OrthoDBi | 1374271at2759 |
PhylomeDBi | Q8N386 |
TreeFami | TF337414 |
Enzyme and pathway databases
PathwayCommonsi | Q8N386 |
Miscellaneous databases
BioGRID-ORCSi | 126364, 3 hits in 872 CRISPR screens |
ChiTaRSi | LRRC25, human |
GenomeRNAii | 126364 |
Pharosi | Q8N386, Tbio |
PROi | PR:Q8N386 |
RNActi | Q8N386, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000175489, Expressed in blood and 127 other tissues |
Genevisiblei | Q8N386, HS |
Family and domain databases
Gene3Di | 3.80.10.10, 1 hit |
InterProi | View protein in InterPro IPR032675, LRR_dom_sf IPR039243, LRRC25 |
PANTHERi | PTHR20878, PTHR20878, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | LRC25_HUMAN | |
Accessioni | Q8N386Primary (citable) accession number: Q8N386 Secondary accession number(s): Q6IQ00, Q8N9A5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 24, 2004 |
Last sequence update: | May 24, 2004 | |
Last modified: | February 10, 2021 | |
This is version 141 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot