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UniProtKB - Q8N328 (PGBD3_HUMAN)
Protein
PiggyBac transposable element-derived protein 3
Gene
PGBD3
Organism
Homo sapiens (Human)
Status
Functioni
Binds in vitro to PGBD3-related transposable elements, called MER85s; these non-autonomous 140 bp elements are characterized by the presence of PGBD3 terminal inverted repeats and the absence of internal transposase ORF.
1 PublicationMiscellaneous
PGBD3 gene is located within ERCC6 intron 5.1 Publication
GO - Molecular functioni
- sequence-specific DNA binding Source: UniProtKB
Keywordsi
Molecular function | DNA-binding |
Enzyme and pathway databases
PathwayCommonsi | Q8N328 |
SignaLinki | Q8N328 |
Names & Taxonomyi
Protein namesi | Recommended name: PiggyBac transposable element-derived protein 3 |
Gene namesi | Name:PGBD3 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:19400, PGBD3 |
MIMi | 609413, gene |
neXtProti | NX_Q8N328 |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Nucleus
- nucleus Source: UniProtKB-SubCell
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 267004 |
MalaCardsi | PGBD3 |
PharmGKBi | PA134927747 |
Miscellaneous databases
Pharosi | Q8N328, Tbio |
Genetic variation databases
BioMutai | HGNC:19400 |
DMDMi | 296439278 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000288054 | 1 – 593 | PiggyBac transposable element-derived protein 3Add BLAST | 593 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 86 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q8N328 |
jPOSTi | Q8N328 |
MassIVEi | Q8N328 |
MaxQBi | Q8N328 |
PaxDbi | Q8N328 |
PeptideAtlasi | Q8N328 |
PRIDEi | Q8N328 |
ProteomicsDBi | 71758 |
PTM databases
iPTMneti | Q8N328 |
PhosphoSitePlusi | Q8N328 |
Expressioni
Tissue specificityi
Expressed in heart and oocytes, but not in granulosa cells (at protein level).1 Publication
Gene expression databases
Bgeei | ENSG00000243251, Expressed in skeletal muscle tissue and 109 other tissues |
ExpressionAtlasi | Q8N328, baseline and differential |
Genevisiblei | Q8N328, HS |
Interactioni
Protein-protein interaction databases
BioGRIDi | 129356, 6 interactors |
IntActi | Q8N328, 1 interactor |
Miscellaneous databases
RNActi | Q8N328, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 27 – 53 | DisorderedSequence analysisAdd BLAST | 27 | |
Regioni | 69 – 105 | DisorderedSequence analysisAdd BLAST | 37 |
Phylogenomic databases
HOGENOMi | CLU_013052_2_2_1 |
InParanoidi | Q8N328 |
TreeFami | TF328011 |
Family and domain databases
InterProi | View protein in InterPro IPR029526, PGBD |
Pfami | View protein in Pfam PF13843, DDE_Tnp_1_7, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform PGBD3 (identifier: Q8N328-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MPRTLSLHEI TDLLETDDSI EASAIVIQPP ENATAPVSDE ESGDEEGGTI
60 70 80 90 100
NNLPGSLLHT AAYLIQDGSD AESDSDDPSY APKDDSPDEV PSTFTVQQPP
110 120 130 140 150
PSRRRKMTKI LCKWKKADLT VQPVAGRVTA PPNDFFTVMR TPTEILELFL
160 170 180 190 200
DDEVIELIVK YSNLYACSKG VHLGLTSSEF KCFLGIIFLS GYVSVPRRRM
210 220 230 240 250
FWEQRTDVHN VLVSAAMRRD RFETIFSNLH VADNANLDPV DKFSKLRPLI
260 270 280 290 300
SKLNERCMKF VPNETYFSFD EFMVPYFGRH GCKQFIRGKP IRFGYKFWCG
310 320 330 340 350
ATCLGYICWF QPYQGKNPNT KHEEYGVGAS LVLQFSEALT EAHPGQYHFV
360 370 380 390 400
FNNFFTSIAL LDKLSSMGHQ ATGTVRKDHI DRVPLESDVA LKKKERGTFD
410 420 430 440 450
YRIDGKGNIV CRWNDNSVVT VASSGAGIHP LCLVSRYSQK LKKKIQVQQP
460 470 480 490 500
NMIKVYNQFM GGVDRADENI DKYRASIRGK KWYSSPLLFC FELVLQNAWQ
510 520 530 540 550
LHKTYDEKPV DFLEFRRRVV CHYLETHGHP PEPGQKGRPQ KRNIDSRYDG
560 570 580 590
INHVIVKQGK QTRCAECHKN TTFRCEKCDV ALHVKCSVEY HTE
Isoform CSB-PGBD31 Publication (identifier: P0DP91-1) [UniParc] [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry P0DP91.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_032391 | 382 | R → K2 PublicationsCorresponds to variant dbSNP:rs4253072Ensembl. | 1 | |
Natural variantiVAR_035621 | 415 | D → G in a breast cancer sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_051274 | 446 | Q → E. Corresponds to variant dbSNP:rs11101143Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK074682 mRNA Translation: BAG51986.1 AL138760 Genomic DNA No translation available. BC028954 mRNA Translation: AAH28954.2 BC063690 mRNA Translation: AAH63690.1 |
CCDSi | CCDS7230.1 [Q8N328-1] |
RefSeqi | NP_736609.2, NM_170753.3 [Q8N328-1] |
Genome annotation databases
GeneIDi | 267004 |
KEGGi | hsa:267004 |
UCSCi | uc057tet.1, human [Q8N328-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK074682 mRNA Translation: BAG51986.1 AL138760 Genomic DNA No translation available. BC028954 mRNA Translation: AAH28954.2 BC063690 mRNA Translation: AAH63690.1 |
CCDSi | CCDS7230.1 [Q8N328-1] |
RefSeqi | NP_736609.2, NM_170753.3 [Q8N328-1] |
3D structure databases
AlphaFoldDBi | Q8N328 |
SMRi | Q8N328 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 129356, 6 interactors |
IntActi | Q8N328, 1 interactor |
PTM databases
iPTMneti | Q8N328 |
PhosphoSitePlusi | Q8N328 |
Genetic variation databases
BioMutai | HGNC:19400 |
DMDMi | 296439278 |
Proteomic databases
EPDi | Q8N328 |
jPOSTi | Q8N328 |
MassIVEi | Q8N328 |
MaxQBi | Q8N328 |
PaxDbi | Q8N328 |
PeptideAtlasi | Q8N328 |
PRIDEi | Q8N328 |
ProteomicsDBi | 71758 |
Protocols and materials databases
DNASUi | 267004 |
Genome annotation databases
GeneIDi | 267004 |
KEGGi | hsa:267004 |
UCSCi | uc057tet.1, human [Q8N328-1] |
Organism-specific databases
CTDi | 267004 |
DisGeNETi | 267004 |
GeneCardsi | PGBD3 |
HGNCi | HGNC:19400, PGBD3 |
MalaCardsi | PGBD3 |
MIMi | 609413, gene |
neXtProti | NX_Q8N328 |
PharmGKBi | PA134927747 |
GenAtlasi | Search... |
Phylogenomic databases
HOGENOMi | CLU_013052_2_2_1 |
InParanoidi | Q8N328 |
TreeFami | TF328011 |
Enzyme and pathway databases
PathwayCommonsi | Q8N328 |
SignaLinki | Q8N328 |
Miscellaneous databases
BioGRID-ORCSi | 2074, 26 hits in 1068 CRISPR screens 267004, 30 hits in 1062 CRISPR screens |
Pharosi | Q8N328, Tbio |
PROi | PR:Q8N328 |
RNActi | Q8N328, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000243251, Expressed in skeletal muscle tissue and 109 other tissues |
ExpressionAtlasi | Q8N328, baseline and differential |
Genevisiblei | Q8N328, HS |
Family and domain databases
InterProi | View protein in InterPro IPR029526, PGBD |
Pfami | View protein in Pfam PF13843, DDE_Tnp_1_7, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PGBD3_HUMAN | |
Accessioni | Q8N328Primary (citable) accession number: Q8N328 Secondary accession number(s): B3KQC4, Q5W0M0, Q6PIH0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 29, 2007 |
Last sequence update: | May 18, 2010 | |
Last modified: | May 25, 2022 | |
This is version 127 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot