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Entry version 132 (18 Sep 2019)
Sequence version 3 (11 Jan 2011)
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Protein

Iporin

Gene

RUSC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Iporin
Alternative name(s):
Interacting protein of Rab1
RUN and SH3 domain-containing protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RUSC2
Synonyms:KIAA0375
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:23625 RUSC2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
611053 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8N2Y8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Mental retardation, autosomal recessive 61 (MRT61)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of mental retardation, a disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRT61 patients manifest delayed psychomotor development, moderate to severe intellectual disability, and variable dysmorphic facial features. Refractory seizures and brain abnormalities are present in severely affected patients.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_080461866 – 1516Missing in MRT61; unknown pathological significance. 1 PublicationAdd BLAST651
Natural variantiVAR_0804621318 – 1516Missing in MRT61; unknown pathological significance. 1 PublicationAdd BLAST199

Keywords - Diseasei

Disease mutation, Mental retardation

Organism-specific databases

DisGeNET

More...
DisGeNETi
9853

MalaCards human disease database

More...
MalaCardsi
RUSC2
MIMi617773 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000198853

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134956488

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
RUSC2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
317373513

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000975341 – 1516IporinAdd BLAST1516

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei536PhosphoserineCombined sources1
Modified residuei543PhosphoserineCombined sources1
Modified residuei559PhosphoserineCombined sources1
Modified residuei656PhosphoserineCombined sources1
Modified residuei781PhosphoserineCombined sources1
Modified residuei1368PhosphoserineCombined sources1
Modified residuei1380PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8N2Y8

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8N2Y8

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8N2Y8

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8N2Y8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8N2Y8

PeptideAtlas

More...
PeptideAtlasi
Q8N2Y8

PRoteomics IDEntifications database

More...
PRIDEi
Q8N2Y8

ProteomicsDB human proteome resource

More...
ProteomicsDBi
71741

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8N2Y8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8N2Y8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed, with highest levels in brain and testis.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000198853 Expressed in 197 organ(s), highest expression level in anterior cingulate cortex

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8N2Y8 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA021297

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with active RAB1A and RAB1B, and with GOLGA2.

1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
115187, 19 interactors

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...
ELMi
Q8N2Y8

Protein interaction database and analysis system

More...
IntActi
Q8N2Y8, 22 interactors

Molecular INTeraction database

More...
MINTi
Q8N2Y8

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000393922

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11516
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8N2Y8

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1031 – 1175RUNPROSITE-ProRule annotationAdd BLAST145
Domaini1447 – 1506SH3PROSITE-ProRule annotationAdd BLAST60

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1239 – 1249Poly-GluAdd BLAST11

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The RUN domain is required for the interaction with RAB1A and RAB1B.

Keywords - Domaini

SH3 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IFB8 Eukaryota
ENOG410XPGW LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00900000141033

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000133098

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8N2Y8

KEGG Orthology (KO)

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KOi
K23291

Identification of Orthologs from Complete Genome Data

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OMAi
HCRCSST

Database of Orthologous Groups

More...
OrthoDBi
373320at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8N2Y8

TreeFam database of animal gene trees

More...
TreeFami
TF332235

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004012 Run_dom
IPR037213 Run_dom_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02759 RUN, 1 hit
PF07653 SH3_2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00593 RUN, 1 hit
SM00326 SH3, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF140741 SSF140741, 1 hit
SSF50044 SSF50044, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50826 RUN, 1 hit
PS50002 SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8N2Y8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDSPPKLTGE TLIVHHIPLV HCQVPDRQCC GGAGGGGGST RPNPFCPPEL
60 70 80 90 100
GITQPDQDLG QADSLLFSSL HSTPGGTARS IDSTKSRSRD GRGPGAPKRH
110 120 130 140 150
NPFLLQEGVG EPGLGDLYDD SIGDSATQQS FHLHGTGQPN FHLSSFQLPP
160 170 180 190 200
SGPRVGRPWG TTRSRAGVVE GQEQEPVMTL DTQQCGTSHC CRPELEAETM
210 220 230 240 250
ELDECGGPGG SGSGGGASDT SGFSFDQEWK LSSDESPRNP GCSGSGDQHC
260 270 280 290 300
RCSSTSSQSE AADQSMGYVS DSSCNSSDGV LVTFSTLYNK MHGTPRANLN
310 320 330 340 350
SAPQSCSDSS FCSHSDPGAF YLDLQPSPFE SKMSYESHHP ESGGREGGYG
360 370 380 390 400
CPHASSPELD ANCNSYRPHC EPCPAVADLT ACFQSQARLV VATQNYYKLV
410 420 430 440 450
TCDLSSQSSP SPAGSSITSC SEEHTKISPP PGPGPDPGPS QPSEYYLFQK
460 470 480 490 500
PEVQPEEQEA VSSSTQAAAA VGPTVLEGQV YTNTSPPNLS TGRQRSRSYD
510 520 530 540 550
RSLQRSPPVR LGSLERMLSC PVRLSEGPAA MAGPGSPPRR VTSFAELAKG
560 570 580 590 600
RKKTGGSGSP PLRVSVGDSS QEFSPIQEAQ QDRGAPLDEG TCCSHSLPPM
610 620 630 640 650
PLGPGMDLLG PDPSPPWSTQ VCQGPHSSEM PPAGLRATGQ GPLAQLMDPG
660 670 680 690 700
PALPGSPANS HTQRDARARA DGGGTESRPV LRYSKEQRPT TLPIQPFVFQ
710 720 730 740 750
HHFPKQLAKA RALHSLSQLY SLSGCSRTQQ PAPLAAPAAQ VSVPAPSGEP
760 770 780 790 800
QASTPRATGR GARKAGSEPE TSRPSPLGSY SPIRSVGPFG PSTDSSASTS
810 820 830 840 850
CSPPPEQPTA TESLPPWSHS CPSAVRPATS QQPQKEDQKI LTLTEYRLHG
860 870 880 890 900
TGSLPPLGSW RSGLSRAESL ARGGGEGSMA TRPSNANHLS PQALKWREYR
910 920 930 940 950
RKNPLGPPGL SGSLDRRSQE ARLARRNPIF EFPGSLSAAS HLNCRLNGQA
960 970 980 990 1000
VKPLPLTCPD FQDPFSLTEK PPAEFCLSPD GSSEAISIDL LQKKGLVKAV
1010 1020 1030 1040 1050
NIAVDLIVAH FGTSRDPGVK AKLGNSSVSP NVGHLVLKYL CPAVRAVLED
1060 1070 1080 1090 1100
GLKAFVLDVI IGQRKNMPWS VVEASTQLGP STKVLHGLYN KVSQFPELTS
1110 1120 1130 1140 1150
HTMRFNAFIL GLLNIRSLEF WFNHLYNHED IIQTHYQPWG FLSAAHTVCP
1160 1170 1180 1190 1200
GLFEELLLLL QPLALLPFSL DLLFQHRLLQ SGQQQRQHKE LLRVSQDLLL
1210 1220 1230 1240 1250
SAHSTLQLAR ARGQEGPGDV DRAAQGERVK GVGASEGGEE EEEEEETEEV
1260 1270 1280 1290 1300
AEAAGGSGRA RWARGGQAGW WYQLMQSSQV YIDGSIEGSR FPRGSSNSSS
1310 1320 1330 1340 1350
EKKKGAGGGG PPQAPPPREG VVEGAEACPA SEEALGRERG WPFWMGSPPD
1360 1370 1380 1390 1400
SVLAELRRSR EREGPAASPA ENEEGASEPS PGGIKWGHLF GSRKAQREAR
1410 1420 1430 1440 1450
PTNRLPSDWL SLDKSMFQLV AQTVGSRREP EPKESLQEPH SPALPSSPPC
1460 1470 1480 1490 1500
EVQALCHHLA TGPGQLSFHK GDILRVLGRA GGDWLRCSRG PDSGLVPLAY
1510
VTLTPTPSPT PGSSQN
Length:1,516
Mass (Da):161,225
Last modified:January 11, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE96E1180A1E18CF8
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA20830 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03465373T → A3 PublicationsCorresponds to variant dbSNP:rs1535422Ensembl.1
Natural variantiVAR_034654654P → L. Corresponds to variant dbSNP:rs3750427Ensembl.1
Natural variantiVAR_080461866 – 1516Missing in MRT61; unknown pathological significance. 1 PublicationAdd BLAST651
Natural variantiVAR_0804621318 – 1516Missing in MRT61; unknown pathological significance. 1 PublicationAdd BLAST199

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB002373 mRNA Translation: BAA20830.2 Different initiation.
AL133476 Genomic DNA No translation available.
CH471071 Genomic DNA Translation: EAW58377.1
BC029647 mRNA Translation: AAH29647.1
BC064843 mRNA Translation: AAH64843.1
BC082245 mRNA Translation: AAH82245.1
BC132766 mRNA Translation: AAI32767.1
BC132770 mRNA Translation: AAI32771.1
BC146654 mRNA Translation: AAI46655.1
BC150262 mRNA Translation: AAI50263.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS35008.1

NCBI Reference Sequences

More...
RefSeqi
NP_001129471.1, NM_001135999.1
NP_055621.1, NM_014806.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000361226; ENSP00000355177; ENSG00000198853
ENST00000455600; ENSP00000393922; ENSG00000198853

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
9853

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:9853

UCSC genome browser

More...
UCSCi
uc003zww.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB002373 mRNA Translation: BAA20830.2 Different initiation.
AL133476 Genomic DNA No translation available.
CH471071 Genomic DNA Translation: EAW58377.1
BC029647 mRNA Translation: AAH29647.1
BC064843 mRNA Translation: AAH64843.1
BC082245 mRNA Translation: AAH82245.1
BC132766 mRNA Translation: AAI32767.1
BC132770 mRNA Translation: AAI32771.1
BC146654 mRNA Translation: AAI46655.1
BC150262 mRNA Translation: AAI50263.1
CCDSiCCDS35008.1
RefSeqiNP_001129471.1, NM_001135999.1
NP_055621.1, NM_014806.4

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6IF2X-ray2.40A983-1181[»]
SMRiQ8N2Y8
ModBaseiSearch...

Protein-protein interaction databases

BioGridi115187, 19 interactors
ELMiQ8N2Y8
IntActiQ8N2Y8, 22 interactors
MINTiQ8N2Y8
STRINGi9606.ENSP00000393922

PTM databases

iPTMnetiQ8N2Y8
PhosphoSitePlusiQ8N2Y8

Polymorphism and mutation databases

BioMutaiRUSC2
DMDMi317373513

Proteomic databases

EPDiQ8N2Y8
jPOSTiQ8N2Y8
MassIVEiQ8N2Y8
MaxQBiQ8N2Y8
PaxDbiQ8N2Y8
PeptideAtlasiQ8N2Y8
PRIDEiQ8N2Y8
ProteomicsDBi71741

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361226; ENSP00000355177; ENSG00000198853
ENST00000455600; ENSP00000393922; ENSG00000198853
GeneIDi9853
KEGGihsa:9853
UCSCiuc003zww.4 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
9853
DisGeNETi9853

GeneCards: human genes, protein and diseases

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GeneCardsi
RUSC2
HGNCiHGNC:23625 RUSC2
HPAiHPA021297
MalaCardsiRUSC2
MIMi611053 gene
617773 phenotype
neXtProtiNX_Q8N2Y8
OpenTargetsiENSG00000198853
PharmGKBiPA134956488

Human Unidentified Gene-Encoded large proteins database

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HUGEi
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GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410IFB8 Eukaryota
ENOG410XPGW LUCA
GeneTreeiENSGT00900000141033
HOGENOMiHOG000133098
InParanoidiQ8N2Y8
KOiK23291
OMAiHCRCSST
OrthoDBi373320at2759
PhylomeDBiQ8N2Y8
TreeFamiTF332235

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
RUSC2 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
9853

Pharos

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Pharosi
Q8N2Y8

Protein Ontology

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PROi
PR:Q8N2Y8

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000198853 Expressed in 197 organ(s), highest expression level in anterior cingulate cortex
GenevisibleiQ8N2Y8 HS

Family and domain databases

InterProiView protein in InterPro
IPR004012 Run_dom
IPR037213 Run_dom_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PfamiView protein in Pfam
PF02759 RUN, 1 hit
PF07653 SH3_2, 1 hit
SMARTiView protein in SMART
SM00593 RUN, 1 hit
SM00326 SH3, 1 hit
SUPFAMiSSF140741 SSF140741, 1 hit
SSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS50826 RUN, 1 hit
PS50002 SH3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRUSC2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8N2Y8
Secondary accession number(s): A2RU62
, A7E2A9, O15080, Q5W134, Q641Q6, Q6P1W7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: January 11, 2011
Last modified: September 18, 2019
This is version 132 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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