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Protein

Small vasohibin-binding protein

Gene

SVBP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Enhances the solubility and secretion of VASH1 and prevents its ubiquitination. Also enhances secretion of VASH2.1 Publication

GO - Biological processi

  • negative regulation of endothelial cell migration Source: MGI
  • negative regulation of protein ubiquitination Source: MGI
  • protein secretion Source: MGI

Names & Taxonomyi

Protein namesi
Recommended name:
Small vasohibin-binding protein1 Publication
Alternative name(s):
Coiled coil domain-containing protein 23Imported
Gene namesi
Name:SVBP1 Publication
Synonyms:CCDC23Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000177868.11
HGNCiHGNC:29204 SVBP
MIMi617853 gene
neXtProtiNX_Q8N300

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi374969
OpenTargetsiENSG00000177868
PharmGKBiPA142672181

Polymorphism and mutation databases

BioMutaiCCDC23

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002336631 – 66Small vasohibin-binding proteinAdd BLAST66

Proteomic databases

EPDiQ8N300
MaxQBiQ8N300
PaxDbiQ8N300
PeptideAtlasiQ8N300
PRIDEiQ8N300
ProteomicsDBi71745

PTM databases

iPTMnetiQ8N300
PhosphoSitePlusiQ8N300

Expressioni

Gene expression databases

BgeeiENSG00000177868
CleanExiHS_CCDC23
GenevisibleiQ8N300 HS

Organism-specific databases

HPAiHPA008507

Interactioni

Subunit structurei

Interacts with VASH1 and VASH2.1 Publication

Protein-protein interaction databases

BioGridi131942, 1 interactor
STRINGi9606.ENSP00000361599

Structurei

3D structure databases

ProteinModelPortaliQ8N300
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili5 – 52Sequence analysisAdd BLAST48

Sequence similaritiesi

Belongs to the SVBP family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410J1TQ Eukaryota
ENOG410Y1K2 LUCA
GeneTreeiENSGT00390000006113
HOGENOMiHOG000231086
HOVERGENiHBG080111
InParanoidiQ8N300
OMAiCRKDKPK
OrthoDBiEOG091G15ZE
PhylomeDBiQ8N300
TreeFamiTF344015

Family and domain databases

InterProiView protein in InterPro
IPR031378 SVBP
PANTHERiPTHR34762 PTHR34762, 1 hit
PfamiView protein in Pfam
PF15674 CCDC23, 1 hit

Sequencei

Sequence statusi: Complete.

Q8N300-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPPARKEKT KVKESVSRVE KAKQKSAQQE LKQRQRAEIY ALNRVMTELE
60
QQQFDEFCKQ MQPPGE
Length:66
Mass (Da):7,808
Last modified:October 1, 2002 - v1
Checksum:i9B128ABBF6ECD858
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK291356 mRNA Translation: BAF84045.1
AC098484 Genomic DNA No translation available.
AL512353 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX07134.1
CH471059 Genomic DNA Translation: EAX07135.1
BC029427 mRNA Translation: AAH29427.1
CCDSiCCDS474.1
RefSeqiNP_955374.1, NM_199342.3
XP_016856715.1, XM_017001226.1
UniGeneiHs.113919

Genome annotation databases

EnsembliENST00000372521; ENSP00000361599; ENSG00000177868
ENST00000372522; ENSP00000361600; ENSG00000177868
GeneIDi374969
KEGGihsa:374969
UCSCiuc001cib.3 human

Similar proteinsi

Entry informationi

Entry nameiSVBP_HUMAN
AccessioniPrimary (citable) accession number: Q8N300
Secondary accession number(s): A8K5P1, D3DPW7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: October 1, 2002
Last modified: June 20, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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