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Entry version 119 (07 Apr 2021)
Sequence version 1 (01 Oct 2002)
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Protein

Small vasohibin-binding protein

Gene

SVBP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enhances the tyrosine carboxypeptidase activity of VASH1 and VASH2, thereby promoting the removal of the C-terminal tyrosine residue of alpha-tubulin (PubMed:29146869, PubMed:31270470, PubMed:31235911, PubMed:31324789, PubMed:31171830, PubMed:31235910). This activity is critical for spindle function and accurate chromosome segregation during mitosis since microtuble detyronisation regulates mitotic spindle length and postioning (PubMed:31171830). Also required to enhance the solubility and secretion of VASH1 and VASH2 (PubMed:20736312, PubMed:27879017, PubMed:30607023). Plays a role in axon and excitatory synapse formation (PubMed:31235911).9 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • microtubule binding Source: UniProtKB

GO - Biological processi

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q8N300

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-8955332, Carboxyterminal post-translational modifications of tubulin

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Small vasohibin-binding protein1 Publication
Alternative name(s):
Coiled coil domain-containing protein 23Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SVBP1 PublicationImported
Synonyms:CCDC23Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:29204, SVBP

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
617853, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8N300

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000177868.11

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Neurodevelopmental disorder with ataxia, hypotonia, and microcephaly (NEDAHM)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive neurodevelopmental disorder characterized by intellectual disability, microcephaly, ataxia, and muscular hypotonia.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_08302728 – 66Missing in NEDAHM; probably not expressed at protein level; impaired VASH1 secretion and solubility. 1 PublicationAdd BLAST39

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi32K → E: Decreased VASH1 tyrosine carboxypeptidase activity on alpha-tubulin. 1 Publication1
Mutagenesisi34R → E: No effect on VASH1 tyrosine carboxypeptidase activity on alpha-tubulin. 1 Publication1
Mutagenesisi35 – 36QR → AA: Strongly decreased interaction with VASH1. Decreased VASH1 tyrosine carboxypeptidase activity on alpha-tubulin. Strongly decreased interaction with VASH2. Decreased VASH2 tyrosine carboxypeptidase activity on alpha-tubulin. 2 Publications2
Mutagenesisi35Q → A: Decreased VASH1 tyrosine carboxypeptidase activity on alpha-tubulin. 1 Publication1
Mutagenesisi36R → E: Decreased VASH1 tyrosine carboxypeptidase activity on alpha-tubulin. 1 Publication1
Mutagenesisi39 – 42IYAL → EALE: Strongly decreased VASH1 tyrosine carboxypeptidase activity on alpha-tubulin. 1 Publication4
Mutagenesisi39 – 40IY → AA: Strongly decreased interaction with VASH1. Decreased VASH1 tyrosine carboxypeptidase activity on alpha-tubulin. Disrupted interaction with VASH2. Decreased VASH2 tyrosine carboxypeptidase activity on alpha-tubulin. 2 Publications2
Mutagenesisi39I → E: No effect on VASH1 tyrosine carboxypeptidase activity on alpha-tubulin. 1 Publication1
Mutagenesisi40Y → F: No effect on VASH1 tyrosine carboxypeptidase activity on alpha-tubulin. 1 Publication1
Mutagenesisi42 – 43LN → AA: Decreased interaction with VASH1. Almost abolished VASH1 tyrosine carboxypeptidase activity on alpha-tubulin. Strongly decreased interaction with VASH2. Decreased VASH2 tyrosine carboxypeptidase activity on alpha-tubulin. 2 Publications2
Mutagenesisi42L → E: No effect on VASH1 tyrosine carboxypeptidase activity on alpha-tubulin. 1 Publication1
Mutagenesisi43N → A: Decreased VASH1 tyrosine carboxypeptidase activity on alpha-tubulin. 1 Publication1
Mutagenesisi45 – 46VM → AA: Slightly decreased interaction with VASH1. Decreased VASH1 tyrosine carboxypeptidase activity on alpha-tubulin. No effect on interaction with VASH2. No effect on VASH2 tyrosine carboxypeptidase activity on alpha-tubulin. 2 Publications2
Mutagenesisi47T → D: Decreased VASH1 tyrosine carboxypeptidase activity on alpha-tubulin. 1 Publication1
Mutagenesisi50 – 54EQQQF → AQQQA: No effect on interaction with VASH2. No effect on VASH2 tyrosine carboxypeptidase activity on alpha-tubulin. 1 Publication5

Keywords - Diseasei

Disease variant, Mental retardation

Organism-specific databases

DisGeNET

More...
DisGeNETi
374969

MalaCards human disease database

More...
MalaCardsi
SVBP
MIMi618569, phenotype

Open Targets

More...
OpenTargetsi
ENSG00000177868

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
528084, Non-specific syndromic intellectual disability

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142672181

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8N300, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SVBP

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002336631 – 66Small vasohibin-binding proteinAdd BLAST66

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8N300

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8N300

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8N300

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8N300

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8N300

PeptideAtlas

More...
PeptideAtlasi
Q8N300

PRoteomics IDEntifications database

More...
PRIDEi
Q8N300

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
71745

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8N300

MetOSite database of methionine sulfoxide sites

More...
MetOSitei
Q8N300

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8N300

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000177868, Expressed in cortical plate and 206 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8N300, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000177868, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with VASH1 and VASH2.

8 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
131942, 1 interactor

Protein interaction database and analysis system

More...
IntActi
Q8N300, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000361599

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8N300, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

166
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q8N300

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili5 – 52Sequence analysisAdd BLAST48

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SVBP family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502S99I, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000006113

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_2830589_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8N300

Identification of Orthologs from Complete Genome Data

More...
OMAi
AMDPPAR

Database of Orthologous Groups

More...
OrthoDBi
1606567at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8N300

TreeFam database of animal gene trees

More...
TreeFami
TF344015

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR031378, SVBP

The PANTHER Classification System

More...
PANTHERi
PTHR34762, PTHR34762, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15674, CCDC23, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8N300-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDPPARKEKT KVKESVSRVE KAKQKSAQQE LKQRQRAEIY ALNRVMTELE
60
QQQFDEFCKQ MQPPGE
Length:66
Mass (Da):7,808
Last modified:October 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9B128ABBF6ECD858
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_08302728 – 66Missing in NEDAHM; probably not expressed at protein level; impaired VASH1 secretion and solubility. 1 PublicationAdd BLAST39

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK291356 mRNA Translation: BAF84045.1
AC098484 Genomic DNA No translation available.
AL512353 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX07134.1
CH471059 Genomic DNA Translation: EAX07135.1
BC029427 mRNA Translation: AAH29427.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS474.1

NCBI Reference Sequences

More...
RefSeqi
NP_955374.1, NM_199342.3
XP_016856715.1, XM_017001226.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000372521; ENSP00000361599; ENSG00000177868
ENST00000372522; ENSP00000361600; ENSG00000177868

Database of genes from NCBI RefSeq genomes

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GeneIDi
374969

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:374969

UCSC genome browser

More...
UCSCi
uc001cib.3, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK291356 mRNA Translation: BAF84045.1
AC098484 Genomic DNA No translation available.
AL512353 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX07134.1
CH471059 Genomic DNA Translation: EAX07135.1
BC029427 mRNA Translation: AAH29427.1
CCDSiCCDS474.1
RefSeqiNP_955374.1, NM_199342.3
XP_016856715.1, XM_017001226.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6J4OX-ray2.30B1-66[»]
6J4PX-ray1.60B1-66[»]
6J4QX-ray2.70B/D/G/K1-66[»]
6J4SX-ray2.80B1-66[»]
6J4UX-ray2.00B1-66[»]
6J4VX-ray2.10B1-66[»]
6J7BX-ray1.62B1-52[»]
6J8FX-ray2.28A3-48[»]
6J8NX-ray1.95A/C1-66[»]
6J8OX-ray1.85A3-49[»]
6J91X-ray3.50A1-66[»]
6J9HX-ray2.31A/C1-66[»]
6JZCX-ray2.20C/D1-66[»]
6JZDX-ray2.48B1-66[»]
6JZEX-ray2.51B1-66[»]
6K81X-ray2.28B1-66[»]
6LPGX-ray2.30B2-66[»]
6NVQX-ray2.10B1-66[»]
6OCFX-ray2.10B18-66[»]
6OCGX-ray1.83B26-51[»]
6OCHX-ray2.00B/D25-52[»]
6QBYX-ray2.09B/D1-66[»]
6WSLelectron microscopy3.10D/H1-66[»]
SMRiQ8N300
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi131942, 1 interactor
IntActiQ8N300, 1 interactor
STRINGi9606.ENSP00000361599

PTM databases

iPTMnetiQ8N300
MetOSiteiQ8N300
PhosphoSitePlusiQ8N300

Genetic variation databases

BioMutaiSVBP

Proteomic databases

EPDiQ8N300
jPOSTiQ8N300
MassIVEiQ8N300
MaxQBiQ8N300
PaxDbiQ8N300
PeptideAtlasiQ8N300
PRIDEiQ8N300
ProteomicsDBi71745

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
2034, 57 antibodies

Genome annotation databases

EnsembliENST00000372521; ENSP00000361599; ENSG00000177868
ENST00000372522; ENSP00000361600; ENSG00000177868
GeneIDi374969
KEGGihsa:374969
UCSCiuc001cib.3, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
374969
DisGeNETi374969

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SVBP
HGNCiHGNC:29204, SVBP
HPAiENSG00000177868, Low tissue specificity
MalaCardsiSVBP
MIMi617853, gene
618569, phenotype
neXtProtiNX_Q8N300
OpenTargetsiENSG00000177868
Orphaneti528084, Non-specific syndromic intellectual disability
PharmGKBiPA142672181
VEuPathDBiHostDB:ENSG00000177868.11

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502S99I, Eukaryota
GeneTreeiENSGT00390000006113
HOGENOMiCLU_2830589_0_0_1
InParanoidiQ8N300
OMAiAMDPPAR
OrthoDBi1606567at2759
PhylomeDBiQ8N300
TreeFamiTF344015

Enzyme and pathway databases

PathwayCommonsiQ8N300
ReactomeiR-HSA-8955332, Carboxyterminal post-translational modifications of tubulin

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
374969, 148 hits in 979 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
SVBP, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
374969
PharosiQ8N300, Tdark

Protein Ontology

More...
PROi
PR:Q8N300
RNActiQ8N300, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000177868, Expressed in cortical plate and 206 other tissues
GenevisibleiQ8N300, HS

Family and domain databases

InterProiView protein in InterPro
IPR031378, SVBP
PANTHERiPTHR34762, PTHR34762, 1 hit
PfamiView protein in Pfam
PF15674, CCDC23, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSVBP_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8N300
Secondary accession number(s): A8K5P1, D3DPW7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: October 1, 2002
Last modified: April 7, 2021
This is version 119 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families
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