UniProtKB - Q8N336 (ELMD1_HUMAN)
Protein
ELMO domain-containing protein 1
Gene
ELMOD1
Organism
Homo sapiens (Human)
Status
Functioni
Acts as a GTPase-activating protein (GAP) toward guanine nucleotide exchange factors like ARL2, ARL3, ARF1 and ARF6, but not for GTPases outside the Arf family.1 Publication
GO - Molecular functioni
- GTPase activator activity Source: UniProtKB
Keywordsi
Molecular function | GTPase activation |
Enzyme and pathway databases
PathwayCommonsi | Q8N336 |
Names & Taxonomyi
Protein namesi | Recommended name: ELMO domain-containing protein 1 |
Gene namesi | Name:ELMOD1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000110675.12 |
HGNCi | HGNC:25334, ELMOD1 |
MIMi | 615456, gene |
neXtProti | NX_Q8N336 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 55531 |
OpenTargetsi | ENSG00000110675 |
PharmGKBi | PA134903991 |
Miscellaneous databases
Pharosi | Q8N336, Tbio |
Polymorphism and mutation databases
BioMutai | ELMOD1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000225014 | 1 – 334 | ELMO domain-containing protein 1Add BLAST | 334 |
Proteomic databases
MassIVEi | Q8N336 |
PaxDbi | Q8N336 |
PeptideAtlasi | Q8N336 |
PRIDEi | Q8N336 |
ProteomicsDBi | 34030 71760 [Q8N336-1] |
PTM databases
iPTMneti | Q8N336 |
PhosphoSitePlusi | Q8N336 |
Expressioni
Gene expression databases
Bgeei | ENSG00000110675, Expressed in caudate nucleus and 152 other tissues |
ExpressionAtlasi | Q8N336, baseline and differential |
Genevisiblei | Q8N336, HS |
Organism-specific databases
HPAi | ENSG00000110675, Group enriched (brain, pituitary gland, skin) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 120702, 9 interactors |
IntActi | Q8N336, 5 interactors |
STRINGi | 9606.ENSP00000265840 |
Miscellaneous databases
RNActi | Q8N336, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 133 – 314 | ELMOPROSITE-ProRule annotationAdd BLAST | 182 |
Phylogenomic databases
eggNOGi | KOG2998, Eukaryota |
GeneTreei | ENSGT00940000159782 |
HOGENOMi | CLU_056289_0_0_1 |
InParanoidi | Q8N336 |
OMAi | LVYFAEW |
OrthoDBi | 1282549at2759 |
PhylomeDBi | Q8N336 |
TreeFami | TF323472 |
Family and domain databases
InterProi | View protein in InterPro IPR006816, ELMO_dom IPR030722, ELMOD1 |
PANTHERi | PTHR12771:SF18, PTHR12771:SF18, 1 hit |
Pfami | View protein in Pfam PF04727, ELMO_CED12, 1 hit |
PROSITEi | View protein in PROSITE PS51335, ELMO, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: Q8N336-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MKHFLRMLIQ VCLYFYCKFL WRCLKFVMRK LTGRCELQRI CYNTKPGASR
60 70 80 90 100
TMKIETSLRD SKSKLLQTSV SVHPDAIEKT IEDIMELKKI NPDVNPQLGI
110 120 130 140 150
SLQACLLQIV GYRNLIADVE KLRREAYDSD NPQHEEMLLK LWKFLKPNTP
160 170 180 190 200
LESRISKQWC EIGFQGDDPK TDFRGMGLLG LYNLQYFAER DATAAQQVLS
210 220 230 240 250
DSLHPKCRDI TKEEISKFSK AEWEKKRMDK AIGYSFAIVG INITDLAYNL
260 270 280 290 300
LVSGALKTHF YNIAPEAPTL SHFQQTFCYL MHEFHKFWIE EDPMDIMEFN
310 320 330
RVREKFRKRI IKQLQNPDMA LCPHFAASEG LINM
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketE9PLM8 | E9PLM8_HUMAN | ELMO domain-containing protein 1 | ELMOD1 | 328 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_044832 | 1 – 136 | Missing in isoform 2. 1 PublicationAdd BLAST | 136 | |
Alternative sequenceiVSP_044833 | 208 – 215 | Missing in isoform 2 and isoform 3. 1 Publication | 8 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK303689 mRNA Translation: BAG64679.1 AP000889 Genomic DNA No translation available. AP002353 Genomic DNA No translation available. CH471065 Genomic DNA Translation: EAW67091.1 BC028725 mRNA Translation: AAH28725.3 AL359601 mRNA Translation: CAB94879.1 |
CCDSi | CCDS44723.1 [Q8N336-1] CCDS44724.1 [Q8N336-3] |
PIRi | T50627 |
RefSeqi | NP_001123509.1, NM_001130037.1 [Q8N336-3] NP_001294947.1, NM_001308018.1 NP_061182.3, NM_018712.3 [Q8N336-1] |
Genome annotation databases
Ensembli | ENST00000265840; ENSP00000265840; ENSG00000110675 [Q8N336-1] ENST00000443271; ENSP00000412257; ENSG00000110675 [Q8N336-3] |
GeneIDi | 55531 |
KEGGi | hsa:55531 |
UCSCi | uc001pjm.4, human [Q8N336-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK303689 mRNA Translation: BAG64679.1 AP000889 Genomic DNA No translation available. AP002353 Genomic DNA No translation available. CH471065 Genomic DNA Translation: EAW67091.1 BC028725 mRNA Translation: AAH28725.3 AL359601 mRNA Translation: CAB94879.1 |
CCDSi | CCDS44723.1 [Q8N336-1] CCDS44724.1 [Q8N336-3] |
PIRi | T50627 |
RefSeqi | NP_001123509.1, NM_001130037.1 [Q8N336-3] NP_001294947.1, NM_001308018.1 NP_061182.3, NM_018712.3 [Q8N336-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 120702, 9 interactors |
IntActi | Q8N336, 5 interactors |
STRINGi | 9606.ENSP00000265840 |
PTM databases
iPTMneti | Q8N336 |
PhosphoSitePlusi | Q8N336 |
Polymorphism and mutation databases
BioMutai | ELMOD1 |
Proteomic databases
MassIVEi | Q8N336 |
PaxDbi | Q8N336 |
PeptideAtlasi | Q8N336 |
PRIDEi | Q8N336 |
ProteomicsDBi | 34030 71760 [Q8N336-1] |
Protocols and materials databases
Antibodypediai | 45528, 121 antibodies |
DNASUi | 55531 |
Genome annotation databases
Ensembli | ENST00000265840; ENSP00000265840; ENSG00000110675 [Q8N336-1] ENST00000443271; ENSP00000412257; ENSG00000110675 [Q8N336-3] |
GeneIDi | 55531 |
KEGGi | hsa:55531 |
UCSCi | uc001pjm.4, human [Q8N336-1] |
Organism-specific databases
CTDi | 55531 |
DisGeNETi | 55531 |
EuPathDBi | HostDB:ENSG00000110675.12 |
GeneCardsi | ELMOD1 |
HGNCi | HGNC:25334, ELMOD1 |
HPAi | ENSG00000110675, Group enriched (brain, pituitary gland, skin) |
MIMi | 615456, gene |
neXtProti | NX_Q8N336 |
OpenTargetsi | ENSG00000110675 |
PharmGKBi | PA134903991 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2998, Eukaryota |
GeneTreei | ENSGT00940000159782 |
HOGENOMi | CLU_056289_0_0_1 |
InParanoidi | Q8N336 |
OMAi | LVYFAEW |
OrthoDBi | 1282549at2759 |
PhylomeDBi | Q8N336 |
TreeFami | TF323472 |
Enzyme and pathway databases
PathwayCommonsi | Q8N336 |
Miscellaneous databases
BioGRID-ORCSi | 55531, 6 hits in 848 CRISPR screens |
ChiTaRSi | ELMOD1, human |
GenomeRNAii | 55531 |
Pharosi | Q8N336, Tbio |
PROi | PR:Q8N336 |
RNActi | Q8N336, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000110675, Expressed in caudate nucleus and 152 other tissues |
ExpressionAtlasi | Q8N336, baseline and differential |
Genevisiblei | Q8N336, HS |
Family and domain databases
InterProi | View protein in InterPro IPR006816, ELMO_dom IPR030722, ELMOD1 |
PANTHERi | PTHR12771:SF18, PTHR12771:SF18, 1 hit |
Pfami | View protein in Pfam PF04727, ELMO_CED12, 1 hit |
PROSITEi | View protein in PROSITE PS51335, ELMO, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ELMD1_HUMAN | |
Accessioni | Q8N336Primary (citable) accession number: Q8N336 Secondary accession number(s): B4E167, G5E9S5, Q9NPW3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 7, 2006 |
Last sequence update: | March 7, 2006 | |
Last modified: | December 2, 2020 | |
This is version 131 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM