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UniProtKB - Q8N344 (MIER2_HUMAN)
Protein
Mesoderm induction early response protein 2
Gene
MIER2
Organism
Homo sapiens (Human)
Status
Functioni
Transcriptional repressor.
By similarityGO - Molecular functioni
- histone deacetylase binding Source: UniProtKB
- transcription corepressor activity Source: GO_Central
GO - Biological processi
- histone deacetylation Source: UniProtKB
- negative regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | Repressor |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | Q8N344 |
SignaLinki | Q8N344 |
Names & Taxonomyi
Protein namesi | Recommended name: Mesoderm induction early response protein 2Short name: Mi-er2 |
Gene namesi | Name:MIER2 Synonyms:KIAA1193 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:29210, MIER2 |
neXtProti | NX_Q8N344 |
VEuPathDBi | HostDB:ENSG00000105556 |
Subcellular locationi
Nucleus
- Nucleus PROSITE-ProRule annotation
Nucleus
- nucleoplasm Source: GO_Central
- nucleus Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB
- protein-containing complex Source: UniProtKB
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 54531 |
OpenTargetsi | ENSG00000105556 |
PharmGKBi | PA134925804 |
Miscellaneous databases
Pharosi | Q8N344, Tbio |
Genetic variation databases
BioMutai | MIER2 |
DMDMi | 74750947 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000313678 | 1 – 545 | Mesoderm induction early response protein 2Add BLAST | 545 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 11 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q8N344 |
jPOSTi | Q8N344 |
MassIVEi | Q8N344 |
MaxQBi | Q8N344 |
PaxDbi | Q8N344 |
PeptideAtlasi | Q8N344 |
PRIDEi | Q8N344 |
ProteomicsDBi | 71762 |
PTM databases
iPTMneti | Q8N344 |
PhosphoSitePlusi | Q8N344 |
Expressioni
Gene expression databases
Bgeei | ENSG00000105556, Expressed in stomach and 179 other tissues |
ExpressionAtlasi | Q8N344, baseline and differential |
Genevisiblei | Q8N344, HS |
Organism-specific databases
HPAi | ENSG00000105556, Low tissue specificity |
Interactioni
Subunit structurei
Part of a complex containing at least CDYL, MIER1, MIER2, HDAC1 and HDAC2.
1 PublicationBinary interactionsi
Q8N344
With | #Exp. | IntAct |
---|---|---|
IL16 - isoform 2 [Q14005-2] | 5 | EBI-3504938,EBI-17178971 |
MCRS1 [Q96EZ8] | 5 | EBI-3504938,EBI-348259 |
GO - Molecular functioni
- histone deacetylase binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 120019, 35 interactors |
IntActi | Q8N344, 28 interactors |
STRINGi | 9606.ENSP00000264819 |
Miscellaneous databases
RNActi | Q8N344, protein |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 195 – 292 | ELM2PROSITE-ProRule annotationAdd BLAST | 98 | |
Domaini | 297 – 349 | SANTPROSITE-ProRule annotationAdd BLAST | 53 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 100 – 189 | DisorderedSequence analysisAdd BLAST | 90 | |
Regioni | 364 – 464 | DisorderedSequence analysisAdd BLAST | 101 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 143 – 159 | Polar residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 166 – 180 | Basic and acidic residuesSequence analysisAdd BLAST | 15 |
Phylogenomic databases
eggNOGi | KOG4329, Eukaryota |
GeneTreei | ENSGT01030000234573 |
HOGENOMi | CLU_027202_3_1_1 |
InParanoidi | Q8N344 |
OMAi | HQACPAP |
OrthoDBi | 1062529at2759 |
PhylomeDBi | Q8N344 |
TreeFami | TF106453 |
Family and domain databases
InterProi | View protein in InterPro IPR000949, ELM2_dom IPR009057, Homeobox-like_sf IPR040138, MIER/MTA IPR001005, SANT/Myb IPR017884, SANT_dom |
PANTHERi | PTHR10865, PTHR10865, 1 hit |
Pfami | View protein in Pfam PF01448, ELM2, 1 hit |
SMARTi | View protein in SMART SM01189, ELM2, 1 hit SM00717, SANT, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS51156, ELM2, 1 hit PS51293, SANT, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q8N344-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAEASSLGRQ SPRVVSCLEH SLCPGEPGLQ TTAVVSMGSG DHQFNLAEIL
60 70 80 90 100
SQNYSVRGEC EEASRCPDKP KEELEKDFIS QSNDMPFDEL LALYGYEASD
110 120 130 140 150
PISDRESEGG DVAPNLPDMT LDKEQIAKDL LSGEEEEETQ SSADDLTPSV
160 170 180 190 200
TSHEASDLFP NRSGSRFLAD EDREPGSSAS SDTEEDSLPA NKCKKEIMVG
210 220 230 240 250
PQFQADLSNL HLNRHCEKIY ENEDQLLWDP SVLPEREVEE FLYRAVKRRW
260 270 280 290 300
HEMAGPQLPE GEAVKDSEQA LYELVKCNFN VEEALRRLRF NVKVIRDGLC
310 320 330 340 350
AWSEEECRNF EHGFRVHGKN FHLIQANKVR TRSVGECVEY YYLWKKSERY
360 370 380 390 400
DYFAQQTRLG RRKYVPSGTT DADQDLDGSD PDGPGRPRPE QDTLTGMRTD
410 420 430 440 450
PLSVDGTAGG LDEPGVASDG LPSSEPGPCS FQQLDESPAV PLSHRPPALA
460 470 480 490 500
DPASYQPAVT APEPDASPRL AVDFALPKEL PLISSHVDLS GDPEETVAPA
510 520 530 540
QVALSVTEFG LIGIGDVNPF LAAHPTCPAP GLHSEPLSHC NVMTC
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A087WZA4 | A0A087WZA4_HUMAN | Mesoderm induction early response p... | MIER2 | 210 | Annotation score: | ||
A0A1B0GUC1 | A0A1B0GUC1_HUMAN | Mesoderm induction early response p... | MIER2 | 88 | Annotation score: |
Sequence cautioni
The sequence BAA86507 differs from that shown. Reason: Erroneous translation. Wrong choice of frame.Curated
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_037695 | 68 | D → N. Corresponds to variant dbSNP:rs7507468Ensembl. | 1 | |
Natural variantiVAR_037696 | 104 | D → N. Corresponds to variant dbSNP:rs10421231Ensembl. | 1 | |
Natural variantiVAR_078065 | 289 | R → W Unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs148482834Ensembl. | 1 | |
Natural variantiVAR_037697 | 464 | P → S. Corresponds to variant dbSNP:rs34129568Ensembl. | 1 | |
Natural variantiVAR_037698 | 485 | S → G. Corresponds to variant dbSNP:rs35042658Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC028203 mRNA Translation: AAH28203.2 AB033019 mRNA Translation: BAA86507.2 Sequence problems. |
CCDSi | CCDS32855.1 |
RefSeqi | NP_060020.1, NM_017550.2 |
Genome annotation databases
Ensembli | ENST00000264819; ENSP00000264819; ENSG00000105556 |
GeneIDi | 54531 |
KEGGi | hsa:54531 |
MANE-Selecti | ENST00000264819.7; ENSP00000264819.3; NM_017550.3; NP_060020.1 |
UCSCi | uc002lok.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC028203 mRNA Translation: AAH28203.2 AB033019 mRNA Translation: BAA86507.2 Sequence problems. |
CCDSi | CCDS32855.1 |
RefSeqi | NP_060020.1, NM_017550.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 120019, 35 interactors |
IntActi | Q8N344, 28 interactors |
STRINGi | 9606.ENSP00000264819 |
PTM databases
iPTMneti | Q8N344 |
PhosphoSitePlusi | Q8N344 |
Genetic variation databases
BioMutai | MIER2 |
DMDMi | 74750947 |
Proteomic databases
EPDi | Q8N344 |
jPOSTi | Q8N344 |
MassIVEi | Q8N344 |
MaxQBi | Q8N344 |
PaxDbi | Q8N344 |
PeptideAtlasi | Q8N344 |
PRIDEi | Q8N344 |
ProteomicsDBi | 71762 |
Protocols and materials databases
Antibodypediai | 42088, 246 antibodies from 24 providers |
DNASUi | 54531 |
Genome annotation databases
Ensembli | ENST00000264819; ENSP00000264819; ENSG00000105556 |
GeneIDi | 54531 |
KEGGi | hsa:54531 |
MANE-Selecti | ENST00000264819.7; ENSP00000264819.3; NM_017550.3; NP_060020.1 |
UCSCi | uc002lok.1, human |
Organism-specific databases
CTDi | 54531 |
DisGeNETi | 54531 |
GeneCardsi | MIER2 |
HGNCi | HGNC:29210, MIER2 |
HPAi | ENSG00000105556, Low tissue specificity |
neXtProti | NX_Q8N344 |
OpenTargetsi | ENSG00000105556 |
PharmGKBi | PA134925804 |
VEuPathDBi | HostDB:ENSG00000105556 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4329, Eukaryota |
GeneTreei | ENSGT01030000234573 |
HOGENOMi | CLU_027202_3_1_1 |
InParanoidi | Q8N344 |
OMAi | HQACPAP |
OrthoDBi | 1062529at2759 |
PhylomeDBi | Q8N344 |
TreeFami | TF106453 |
Enzyme and pathway databases
PathwayCommonsi | Q8N344 |
SignaLinki | Q8N344 |
Miscellaneous databases
BioGRID-ORCSi | 54531, 7 hits in 1047 CRISPR screens |
ChiTaRSi | MIER2, human |
GenomeRNAii | 54531 |
Pharosi | Q8N344, Tbio |
PROi | PR:Q8N344 |
RNActi | Q8N344, protein |
Gene expression databases
Bgeei | ENSG00000105556, Expressed in stomach and 179 other tissues |
ExpressionAtlasi | Q8N344, baseline and differential |
Genevisiblei | Q8N344, HS |
Family and domain databases
InterProi | View protein in InterPro IPR000949, ELM2_dom IPR009057, Homeobox-like_sf IPR040138, MIER/MTA IPR001005, SANT/Myb IPR017884, SANT_dom |
PANTHERi | PTHR10865, PTHR10865, 1 hit |
Pfami | View protein in Pfam PF01448, ELM2, 1 hit |
SMARTi | View protein in SMART SM01189, ELM2, 1 hit SM00717, SANT, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS51156, ELM2, 1 hit PS51293, SANT, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | MIER2_HUMAN | |
Accessioni | Q8N344Primary (citable) accession number: Q8N344 Secondary accession number(s): Q9ULM7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 15, 2008 |
Last sequence update: | July 5, 2004 | |
Last modified: | February 23, 2022 | |
This is version 144 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports