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Protein

Circadian-associated transcriptional repressor

Gene

CIART

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional repressor which forms a negative regulatory component of the circadian clock and acts independently of the circadian transcriptional repressors: CRY1, CRY2 and BHLHE41. In a histone deacetylase-dependent manner represses the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Abrogates the interaction of ARNTL/BMAL1 with the transcriptional coactivator CREBBP and can repress the histone acetyl-transferase activity of the CLOCK-ARNTL/BMAL1 heterodimer, reducing histone acetylation of its target genes. Rhythmically binds the E-box elements (5'-CACGTG-3') on circadian gene promoters and its occupancy shows circadian oscillation antiphasic to ARNTL/BMAL1. Interacts with the glucocorticoid receptor (NR3C1) and contributes to the repressive function in the glucocorticoid response (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRepressor
Biological processBiological rhythms, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Circadian-associated transcriptional repressor
Alternative name(s):
ChIP-derived repressor of network oscillator
Short name:
Chrono
Computationally highlighted repressor of the network oscillator
Gene namesi
Name:CIART
Synonyms:C1orf51
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000159208.15
HGNCiHGNC:25200 CIART
MIMi615782 gene
neXtProtiNX_Q8N365

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000159208
PharmGKBiPA134921053

Polymorphism and mutation databases

BioMutaiC1orf51

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002511931 – 385Circadian-associated transcriptional repressorAdd BLAST385

Proteomic databases

PaxDbiQ8N365
PeptideAtlasiQ8N365
PRIDEiQ8N365
ProteomicsDBi71767
71768 [Q8N365-2]

PTM databases

iPTMnetiQ8N365
PhosphoSitePlusiQ8N365

Expressioni

Gene expression databases

BgeeiENSG00000159208 Expressed in 160 organ(s), highest expression level in quadriceps femoris
CleanExiHS_C1orf51
ExpressionAtlasiQ8N365 baseline and differential
GenevisibleiQ8N365 HS

Organism-specific databases

HPAiHPA027515
HPA054349

Interactioni

Subunit structurei

Interacts with PER2, CRY2, BHLHE41, HDAC1 and NR3C1 (By similarity). Interacts with ARNTL/BMAL1.By similarity1 Publication

Binary interactionsi

Protein-protein interaction databases

BioGridi127153, 7 interactors
DIPiDIP-60822N
IntActiQ8N365, 7 interactors
STRINGi9606.ENSP00000290363

Structurei

3D structure databases

ProteinModelPortaliQ8N365
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi3 – 34Ser-richAdd BLAST32

Phylogenomic databases

eggNOGiENOG410IICF Eukaryota
ENOG410YK16 LUCA
GeneTreeiENSGT00390000018360
HOGENOMiHOG000236332
HOVERGENiHBG058566
InParanoidiQ8N365
KOiK21599
OMAiNSDFGFP
OrthoDBiEOG091G088K
PhylomeDBiQ8N365
TreeFamiTF332541

Family and domain databases

InterProiView protein in InterPro
IPR031373 Ciart
PANTHERiPTHR35441 PTHR35441, 1 hit
PfamiView protein in Pfam
PF15673 Ciart, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8N365-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDSPSSVSSY SSYSLSSSFP TSPVNSDFGF PSDSEREDKG AHGPRPDTVG
60 70 80 90 100
QRGGSRPSPG PIRCRHRSKV SGNQHTPSHP KQRGSASPMA GSGAKRSRDG
110 120 130 140 150
ELETSLNTQG CTTEGDLLFA QKCKELQGFI PPLTDLLNGL KMGRFERGLS
160 170 180 190 200
SFQQSVAMDR IQRIVGVLQK PQMGERYLGT LLQVEGMLKT WFPQIAAQKS
210 220 230 240 250
SLGGGKHQLT KHFPSHHSDS AASSPASPME KMDQTQLGHL ALKPKQPWHL
260 270 280 290 300
TQWPAMNLTW IHTTPICNPP LSSPGTISFS HGPLGTGTGI GVILFLQHGV
310 320 330 340 350
QPFTHSAPTT PVPPTTASPV IPGEPMKLSG EGPRCYSLPV TLPSDWSYTL
360 370 380
SPPSLPTLAR KMTIGHREQQ RSHPPVAADA HLLNL
Length:385
Mass (Da):41,443
Last modified:October 1, 2002 - v1
Checksum:i3242FA7CA663493E
GO
Isoform 2 (identifier: Q8N365-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     123-123: C → D
     124-385: Missing.

Note: No experimental confirmation available.
Show »
Length:123
Mass (Da):12,982
Checksum:i0C8183FC432BCC38
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5TB12Q5TB12_HUMAN
Chromosome 1 open reading frame 51,...
CIART C1orf51, hCG_1780614, RP4-790G17.5-003
297Annotation score:
Q5TB13Q5TB13_HUMAN
Chromosome 1 open reading frame 51
CIART C1orf51, RP4-790G17.5-004
238Annotation score:
A0A1B0GX20A0A1B0GX20_HUMAN
Circadian-associated transcriptiona...
CIART
225Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti187M → L in BAB71326 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_020743123C → D in isoform 2. 1 Publication1
Alternative sequenceiVSP_020744124 – 385Missing in isoform 2. 1 PublicationAdd BLAST262

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056960 mRNA Translation: BAB71326.1
AK098755 mRNA Translation: BAC05404.1
AK315397 mRNA Translation: BAG37790.1
AL138795 Genomic DNA Translation: CAI22816.1
CH471121 Genomic DNA Translation: EAW53560.1
CH471121 Genomic DNA Translation: EAW53564.1
BC027999 mRNA Translation: AAH27999.1
BC047238 mRNA Translation: AAH47238.1
CCDSiCCDS949.1 [Q8N365-1]
RefSeqiNP_001287767.1, NM_001300838.1 [Q8N365-1]
NP_001287769.1, NM_001300840.1
NP_001287770.1, NM_001300841.1
NP_653298.1, NM_144697.3 [Q8N365-1]
UniGeneiHs.54680

Genome annotation databases

EnsembliENST00000290363; ENSP00000290363; ENSG00000159208 [Q8N365-1]
ENST00000369095; ENSP00000358091; ENSG00000159208 [Q8N365-1]
GeneIDi148523
KEGGihsa:148523
UCSCiuc001euh.4 human [Q8N365-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056960 mRNA Translation: BAB71326.1
AK098755 mRNA Translation: BAC05404.1
AK315397 mRNA Translation: BAG37790.1
AL138795 Genomic DNA Translation: CAI22816.1
CH471121 Genomic DNA Translation: EAW53560.1
CH471121 Genomic DNA Translation: EAW53564.1
BC027999 mRNA Translation: AAH27999.1
BC047238 mRNA Translation: AAH47238.1
CCDSiCCDS949.1 [Q8N365-1]
RefSeqiNP_001287767.1, NM_001300838.1 [Q8N365-1]
NP_001287769.1, NM_001300840.1
NP_001287770.1, NM_001300841.1
NP_653298.1, NM_144697.3 [Q8N365-1]
UniGeneiHs.54680

3D structure databases

ProteinModelPortaliQ8N365
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127153, 7 interactors
DIPiDIP-60822N
IntActiQ8N365, 7 interactors
STRINGi9606.ENSP00000290363

PTM databases

iPTMnetiQ8N365
PhosphoSitePlusiQ8N365

Polymorphism and mutation databases

BioMutaiC1orf51

Proteomic databases

PaxDbiQ8N365
PeptideAtlasiQ8N365
PRIDEiQ8N365
ProteomicsDBi71767
71768 [Q8N365-2]

Protocols and materials databases

DNASUi148523
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000290363; ENSP00000290363; ENSG00000159208 [Q8N365-1]
ENST00000369095; ENSP00000358091; ENSG00000159208 [Q8N365-1]
GeneIDi148523
KEGGihsa:148523
UCSCiuc001euh.4 human [Q8N365-1]

Organism-specific databases

CTDi148523
EuPathDBiHostDB:ENSG00000159208.15
GeneCardsiCIART
HGNCiHGNC:25200 CIART
HPAiHPA027515
HPA054349
MIMi615782 gene
neXtProtiNX_Q8N365
OpenTargetsiENSG00000159208
PharmGKBiPA134921053
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IICF Eukaryota
ENOG410YK16 LUCA
GeneTreeiENSGT00390000018360
HOGENOMiHOG000236332
HOVERGENiHBG058566
InParanoidiQ8N365
KOiK21599
OMAiNSDFGFP
OrthoDBiEOG091G088K
PhylomeDBiQ8N365
TreeFamiTF332541

Miscellaneous databases

GenomeRNAii148523
PROiPR:Q8N365
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000159208 Expressed in 160 organ(s), highest expression level in quadriceps femoris
CleanExiHS_C1orf51
ExpressionAtlasiQ8N365 baseline and differential
GenevisibleiQ8N365 HS

Family and domain databases

InterProiView protein in InterPro
IPR031373 Ciart
PANTHERiPTHR35441 PTHR35441, 1 hit
PfamiView protein in Pfam
PF15673 Ciart, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCIART_HUMAN
AccessioniPrimary (citable) accession number: Q8N365
Secondary accession number(s): B2RD43
, D3DV01, Q8N795, Q96MG6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: October 1, 2002
Last modified: October 10, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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