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Entry version 117 (10 Apr 2019)
Sequence version 3 (11 Jan 2011)
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Protein

Mucin-20

Gene

MUC20

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May regulate MET signaling cascade. Seems to decrease hepatocyte growth factor (HGF)-induced transient MAPK activation. Blocks GRB2 recruitment to MET thus suppressing the GRB2-RAS pathway. Inhibits HGF-induced proliferation of MMP1 and MMP9 expression.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-5083625 Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC)
R-HSA-5083632 Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)
R-HSA-5083636 Defective GALNT12 causes colorectal cancer 1 (CRCS1)
R-HSA-5621480 Dectin-2 family
R-HSA-8851805 MET activates RAS signaling
R-HSA-913709 O-linked glycosylation of mucins
R-HSA-977068 Termination of O-glycan biosynthesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Mucin-20
Short name:
MUC-20
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MUC20
Synonyms:KIAA1359
ORF Names:UNQ2782/PRO7170
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000176945.16

Human Gene Nomenclature Database

More...
HGNCi
HGNC:23282 MUC20

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
610360 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8N307

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell membrane, Cell projection, Membrane, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
200958

Open Targets

More...
OpenTargetsi
ENSG00000176945

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134939730

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MUC20

Domain mapping of disease mutations (DMDM)

More...
DMDMi
317373415

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 25Sequence analysisAdd BLAST25
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000031746926 – 709Mucin-20Add BLAST684

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi423N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi616N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi622N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q8N307

PeptideAtlas

More...
PeptideAtlasi
Q8N307

PRoteomics IDEntifications database

More...
PRIDEi
Q8N307

ProteomicsDB human proteome resource

More...
ProteomicsDBi
71749
71750 [Q8N307-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8N307

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8N307

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in kidney, moderately in placenta, lung, prostate, liver, and digestive system. In the kidney, localized in the proximal tubules but not in the glomerulus or distal tubules. Detected in most of the male urogenital tract epithelia, with the exception of epididymis.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000176945 Expressed in 87 organ(s), highest expression level in right uterine tube

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q8N307 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8N307 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA042249

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with MET; oligomerization increases affinity for MET.1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
128360, 24 interactors

Protein interaction database and analysis system

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IntActi
Q8N307, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000414350

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q8N307

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati173 – 19211 PublicationAdd BLAST20
Repeati193 – 21121 PublicationAdd BLAST19
Repeati212 – 23031 PublicationAdd BLAST19
Repeati231 – 24941 PublicationAdd BLAST19
Repeati250 – 26851 PublicationAdd BLAST19
Repeati269 – 28761 PublicationAdd BLAST19
Repeati288 – 30671 PublicationAdd BLAST19
Repeati307 – 32581 PublicationAdd BLAST19
Repeati326 – 34491 PublicationAdd BLAST19
Repeati345 – 363101 PublicationAdd BLAST19
Repeati364 – 382111 PublicationAdd BLAST19
Repeati383 – 40012; approximate1 PublicationAdd BLAST18

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni173 – 40012 X 20 AA approximate tandem repeats of S-S-E-S-S-A-S-S-D-S-P-H-P-V-I-T-P-S-R-AAdd BLAST228
Regioni450 – 656Involved in oligomerizationAdd BLAST207
Regioni657 – 709Interaction with MET1 PublicationAdd BLAST53

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi173 – 389Ser-richAdd BLAST217
Compositional biasi585 – 652Thr-richAdd BLAST68

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IVUU Eukaryota
ENOG4111Y2D LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00730000111453

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG108160

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q8N307

KEGG Orthology (KO)

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KOi
K22021

Database of Orthologous Groups

More...
OrthoDBi
1004544at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8N307

TreeFam database of animal gene trees

More...
TreeFami
TF338458

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR034551 MUC20

The PANTHER Classification System

More...
PANTHERi
PTHR37358 PTHR37358, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 15 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8N307-1) [UniParc]FASTAAdd to basket
Also known as: hMUC20-L

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGCLWGLALP LFFFCWEVGV SGSSAGPSTR RADTAMTTDD TEVPAMTLAP
60 70 80 90 100
GHAALETQTL SAETSSRAST PAGPIPEAET RGAKRISPAR ETRSFTKTSP
110 120 130 140 150
NFMVLIATSV ETSAASGSPE GAGMTTVQTI TGSDPREAIF DTLCTDDSSE
160 170 180 190 200
EAKTLTMDIL TLAHTSTEAK GLSSESSASS DSPHPVITPS RASESSASSD
210 220 230 240 250
GPHPVITPSR ASESSASSDG PHPVITPSRA SESSASSDGP HPVITPSRAS
260 270 280 290 300
ESSASSDGPH PVITPSRASE SSASSDGPHP VITPSRASES SASSDGPHPV
310 320 330 340 350
ITPSRASESS ASSDGPHPVI TPSRASESSA SSDGPHPVIT PSRASESSAS
360 370 380 390 400
SDGLHPVITP SRASESSASS DGPHPVITPS RASESSASSD GPHPVITPSW
410 420 430 440 450
SPGSDVTLLA EALVTVTNIE VINCSITEIE TTTSSIPGAS DTDLIPTEGV
460 470 480 490 500
KASSTSDPPA LPDSTEAKPH ITEVTASAET LSTAGTTESA APDATVGTPL
510 520 530 540 550
PTNSATEREV TAPGATTLSG ALVTVSRNPL EETSALSVET PSYVKVSGAA
560 570 580 590 600
PVSIEAGSAV GKTTSFAGSS ASSYSPSEAA LKNFTPSETP TMDIATKGPF
610 620 630 640 650
PTSRDPLPSV PPTTTNSSRG TNSTLAKITT SAKTTMKPPT ATPTTARTRP
660 670 680 690 700
TTDVSAGENG GFLLLRLSVA SPEDLTDPRV AERLMQQLHR ELHAHAPHFQ

VSLLRVRRG
Length:709
Mass (Da):71,982
Last modified:January 11, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDD344A6014D39172
GO
Isoform 2 (identifier: Q8N307-3) [UniParc]FASTAAdd to basket
Also known as: hMUC20-S

The sequence of this isoform differs from the canonical sequence as follows:
     1-35: Missing.

Show »
Length:674
Mass (Da):68,308
Checksum:i2834A68A1250F5E1
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 15 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PH32E9PH32_HUMAN
Mucin-20
MUC20
538Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JJE7C9JJE7_HUMAN
Mucin-20
MUC20
723Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JR26A0A0G2JR26_HUMAN
Mucin-20
MUC20
535Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JN31A0A0G2JN31_HUMAN
Mucin-20
MUC20
555Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JSE2A0A0G2JSE2_HUMAN
Mucin-20
MUC20
538Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JRM4A0A0G2JRM4_HUMAN
Mucin-20
MUC20
549Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JRT2A0A0G2JRT2_HUMAN
Mucin-20
MUC20
569Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JRI9A0A0G2JRI9_HUMAN
Mucin-20
MUC20
552Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C102H7C102_HUMAN
Mucin-20
MUC20
128Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JQF3A0A0G2JQF3_HUMAN
Mucin-20
MUC20
127Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAQ88814 differs from that shown. Reason: Frameshift at position 638.Curated
The sequence BAA92597 differs from that shown. Dubious isoform. Probable cloning artifact.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti75I → V in AAH29267 (PubMed:15489334).Curated1
Sequence conflicti136R → E in BAD06718 (PubMed:14565953).Curated1
Sequence conflicti136R → E in BAD06720 (PubMed:14565953).Curated1
Sequence conflicti136R → E in AAQ88814 (PubMed:12975309).Curated1
Sequence conflicti136R → E in BAB55035 (PubMed:14702039).Curated1
Sequence conflicti136R → E in AAH29267 (PubMed:15489334).Curated1
Sequence conflicti136R → E in AAH44243 (PubMed:15489334).Curated1
Sequence conflicti182S → G in BAD06718 (PubMed:14565953).Curated1
Sequence conflicti182S → G in BAD06720 (PubMed:14565953).Curated1
Sequence conflicti182S → G in AAQ88814 (PubMed:12975309).Curated1
Sequence conflicti182S → G in BAB55035 (PubMed:14702039).Curated1
Sequence conflicti182S → G in AAH29267 (PubMed:15489334).Curated1
Sequence conflicti182S → G in AAH44243 (PubMed:15489334).Curated1
Sequence conflicti221P → L in BAA92597 (PubMed:10718198).Curated1
Sequence conflicti407T → A in BAB55035 (PubMed:14702039).Curated1
Sequence conflicti433T → A in BAC11428 (PubMed:14702039).Curated1
Sequence conflicti444L → P in AAH29267 (PubMed:15489334).Curated1
Sequence conflicti493D → H in BAD06718 (PubMed:14565953).Curated1
Sequence conflicti493D → H in BAD06720 (PubMed:14565953).Curated1
Sequence conflicti493D → H in AAQ88814 (PubMed:12975309).Curated1
Sequence conflicti493D → H in BAC11428 (PubMed:14702039).Curated1
Sequence conflicti493D → H in AAH44243 (PubMed:15489334).Curated1
Sequence conflicti496V → I in AAH29267 (PubMed:15489334).Curated1
Sequence conflicti505 – 506AT → TI in AAH29267 (PubMed:15489334).Curated2
Sequence conflicti523 – 527VTVSR → ATG in AAH29267 (PubMed:15489334).Curated5
Sequence conflicti592M → T in AAH29267 (PubMed:15489334).Curated1
Sequence conflicti654V → M in AAH29267 (PubMed:15489334).Curated1

<p>This subsection of the ‘Sequence’ section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement_in_disease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

The region encoding the tandem repeats is highly polymorphic. Divergence of the number of tandem repeats was seen in different cDNA libraries.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0385363C → S. Corresponds to variant dbSNP:rs7627924Ensembl.1
Natural variantiVAR_03853718V → G. Corresponds to variant dbSNP:rs1811139Ensembl.1
Natural variantiVAR_054139130 – 376Missing . Add BLAST247
Natural variantiVAR_054140184 – 354Missing 4 PublicationsAdd BLAST171
Natural variantiVAR_054141203 – 354Missing . Add BLAST152
Natural variantiVAR_054142241 – 354Missing 2 PublicationsAdd BLAST114
Natural variantiVAR_038538442T → I4 PublicationsCorresponds to variant dbSNP:rs2550232Ensembl.1
Natural variantiVAR_054143483 – 533Missing 1 PublicationAdd BLAST51
Natural variantiVAR_056641514G → R. Corresponds to variant dbSNP:rs3828410Ensembl.1
Natural variantiVAR_038539590P → L1 PublicationCorresponds to variant dbSNP:rs3828408Ensembl.1
Natural variantiVAR_038540666R → W. Corresponds to variant dbSNP:rs11923495Ensembl.1
Natural variantiVAR_038541671S → C. Corresponds to variant dbSNP:rs3762739Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0309801 – 35Missing in isoform 2. 1 PublicationAdd BLAST35

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB098731 mRNA Translation: BAD06718.1
AB098733 Genomic DNA Translation: BAD06720.1
AY358449 mRNA Translation: AAQ88814.1 Frameshift.
AK027314 mRNA Translation: BAB55035.1
AK075138 mRNA Translation: BAC11428.1
AC069513 Genomic DNA No translation available.
BC029267 mRNA Translation: AAH29267.1
BC044243 mRNA Translation: AAH44243.1
AB037780 mRNA Translation: BAA92597.1 Sequence problems.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS63877.1 [Q8N307-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001269435.1, NM_001282506.1 [Q8N307-1]
NP_001278762.1, NM_001291833.1
NP_065841.1, NM_020790.1
NP_689886.3, NM_152673.3

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.308992

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000445522; ENSP00000405629; ENSG00000176945 [Q8N307-3]
ENST00000447234; ENSP00000414350; ENSG00000176945 [Q8N307-1]
ENST00000610415; ENSP00000479947; ENSG00000278114 [Q8N307-1]
ENST00000615394; ENSP00000483878; ENSG00000276583 [Q8N307-1]
ENST00000620530; ENSP00000479182; ENSG00000275501 [Q8N307-1]
ENST00000625274; ENSP00000485837; ENSG00000278114 [Q8N307-3]
ENST00000627739; ENSP00000485855; ENSG00000276583 [Q8N307-3]
ENST00000630334; ENSP00000485921; ENSG00000275501 [Q8N307-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
200958

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:200958

UCSC genome browser

More...
UCSCi
uc032soi.2 human [Q8N307-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Mucin database

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB098731 mRNA Translation: BAD06718.1
AB098733 Genomic DNA Translation: BAD06720.1
AY358449 mRNA Translation: AAQ88814.1 Frameshift.
AK027314 mRNA Translation: BAB55035.1
AK075138 mRNA Translation: BAC11428.1
AC069513 Genomic DNA No translation available.
BC029267 mRNA Translation: AAH29267.1
BC044243 mRNA Translation: AAH44243.1
AB037780 mRNA Translation: BAA92597.1 Sequence problems.
CCDSiCCDS63877.1 [Q8N307-1]
RefSeqiNP_001269435.1, NM_001282506.1 [Q8N307-1]
NP_001278762.1, NM_001291833.1
NP_065841.1, NM_020790.1
NP_689886.3, NM_152673.3
UniGeneiHs.308992

3D structure databases

ProteinModelPortaliQ8N307
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128360, 24 interactors
IntActiQ8N307, 2 interactors
STRINGi9606.ENSP00000414350

PTM databases

iPTMnetiQ8N307
PhosphoSitePlusiQ8N307

Polymorphism and mutation databases

BioMutaiMUC20
DMDMi317373415

Proteomic databases

PaxDbiQ8N307
PeptideAtlasiQ8N307
PRIDEiQ8N307
ProteomicsDBi71749
71750 [Q8N307-3]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
200958
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000445522; ENSP00000405629; ENSG00000176945 [Q8N307-3]
ENST00000447234; ENSP00000414350; ENSG00000176945 [Q8N307-1]
ENST00000610415; ENSP00000479947; ENSG00000278114 [Q8N307-1]
ENST00000615394; ENSP00000483878; ENSG00000276583 [Q8N307-1]
ENST00000620530; ENSP00000479182; ENSG00000275501 [Q8N307-1]
ENST00000625274; ENSP00000485837; ENSG00000278114 [Q8N307-3]
ENST00000627739; ENSP00000485855; ENSG00000276583 [Q8N307-3]
ENST00000630334; ENSP00000485921; ENSG00000275501 [Q8N307-3]
GeneIDi200958
KEGGihsa:200958
UCSCiuc032soi.2 human [Q8N307-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
200958
DisGeNETi200958
EuPathDBiHostDB:ENSG00000176945.16

GeneCards: human genes, protein and diseases

More...
GeneCardsi
MUC20
HGNCiHGNC:23282 MUC20
HPAiHPA042249
MIMi610360 gene
neXtProtiNX_Q8N307
OpenTargetsiENSG00000176945
PharmGKBiPA134939730

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IVUU Eukaryota
ENOG4111Y2D LUCA
GeneTreeiENSGT00730000111453
HOVERGENiHBG108160
InParanoidiQ8N307
KOiK22021
OrthoDBi1004544at2759
PhylomeDBiQ8N307
TreeFamiTF338458

Enzyme and pathway databases

ReactomeiR-HSA-5083625 Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC)
R-HSA-5083632 Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)
R-HSA-5083636 Defective GALNT12 causes colorectal cancer 1 (CRCS1)
R-HSA-5621480 Dectin-2 family
R-HSA-8851805 MET activates RAS signaling
R-HSA-913709 O-linked glycosylation of mucins
R-HSA-977068 Termination of O-glycan biosynthesis

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
MUC20

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
200958

Protein Ontology

More...
PROi
PR:Q8N307

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000176945 Expressed in 87 organ(s), highest expression level in right uterine tube
ExpressionAtlasiQ8N307 baseline and differential
GenevisibleiQ8N307 HS

Family and domain databases

InterProiView protein in InterPro
IPR034551 MUC20
PANTHERiPTHR37358 PTHR37358, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMUC20_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8N307
Secondary accession number(s): Q6UX97
, Q76I83, Q76I85, Q86ST8, Q8NBY6, Q96KA1, Q9P2I8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: January 11, 2011
Last modified: April 10, 2019
This is version 117 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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