UniProtKB - Q8N344 (MIER2_HUMAN)

BLAST

>sp|Q8N344|MIER2_HUMAN Mesoderm induction early response protein 2 OS=Homo sapiens OX=9606 GN=MIER2 PE=1 SV=2
MAEASSLGRQSPRVVSCLEHSLCPGEPGLQTTAVVSMGSGDHQFNLAEILSQNYSVRGEC
EEASRCPDKPKEELEKDFISQSNDMPFDELLALYGYEASDPISDRESEGGDVAPNLPDMT
LDKEQIAKDLLSGEEEEETQSSADDLTPSVTSHEASDLFPNRSGSRFLADEDREPGSSAS
SDTEEDSLPANKCKKEIMVGPQFQADLSNLHLNRHCEKIYENEDQLLWDPSVLPEREVEE
FLYRAVKRRWHEMAGPQLPEGEAVKDSEQALYELVKCNFNVEEALRRLRFNVKVIRDGLC
AWSEEECRNFEHGFRVHGKNFHLIQANKVRTRSVGECVEYYYLWKKSERYDYFAQQTRLG
RRKYVPSGTTDADQDLDGSDPDGPGRPRPEQDTLTGMRTDPLSVDGTAGGLDEPGVASDG
LPSSEPGPCSFQQLDESPAVPLSHRPPALADPASYQPAVTAPEPDASPRLAVDFALPKEL
PLISSHVDLSGDPEETVAPAQVALSVTEFGLIGIGDVNPFLAAHPTCPAPGLHSEPLSHC
NVMTC

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History
Entry version 123 (07 Nov 2018)
Sequence version 2 (05 Jul 2004)
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Protein

Mesoderm induction early response protein 2

Gene

MIER2

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Transcriptional repressor.By similarity

GO - Molecular functionⁱ

DNA binding Source: InterPro
DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
histone deacetylase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 28046085
histone deacetylase binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 28046085
RNA polymerase II repressing transcription factor binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
transcription corepressor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

histone deacetylation
Source: UniProtKB
Inferred from direct assayⁱ
- 28046085
negative regulation of transcription by RNA polymerase II
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Repressor
Biological process	Transcription, Transcription regulation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Mesoderm induction early response protein 2 Short name: Mi-er2
Gene namesⁱ	Name:MIER2 Synonyms:KIAA1193
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 19

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000105556.10
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:29210 MIER2
neXtProtⁱ	NX_Q8N344

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	54531
Open Targets More...OpenTargetsⁱ	ENSG00000105556
PharmGKBⁱ	PA134925804

Polymorphism and mutation databases

BioMutaⁱ	MIER2
DMDMⁱ	74750947

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000313678	1 – 545	Mesoderm induction early response protein 2Add BLAST		545

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	11	PhosphoserineCombined sources		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q8N344
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q8N344
PaxDbⁱ	Q8N344
PeptideAtlas More...PeptideAtlasⁱ	Q8N344
PRIDEⁱ	Q8N344
ProteomicsDBⁱ	71762

PTM databases

iPTMnetⁱ	Q8N344
PhosphoSitePlusⁱ	Q8N344

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000105556 Expressed in 159 organ(s), highest expression level in right testis
CleanExⁱ	HS_MIER2
ExpressionAtlasⁱ	Q8N344 baseline and differential
Genevisibleⁱ	Q8N344 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA041439

HPAⁱ

HPA041439

Interactionⁱ

Subunit structureⁱ

Part of a complex containing at least CDYL, MIER1, MIER2, HDAC1 and HDAC2.1 Publication

GO - Molecular functionⁱ

histone deacetylase binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 28046085
RNA polymerase II repressing transcription factor binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	120019, 32 interactors
IntActⁱ	Q8N344, 6 interactors
STRINGⁱ	9606.ENSP00000264819

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8N344
SMRⁱ	Q8N344
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	195 – 292	ELM2PROSITE-ProRule annotationAdd BLAST		98
Domainⁱ	297 – 349	SANTPROSITE-ProRule annotationAdd BLAST		53

Phylogenomic databases

eggNOGⁱ	KOG4329 Eukaryota ENOG410Y9DJ LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00510000046482
HOGENOMⁱ	HOG000015798
HOVERGENⁱ	HBG052923
InParanoidⁱ	Q8N344
OMAⁱ	WDPNILP
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0BKH
PhylomeDBⁱ	Q8N344
TreeFamⁱ	TF106453

Family and domain databases

InterProⁱ	View protein in InterPro IPR000949 ELM2_dom IPR009057 Homeobox-like_sf IPR001005 SANT/Myb IPR017884 SANT_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01448 ELM2, 1 hit
SMARTⁱ	View protein in SMART SM01189 ELM2, 1 hit SM00717 SANT, 1 hit
SUPFAMⁱ	SSF46689 SSF46689, 1 hit
PROSITEⁱ	View protein in PROSITE PS51156 ELM2, 1 hit PS51293 SANT, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show all Align All

Q8N344-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAEASSLGRQ SPRVVSCLEH SLCPGEPGLQ TTAVVSMGSG DHQFNLAEIL 
        60         70         80         90        100
SQNYSVRGEC EEASRCPDKP KEELEKDFIS QSNDMPFDEL LALYGYEASD 
       110        120        130        140        150
PISDRESEGG DVAPNLPDMT LDKEQIAKDL LSGEEEEETQ SSADDLTPSV 
       160        170        180        190        200
TSHEASDLFP NRSGSRFLAD EDREPGSSAS SDTEEDSLPA NKCKKEIMVG 
       210        220        230        240        250
PQFQADLSNL HLNRHCEKIY ENEDQLLWDP SVLPEREVEE FLYRAVKRRW 
       260        270        280        290        300
HEMAGPQLPE GEAVKDSEQA LYELVKCNFN VEEALRRLRF NVKVIRDGLC 
       310        320        330        340        350
AWSEEECRNF EHGFRVHGKN FHLIQANKVR TRSVGECVEY YYLWKKSERY 
       360        370        380        390        400
DYFAQQTRLG RRKYVPSGTT DADQDLDGSD PDGPGRPRPE QDTLTGMRTD 
       410        420        430        440        450
PLSVDGTAGG LDEPGVASDG LPSSEPGPCS FQQLDESPAV PLSHRPPALA 
       460        470        480        490        500
DPASYQPAVT APEPDASPRL AVDFALPKEL PLISSHVDLS GDPEETVAPA 
       510        520        530        540 
QVALSVTEFG LIGIGDVNPF LAAHPTCPAP GLHSEPLSHC NVMTC

Length:545

Mass (Da):59,944

Last modified:July 5, 2004 - v2

Checksum:ⁱ891526F8094F18D8

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A0A087WZA4	A0A087WZA4_HUMAN	Mesoderm induction early response p... Mesoderm induction early response protein 2	MIER2	210	Annotation score:
A0A1B0GUC1	A0A1B0GUC1_HUMAN	Mesoderm induction early response p... Mesoderm induction early response protein 2	MIER2	88	Annotation score:

Sequence cautionⁱ

The sequence BAA86507 differs from that shown. Reason: Erroneous translation. Wrong choice of frame.Curated

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_037695	68	D → N. Corresponds to variant dbSNP:rs7507468Ensembl.	1
Natural variantⁱVAR_037696	104	D → N. Corresponds to variant dbSNP:rs10421231Ensembl.	1
Natural variantⁱVAR_078065	289	R → W Unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs148482834Ensembl.	1
Natural variantⁱVAR_037697	464	P → S. Corresponds to variant dbSNP:rs34129568Ensembl.	1
Natural variantⁱVAR_037698	485	S → G. Corresponds to variant dbSNP:rs35042658Ensembl.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BC028203 mRNA Translation: AAH28203.2 AB033019 mRNA Translation: BAA86507.2 Sequence problems.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS32855.1
NCBI Reference Sequences More...RefSeqⁱ	NP_060020.1, NM_017550.2
UniGeneⁱ	Hs.101891

Genome annotation databases

Ensemblⁱ	ENST00000264819; ENSP00000264819; ENSG00000105556
GeneIDⁱ	54531
KEGGⁱ	hsa:54531
UCSC genome browser More...UCSCⁱ	uc002lok.1 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q8N344	Uncharacterized protein		PAPAN		549	UniRef90_Q8N344
MIER family member 2		SAIBB		547
Mesoderm induction early response protein 2		CALJA		546
Uncharacterized protein		CERAT		545
MIER2 isoform 2		PONAB		545
+61

Protein	Similar proteins		Species	Score	Length	Source
Q8N344	Uncharacterized protein		PAPAN		549	UniRef50_Q8N344
MIER family member 2		SAIBB		547
Mesoderm induction early response protein 2		CALJA		546
MIER family member 2		RHIBE		545
Mesoderm induction early response protein 2		MACMU		545
+127

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BC028203 mRNA Translation: AAH28203.2 AB033019 mRNA Translation: BAA86507.2 Sequence problems.
CCDSⁱ	CCDS32855.1
RefSeqⁱ	NP_060020.1, NM_017550.2
UniGeneⁱ	Hs.101891

3D structure databases

ProteinModelPortalⁱ	Q8N344
SMRⁱ	Q8N344
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	120019, 32 interactors
IntActⁱ	Q8N344, 6 interactors
STRINGⁱ	9606.ENSP00000264819

PTM databases

iPTMnetⁱ	Q8N344
PhosphoSitePlusⁱ	Q8N344

Polymorphism and mutation databases

BioMutaⁱ	MIER2
DMDMⁱ	74750947

Proteomic databases

EPDⁱ	Q8N344
MaxQBⁱ	Q8N344
PaxDbⁱ	Q8N344
PeptideAtlasⁱ	Q8N344
PRIDEⁱ	Q8N344
ProteomicsDBⁱ	71762

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000264819; ENSP00000264819; ENSG00000105556
GeneIDⁱ	54531
KEGGⁱ	hsa:54531
UCSCⁱ	uc002lok.1 human

Organism-specific databases

CTDⁱ	54531
DisGeNETⁱ	54531
EuPathDBⁱ	HostDB:ENSG00000105556.10
GeneCardsⁱ	MIER2
H-InvDBⁱ	HIX0014549
HGNCⁱ	HGNC:29210 MIER2
HPAⁱ	HPA041439
neXtProtⁱ	NX_Q8N344
OpenTargetsⁱ	ENSG00000105556
PharmGKBⁱ	PA134925804
HUGEⁱ	Search...
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG4329 Eukaryota ENOG410Y9DJ LUCA
GeneTreeⁱ	ENSGT00510000046482
HOGENOMⁱ	HOG000015798
HOVERGENⁱ	HBG052923
InParanoidⁱ	Q8N344
OMAⁱ	WDPNILP
OrthoDBⁱ	EOG091G0BKH
PhylomeDBⁱ	Q8N344
TreeFamⁱ	TF106453

Miscellaneous databases

ChiTaRSⁱ	MIER2 human
GenomeRNAiⁱ	54531
Protein Ontology More...PROⁱ	PR:Q8N344

Gene expression databases

Bgeeⁱ	ENSG00000105556 Expressed in 159 organ(s), highest expression level in right testis
CleanExⁱ	HS_MIER2
ExpressionAtlasⁱ	Q8N344 baseline and differential
Genevisibleⁱ	Q8N344 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR000949 ELM2_dom IPR009057 Homeobox-like_sf IPR001005 SANT/Myb IPR017884 SANT_dom
Pfamⁱ	View protein in Pfam PF01448 ELM2, 1 hit
SMARTⁱ	View protein in SMART SM01189 ELM2, 1 hit SM00717 SANT, 1 hit
SUPFAMⁱ	SSF46689 SSF46689, 1 hit
PROSITEⁱ	View protein in PROSITE PS51156 ELM2, 1 hit PS51293 SANT, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	MIER2_HUMAN
Accessionⁱ	Q8N344Primary (citable) accession number: Q8N344 Secondary accession number(s): Q9ULM7
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
	Last sequence update:	July 5, 2004
	Last modified:	November 7, 2018
	This is version 123 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM

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UniProtKB - Q8N344 (MIER2_HUMAN)

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Mesoderm induction early response protein 2

MIER2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ