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Protein

NXPE family member 1

Gene

NXPE1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
NXPE family member 1
Alternative name(s):
Protein FAM55A
Gene namesi
Name:NXPE1
Synonyms:FAM55A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000095110.7
HGNCiHGNC:28527 NXPE1
neXtProtiNX_Q8N323

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi120400
OpenTargetsiENSG00000095110
PharmGKBiPA134910690

Polymorphism and mutation databases

DMDMi160014059

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000030793022 – 547NXPE family member 1Add BLAST526

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi39N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi211N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8N323
PeptideAtlasiQ8N323
PRIDEiQ8N323
ProteomicsDBi71755
71756 [Q8N323-2]

PTM databases

iPTMnetiQ8N323
PhosphoSitePlusiQ8N323

Expressioni

Gene expression databases

BgeeiENSG00000095110
ExpressionAtlasiQ8N323 baseline and differential
GenevisibleiQ8N323 HS

Organism-specific databases

HPAiHPA049133

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000251921

Structurei

3D structure databases

ProteinModelPortaliQ8N323
SMRiQ8N323
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NXPE family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IF0E Eukaryota
ENOG410YBMF LUCA
GeneTreeiENSGT00530000062893
HOGENOMiHOG000048706
HOVERGENiHBG004824
InParanoidiQ8N323
OMAiPDHVIGN
OrthoDBiEOG091G05H8
PhylomeDBiQ8N323
TreeFamiTF329555

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
IPR026845 NXPH/NXPE
PfamiView protein in Pfam
PF06312 Neurexophilin, 1 hit
SUPFAMiSSF81296 SSF81296, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N323-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSSNTMLQKT LLILISFSVV TWMIFIISQN FTKLWSALNL SISVHYWNNS
60 70 80 90 100
AKSLFPKTSL IPLKPLTETE LRIKEIIEKL DQQIPPRPFT HVNTTTSATH
110 120 130 140 150
STATILNPRD TYCRGDQLDI LLEVRDHLGQ RKQYGGDFLR ARMSSPALTA
160 170 180 190 200
GASGKVMDFN NGTYLVSFTL FWEGQVSLSL LLIHPSEGAS ALWRARNQGY
210 220 230 240 250
DKIIFKGKFV NGTSHVFTEC GLTLNSNAEL CEYLDDRDQE AFYCMKPQHM
260 270 280 290 300
PCEALTYMTT RNREVSYLTD KENSLFHRSK VGVEMMKDRK HIDVTNCNKR
310 320 330 340 350
EKIEETCQVG MKPPVPGGYT LQGKWITTFC NQVQLDTIKI NGCLKGKLIY
360 370 380 390 400
LLGDSTLRQW IYYFPKVVKT LKFFDLHETG IFKKHLLLDA ERHTQIQWKK
410 420 430 440 450
HSYPFVTFQL YSLIDHDYIP REIDRLSGDK NTAIVITFGQ HFRPFPIDIF
460 470 480 490 500
IRRAIGVQKA IERLFLRSPA TKVIIKTENI REMHIETERF GDFHGYIHYL
510 520 530 540
IMKDIFKDLN VGIIDAWDMT IAYGTDTIHP PDHVIGNQIN MFLNYIC
Length:547
Mass (Da):63,178
Last modified:October 23, 2007 - v2
Checksum:iE4BA67FFD78F94AA
GO
Isoform 2 (identifier: Q8N323-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-142: Missing.

Show »
Length:405
Mass (Da):46,866
Checksum:iBD8B6D93A038BD6E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti491G → V in AAH29049 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_036712353G → R. Corresponds to variant dbSNP:rs10891692Ensembl.1
Natural variantiVAR_036713423I → T. Corresponds to variant dbSNP:rs34993124Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0288721 – 142Missing in isoform 2. 1 PublicationAdd BLAST142

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC020549 Genomic DNA No translation available.
EF444977 Genomic DNA Translation: ACA05991.1
CH471065 Genomic DNA Translation: EAW67252.1
BC029049 mRNA Translation: AAH29049.1
CCDSiCCDS8372.1 [Q8N323-2]
RefSeqiNP_689528.2, NM_152315.3 [Q8N323-2]
XP_011540896.1, XM_011542594.2 [Q8N323-1]
XP_011540897.1, XM_011542595.2 [Q8N323-1]
XP_011540898.1, XM_011542596.2 [Q8N323-1]
XP_011540899.1, XM_011542597.2 [Q8N323-1]
XP_011540900.1, XM_011542598.2 [Q8N323-1]
XP_011540901.1, XM_011542599.2 [Q8N323-1]
UniGeneiHs.550126
Hs.721328
Hs.735553

Genome annotation databases

EnsembliENST00000251921; ENSP00000251921; ENSG00000095110 [Q8N323-2]
ENST00000424269; ENSP00000411690; ENSG00000095110 [Q8N323-1]
ENST00000534921; ENSP00000439503; ENSG00000095110 [Q8N323-1]
GeneIDi120400
KEGGihsa:120400
UCSCiuc001ppa.5 human [Q8N323-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiNXPE1_HUMAN
AccessioniPrimary (citable) accession number: Q8N323
Secondary accession number(s): B0YJ13
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: October 23, 2007
Last modified: June 20, 2018
This is version 104 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

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