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UniProtKB - Q8N328 (PGBD3_HUMAN)

Entry version 127 (25 May 2022)
Sequence version 3 (18 May 2010)
Previous versions | rss
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Protein

PiggyBac transposable element-derived protein 3

Gene

PGBD3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binds in vitro to PGBD3-related transposable elements, called MER85s; these non-autonomous 140 bp elements are characterized by the presence of PGBD3 terminal inverted repeats and the absence of internal transposase ORF.

1 Publication

Miscellaneous

PGBD3 gene is located within ERCC6 intron 5.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q8N328

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q8N328

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
PiggyBac transposable element-derived protein 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PGBD3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:19400, PGBD3

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		609413, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8N328

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		267004

MalaCards human disease database

More...MalaCardsi		PGBD3

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134927747

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q8N328, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		HGNC:19400

Domain mapping of disease mutations (DMDM)

More...DMDMi		296439278

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002880541 – 593PiggyBac transposable element-derived protein 3Add BLAST593

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei86PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q8N328

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q8N328

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q8N328

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q8N328

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8N328

PeptideAtlas

More...PeptideAtlasi		Q8N328

PRoteomics IDEntifications database

More...PRIDEi		Q8N328

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		71758

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8N328

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8N328

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in heart and oocytes, but not in granulosa cells (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000243251, Expressed in skeletal muscle tissue and 109 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q8N328, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8N328, HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		129356, 6 interactors

Protein interaction database and analysis system

More...IntActi		Q8N328, 1 interactor

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8N328, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q8N328

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8N328

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni27 – 53DisorderedSequence analysisAdd BLAST27
Regioni69 – 105DisorderedSequence analysisAdd BLAST37

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_013052_2_2_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8N328

TreeFam database of animal gene trees

More...TreeFami		TF328011

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR029526, PGBD

Pfam protein domain database

More...Pfami		View protein in Pfam
PF13843, DDE_Tnp_1_7, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform PGBD3 (identifier: Q8N328-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPRTLSLHEI TDLLETDDSI EASAIVIQPP ENATAPVSDE ESGDEEGGTI 
        60         70         80         90        100
NNLPGSLLHT AAYLIQDGSD AESDSDDPSY APKDDSPDEV PSTFTVQQPP 
       110        120        130        140        150
PSRRRKMTKI LCKWKKADLT VQPVAGRVTA PPNDFFTVMR TPTEILELFL 
       160        170        180        190        200
DDEVIELIVK YSNLYACSKG VHLGLTSSEF KCFLGIIFLS GYVSVPRRRM 
       210        220        230        240        250
FWEQRTDVHN VLVSAAMRRD RFETIFSNLH VADNANLDPV DKFSKLRPLI 
       260        270        280        290        300
SKLNERCMKF VPNETYFSFD EFMVPYFGRH GCKQFIRGKP IRFGYKFWCG 
       310        320        330        340        350
ATCLGYICWF QPYQGKNPNT KHEEYGVGAS LVLQFSEALT EAHPGQYHFV 
       360        370        380        390        400
FNNFFTSIAL LDKLSSMGHQ ATGTVRKDHI DRVPLESDVA LKKKERGTFD 
       410        420        430        440        450
YRIDGKGNIV CRWNDNSVVT VASSGAGIHP LCLVSRYSQK LKKKIQVQQP 
       460        470        480        490        500
NMIKVYNQFM GGVDRADENI DKYRASIRGK KWYSSPLLFC FELVLQNAWQ 
       510        520        530        540        550
LHKTYDEKPV DFLEFRRRVV CHYLETHGHP PEPGQKGRPQ KRNIDSRYDG 
       560        570        580        590 
INHVIVKQGK QTRCAECHKN TTFRCEKCDV ALHVKCSVEY HTE
Length:593
Mass (Da):67,595
Last modified:May 18, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB2387127F9A9A369
GO
Isoform CSB-PGBD31 Publication (identifier: P0DP91-1) [UniParc] [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry P0DP91.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:1,061
Mass (Da):119,487
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_032391382R → K2 PublicationsCorresponds to variant dbSNP:rs4253072Ensembl.1
Natural variantiVAR_035621415D → G in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_051274446Q → E. Corresponds to variant dbSNP:rs11101143Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK074682 mRNA Translation: BAG51986.1
AL138760 Genomic DNA No translation available.
BC028954 mRNA Translation: AAH28954.2
BC063690 mRNA Translation: AAH63690.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS7230.1 [Q8N328-1]

NCBI Reference Sequences

More...RefSeqi		NP_736609.2, NM_170753.3 [Q8N328-1]

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...GeneIDi		267004

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:267004

UCSC genome browser

More...UCSCi		uc057tet.1, human [Q8N328-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074682 mRNA Translation: BAG51986.1
AL138760 Genomic DNA No translation available.
BC028954 mRNA Translation: AAH28954.2
BC063690 mRNA Translation: AAH63690.1
CCDSiCCDS7230.1 [Q8N328-1]
RefSeqiNP_736609.2, NM_170753.3 [Q8N328-1]

3D structure databases

AlphaFoldDBiQ8N328
SMRiQ8N328
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi129356, 6 interactors
IntActiQ8N328, 1 interactor

PTM databases

iPTMnetiQ8N328
PhosphoSitePlusiQ8N328

Genetic variation databases

BioMutaiHGNC:19400
DMDMi296439278

Proteomic databases

EPDiQ8N328
jPOSTiQ8N328
MassIVEiQ8N328
MaxQBiQ8N328
PaxDbiQ8N328
PeptideAtlasiQ8N328
PRIDEiQ8N328
ProteomicsDBi71758

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		267004

Genome annotation databases

GeneIDi267004
KEGGihsa:267004
UCSCiuc057tet.1, human [Q8N328-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		267004
DisGeNETi267004

GeneCards: human genes, protein and diseases

More...GeneCardsi		PGBD3
HGNCiHGNC:19400, PGBD3
MalaCardsiPGBD3
MIMi609413, gene
neXtProtiNX_Q8N328
PharmGKBiPA134927747

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

HOGENOMiCLU_013052_2_2_1
InParanoidiQ8N328
TreeFamiTF328011

Enzyme and pathway databases

PathwayCommonsiQ8N328
SignaLinkiQ8N328

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		2074, 26 hits in 1068 CRISPR screens
267004, 30 hits in 1062 CRISPR screens
PharosiQ8N328, Tbio

Protein Ontology

More...PROi		PR:Q8N328
RNActiQ8N328, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000243251, Expressed in skeletal muscle tissue and 109 other tissues
ExpressionAtlasiQ8N328, baseline and differential
GenevisibleiQ8N328, HS

Family and domain databases

InterProiView protein in InterPro
IPR029526, PGBD
PfamiView protein in Pfam
PF13843, DDE_Tnp_1_7, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPGBD3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8N328
Secondary accession number(s): B3KQC4, Q5W0M0, Q6PIH0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: May 18, 2010
Last modified: May 25, 2022
This is version 127 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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