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Protein

Metallothionein-1M

Gene

MT1M

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi5Divalent metal cation; cluster B1
Metal bindingi7Divalent metal cation; cluster B1
Metal bindingi13Divalent metal cation; cluster B1
Metal bindingi15Divalent metal cation; cluster B1
Metal bindingi19Divalent metal cation; cluster B1
Metal bindingi21Divalent metal cation; cluster B1
Metal bindingi24Divalent metal cation; cluster B1
Metal bindingi26Divalent metal cation; cluster B1
Metal bindingi29Divalent metal cation; cluster B1
Metal bindingi33Divalent metal cation; cluster A1
Metal bindingi34Divalent metal cation; cluster A1
Metal bindingi36Divalent metal cation; cluster A1
Metal bindingi37Divalent metal cation; cluster A1
Metal bindingi41Divalent metal cation; cluster A1
Metal bindingi44Divalent metal cation; cluster A1
Metal bindingi48Divalent metal cation; cluster A1
Metal bindingi50Divalent metal cation; cluster A1
Metal bindingi57Divalent metal cation; cluster A1
Metal bindingi59Divalent metal cation; cluster A1
Metal bindingi60Divalent metal cation; cluster A1

GO - Molecular functioni

  • metal ion binding Source: GO_Central
  • zinc ion binding Source: UniProtKB

GO - Biological processi

Keywordsi

LigandCadmium, Copper, Metal-binding, Metal-thiolate cluster, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-5661231 Metallothioneins bind metals

Names & Taxonomyi

Protein namesi
Recommended name:
Metallothionein-1M
Short name:
MT-1M
Alternative name(s):
Metallothionein-IM
Short name:
MT-IM
Gene namesi
Name:MT1M
Synonyms:MT1K
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000205364.3
HGNCiHGNC:14296 MT1M
MIMi156357 gene
neXtProtiNX_Q8N339

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi4499
OpenTargetsiENSG00000205364
PharmGKBiPA142671312

Polymorphism and mutation databases

BioMutaiMT1M
DMDMi88913543

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002231801 – 61Metallothionein-1MAdd BLAST61

Proteomic databases

MaxQBiQ8N339
PaxDbiQ8N339
PeptideAtlasiQ8N339
PRIDEiQ8N339
ProteomicsDBi71761

PTM databases

iPTMnetiQ8N339
PhosphoSitePlusiQ8N339

Expressioni

Gene expression databases

BgeeiENSG00000205364 Expressed in 186 organ(s), highest expression level in tibial artery
CleanExiHS_MT1M
ExpressionAtlasiQ8N339 baseline and differential
GenevisibleiQ8N339 HS

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

BioGridi110605, 8 interactors
IntActiQ8N339, 7 interactors
STRINGi9606.ENSP00000369146

Structurei

3D structure databases

ProteinModelPortaliQ8N339
SMRiQ8N339
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 29BetaAdd BLAST29
Regioni30 – 61AlphaAdd BLAST32

Domaini

Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00920000150585
HOGENOMiHOG000236262
HOVERGENiHBG009063
InParanoidiQ8N339
KOiK14739
OMAiLENCSCC
PhylomeDBiQ8N339
TreeFamiTF336054

Family and domain databases

Gene3Di4.10.10.10, 1 hit
InterProiView protein in InterPro
IPR003019 Metalthion
IPR017854 Metalthion_dom_sf
IPR023587 Metalthion_dom_sf_vert
IPR000006 Metalthion_vert
IPR018064 Metalthion_vert_metal_BS
PANTHERiPTHR23299 PTHR23299, 1 hit
PfamiView protein in Pfam
PF00131 Metallothio, 1 hit
PRINTSiPR00860 MTVERTEBRATE
SUPFAMiSSF57868 SSF57868, 1 hit
PROSITEiView protein in PROSITE
PS00203 METALLOTHIONEIN_VRT, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8N339-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDPNCSCTTG VSCACTGSCT CKECKCTSCK KSCCSCCPVG CAKCAHGCVC
60
KGTLENCSCC A
Length:61
Mass (Da):6,110
Last modified:February 7, 2006 - v2
Checksum:i754753ED088411CE
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BUC6H3BUC6_HUMAN
Metallothionein
MT1M
69Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02531020T → K2 PublicationsCorresponds to variant dbSNP:rs1827210Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF136177 mRNA Translation: AAP97267.1
AF348671 Genomic DNA Translation: AAL83902.1
BC028280 mRNA Translation: AAH28280.1
BC103841 mRNA Translation: AAI03842.1
CCDSiCCDS42166.1
RefSeqiNP_789846.1, NM_176870.2
UniGeneiHs.647370

Genome annotation databases

EnsembliENST00000379818; ENSP00000369146; ENSG00000205364
GeneIDi4499
KEGGihsa:4499
UCSCiuc002ejn.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF136177 mRNA Translation: AAP97267.1
AF348671 Genomic DNA Translation: AAL83902.1
BC028280 mRNA Translation: AAH28280.1
BC103841 mRNA Translation: AAI03842.1
CCDSiCCDS42166.1
RefSeqiNP_789846.1, NM_176870.2
UniGeneiHs.647370

3D structure databases

ProteinModelPortaliQ8N339
SMRiQ8N339
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110605, 8 interactors
IntActiQ8N339, 7 interactors
STRINGi9606.ENSP00000369146

PTM databases

iPTMnetiQ8N339
PhosphoSitePlusiQ8N339

Polymorphism and mutation databases

BioMutaiMT1M
DMDMi88913543

Proteomic databases

MaxQBiQ8N339
PaxDbiQ8N339
PeptideAtlasiQ8N339
PRIDEiQ8N339
ProteomicsDBi71761

Protocols and materials databases

DNASUi4499
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000379818; ENSP00000369146; ENSG00000205364
GeneIDi4499
KEGGihsa:4499
UCSCiuc002ejn.4 human

Organism-specific databases

CTDi4499
DisGeNETi4499
EuPathDBiHostDB:ENSG00000205364.3
GeneCardsiMT1M
HGNCiHGNC:14296 MT1M
MIMi156357 gene
neXtProtiNX_Q8N339
OpenTargetsiENSG00000205364
PharmGKBiPA142671312
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00920000150585
HOGENOMiHOG000236262
HOVERGENiHBG009063
InParanoidiQ8N339
KOiK14739
OMAiLENCSCC
PhylomeDBiQ8N339
TreeFamiTF336054

Enzyme and pathway databases

ReactomeiR-HSA-5661231 Metallothioneins bind metals

Miscellaneous databases

GeneWikiiMT1M
GenomeRNAii4499
PROiPR:Q8N339
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000205364 Expressed in 186 organ(s), highest expression level in tibial artery
CleanExiHS_MT1M
ExpressionAtlasiQ8N339 baseline and differential
GenevisibleiQ8N339 HS

Family and domain databases

Gene3Di4.10.10.10, 1 hit
InterProiView protein in InterPro
IPR003019 Metalthion
IPR017854 Metalthion_dom_sf
IPR023587 Metalthion_dom_sf_vert
IPR000006 Metalthion_vert
IPR018064 Metalthion_vert_metal_BS
PANTHERiPTHR23299 PTHR23299, 1 hit
PfamiView protein in Pfam
PF00131 Metallothio, 1 hit
PRINTSiPR00860 MTVERTEBRATE
SUPFAMiSSF57868 SSF57868, 1 hit
PROSITEiView protein in PROSITE
PS00203 METALLOTHIONEIN_VRT, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMT1M_HUMAN
AccessioniPrimary (citable) accession number: Q8N339
Secondary accession number(s): Q8TDN3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: February 7, 2006
Last modified: November 7, 2018
This is version 129 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Metallothioneins
    Classification of metallothioneins and list of entries
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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