UniProtKB - Q8N365 (CIART_HUMAN)
Protein
Circadian-associated transcriptional repressor
Gene
CIART
Organism
Homo sapiens (Human)
Status
Functioni
Transcriptional repressor which forms a negative regulatory component of the circadian clock and acts independently of the circadian transcriptional repressors: CRY1, CRY2 and BHLHE41. In a histone deacetylase-dependent manner represses the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Abrogates the interaction of ARNTL/BMAL1 with the transcriptional coactivator CREBBP and can repress the histone acetyl-transferase activity of the CLOCK-ARNTL/BMAL1 heterodimer, reducing histone acetylation of its target genes. Rhythmically binds the E-box elements (5'-CACGTG-3') on circadian gene promoters and its occupancy shows circadian oscillation antiphasic to ARNTL/BMAL1. Interacts with the glucocorticoid receptor (NR3C1) and contributes to the repressive function in the glucocorticoid response (By similarity).By similarity
GO - Molecular functioni
- E-box binding Source: UniProtKB
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- circadian regulation of gene expression Source: UniProtKB
- locomotor rhythm Source: UniProtKB
- negative regulation of transcription, DNA-templated Source: UniProtKB
Keywordsi
Molecular function | Repressor |
Biological process | Biological rhythms, Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | Q8N365 |
Names & Taxonomyi
Protein namesi | Recommended name: Circadian-associated transcriptional repressorAlternative name(s): ChIP-derived repressor of network oscillator Short name: Chrono Computationally highlighted repressor of the network oscillator |
Gene namesi | Name:CIART Synonyms:C1orf51 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:25200, CIART |
MIMi | 615782, gene |
neXtProti | NX_Q8N365 |
VEuPathDBi | HostDB:ENSG00000159208.15 |
Pathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000159208 |
PharmGKBi | PA134921053 |
Miscellaneous databases
Pharosi | Q8N365, Tbio |
Genetic variation databases
BioMutai | CIART |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000251193 | 1 – 385 | Circadian-associated transcriptional repressorAdd BLAST | 385 |
Proteomic databases
MassIVEi | Q8N365 |
PaxDbi | Q8N365 |
PeptideAtlasi | Q8N365 |
PRIDEi | Q8N365 |
ProteomicsDBi | 71767 [Q8N365-1] 71768 [Q8N365-2] |
PTM databases
iPTMneti | Q8N365 |
PhosphoSitePlusi | Q8N365 |
Expressioni
Gene expression databases
Bgeei | ENSG00000159208, Expressed in quadriceps femoris and 175 other tissues |
ExpressionAtlasi | Q8N365, baseline and differential |
Genevisiblei | Q8N365, HS |
Organism-specific databases
HPAi | ENSG00000159208, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with PER2, CRY2, BHLHE41, HDAC1 and NR3C1 (By similarity).
Interacts with ARNTL/BMAL1.
By similarity1 PublicationBinary interactionsi
Hide detailsQ8N365
Protein-protein interaction databases
BioGRIDi | 127153, 8 interactors |
DIPi | DIP-60822N |
IntActi | Q8N365, 12 interactors |
STRINGi | 9606.ENSP00000290363 |
Miscellaneous databases
RNActi | Q8N365, protein |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 3 – 34 | Ser-richAdd BLAST | 32 |
Phylogenomic databases
eggNOGi | ENOG502RZ6H, Eukaryota |
GeneTreei | ENSGT00390000018360 |
HOGENOMi | CLU_060548_0_0_1 |
InParanoidi | Q8N365 |
OMAi | HTASHPE |
OrthoDBi | 972715at2759 |
PhylomeDBi | Q8N365 |
TreeFami | TF332541 |
Family and domain databases
InterProi | View protein in InterPro IPR031373, Ciart |
PANTHERi | PTHR35441, PTHR35441, 1 hit |
Pfami | View protein in Pfam PF15673, Ciart, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q8N365-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MDSPSSVSSY SSYSLSSSFP TSPVNSDFGF PSDSEREDKG AHGPRPDTVG
60 70 80 90 100
QRGGSRPSPG PIRCRHRSKV SGNQHTPSHP KQRGSASPMA GSGAKRSRDG
110 120 130 140 150
ELETSLNTQG CTTEGDLLFA QKCKELQGFI PPLTDLLNGL KMGRFERGLS
160 170 180 190 200
SFQQSVAMDR IQRIVGVLQK PQMGERYLGT LLQVEGMLKT WFPQIAAQKS
210 220 230 240 250
SLGGGKHQLT KHFPSHHSDS AASSPASPME KMDQTQLGHL ALKPKQPWHL
260 270 280 290 300
TQWPAMNLTW IHTTPICNPP LSSPGTISFS HGPLGTGTGI GVILFLQHGV
310 320 330 340 350
QPFTHSAPTT PVPPTTASPV IPGEPMKLSG EGPRCYSLPV TLPSDWSYTL
360 370 380
SPPSLPTLAR KMTIGHREQQ RSHPPVAADA HLLNL
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ5TB12 | Q5TB12_HUMAN | Chromosome 1 open reading frame 51 | CIART C1orf51, hCG_1780614, RP4-790G17.5-003 | 297 | Annotation score: | ||
Q5TB13 | Q5TB13_HUMAN | Chromosome 1 open reading frame 51 | CIART C1orf51, RP4-790G17.5-004 | 238 | Annotation score: | ||
A0A1B0GX20 | A0A1B0GX20_HUMAN | Circadian-associated transcriptiona... | CIART | 225 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 187 | M → L in BAB71326 (PubMed:14702039).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_020743 | 123 | C → D in isoform 2. 1 Publication | 1 | |
Alternative sequenceiVSP_020744 | 124 – 385 | Missing in isoform 2. 1 PublicationAdd BLAST | 262 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK056960 mRNA Translation: BAB71326.1 AK098755 mRNA Translation: BAC05404.1 AK315397 mRNA Translation: BAG37790.1 AL138795 Genomic DNA Translation: CAI22816.1 CH471121 Genomic DNA Translation: EAW53560.1 CH471121 Genomic DNA Translation: EAW53564.1 BC027999 mRNA Translation: AAH27999.1 BC047238 mRNA Translation: AAH47238.1 |
CCDSi | CCDS949.1 [Q8N365-1] |
RefSeqi | NP_001287767.1, NM_001300838.1 [Q8N365-1] NP_001287769.1, NM_001300840.1 NP_001287770.1, NM_001300841.1 NP_653298.1, NM_144697.3 [Q8N365-1] |
Genome annotation databases
Ensembli | ENST00000290363; ENSP00000290363; ENSG00000159208 [Q8N365-1] ENST00000369095; ENSP00000358091; ENSG00000159208 [Q8N365-1] |
GeneIDi | 148523 |
KEGGi | hsa:148523 |
UCSCi | uc001euh.4, human [Q8N365-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK056960 mRNA Translation: BAB71326.1 AK098755 mRNA Translation: BAC05404.1 AK315397 mRNA Translation: BAG37790.1 AL138795 Genomic DNA Translation: CAI22816.1 CH471121 Genomic DNA Translation: EAW53560.1 CH471121 Genomic DNA Translation: EAW53564.1 BC027999 mRNA Translation: AAH27999.1 BC047238 mRNA Translation: AAH47238.1 |
CCDSi | CCDS949.1 [Q8N365-1] |
RefSeqi | NP_001287767.1, NM_001300838.1 [Q8N365-1] NP_001287769.1, NM_001300840.1 NP_001287770.1, NM_001300841.1 NP_653298.1, NM_144697.3 [Q8N365-1] |
3D structure databases
SMRi | Q8N365 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 127153, 8 interactors |
DIPi | DIP-60822N |
IntActi | Q8N365, 12 interactors |
STRINGi | 9606.ENSP00000290363 |
PTM databases
iPTMneti | Q8N365 |
PhosphoSitePlusi | Q8N365 |
Genetic variation databases
BioMutai | CIART |
Proteomic databases
MassIVEi | Q8N365 |
PaxDbi | Q8N365 |
PeptideAtlasi | Q8N365 |
PRIDEi | Q8N365 |
ProteomicsDBi | 71767 [Q8N365-1] 71768 [Q8N365-2] |
Protocols and materials databases
Antibodypediai | 34023, 138 antibodies |
DNASUi | 148523 |
Genome annotation databases
Ensembli | ENST00000290363; ENSP00000290363; ENSG00000159208 [Q8N365-1] ENST00000369095; ENSP00000358091; ENSG00000159208 [Q8N365-1] |
GeneIDi | 148523 |
KEGGi | hsa:148523 |
UCSCi | uc001euh.4, human [Q8N365-1] |
Organism-specific databases
CTDi | 148523 |
GeneCardsi | CIART |
HGNCi | HGNC:25200, CIART |
HPAi | ENSG00000159208, Low tissue specificity |
MIMi | 615782, gene |
neXtProti | NX_Q8N365 |
OpenTargetsi | ENSG00000159208 |
PharmGKBi | PA134921053 |
VEuPathDBi | HostDB:ENSG00000159208.15 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502RZ6H, Eukaryota |
GeneTreei | ENSGT00390000018360 |
HOGENOMi | CLU_060548_0_0_1 |
InParanoidi | Q8N365 |
OMAi | HTASHPE |
OrthoDBi | 972715at2759 |
PhylomeDBi | Q8N365 |
TreeFami | TF332541 |
Enzyme and pathway databases
PathwayCommonsi | Q8N365 |
Miscellaneous databases
BioGRID-ORCSi | 148523, 7 hits in 853 CRISPR screens |
GenomeRNAii | 148523 |
Pharosi | Q8N365, Tbio |
PROi | PR:Q8N365 |
RNActi | Q8N365, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000159208, Expressed in quadriceps femoris and 175 other tissues |
ExpressionAtlasi | Q8N365, baseline and differential |
Genevisiblei | Q8N365, HS |
Family and domain databases
InterProi | View protein in InterPro IPR031373, Ciart |
PANTHERi | PTHR35441, PTHR35441, 1 hit |
Pfami | View protein in Pfam PF15673, Ciart, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CIART_HUMAN | |
Accessioni | Q8N365Primary (citable) accession number: Q8N365 Secondary accession number(s): B2RD43 Q96MG6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 3, 2006 |
Last sequence update: | October 1, 2002 | |
Last modified: | February 10, 2021 | |
This is version 121 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot