UniProtKB - Q8N365 (CIART_HUMAN)

BLAST

>sp|Q8N365|CIART_HUMAN Circadian-associated transcriptional repressor OS=Homo sapiens OX=9606 GN=CIART PE=1 SV=1
MDSPSSVSSYSSYSLSSSFPTSPVNSDFGFPSDSEREDKGAHGPRPDTVGQRGGSRPSPG
PIRCRHRSKVSGNQHTPSHPKQRGSASPMAGSGAKRSRDGELETSLNTQGCTTEGDLLFA
QKCKELQGFIPPLTDLLNGLKMGRFERGLSSFQQSVAMDRIQRIVGVLQKPQMGERYLGT
LLQVEGMLKTWFPQIAAQKSSLGGGKHQLTKHFPSHHSDSAASSPASPMEKMDQTQLGHL
ALKPKQPWHLTQWPAMNLTWIHTTPICNPPLSSPGTISFSHGPLGTGTGIGVILFLQHGV
QPFTHSAPTTPVPPTTASPVIPGEPMKLSGEGPRCYSLPVTLPSDWSYTLSPPSLPTLAR
KMTIGHREQQRSHPPVAADAHLLNL

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History
Entry version 107 (10 Oct 2018)
Sequence version 1 (01 Oct 2002)
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Protein

Circadian-associated transcriptional repressor

Gene

CIART

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Transcriptional repressor which forms a negative regulatory component of the circadian clock and acts independently of the circadian transcriptional repressors: CRY1, CRY2 and BHLHE41. In a histone deacetylase-dependent manner represses the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Abrogates the interaction of ARNTL/BMAL1 with the transcriptional coactivator CREBBP and can repress the histone acetyl-transferase activity of the CLOCK-ARNTL/BMAL1 heterodimer, reducing histone acetylation of its target genes. Rhythmically binds the E-box elements (5'-CACGTG-3') on circadian gene promoters and its occupancy shows circadian oscillation antiphasic to ARNTL/BMAL1. Interacts with the glucocorticoid receptor (NR3C1) and contributes to the repressive function in the glucocorticoid response (By similarity).By similarity

GO - Molecular functionⁱ

E-box binding Source: UniProtKB
RNA polymerase II distal enhancer sequence-specific DNA binding Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

circadian regulation of gene expression Source: UniProtKB
locomotor rhythm Source: UniProtKB
negative regulation of transcription, DNA-templated Source: UniProtKB
transcription, DNA-templated Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Repressor
Biological process	Biological rhythms, Transcription, Transcription regulation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Circadian-associated transcriptional repressor Alternative name(s): ChIP-derived repressor of network oscillator Short name: Chrono Computationally highlighted repressor of the network oscillator
Gene namesⁱ	Name:CIART Synonyms:C1orf51
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000159208.15
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:25200 CIART
MIMⁱ	615782 gene
neXtProtⁱ	NX_Q8N365

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000159208
PharmGKBⁱ	PA134921053

Polymorphism and mutation databases

BioMutaⁱ	C1orf51

BioMutaⁱ

C1orf51

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000251193	1 – 385	Circadian-associated transcriptional repressorAdd BLAST		385

Proteomic databases

PaxDbⁱ	Q8N365
PeptideAtlas More...PeptideAtlasⁱ	Q8N365
PRIDEⁱ	Q8N365
ProteomicsDBⁱ	71767 71768 [Q8N365-2]

PTM databases

iPTMnetⁱ	Q8N365
PhosphoSitePlusⁱ	Q8N365

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000159208 Expressed in 160 organ(s), highest expression level in quadriceps femoris
CleanExⁱ	HS_C1orf51
ExpressionAtlasⁱ	Q8N365 baseline and differential
Genevisibleⁱ	Q8N365 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA027515 HPA054349

HPAⁱ

HPA027515
HPA054349

Interactionⁱ

Subunit structureⁱ

Interacts with PER2, CRY2, BHLHE41, HDAC1 and NR3C1 (By similarity). Interacts with ARNTL/BMAL1.By similarity1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
Arntl	Q9WTL8	6	EBI-10265133,EBI-644534	From Mus musculus.
DAB1	O75553	3	EBI-10265133,EBI-7875264
Per2	O54943	4	EBI-10265133,EBI-1266779	From Mus musculus.

Protein-protein interaction databases

BioGridⁱ	127153, 7 interactors
Database of interacting proteins More...DIPⁱ	DIP-60822N
IntActⁱ	Q8N365, 7 interactors
STRINGⁱ	9606.ENSP00000290363

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8N365
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	3 – 34	Ser-richAdd BLAST		32

Phylogenomic databases

eggNOGⁱ	ENOG410IICF Eukaryota ENOG410YK16 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000018360
HOGENOMⁱ	HOG000236332
HOVERGENⁱ	HBG058566
InParanoidⁱ	Q8N365
KEGG Orthology (KO) More...KOⁱ	K21599
OMAⁱ	NSDFGFP
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G088K
PhylomeDBⁱ	Q8N365
TreeFamⁱ	TF332541

Family and domain databases

InterProⁱ	View protein in InterPro IPR031373 Ciart
PANTHERⁱ	PTHR35441 PTHR35441, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF15673 Ciart, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q8N365-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDSPSSVSSY SSYSLSSSFP TSPVNSDFGF PSDSEREDKG AHGPRPDTVG 
        60         70         80         90        100
QRGGSRPSPG PIRCRHRSKV SGNQHTPSHP KQRGSASPMA GSGAKRSRDG 
       110        120        130        140        150
ELETSLNTQG CTTEGDLLFA QKCKELQGFI PPLTDLLNGL KMGRFERGLS 
       160        170        180        190        200
SFQQSVAMDR IQRIVGVLQK PQMGERYLGT LLQVEGMLKT WFPQIAAQKS 
       210        220        230        240        250
SLGGGKHQLT KHFPSHHSDS AASSPASPME KMDQTQLGHL ALKPKQPWHL 
       260        270        280        290        300
TQWPAMNLTW IHTTPICNPP LSSPGTISFS HGPLGTGTGI GVILFLQHGV 
       310        320        330        340        350
QPFTHSAPTT PVPPTTASPV IPGEPMKLSG EGPRCYSLPV TLPSDWSYTL 
       360        370        380 
SPPSLPTLAR KMTIGHREQQ RSHPPVAADA HLLNL

Length:385

Mass (Da):41,443

Last modified:October 1, 2002 - v1

Checksum:ⁱ3242FA7CA663493E

Isoform 2 (identifier: Q8N365-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
123-123: C → D
124-385: Missing.

« Hide

        10         20         30         40         50
MDSPSSVSSY SSYSLSSSFP TSPVNSDFGF PSDSEREDKG AHGPRPDTVG 
        60         70         80         90        100
QRGGSRPSPG PIRCRHRSKV SGNQHTPSHP KQRGSASPMA GSGAKRSRDG 
       110        120 
ELETSLNTQG CTTEGDLLFA QKD

Note: No experimental confirmation available.

Show »

Length:123

Mass (Da):12,982

Checksum:ⁱ0C8183FC432BCC38

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

Q5TB12	Q5TB12_HUMAN	Chromosome 1 open reading frame 51,... Chromosome 1 open reading frame 51, isoform CRA_c (Circadian-associated transcriptional repressor)	CIART C1orf51, hCG_1780614, RP4-790G17.5-003	297	Annotation score:
Q5TB13	Q5TB13_HUMAN	Chromosome 1 open reading frame 51 Chromosome 1 open reading frame 51 (Circadian-associated transcriptional repressor)	CIART C1orf51, RP4-790G17.5-004	238	Annotation score:
A0A1B0GX20	A0A1B0GX20_HUMAN	Circadian-associated transcriptiona... Circadian-associated transcriptional repressor	CIART	225	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	187	M → L in BAB71326 (PubMed:14702039).Curated		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_020743	123	C → D in isoform 2. 1 Publication		1
Alternative sequenceⁱVSP_020744	124 – 385	Missing in isoform 2. 1 PublicationAdd BLAST		262

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK056960 mRNA Translation: BAB71326.1 AK098755 mRNA Translation: BAC05404.1 AK315397 mRNA Translation: BAG37790.1 AL138795 Genomic DNA Translation: CAI22816.1 CH471121 Genomic DNA Translation: EAW53560.1 CH471121 Genomic DNA Translation: EAW53564.1 BC027999 mRNA Translation: AAH27999.1 BC047238 mRNA Translation: AAH47238.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS949.1 [Q8N365-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001287767.1, NM_001300838.1 [Q8N365-1] NP_001287769.1, NM_001300840.1 NP_001287770.1, NM_001300841.1 NP_653298.1, NM_144697.3 [Q8N365-1]
UniGeneⁱ	Hs.54680

Genome annotation databases

Ensemblⁱ	ENST00000290363; ENSP00000290363; ENSG00000159208 [Q8N365-1] ENST00000369095; ENSP00000358091; ENSG00000159208 [Q8N365-1]
GeneIDⁱ	148523
KEGGⁱ	hsa:148523
UCSC genome browser More...UCSCⁱ	uc001euh.4 human [Q8N365-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q8N365	Chromosome 1 open reading frame 51 (Fragment)		HUMAN		238	UniRef100_Q8N365
Circadian-associated transcriptional repressor (Fragment)		HUMAN		225
Chromosome 1 open reading frame 51 (Fragment)		HUMAN		226
Chromosome 1 open reading frame 51, isoform CRA_c		HUMAN		297
UPI0000EE69A0		HUMAN		228

Protein	Similar proteins		Species	Score	Length	Source
Q8N365	Chromosome 1 open reading frame 51 (Fragment)		HUMAN		238	UniRef90_Q8N365
Uncharacterized protein		MACFA		395
Uncharacterized protein		CALJA		385
CIART isoform 3		PANTR		385
Uncharacterized protein		PANPA		385
+41

Protein	Similar proteins		Species	Score	Length	Source
Q8N365	Chromosome 1 open reading frame 51 (Fragment)		HUMAN		238	UniRef50_Q8N365
Uncharacterized protein		MACFA		395
Uncharacterized protein		CERAT		385
Circadian associated repressor of transcription		SAIBB		385
CIART isoform 3		PANTR		385
+52

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK056960 mRNA Translation: BAB71326.1 AK098755 mRNA Translation: BAC05404.1 AK315397 mRNA Translation: BAG37790.1 AL138795 Genomic DNA Translation: CAI22816.1 CH471121 Genomic DNA Translation: EAW53560.1 CH471121 Genomic DNA Translation: EAW53564.1 BC027999 mRNA Translation: AAH27999.1 BC047238 mRNA Translation: AAH47238.1
CCDSⁱ	CCDS949.1 [Q8N365-1]
RefSeqⁱ	NP_001287767.1, NM_001300838.1 [Q8N365-1] NP_001287769.1, NM_001300840.1 NP_001287770.1, NM_001300841.1 NP_653298.1, NM_144697.3 [Q8N365-1]
UniGeneⁱ	Hs.54680

3D structure databases

ProteinModelPortalⁱ	Q8N365
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	127153, 7 interactors
DIPⁱ	DIP-60822N
IntActⁱ	Q8N365, 7 interactors
STRINGⁱ	9606.ENSP00000290363

PTM databases

iPTMnetⁱ	Q8N365
PhosphoSitePlusⁱ	Q8N365

Polymorphism and mutation databases

BioMutaⁱ	C1orf51

BioMutaⁱ

C1orf51

Proteomic databases

PaxDbⁱ	Q8N365
PeptideAtlasⁱ	Q8N365
PRIDEⁱ	Q8N365
ProteomicsDBⁱ	71767 71768 [Q8N365-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	148523
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000290363; ENSP00000290363; ENSG00000159208 [Q8N365-1] ENST00000369095; ENSP00000358091; ENSG00000159208 [Q8N365-1]
GeneIDⁱ	148523
KEGGⁱ	hsa:148523
UCSCⁱ	uc001euh.4 human [Q8N365-1]

Organism-specific databases

CTDⁱ	148523
EuPathDBⁱ	HostDB:ENSG00000159208.15
GeneCardsⁱ	CIART
HGNCⁱ	HGNC:25200 CIART
HPAⁱ	HPA027515 HPA054349
MIMⁱ	615782 gene
neXtProtⁱ	NX_Q8N365
OpenTargetsⁱ	ENSG00000159208
PharmGKBⁱ	PA134921053
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IICF Eukaryota ENOG410YK16 LUCA
GeneTreeⁱ	ENSGT00390000018360
HOGENOMⁱ	HOG000236332
HOVERGENⁱ	HBG058566
InParanoidⁱ	Q8N365
KOⁱ	K21599
OMAⁱ	NSDFGFP
OrthoDBⁱ	EOG091G088K
PhylomeDBⁱ	Q8N365
TreeFamⁱ	TF332541

Miscellaneous databases

GenomeRNAiⁱ	148523
Protein Ontology More...PROⁱ	PR:Q8N365
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000159208 Expressed in 160 organ(s), highest expression level in quadriceps femoris
CleanExⁱ	HS_C1orf51
ExpressionAtlasⁱ	Q8N365 baseline and differential
Genevisibleⁱ	Q8N365 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR031373 Ciart
PANTHERⁱ	PTHR35441 PTHR35441, 1 hit
Pfamⁱ	View protein in Pfam PF15673 Ciart, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CIART_HUMAN
Accessionⁱ	Q8N365Primary (citable) accession number: Q8N365 Secondary accession number(s): B2RD43 , D3DV01, Q8N795, Q96MG6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 3, 2006
	Last sequence update:	October 1, 2002
	Last modified:	October 10, 2018
	This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q8N365 (CIART_HUMAN)

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Circadian-associated transcriptional repressor

CIART

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Phylogenomic databases

Family and domain databases

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ