GPD1L

Functionⁱ

Plays a role in regulating cardiac sodium current; decreased enzymatic activity with resulting increased levels of glycerol 3-phosphate activating the DPD1L-dependent SCN5A phosphorylation pathway, may ultimately lead to decreased sodium current; cardiac sodium current may also be reduced due to alterations of NAD(H) balance induced by DPD1L.2 Publications

Catalytic activityⁱ

sn-glycerol 3-phosphate + NAD⁺ = glycerone phosphate + NADH.

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	43	NADBy similarity	1
Binding siteⁱ	99	NADBy similarity	1
Binding siteⁱ	122	SubstrateBy similarity	1
Binding siteⁱ	155	NAD; via amide nitrogen1 Publication	1
Active siteⁱ	206	Proton acceptor	1
Binding siteⁱ	271	NADBy similarity	1
Binding siteⁱ	298	NAD; via amide nitrogen1 Publication	1
Binding siteⁱ	300	NADBy similarity	1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	12 – 17	NAD1 Publication		6

GO - Molecular functionⁱ

glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
glycerol-3-phosphate dehydrogenase [NAD+] activity Source: Reactome
ion channel binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 19666841
NAD binding Source: InterPro
protein homodimerization activity Source: InterPro
sodium channel regulator activity
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 17967977
- 19666841

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

carbohydrate metabolic process Source: InterPro
glycerol-3-phosphate catabolic process Source: InterPro
glycerol-3-phosphate metabolic process
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
NADH oxidation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
NAD metabolic process
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 19745168
negative regulation of peptidyl-serine phosphorylation
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 19666841
negative regulation of protein kinase C signaling
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 19666841
phosphatidic acid biosynthetic process Source: Reactome
positive regulation of protein localization to cell surface
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 17967977
- 19666841
positive regulation of sodium ion transport
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
regulation of heart rate
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 17967977
- 19666841
regulation of sodium ion transmembrane transporter activity
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 17967977
- 19666841
regulation of ventricular cardiac muscle cell membrane depolarization
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 17967977
- 19666841
ventricular cardiac muscle cell action potential
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 17967977
- 19666841

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Oxidoreductase
Ligand	NAD

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1483166 Synthesis of PA

Reactomeⁱ

R-HSA-1483166 Synthesis of PA

Chemistry databases

SwissLipidsⁱ	SLP:000000146

SwissLipidsⁱ

SLP:000000146

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Glycerol-3-phosphate dehydrogenase 1-like protein (EC:1.1.1.8) Short name: GPD1-L
Gene namesⁱ	Name:GPD1L Synonyms:KIAA0089
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 3

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000152642.10
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:28956 GPD1L
MIMⁱ	611778 gene
neXtProtⁱ	NX_Q8N335

Keywords - Cellular componentⁱ

Cytoplasm

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Brugada syndrome 2 (BRGDA2)4 Publications

The gene represented in this entry may be involved in disease pathogenesis.

Disease descriptionA tachyarrhythmia characterized by right bundle branch block and ST segment elevation on an electrocardiogram (ECG). It can cause the ventricles to beat so fast that the blood is prevented from circulating efficiently in the body. When this situation occurs, the individual will faint and may die in a few minutes if the heart is not reset.

Keywords - Diseaseⁱ

Brugada syndrome, Disease mutation

Organism-specific databases

DisGeNET More...DisGeNETⁱ	23171
GeneReviewsⁱ	GPD1L
MalaCards human disease database More...MalaCardsⁱ	GPD1L
MIMⁱ	611777 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000152642
Orphanetⁱ	130 Brugada syndrome
PharmGKBⁱ	PA134986345

Polymorphism and mutation databases

BioMutaⁱ	GPD1L
DMDMⁱ	74750945

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000286511	1 – 351	Glycerol-3-phosphate dehydrogenase 1-like proteinAdd BLAST		351

Proteomic databases

EPDⁱ	Q8N335
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q8N335
PaxDbⁱ	Q8N335
PeptideAtlas More...PeptideAtlasⁱ	Q8N335
PRIDEⁱ	Q8N335
ProteomicsDBⁱ	71759

PTM databases

iPTMnetⁱ	Q8N335
PhosphoSitePlusⁱ	Q8N335

Expressionⁱ

Tissue specificityⁱ

Gene expression databases

Bgeeⁱ	ENSG00000152642 Expressed in 231 organ(s), highest expression level in myocardium
CleanExⁱ	HS_GPD1L
ExpressionAtlasⁱ	Q8N335 baseline and differential
Genevisibleⁱ	Q8N335 HS

Interactionⁱ

Subunit structureⁱ

Interacts with SCN5A.2 Publications

GO - Molecular functionⁱ

ion channel binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 19666841
protein homodimerization activity Source: InterPro

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	116783, 37 interactors
IntActⁱ	Q8N335, 1 interactor
STRINGⁱ	9606.ENSP00000282541

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	8 – 11	Combined sources	4
Helixⁱ	15 – 28	Combined sources	14
Beta strandⁱ	38 – 41	Combined sources	4
Helixⁱ	52 – 59	Combined sources	8
Turnⁱ	63 – 65	Combined sources	3
Beta strandⁱ	75 – 79	Combined sources	5
Helixⁱ	81 – 85	Combined sources	5
Beta strandⁱ	89 – 93	Combined sources	5
Helixⁱ	97 – 99	Combined sources	3
Helixⁱ	100 – 107	Combined sources	8
Beta strandⁱ	116 – 119	Combined sources	4
Beta strandⁱ	124 – 127	Combined sources	4
Beta strandⁱ	130 – 133	Combined sources	4
Helixⁱ	134 – 142	Combined sources	9
Beta strandⁱ	144 – 152	Combined sources	9
Helixⁱ	155 – 159	Combined sources	5
Beta strandⁱ	164 – 169	Combined sources	6
Helixⁱ	173 – 183	Combined sources	11
Beta strandⁱ	188 – 194	Combined sources	7
Helixⁱ	196 – 218	Combined sources	23
Helixⁱ	223 – 244	Combined sources	22
Beta strandⁱ	245 – 247	Combined sources	3
Helixⁱ	251 – 254	Combined sources	4
Turnⁱ	257 – 259	Combined sources	3
Helixⁱ	260 – 269	Combined sources	10
Helixⁱ	271 – 282	Combined sources	12
Helixⁱ	286 – 294	Combined sources	9
Helixⁱ	301 – 315	Combined sources	15
Helixⁱ	318 – 320	Combined sources	3
Helixⁱ	322 – 332	Combined sources	11
Helixⁱ	339 – 345	Combined sources	7

Show more details

3D structure databases

ProteinModelPortalⁱ	Q8N335
SMRⁱ	Q8N335
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q8N335

EvolutionaryTraceⁱ

Q8N335

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	271 – 272	Substrate binding		2

Sequence similaritiesⁱ

Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.Curated

Phylogenomic databases

eggNOGⁱ	KOG2711 Eukaryota COG0240 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000003114
HOGENOMⁱ	HOG000246855
HOVERGENⁱ	HBG003669
InParanoidⁱ	Q8N335
KEGG Orthology (KO) More...KOⁱ	K00006
OMAⁱ	NFRSAKH
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0DO6
PhylomeDBⁱ	Q8N335
TreeFamⁱ	TF300836

Family and domain databases

Gene3Dⁱ	1.10.1040.10, 1 hit
InterProⁱ	View protein in InterPro IPR008927 6-PGluconate_DH-like_C_sf IPR013328 6PGD_dom2 IPR006168 G3P_DH_NAD-dep IPR006109 G3P_DH_NAD-dep_C IPR017751 G3P_DH_NAD-dep_euk IPR011128 G3P_DH_NAD-dep_N IPR036291 NAD(P)-bd_dom_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07479 NAD_Gly3P_dh_C, 1 hit PF01210 NAD_Gly3P_dh_N, 1 hit
PIRSFⁱ	PIRSF000114 Glycerol-3-P_dh, 1 hit
PRINTSⁱ	PR00077 GPDHDRGNASE
SUPFAMⁱ	SSF48179 SSF48179, 1 hit SSF51735 SSF51735, 1 hit
TIGRFAMsⁱ	TIGR03376 glycerol3P_DH, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show all Align All

Q8N335-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAAAPLKVCI VGSGNWGSAV AKIIGNNVKK LQKFASTVKM WVFEETVNGR 
        60         70         80         90        100
KLTDIINNDH ENVKYLPGHK LPENVVAMSN LSEAVQDADL LVFVIPHQFI 
       110        120        130        140        150
HRICDEITGR VPKKALGITL IKGIDEGPEG LKLISDIIRE KMGIDISVLM 
       160        170        180        190        200
GANIANEVAA EKFCETTIGS KVMENGLLFK ELLQTPNFRI TVVDDADTVE 
       210        220        230        240        250
LCGALKNIVA VGAGFCDGLR CGDNTKAAVI RLGLMEMIAF ARIFCKGQVS 
       260        270        280        290        300
TATFLESCGV ADLITTCYGG RNRRVAEAFA RTGKTIEELE KEMLNGQKLQ 
       310        320        330        340        350
GPQTSAEVYR ILKQKGLLDK FPLFTAVYQI CYESRPVQEM LSCLQSHPEH 

T

Length:351

Mass (Da):38,419

Last modified:October 1, 2002 - v1

Checksum:ⁱ74C3B27EEB41DE89

GO

Computationally mapped potential isoform sequencesⁱ

There are 4 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

C9JM46	C9JM46_HUMAN	Glycerol-3-phosphate dehydrogenase ... Glycerol-3-phosphate dehydrogenase [NAD(+)], EC 1.1.1.8	GPD1L	173	Annotation score:
C9JFA7	C9JFA7_HUMAN	Glycerol-3-phosphate dehydrogenase ... Glycerol-3-phosphate dehydrogenase 1-like protein	GPD1L	144	Annotation score:
C9K0P5	C9K0P5_HUMAN	Glycerol-3-phosphate dehydrogenase ... Glycerol-3-phosphate dehydrogenase 1-like protein	GPD1L	127	Annotation score:
F8WC16	F8WC16_HUMAN	Glycerol-3-phosphate dehydrogenase ... Glycerol-3-phosphate dehydrogenase 1-like protein	GPD1L	64	Annotation score:

Sequence cautionⁱ

The sequence BAA07648 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_044044	83	E → K in BRGDA2; unknown pathological significance; decreased enzymatic activity and significant reduction of sodium current when coexpressed with SCN5A in HEK cells. 2 PublicationsCorresponds to variant dbSNP:rs72552292EnsemblClinVar.	1
Natural variantⁱVAR_044045	124	I → V in BRGDA2; unknown pathological significance; significant reduction of sodium current when coexpressed with SCN5A in HEK cells. 1 PublicationCorresponds to variant dbSNP:rs72552293EnsemblClinVar.	1
Natural variantⁱVAR_032114	178	L → F. Corresponds to variant dbSNP:rs35447795Ensembl.	1
Natural variantⁱVAR_044046	273	R → C in BRGDA2; unknown pathological significance; significant reduction of sodium current when coexpressed with SCN5A in HEK cells. 1 PublicationCorresponds to variant dbSNP:rs72552294EnsemblClinVar.	1
Natural variantⁱVAR_044047	280	A → V in BRGDA2; unknown pathological significance; decreased enzymatic activity; affects SCN5A membrane expression; reduction of sodium current when coexpressed with SCN5A in HEK cells. 3 PublicationsCorresponds to variant dbSNP:rs72552291EnsemblClinVar.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	D42047 mRNA Translation: BAA07648.1 Different initiation. AK292808 mRNA Translation: BAF85497.1 CH471055 Genomic DNA Translation: EAW64422.1 BC006168 mRNA Translation: AAH06168.1 BC028726 mRNA Translation: AAH28726.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS33729.1
NCBI Reference Sequences More...RefSeqⁱ	NP_055956.1, NM_015141.3
UniGeneⁱ	Hs.82432

Genome annotation databases

Ensemblⁱ	ENST00000282541; ENSP00000282541; ENSG00000152642
GeneIDⁱ	23171
KEGGⁱ	hsa:23171
UCSC genome browser More...UCSCⁱ	uc003cew.4 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q8N335	Glycerol-3-phosphate dehydrogenase [NAD(+)]		PANTR		351	UniRef100_Q8N335
Glycerol-3-phosphate dehydrogenase [NAD(+)]		PANPA		351
Glycerol-3-phosphate dehydrogenase 1-like protein (Fragment)		HUMAN		144
GPD1L isoform 5 (Fragment)		PANTR		144
Glycerol-3-phosphate dehydrogenase [NAD(+)]		PANTR		281
+3

Protein	Similar proteins		Species	Score	Length	Source
Q8N335	Glycerol-3-phosphate dehydrogenase 1-like protein		MOUSE		351	UniRef90_Q8N335
Glycerol-3-phosphate dehydrogenase 1-like protein		PONAB		351
Glycerol-3-phosphate dehydrogenase [NAD(+)]		PANTR		351
Glycerol-3-phosphate dehydrogenase [NAD(+)]		PANPA		351
Glycerol-3-phosphate dehydrogenase 1-like protein (Fragment)		HUMAN		144
+133

Protein	Similar proteins		Species	Score	Length	Source
Q8N335	Glycerol-3-phosphate dehydrogenase 1-like protein		PONAB		351	UniRef50_Q8N335
Glycerol-3-phosphate dehydrogenase 1-like protein		MOUSE		351
Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic		TAKRU		351
Glycerol-3-phosphate dehydrogenase [NAD(+)]		PANTR		351
Glycerol-3-phosphate dehydrogenase [NAD(+)]		PANPA		351
+482

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	D42047 mRNA Translation: BAA07648.1 Different initiation. AK292808 mRNA Translation: BAF85497.1 CH471055 Genomic DNA Translation: EAW64422.1 BC006168 mRNA Translation: AAH06168.1 BC028726 mRNA Translation: AAH28726.1
CCDSⁱ	CCDS33729.1
RefSeqⁱ	NP_055956.1, NM_015141.3
UniGeneⁱ	Hs.82432

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2PLA	X-ray	2.51	A/B	1-349	[»]
ProteinModelPortalⁱ	Q8N335
SMRⁱ	Q8N335
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	116783, 37 interactors
IntActⁱ	Q8N335, 1 interactor
STRINGⁱ	9606.ENSP00000282541

Chemistry databases

SwissLipidsⁱ	SLP:000000146

SwissLipidsⁱ

SLP:000000146

PTM databases

iPTMnetⁱ	Q8N335
PhosphoSitePlusⁱ	Q8N335

Polymorphism and mutation databases

BioMutaⁱ	GPD1L
DMDMⁱ	74750945

Proteomic databases

EPDⁱ	Q8N335
MaxQBⁱ	Q8N335
PaxDbⁱ	Q8N335
PeptideAtlasⁱ	Q8N335
PRIDEⁱ	Q8N335
ProteomicsDBⁱ	71759

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000282541; ENSP00000282541; ENSG00000152642
GeneIDⁱ	23171
KEGGⁱ	hsa:23171
UCSCⁱ	uc003cew.4 human

Organism-specific databases

CTDⁱ	23171
DisGeNETⁱ	23171
EuPathDBⁱ	HostDB:ENSG00000152642.10
GeneCardsⁱ	GPD1L
GeneReviewsⁱ	GPD1L
HGNCⁱ	HGNC:28956 GPD1L
MalaCardsⁱ	GPD1L
MIMⁱ	611777 phenotype 611778 gene
neXtProtⁱ	NX_Q8N335
OpenTargetsⁱ	ENSG00000152642
Orphanetⁱ	130 Brugada syndrome
PharmGKBⁱ	PA134986345
HUGEⁱ	Search...
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG2711 Eukaryota COG0240 LUCA
GeneTreeⁱ	ENSGT00390000003114
HOGENOMⁱ	HOG000246855
HOVERGENⁱ	HBG003669
InParanoidⁱ	Q8N335
KOⁱ	K00006
OMAⁱ	NFRSAKH
OrthoDBⁱ	EOG091G0DO6
PhylomeDBⁱ	Q8N335
TreeFamⁱ	TF300836

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1483166 Synthesis of PA

Reactomeⁱ

R-HSA-1483166 Synthesis of PA

Miscellaneous databases

ChiTaRSⁱ	GPD1L human
EvolutionaryTraceⁱ	Q8N335
GenomeRNAiⁱ	23171
Protein Ontology More...PROⁱ	PR:Q8N335
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000152642 Expressed in 231 organ(s), highest expression level in myocardium
CleanExⁱ	HS_GPD1L
ExpressionAtlasⁱ	Q8N335 baseline and differential
Genevisibleⁱ	Q8N335 HS

Family and domain databases

Gene3Dⁱ	1.10.1040.10, 1 hit
InterProⁱ	View protein in InterPro IPR008927 6-PGluconate_DH-like_C_sf IPR013328 6PGD_dom2 IPR006168 G3P_DH_NAD-dep IPR006109 G3P_DH_NAD-dep_C IPR017751 G3P_DH_NAD-dep_euk IPR011128 G3P_DH_NAD-dep_N IPR036291 NAD(P)-bd_dom_sf
Pfamⁱ	View protein in Pfam PF07479 NAD_Gly3P_dh_C, 1 hit PF01210 NAD_Gly3P_dh_N, 1 hit
PIRSFⁱ	PIRSF000114 Glycerol-3-P_dh, 1 hit
PRINTSⁱ	PR00077 GPDHDRGNASE
SUPFAMⁱ	SSF48179 SSF48179, 1 hit SSF51735 SSF51735, 1 hit
TIGRFAMsⁱ	TIGR03376 glycerol3P_DH, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	GPD1L_HUMAN
Accessionⁱ	Q8N335Primary (citable) accession number: Q8N335 Secondary accession number(s): A8K9U3, Q14702, Q9BRM5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 15, 2007
	Last sequence update:	October 1, 2002
	Last modified:	November 7, 2018
	This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

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UniProtKB - Q8N335 (GPD1L_HUMAN)

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Glycerol-3-phosphate dehydrogenase 1-like protein

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Chemistry databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Cytosol

Extracellular region or secreted

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ